The network for 'trna modification' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

trna modification

The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
ELP3 Elp3p 1.000
IKI3 Iki3p 0.999
YNL022C hypothetical protein 0.999
PUS4 Pus4p 0.998
DEG1 Deg1p 0.998
ELP4 Elp4p 0.997
ELP6 Elp6p 0.993
PUS7 Pus7p 0.991
KTI12 Kti12p 0.989
URM1 Urm1p 0.988
PUS1 Pus1p 0.987
IKI1 Iki1p 0.981
NCS6 Ncs6p 0.980
NCS2 Ncs2p 0.959
TRM8 Trm8p 0.939
ELP2 Elp2p 0.934
TRM9 Trm9p 0.883
TRM1 Trm1p 0.882
SMM1 Smm1p 0.880
MTO1 Mto1p 0.777
TRM11 Trm11p 0.722
UBA4 Uba4p 0.716
LOS1 Los1p 0.715
SLM3 Slm3p 0.698
KAE1 Kae1p 0.669
MEX67 Mex67p 0.657
TPA1 Tpa1p 0.645
YIL096C hypothetical protein 0.592
YHR003C hypothetical protein 0.589
YBR242W hypothetical protein 0.581
BER1 Ber1p 0.536
RRP6 Rrp6p 0.450
TRM10 Trm10p 0.431
YKL027W hypothetical protein 0.424
PCC1 Pcc1p 0.410
SUA5 Sua5p 0.410
TAD2 Tad2p 0.365
DPH2 Dph2p 0.363
TAE1 Tae1p 0.361
DUS4 Dus4p 0.346
MSS1 Mss1p 0.335
RIM2 Rim2p 0.329
RTT10 Rtt10p 0.325
TAD3 Tad3p 0.320
POP8 Pop8p 0.319
KTI11 Kti11p 0.293
DBP5 Dbp5p 0.264
YPK3 Ypk3p 0.231
TRM2 Trm2p 0.215
TRM112 Trm112p 0.215
YCR051W hypothetical protein 0.210
RER2 Rer2p 0.207
YJR003C hypothetical protein 0.203
DAS2 Das2p 0.202
NAR1 Nar1p 0.192
TYW3 Tyw3p 0.191
YCK2 Yck2p 0.188
CDC123 Cdc123p 0.184
DRE2 Dre2p 0.182
GFD2 Gfd2p 0.178
POP3 Pop3p 0.178
TRM13 Trm13p 0.171
POP1 Pop1p 0.169
HIS6 His6p 0.166
YIR035C hypothetical protein 0.156
YLR419W hypothetical protein 0.156
NRD1 Nrd1p 0.148
MDM36 Mdm36p 0.147
RAT1 Rat1p 0.147
AIR2 Air2p 0.146
PUS6 Pus6p 0.146
AIR1 Air1p 0.145
YML096W hypothetical protein 0.142
YGR210C hypothetical protein 0.137
YHR122W hypothetical protein 0.137
ATS1 Ats1p 0.134
TAN1 Tan1p 0.134
RNH70 Rnh70p 0.132
UME1 Ume1p 0.130
TAF8 Taf8p 0.129
YPL245W hypothetical protein 0.129
RKM4 Rkm4p 0.129
TRM44 Trm44p 0.128
YML082W hypothetical protein 0.127
NBP2 Nbp2p 0.123
YBR141C hypothetical protein 0.123
PPX1 Ppx1p 0.121
ADE8 Ade8p 0.117
MOD5 Mod5p 0.117
AGE1 Age1p 0.117
IME4 Ime4p 0.117
NBA1 Nba1p 0.116
GIS4 Gis4p 0.116
RPP1 Rpp1p 0.113
CUE2 Cue2p 0.109
PCF11 Pcf11p 0.108
LEU9 Leu9p 0.107
DML1 Dml1p 0.104
TRM82 Trm82p 0.103
SWM2 Swm2p 0.102
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
CELE_W09G3.7 Protein W09G3.7 0.065
F48E8.6 Protein F48E8.6 0.065
CELE_Y75B8A.14 Protein Y75B8A.14 0.049
elpc-3 Protein ELPC-3 0.026
C18A3.3 Protein C18A3.3 0.024
C47E12.7 Protein C47E12.7 0.021
csr-1 Protein CSR-1 0.020
ruvb-1 Protein RUVB-1 0.020
byn-1 Protein BYN-1 0.019
figl-1 Protein FIGL-1 0.017
T27A3.2 Protein T27A3.2 0.017
helq-1 Protein HELQ-1 0.014
ppw-2 Protein PPW-2 0.013
eif-3.B Protein EIF-3.B 0.012
cmd-1 Protein CMD-1 0.012
W07E6.2 Protein W07E6.2 0.011
CELE_ZK1236.1 Protein ZK1236.1 0.010
dao-5 Protein DAO-5 0.010
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Zfrp8 Zinc finger protein RP-8 0.258
Vap-33-1 CG5014 gene product from transcript CG5014-RB 0.215
CkIIbeta Casein kinase II beta subunit 0.171
CG6550 CG6550 gene product from transcript CG6550-RA 0.101
CG1074 CG1074 gene product from transcript CG1074-RA 0.098
Tgt tRNA-guanine transglycosylase 0.077
Actr13E Actin-related protein 13E 0.072
eIF2B-epsilon CG3806 gene product from transcript CG3806-RB 0.068
Fer1HCH Ferritin 1 heavy chain homologue 0.065
CG3434 CG3434 gene product from transcript CG3434-RA 0.063
CG4159 CG4159 gene product from transcript CG4159-RA 0.053
CG6388 CG6388 gene product from transcript CG6388-RA 0.052
Dpit47 DNA polymerase interacting tpr containing protein of 47kD 0.048
skpA CG16983 gene product from transcript CG16983-RD 0.046
CG5451 CG5451 gene product from transcript CG5451-RA 0.042
CG10189 CG10189 gene product from transcript CG10189-RA 0.042
CG10463 CG10463 gene product from transcript CG10463-RA 0.041
CG4858 CG4858 gene product from transcript CG4858-RA 0.041
CG9630 CG9630 gene product from transcript CG9630-RA 0.041
Art8 Arginine methyltransferase 8 0.037
CG14544 CG14544 gene product from transcript CG14544-RA 0.037
CG6751 CG6751 gene product from transcript CG6751-RA 0.035
CG12134 CG12134 gene product from transcript CG12134-RA 0.035
mts microtubule star 0.034
CG2972 CG2972 gene product from transcript CG2972-RA 0.033
CG17904 CG17904 gene product from transcript CG17904-RA 0.031
CG6607 CG6607 gene product from transcript CG6607-RA 0.030
Sucb CG10622 gene product from transcript CG10622-RA 0.029
CG15738 CG15738 gene product from transcript CG15738-RA 0.029
wdb widerborst 0.029
elav embryonic lethal abnormal vision 0.028
CG3808 CG3808 gene product from transcript CG3808-RA 0.027
CG9839 CG9839 gene product from transcript CG9839-RA 0.027
CG14812 CG14812 gene product from transcript CG14812-RA 0.027
Dcp1 Decapping protein 1 0.026
Mocs2 Molybdopterin synthase 2 0.026
CG12267 CG12267 gene product from transcript CG12267-RB 0.026
CG7741 CG7741 gene product from transcript CG7741-RA 0.025
CG5589 CG5589 gene product from transcript CG5589-RA 0.023
Chc Clathrin heavy chain 0.023
CG5190 CG5190 gene product from transcript CG5190-RA 0.023
Rrp4 CG3931 gene product from transcript CG3931-RA 0.023
Psf3 CG2222 gene product from transcript CG2222-RA 0.022
Nop56 CG13849 gene product from transcript CG13849-RA 0.022
CG4933 CG4933 gene product from transcript CG4933-RA 0.022
CG1575 CG1575 gene product from transcript CG1575-RA 0.022
CG7265 CG7265 gene product from transcript CG7265-RA 0.021
Dbp45A DEAD box protein 45A 0.021
Arf79F ADP ribosylation factor 79F 0.020
sni sniffer 0.020
CG13192 CG13192 gene product from transcript CG13192-RA 0.020
CG11859 CG11859 gene product from transcript CG11859-RA 0.020
metl methyltransferase-like 0.020
Rs1 CG2173 gene product from transcript CG2173-RA 0.020
Gfat2 Glutamine:fructose-6-phosphate aminotransferase 2 0.019
CG8132 CG8132 gene product from transcript CG8132-RA 0.019
Prp31 CG6876 gene product from transcript CG6876-RA 0.019
CG8005 CG8005 gene product from transcript CG8005-RA 0.019
brp bruchpilot 0.019
CG7889 CG7889 gene product from transcript CG7889-RA 0.018
lark CG8597 gene product from transcript CG8597-RD 0.018
CG3004 CG3004 gene product from transcript CG3004-RA 0.018
CG14985 CG14985 gene product from transcript CG14985-RB 0.018
fz2 frizzled 2 0.018
pex2 peroxin 2 0.017
CG7747 CG7747 gene product from transcript CG7747-RA 0.017
l(2)09851 lethal (2) 09851 0.017
CG7341 CG7341 gene product from transcript CG7341-RB 0.017
Elp2 Elongator complex protein 2 0.017
ranshi CG9793 gene product from transcript CG9793-RA 0.017
Ipk2 CG13688 gene product from transcript CG13688-RA 0.016
CG12413 CG12413 gene product from transcript CG12413-RA 0.016
CG8064 CG8064 gene product from transcript CG8064-RA 0.016
CG15717 CG15717 gene product from transcript CG15717-RA 0.016
CG1671 CG1671 gene product from transcript CG1671-RA 0.016
14-3-3zeta CG17870 gene product from transcript CG17870-RB 0.016
CG11447 CG11447 gene product from transcript CG11447-RA 0.016
CG6724 CG6724 gene product from transcript CG6724-RA 0.016
Elp3 Elongator complex protein 3 0.016
4EHP CG33100 gene product from transcript CG33100-RA 0.015
CG6144 CG6144 gene product from transcript CG6144-RB 0.015
Nle Notchless 0.015
mbm mushroom body miniature 0.015
ferrochelatase CG2098 gene product from transcript CG2098-RC 0.015
corto CG2530 gene product from transcript CG2530-RA 0.015
CG9286 CG9286 gene product from transcript CG9286-RA 0.015
PP2A-B' CG7913 gene product from transcript CG7913-RK 0.015
Aats-pro Prolyl-tRNA synthetase 0.015
skf skiff 0.015
CG4679 CG4679 gene product from transcript CG4679-RA 0.015
Gmer GDP-4-keto-6-deoxy-D-mannose 3,5-epimerase/4-reductase 0.014
CG5126 CG5126 gene product from transcript CG5126-RA 0.014
CG13185 CG13185 gene product from transcript CG13185-RB 0.014
CG2789 CG2789 gene product from transcript CG2789-RA 0.014
RpI1 RNA polymerase I subunit 0.014
CG2915 CG2915 gene product from transcript CG2915-RB 0.014
CG3448 CG3448 gene product from transcript CG3448-RB 0.014
crn crooked neck 0.014
CG9799 CG9799 gene product from transcript CG9799-RA 0.014
CG4908 CG4908 gene product from transcript CG4908-RB 0.014
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Homo sapiens
Name Description Probability Func Analog Organism
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein 1.000
ELP3 elongation protein 3 homolog (S. cerevisiae) 0.997
ELP2 elongation protein 2 homolog (S. cerevisiae) 0.997
ELP4 elongation protein 4 homolog (S. cerevisiae) 0.936
MDM4 Mdm4 p53 binding protein homolog (mouse) 0.138
TP53RK TP53 regulating kinase 0.083
MMS19 MMS19 nucleotide excision repair homolog (S. cerevisiae) 0.078
DVL3 dishevelled, dsh homolog 3 (Drosophila) 0.061
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase 0.057
ASCC2 activating signal cointegrator 1 complex subunit 2 0.050
NVL nuclear VCP-like 0.048
CSNK1E casein kinase 1, epsilon 0.046
DDX24 DEAD (Asp-Glu-Ala-Asp) box polypeptide 24 0.037
XPO5 exportin 5 0.034
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon 0.032
MCC mutated in colorectal cancers 0.032
OCLN occludin 0.030
ANKRD28 ankyrin repeat domain 28 0.028
COASY CoA synthase 0.028
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 0.025
NUBP2 nucleotide binding protein 2 (MinD homolog, E. coli) 0.025
SNF8 SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae) 0.024
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.024
MYST2 MYST histone acetyltransferase 2 0.023
SARS seryl-tRNA synthetase 0.022
TSEN2 tRNA splicing endonuclease 2 homolog (S. cerevisiae) 0.022
HTT huntingtin 0.021
FASTKD2 FAST kinase domains 2 0.021
MBD1 methyl-CpG binding domain protein 1 0.020
GTF3C1 general transcription factor IIIC, polypeptide 1, alpha 220kDa 0.019
IGBP1 immunoglobulin (CD79A) binding protein 1 0.019
PPP1R14A protein phosphatase 1, regulatory (inhibitor) subunit 14A 0.019
C19orf60 chromosome 19 open reading frame 60 0.019
TBL3 transducin (beta)-like 3 0.019
TELO2 TEL2, telomere maintenance 2, homolog (S. cerevisiae) 0.018
DVL1 dishevelled, dsh homolog 1 (Drosophila) 0.017
FAM110C family with sequence similarity 110, member C 0.017
FAM110A family with sequence similarity 110, member A 0.017
FAM96B family with sequence similarity 96, member B 0.016
DVL2 dishevelled, dsh homolog 2 (Drosophila) 0.016
BBS10 Bardet-Biedl syndrome 10 0.016
FAM173A family with sequence similarity 173, member A 0.015
PSAT1 phosphoserine aminotransferase 1 0.015
LENG1 leukocyte receptor cluster (LRC) member 1 0.015
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1 0.015
ASNS asparagine synthetase (glutamine-hydrolyzing) 0.014
PRMT6 protein arginine methyltransferase 6 0.014
HES1 hairy and enhancer of split 1, (Drosophila) 0.013
NKIRAS2 NFKB inhibitor interacting Ras-like 2 0.013
SAV1 salvador homolog 1 (Drosophila) 0.012
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2 0.011
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 0.011
VPS4A vacuolar protein sorting 4 homolog A (S. cerevisiae) 0.011
HEATR2 HEAT repeat containing 2 0.011
MAP3K7 mitogen-activated protein kinase kinase kinase 7 0.011
ARMC6 armadillo repeat containing 6 0.011
KATNB1 katanin p80 (WD repeat containing) subunit B 1 0.011
FASTK Fas-activated serine/threonine kinase 0.011
C9orf142 chromosome 9 open reading frame 142 0.010
NOC4L nucleolar complex associated 4 homolog (S. cerevisiae) 0.010
C12orf66 chromosome 12 open reading frame 66 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Eif3d eukaryotic translation initiation factor 3, subunit D 0.391
Ddx56 DEAD (Asp-Glu-Ala-Asp) box polypeptide 56 0.326
Wdr74 WD repeat domain 74 0.319
Per2 period homolog 2 (Drosophila) 0.222
Srm spermidine synthase 0.132
Yars tyrosyl-tRNA synthetase 0.101
Per1 period homolog 1 (Drosophila) 0.085
Mrps18b mitochondrial ribosomal protein S18B 0.079
Vps25 vacuolar protein sorting 25 (yeast) 0.067
Mybbp1a MYB binding protein (P160) 1a 0.056
Ddx41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 0.051
Wdr46 WD repeat domain 46 0.050
Tsr1 TSR1, 20S rRNA accumulation, homolog (yeast) 0.050
Smyd5 SET and MYND domain containing 5 0.048
Rrp12 ribosomal RNA processing 12 homolog (S. cerevisiae) 0.045
Arntl aryl hydrocarbon receptor nuclear translocator-like 0.045
Sars seryl-aminoacyl-tRNA synthetase 0.043
Lrrc59 leucine rich repeat containing 59 0.041
Eif3b eukaryotic translation initiation factor 3, subunit B 0.041
Sox4 SRY-box containing gene 4 0.038
Vars valyl-tRNA synthetase 0.033
Parn poly(A)-specific ribonuclease (deadenylation nuclease) 0.033
Imp4 IMP4, U3 small nucleolar ribonucleoprotein, homolog (yeast) 0.032
Noc4l nucleolar complex associated 4 homolog (S. cerevisiae) 0.031
Dus1l dihydrouridine synthase 1-like (S. cerevisiae) 0.031
Ppan peter pan homolog (Drosophila) 0.030
Rrp9 RRP9, small subunit (SSU) processome component, homolog (yeast) 0.027
Rcc2 regulator of chromosome condensation 2 0.027
Eftud2 elongation factor Tu GTP binding domain containing 2 0.025
Drg2 developmentally regulated GTP binding protein 2 0.025
Rrp1 ribosomal RNA processing 1 homolog (S. cerevisiae) 0.023
Elac2 elaC homolog 2 (E. coli) 0.023
2610027L16Rik RIKEN cDNA 2610027L16 gene 0.023
Eif6 eukaryotic translation initiation factor 6 0.022
Grwd1 glutamate-rich WD repeat containing 1 0.022
Ntf3 neurotrophin 3 0.020
Bop1 block of proliferation 1 0.019
Ube2g1 ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, C. elegans) 0.019
Prep prolyl endopeptidase 0.019
Lsg1 large subunit GTPase 1 homolog (S. cerevisiae) 0.018
Cry2 cryptochrome 2 (photolyase-like) 0.018
Ccdc86 coiled-coil domain containing 86 0.017
Tbrg4 transforming growth factor beta regulated gene 4 0.017
Dph5 DPH5 homolog (S. cerevisiae) 0.017
Prpf6 PRP6 pre-mRNA splicing factor 6 homolog (yeast) 0.017
Pwp2 PWP2 periodic tryptophan protein homolog (yeast) 0.016
Nubp2 nucleotide binding protein 2 0.015
Prpf31 PRP31 pre-mRNA processing factor 31 homolog (yeast) 0.015
Rrp36 ribosomal RNA processing 36 homolog (S. cerevisiae) 0.014
Ddx10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 0.014
Lars leucyl-tRNA synthetase 0.014
Clock circadian locomotor output cycles kaput 0.013
Rbm19 RNA binding motif protein 19 0.013
Afg3l1 AFG3(ATPase family gene 3)-like 1 (yeast) 0.012
Ddx49 DEAD (Asp-Glu-Ala-Asp) box polypeptide 49 0.012
Exosc5 exosome component 5 0.012
Xpo5 exportin 5 0.012
Sox11 SRY-box containing gene 11 0.012
Tomm40 translocase of outer mitochondrial membrane 40 homolog (yeast) 0.011
Gars glycyl-tRNA synthetase 0.011
Asna1 arsA arsenite transporter, ATP-binding, homolog 1 (bacterial) 0.011
Utp20 UTP20, small subunit (SSU) processome component, homolog (yeast) 0.010
Cry1 cryptochrome 1 (photolyase-like) 0.010
Ppp1cb protein phosphatase 1, catalytic subunit, beta isoform 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism