The network for 'branched chain amino acid metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

branched chain amino acid metabolic process

The chemical reactions and pathways involving amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
BAT1 Bat1p 0.945
LEU9 Leu9p 0.837
OAC1 Oac1p 0.689
ILV3 Ilv3p 0.667
ILV2 Ilv2p 0.331
MAE1 Mae1p 0.290
LEU1 Leu1p 0.237
ILV5 Ilv5p 0.232
ILV6 Ilv6p 0.206
ALD5 Ald5p 0.148
ARO9 Aro9p 0.128
URA2 Ura2p 0.124
LYS4 Lys4p 0.108
BAT2 Bat2p 0.107
LEU2 Leu2p 0.098
YDL157C hypothetical protein 0.083
ARF2 Arf2p 0.075
ARG8 Arg8p 0.070
GDH1 Gdh1p 0.059
DPS1 Dps1p 0.056
MDH1 Mdh1p 0.054
ARO4 Aro4p 0.051
LYS12 Lys12p 0.049
YLR179C hypothetical protein 0.047
LAT1 Lat1p 0.046
COX2 Cox2p 0.045
CHA1 Cha1p 0.045
BIO2 Bio2p 0.045
LEU4 Leu4p 0.044
HSP60 Hsp60p 0.043
YLR264C-A hypothetical protein 0.034
INM1 Inm1p 0.034
SRD1 Srd1p 0.033
ALD6 Ald6p 0.033
TOS4 Tos4p 0.033
IDP1 Idp1p 0.031
MER1 Mer1p 0.030
YAR068W hypothetical protein 0.029
ARP10 Arp10p 0.029
CIN2 Cin2p 0.029
YLR162W hypothetical protein 0.028
IMD2 Imd2p 0.027
GLT1 Glt1p 0.027
YOL038C-A hypothetical protein 0.026
CUP1-1 Cup1-1p 0.024
ARO3 Aro3p 0.024
NDE1 Nde1p 0.024
DCD1 Dcd1p 0.024
NSE5 Nse5p 0.023
ATP6 Atp6p 0.022
YAR066W hypothetical protein 0.022
DIC1 Dic1p 0.022
YBT1 Ybt1p 0.022
FIT2 Fit2p 0.022
SCM4 Scm4p 0.021
IDH1 Idh1p 0.021
YPR157W hypothetical protein 0.021
REE1 Ree1p 0.021
YLR042C hypothetical protein 0.021
AUA1 Aua1p 0.020
HPF1 Hpf1p 0.020
URA3 Ura3p 0.020
ZPS1 Zps1p 0.020
ACM1 Acm1p 0.020
GNA1 Gna1p 0.020
BSC1 Bsc1p 0.020
HXT3 Hxt3p 0.019
YBR013C hypothetical protein 0.019
YMC1 Ymc1p 0.019
YJL181W hypothetical protein 0.019
ENA5 Ena5p 0.019
SPL2 Spl2p 0.019
YMR122W-A hypothetical protein 0.018
DUG1 Dug1p 0.018
FMT1 Fmt1p 0.018
YOL013W-A hypothetical protein 0.018
CDC60 Cdc60p 0.018
JLP2 Jlp2p 0.018
FCY21 Fcy21p 0.018
HO Hop 0.018
TSC3 Tsc3p 0.017
SAM4 Sam4p 0.017
MF(ALPHA)2 Mf(alpha)2p 0.017
UPS3 Ups3p 0.017
YCH1 Ych1p 0.017
OPT2 Opt2p 0.016
CPD1 Cpd1p 0.016
SWC7 Swc7p 0.016
YJL160C hypothetical protein 0.016
ADH2 Adh2p 0.016
YIR035C hypothetical protein 0.016
YPR063C hypothetical protein 0.016
YLR040C hypothetical protein 0.016
ATO3 Ato3p 0.016
GLN1 Gln1p 0.016
YAL037C-A hypothetical protein 0.016
PTR2 Ptr2p 0.016
YAL064W hypothetical protein 0.015
LYS9 Lys9p 0.015
YPR096C hypothetical protein 0.015
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
ghrb growth hormone receptor b 0.950
aldh7a1 aldehyde dehydrogenase 7 family, member A1 0.673
ghra growth hormone receptor a 0.554
mdh1a malate dehydrogenase 1a, NAD (soluble) 0.486
ivd isovaleryl Coenzyme A dehydrogenase 0.416
gcm2 glial cells missing homolog 2 (Drosophila) 0.351
angptl2 angiopoietin-like 2 0.254
aldh6a1 aldehyde dehydrogenase 6 family, member A1 0.216
dlst dihydrolipoamide S-succinyltransferase 0.128
sdha succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 0.123
dhtkd1 dehydrogenase E1 and transketolase domain containing 1 0.121
gamt guanidinoacetate N-methyltransferase 0.092
bhmt betaine-homocysteine methyltransferase 0.092
zgc:64133 zgc:64133 0.092
ndufv1 NADH dehydrogenase (ubiquinone) flavoprotein 1 0.076
sucla2 succinate-CoA ligase, ADP-forming, beta subunit 0.068
deptor DEP domain containing MTOR-interacting protein 0.068
rbp4 retinol binding protein 4, plasma 0.065
mga MAX gene associated 0.054
ahcy S-adenosylhomocysteine hydrolase 0.051
gyg1 glycogenin 1 0.046
echs1 enoyl Coenzyme A hydratase, short chain, 1, mitochondrial 0.044
etfa electron-transfer-flavoprotein, alpha polypeptide 0.040
ucp1 uncoupling protein 1 0.038
pah phenylalanine hydroxylase 0.038
slc38a4 solute carrier family 38, member 4 0.036
aldob aldolase b, fructose-bisphosphate 0.035
pccb propionyl Coenzyme A carboxylase, beta polypeptide 0.032
zgc:56136 zgc:56136 0.030
timp2a tissue inhibitor of metalloproteinase 2a 0.028
LOC566708 FL cytokine receptor-like 0.024
mpdu1a mannose-P-dolichol utilization defect 1a 0.024
mcoln1 mucolipin 1 0.024
mut methylmalonyl Coenzyme A mutase 0.024
serpinc1 serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1 0.024
lmo7a LIM domain only 7a 0.022
foxi3a forkhead box I3a 0.022
lpar1 lysophosphatidic acid receptor 1 0.022
zgc:194131 zgc:194131 0.022
zgc:56518 zgc:56518 0.021
mat1a methionine adenosyltransferase I, alpha 0.020
pdhb pyruvate dehydrogenase (lipoamide) beta 0.020
hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10 0.020
aldh9a1a aldehyde dehydrogenase 9 family, member A1a 0.019
dldh dihydrolipoamide dehydrogenase 0.019
ech1 enoyl CoA hydratase 1, peroxisomal 0.018
zgc:162544 zgc:162544 0.018
acsf2 acyl-CoA synthetase family member 2 0.018
col12a1 collagen, type XII, alpha 1 0.018
sepp1a selenoprotein P, plasma, 1a 0.018
dnm2l dynamin2-like 0.018
igf2b insulin-like growth factor 2b 0.017
pdcd8 programmed cell death 8 (apoptosis-inducing factor) 0.017
ktn1 kinectin 1 0.017
bcat2 branched chain aminotransferase 2, mitochondrial 0.017
pomt1 protein-O-mannosyltransferase 1 0.016
atp1a1a.4 ATPase, Na+/K+ transporting, alpha 1a.4 polypeptide 0.016
ogdh oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) 0.016
zgc:136894 zgc:136894 0.016
atp5g ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9) 0.016
bckdhb branched chain ketoacid dehydrogenase E1, beta polypeptide 0.016
tkt transketolase 0.016
adkb adenosine kinase b 0.016
slc2a10 solute carrier family 2 (facilitated glucose transporter), member 10 0.016
ldhba lactate dehydrogenase Ba 0.015
aldh4a1 aldehyde dehydrogenase 4 family, member A1 0.015
hgd homogentisate 1,2-dioxygenase 0.015
sfrp1b secreted frizzled-related protein 1b 0.015
eif4a1b eukaryotic translation initiation factor 4A, isoform 1B 0.015
zgc:92090 zgc:92090 0.015
ef1a elongation factor 1-alpha 0.014
st8sia6 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 0.014
tat tyrosine aminotransferase 0.014
slc25a32a solute carrier family 25, member 32a 0.014
slc27a1a solute carrier family 27 (fatty acid transporter), member 1a 0.014
sept7b septin 7b 0.014
celf1 cugbp, Elav-like family member 1 0.013
slc2a1b solute carrier family 2 (facilitated glucose transporter), member 1b 0.013
msrb3 methionine sulfoxide reductase B3 0.013
ak4 adenylate kinase 4 0.013
tob1a transducer of ERBB2, 1a 0.013
sult1st4 sulfotransferase family 1, cytosolic sulfotransferase 4 0.013
pgm1 phosphoglucomutase 1 0.013
metap1 methionyl aminopeptidase 1 0.013
mbnl2 muscleblind-like 2 (Drosophila) 0.013
chchd3 coiled-coil-helix-coiled-coil-helix domain containing 3 0.013
aco2 aconitase 2, mitochondrial 0.013
syk spleen tyrosine kinase 0.012
zbtb4 zinc finger and BTB domain containing 4 0.012
tcea3 transcription elongation factor A (SII), 3 0.012
acox1 acyl-Coenzyme A oxidase 1, palmitoyl 0.012
rrm2b ribonucleotide reductase M2 b 0.012
slc25a11 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11 0.012
brp44 brain protein 44 0.011
xrcc5 X-ray repair complementing defective repair in Chinese hamster cells 5 0.011
bhlhe40 basic helix-loop-helix family, member e40 0.011
agl amylo-1, 6-glucosidase, 4-alpha-glucanotransferase 0.011
fbxo9 F-box protein 9 0.011
LOC560602 novel protein similar to vertebrate solute carrier family 2 (facilitated glucose transporter), member 6 (SLC2A6) 0.011
acat1 acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase) 0.010
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
PTPN1 protein tyrosine phosphatase, non-receptor type 1 1.000
INSR insulin receptor 0.998
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide 0.941
PTPRB protein tyrosine phosphatase, receptor type, B 0.671
JAK2 Janus kinase 2 0.575
PTPN3 protein tyrosine phosphatase, non-receptor type 3 0.563
STAT5A signal transducer and activator of transcription 5A 0.453
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.341
MCCC1 methylcrotonoyl-CoA carboxylase 1 (alpha) 0.244
PTPN2 protein tyrosine phosphatase, non-receptor type 2 0.238
EGFR epidermal growth factor receptor 0.227
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.193
CAV1 caveolin 1, caveolae protein, 22kDa 0.184
BCAR1 breast cancer anti-estrogen resistance 1 0.173
MET met proto-oncogene (hepatocyte growth factor receptor) 0.172
EPOR erythropoietin receptor 0.130
LAT linker for activation of T cells 0.125
ECH1 enoyl CoA hydratase 1, peroxisomal 0.110
PTPN9 protein tyrosine phosphatase, non-receptor type 9 0.108
BCKDHA branched chain keto acid dehydrogenase E1, alpha polypeptide 0.100
C21orf33 chromosome 21 open reading frame 33 0.083
IL2RB interleukin 2 receptor, beta 0.083
STAP2 signal transducing adaptor family member 2 0.082
IGF1R insulin-like growth factor 1 receptor 0.080
HMGCL 3-hydroxymethyl-3-methylglutaryl-CoA lyase 0.069
ACADSB acyl-CoA dehydrogenase, short/branched chain 0.065
BCKDK branched chain ketoacid dehydrogenase kinase 0.056
IRS1 insulin receptor substrate 1 0.054
SOCS2 suppressor of cytokine signaling 2 0.053
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.052
HIBADH 3-hydroxyisobutyrate dehydrogenase 0.048
NNT nicotinamide nucleotide transhydrogenase 0.043
CPT2 carnitine palmitoyltransferase 2 0.041
ALDOA aldolase A, fructose-bisphosphate 0.038
ALDH6A1 aldehyde dehydrogenase 6 family, member A1 0.037
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 0.036
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 0.035
CAT catalase 0.031
STAT5B signal transducer and activator of transcription 5B 0.030
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit 0.028
PHYH phytanoyl-CoA 2-hydroxylase 0.027
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) 0.027
JAK1 Janus kinase 1 0.026
HADH hydroxyacyl-CoA dehydrogenase 0.024
DUSP7 dual specificity phosphatase 7 0.022
PIGP phosphatidylinositol glycan anchor biosynthesis, class P 0.021
SCP2 sterol carrier protein 2 0.019
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 0.017
ECI2 enoyl-CoA delta isomerase 2 0.016
PEX7 peroxisomal biogenesis factor 7 0.015
BCR breakpoint cluster region 0.015
GHR growth hormone receptor 0.015
NCOA2 nuclear receptor coactivator 2 0.015
CYB5A cytochrome b5 type A (microsomal) 0.014
TRAPPC6A trafficking protein particle complex 6A 0.014
DHTKD1 dehydrogenase E1 and transketolase domain containing 1 0.013
ACAD8 acyl-CoA dehydrogenase family, member 8 0.012
PRMT2 protein arginine methyltransferase 2 0.011
PEX19 peroxisomal biogenesis factor 19 0.011
ACADVL acyl-CoA dehydrogenase, very long chain 0.011
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.010
C8orf40 chromosome 8 open reading frame 40 0.010
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Lepr leptin receptor 0.687
Stat5a signal transducer and activator of transcription 5A 0.487
Stat5b signal transducer and activator of transcription 5B 0.430
Lep leptin 0.152
Irf9 interferon regulatory factor 9 0.104
Foxp3 forkhead box P3 0.097
Esr1 estrogen receptor 1 (alpha) 0.094
Ar androgen receptor 0.077
Stat1 signal transducer and activator of transcription 1 0.076
Ghr growth hormone receptor 0.046
Il6st interleukin 6 signal transducer 0.044
Stat3 signal transducer and activator of transcription 3 0.042
Trp53 transformation related protein 53 0.028
Kit kit oncogene 0.028
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.027
Stat2 signal transducer and activator of transcription 2 0.022
Il4ra interleukin 4 receptor, alpha 0.019
Myd88 myeloid differentiation primary response gene 88 0.018
Il1r1 interleukin 1 receptor, type I 0.016
Mccc1 methylcrotonoyl-Coenzyme A carboxylase 1 (alpha) 0.015
Nr3c1 nuclear receptor subfamily 3, group C, member 1 0.015
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.014
Mut methylmalonyl-Coenzyme A mutase 0.013
Il10 interleukin 10 0.013
Prlr prolactin receptor 0.013
Ahr aryl-hydrocarbon receptor 0.013
Tapbp TAP binding protein 0.011
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Gcdh glutaryl-Coenzyme A dehydrogenase 0.519
Adk adenosine kinase 0.450
Echs1 enoyl Coenzyme A hydratase, short chain, 1, mitochondrial 0.354
Mccc2 methylcrotonoyl-Coenzyme A carboxylase 2 (beta) 0.262
Pcca propionyl-coenzyme A carboxylase, alpha polypeptide 0.193
Suclg2 succinate-CoA ligase, GDP-forming, beta subunit 0.156
Adhfe1 alcohol dehydrogenase, iron containing, 1 0.100
Acat1 acetyl-coenzyme A acetyltransferase 1 0.099
Aldh6a1 aldehyde dehydrogenase 6 family, member A1 0.087
Hibadh 3-hydroxyisobutyrate dehydrogenase 0.067
Acsl1 acyl-CoA synthetase long-chain family member 1 0.062
Nfs1 NFS1 nitrogen fixation 1 homolog (S. cerevisiae) 0.057
Acadsb acyl-Coenzyme A dehydrogenase, short/branched chain 0.055
Mut methylmalonyl-Coenzyme A mutase 0.051
Tst thiosulfate sulfurtransferase 0.051
Bckdha branched chain ketoacid dehydrogenase E1, alpha polypeptide 0.044
Dhtkd1 dehydrogenase E1 and transketolase domain containing 1 0.040
Etfdh electron-transferring-flavoprotein dehydrogenase 0.040
Pccb propionyl coenzyme A carboxylase, beta polypeptide 0.035
Ghr growth hormone receptor 0.033
Scp2 sterol carrier protein 2 0.032
Sdha succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 0.030
Nnt nicotinamide nucleotide transhydrogenase 0.030
Isoc1 isochorismatase domain containing 1 0.028
Josd2 Josephin domain containing 2 0.026
Ddt D-dopachrome tautomerase 0.026
Ctf1 cardiotrophin 1 0.025
Adi1 acireductone dioxygenase 1 0.025
Hadh hydroxyacyl-Coenzyme A dehydrogenase 0.024
Glud1 glutamate dehydrogenase 1 0.022
Suox sulfite oxidase 0.022
Bphl biphenyl hydrolase-like (serine hydrolase) 0.022
Clybl citrate lyase beta like 0.022
Suclg1 succinate-CoA ligase, alpha subunit 0.022
Mipep mitochondrial intermediate peptidase 0.020
Gpam glycerol-3-phosphate acyltransferase, mitochondrial 0.020
Acadm acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain 0.019
Ivd isovaleryl coenzyme A dehydrogenase 0.019
Pxmp2 peroxisomal membrane protein 2 0.019
Akr1c14 aldo-keto reductase family 1, member C14 0.018
Gipc1 GIPC PDZ domain containing family, member 1 0.017
Ube2m ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast) 0.017
Gstm7 glutathione S-transferase, mu 7 0.017
Coq7 coenzyme Q7 homolog, ubiquinone (yeast) 0.017
Nfia nuclear factor I/A 0.016
Mtus1 mitochondrial tumor suppressor 1 0.016
Nqo2 NAD(P)H dehydrogenase, quinone 2 0.016
Abhd14b abhydrolase domain containing 14b 0.015
Capn1 calpain 1 0.015
Aldh2 aldehyde dehydrogenase 2 family (mitochondrial) 0.015
Hrsp12 heat-responsive protein 12 0.015
Dcxr dicarbonyl L-xylulose reductase 0.014
Aldh4a1 aldehyde dehydrogenase 4 family, member A1 0.014
Cmbl carboxymethylenebutenolidase homolog (Pseudomonas) 0.014
Pecr peroxisomal trans-2-enoyl-CoA reductase 0.013
Ndufv1 NADH dehydrogenase (ubiquinone) flavoprotein 1 0.013
Bckdhb branched chain keto acid dehydrogenase E1, beta polypeptide 0.013
Ubxn6 UBX domain protein 6 0.013
Cat catalase 0.013
Mccc1 methylcrotonoyl-Coenzyme A carboxylase 1 (alpha) 0.012
Pdk2 pyruvate dehydrogenase kinase, isozyme 2 0.012
Clpb ClpB caseinolytic peptidase B homolog (E. coli) 0.012
Gstm2 glutathione S-transferase mu 2 0.012
Klf15 Kruppel-like factor 15 0.012
Calcrl calcitonin receptor-like 0.012
Yipf3 Yip1 domain family, member 3 0.012
Ddost dolichyl-diphosphooligosaccharide-protein glycosyltransferase 0.011
Cish cytokine inducible SH2-containing protein 0.011
Etfa electron-transfer-flavoprotein, alpha polypeptide 0.011
Hibch 3-hydroxyisobutyryl-Coenzyme A hydrolase 0.011
Hint3 histidine triad nucleotide binding protein 3 0.011
Scand1 SCAN domain-containing 1 0.011
Ddr1 discoidin domain receptor tyrosine kinase 1 0.010
Isoc2b isochorismatase domain containing 2b 0.010
Acot2 acyl-CoA thioesterase 2 0.010
Cd36 CD36 molecule (thrombospondin receptor) 0.010
RGD1303003 homolog of zebrafish ES1 0.010
Insr insulin receptor 0.010
Pcdhga11 protocadherin gamma subfamily A, 11 0.010