The network for 'gluconeogenesis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

gluconeogenesis

The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
ENO1 Eno1p 0.990
TDH3 Tdh3p 0.987
VID30 Vid30p 0.982
GID7 Gid7p 0.968
FYV10 Fyv10p 0.946
FBA1 Fba1p 0.944
PGK1 Pgk1p 0.916
TDH1 Tdh1p 0.914
GID8 Gid8p 0.911
TDH2 Tdh2p 0.848
TPI1 Tpi1p 0.825
RMD5 Rmd5p 0.819
ENO2 Eno2p 0.763
GPM1 Gpm1p 0.705
ADH1 Adh1p 0.609
MOH1 Moh1p 0.575
VID24 Vid24p 0.452
MLS1 Mls1p 0.371
ERR3 Err3p 0.362
PYC2 Pyc2p 0.355
PYC1 Pyc1p 0.320
PDC1 Pdc1p 0.232
SIP4 Sip4p 0.216
PGI1 Pgi1p 0.204
VID28 Vid28p 0.203
HXK1 Hxk1p 0.187
TMA10 Tma10p 0.159
DOG2 Dog2p 0.145
MDH2 Mdh2p 0.122
SPO1 Spo1p 0.117
ERR2 Err2p 0.109
YAP6 Yap6p 0.096
NCE103 Nce103p 0.087
CDC19 Cdc19p 0.086
EMI2 Emi2p 0.080
PFK1 Pfk1p 0.078
HUG1 Hug1p 0.076
ADE12 Ade12p 0.067
BDH1 Bdh1p 0.064
WWM1 Wwm1p 0.062
GLN1 Gln1p 0.059
TRA1 Tra1p 0.057
CAR1 Car1p 0.056
SFC1 Sfc1p 0.055
NMT1 Nmt1p 0.049
REG1 Reg1p 0.048
UBP11 Ubp11p 0.048
ABM1 Abm1p 0.046
YDR186C hypothetical protein 0.046
SSA4 Ssa4p 0.041
SSH4 Ssh4p 0.041
CUE5 Cue5p 0.040
CAT8 Cat8p 0.039
GTO3 Gto3p 0.039
SDS24 Sds24p 0.039
PDI1 Pdi1p 0.037
YMR210W hypothetical protein 0.037
ERR1 Err1p 0.036
MAL32 Mal32p 0.036
SRD1 Srd1p 0.036
ERT1 Ert1p 0.035
YGR017W hypothetical protein 0.035
TIP1 Tip1p 0.035
GAL83 Gal83p 0.033
OSH2 Osh2p 0.033
STP4 Stp4p 0.032
YMR122W-A hypothetical protein 0.032
YML053C hypothetical protein 0.030
GPH1 Gph1p 0.030
COX13 Cox13p 0.029
GPM2 Gpm2p 0.029
YLR264C-A hypothetical protein 0.028
SUR1 Sur1p 0.028
YNR014W hypothetical protein 0.028
CPD1 Cpd1p 0.027
CUP1-1 Cup1-1p 0.027
CIT2 Cit2p 0.027
SAK1 Sak1p 0.027
AGP2 Agp2p 0.027
HSP33 Hsp33p 0.026
LEU2 Leu2p 0.026
YLR162W hypothetical protein 0.026
NCA3 Nca3p 0.025
OYE2 Oye2p 0.025
DBP1 Dbp1p 0.024
ARP10 Arp10p 0.024
AVT7 Avt7p 0.024
EMI5 Emi5p 0.024
COX5B Cox5bp 0.023
YOL014W hypothetical protein 0.023
CTR3 Ctr3p 0.023
FMS1 Fms1p 0.023
YOL038C-A hypothetical protein 0.022
BNA5 Bna5p 0.022
PCL2 Pcl2p 0.022
SSO2 Sso2p 0.022
RSC8 Rsc8p 0.022
IDP3 Idp3p 0.022
URA3 Ura3p 0.021
HEF3 Hef3p 0.021
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
NCOA1 nuclear receptor coactivator 1 0.300
CREBBP CREB binding protein 0.214
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit 0.105
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit 0.090
ESR1 estrogen receptor 1 0.087
AR androgen receptor 0.059
RXRA retinoid X receptor, alpha 0.049
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.040
NCOR2 nuclear receptor corepressor 2 0.027
TADA3 transcriptional adaptor 3 0.023
DDIT3 DNA-damage-inducible transcript 3 0.019
NCOA3 nuclear receptor coactivator 3 0.016
PPP4R2 protein phosphatase 4, regulatory subunit 2 0.016
NCOA2 nuclear receptor coactivator 2 0.012
RARA retinoic acid receptor, alpha 0.012
MED25 mediator complex subunit 25 0.011
GHR growth hormone receptor 0.011
KAT2B K(lysine) acetyltransferase 2B 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Per2 period homolog 2 (Drosophila) 0.993
Arntl aryl hydrocarbon receptor nuclear translocator-like 0.992
Lep leptin 0.992
Clock circadian locomotor output cycles kaput 0.988
Pparg peroxisome proliferator activated receptor gamma 0.940
Cry2 cryptochrome 2 (photolyase-like) 0.936
Kiss1 KiSS-1 metastasis-suppressor 0.911
Insr insulin receptor 0.909
Sirt1 sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae) 0.876
Lepr leptin receptor 0.870
Ren1 renin 1 structural 0.728
Pck1 phosphoenolpyruvate carboxykinase 1, cytosolic 0.686
Irs2 insulin receptor substrate 2 0.665
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.616
Mup10 major urinary protein 10 0.609
Serpina1c serine (or cysteine) peptidase inhibitor, clade A, member 1C 0.576
Prlr prolactin receptor 0.564
Per1 period homolog 1 (Drosophila) 0.548
Cry1 cryptochrome 1 (photolyase-like) 0.511
LOC100048884 novel member of the major urinary protein (Mup) gene family 0.506
Mup19 major urinary protein 19 0.499
Jun Jun oncogene 0.488
Cidec cell death-inducing DFFA-like effector c 0.482
Tgfb1 transforming growth factor, beta 1 0.449
Plin1 perilipin 1 0.409
Spry4 sprouty homolog 4 (Drosophila) 0.385
Thrsp thyroid hormone responsive SPOT14 homolog (Rattus) 0.376
Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 0.376
Esr1 estrogen receptor 1 (alpha) 0.353
Clk1 CDC-like kinase 1 0.336
Gm5506 predicted gene 5506 0.335
Nr1h4 nuclear receptor subfamily 1, group H, member 4 0.303
Pgam1 phosphoglycerate mutase 1 0.295
Clk4 CDC like kinase 4 0.284
Trib3 tribbles homolog 3 (Drosophila) 0.283
Lef1 lymphoid enhancer binding factor 1 0.243
Nos1 nitric oxide synthase 1, neuronal 0.240
Agtr1a angiotensin II receptor, type 1a 0.240
Mup5 major urinary protein 5 0.230
Mup1 major urinary protein 1 0.216
Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 0.215
Stat5a signal transducer and activator of transcription 5A 0.206
Fga fibrinogen alpha chain 0.202
Mup3 major urinary protein 3 0.202
Prkab1 protein kinase, AMP-activated, beta 1 non-catalytic subunit 0.192
Usp2 ubiquitin specific peptidase 2 0.191
Tcf7 transcription factor 7, T-cell specific 0.189
Cps1 carbamoyl-phosphate synthetase 1 0.184
Ccnl2 cyclin L2 0.175
Mup9 major urinary protein 9 0.172
Pnpla2 patatin-like phospholipase domain containing 2 0.172
Egr1 early growth response 1 0.170
Baat bile acid-Coenzyme A: amino acid N-acyltransferase 0.166
Mup12 major urinary protein 12 0.162
Fos FBJ osteosarcoma oncogene 0.146
Mup4 major urinary protein 4 0.141
Mup15 major urinary protein 15 0.138
Mup13 major urinary protein 13 0.135
Mup8 major urinary protein 8 0.135
Mup14 major urinary protein 14 0.133
Cfd complement factor D (adipsin) 0.130
Bscl2 Bernardinelli-Seip congenital lipodystrophy 2 homolog (human) 0.127
Ulk1 Unc-51 like kinase 1 (C. elegans) 0.125
Cidea cell death-inducing DNA fragmentation factor, alpha subunit-like effector A 0.125
LOC100048885 major urinary protein LOC100048885 0.122
Ahsg alpha-2-HS-glycoprotein 0.121
Ldha lactate dehydrogenase A 0.120
Mup17 major urinary protein 17 0.119
Cebpa CCAAT/enhancer binding protein (C/EBP), alpha 0.111
Rbl2 retinoblastoma-like 2 0.109
Dmgdh dimethylglycine dehydrogenase precursor 0.109
Mup11 major urinary protein 11 0.108
Vdr vitamin D receptor 0.106
Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.105
Kdm3a lysine (K)-specific demethylase 3A 0.104
Hif1a hypoxia inducible factor 1, alpha subunit 0.104
Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 0.100
Hmgcs2 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 0.100
Mup7 major urinary protein 7 0.097
Fabp1 fatty acid binding protein 1, liver 0.093
Hamp hepcidin antimicrobial peptide 0.090
Serping1 serine (or cysteine) peptidase inhibitor, clade G, member 1 0.089
Tef thyrotroph embryonic factor 0.087
Gnas GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus 0.087
Cyp2c50 cytochrome P450, family 2, subfamily c, polypeptide 50 0.087
Ar androgen receptor 0.086
Nfil3 nuclear factor, interleukin 3, regulated 0.083
Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 0.082
Mup2 major urinary protein 2 0.082
Pgk1 phosphoglycerate kinase 1 0.077
Fbxl3 F-box and leucine-rich repeat protein 3 0.077
Cav1 caveolin 1, caveolae protein 0.075
Lipe lipase, hormone sensitive 0.071
Hrg histidine-rich glycoprotein 0.070
Pou3f1 POU domain, class 3, transcription factor 1 0.070
Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 0.069
Apoc4 apolipoprotein C-IV 0.068
Akr1c6 aldo-keto reductase family 1, member C6 0.068
Thra thyroid hormone receptor alpha 0.067
Cyp2d26 cytochrome P450, family 2, subfamily d, polypeptide 26 0.065
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Rattus norvegicus
Name Description Probability Func Analog Organism
Aldoa aldolase A, fructose-bisphosphate 0.974
Ldha lactate dehydrogenase A 0.733
Tpi1 triosephosphate isomerase 1 0.583
Dbp D site of albumin promoter (albumin D-box) binding protein 0.532
Pkm2 pyruvate kinase, muscle 0.412
Eno1 enolase 1, (alpha) 0.299
Etfa electron-transfer-flavoprotein, alpha polypeptide 0.228
Pgk1 phosphoglycerate kinase 1 0.141
Nr1d2 nuclear receptor subfamily 1, group D, member 2 0.093
Cox8b cytochrome c oxidase, subunit VIIIb 0.071
PVR poliovirus receptor 0.060
B4galt1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 0.051
Acadvl acyl-Coenzyme A dehydrogenase, very long chain 0.049
Gapdh glyceraldehyde-3-phosphate dehydrogenase 0.046
Gpi glucose phosphate isomerase 0.044
Etfdh electron-transferring-flavoprotein dehydrogenase 0.039
Slc37a4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 0.038
Acsl1 acyl-CoA synthetase long-chain family member 1 0.037
Dusp1 dual specificity phosphatase 1 0.036
Nxf1 nuclear RNA export factor 1 0.035
Grinl1a glutamate receptor, ionotropic, N-methyl D-aspartate-like 1A 0.030
Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 0.028
Pxmp2 peroxisomal membrane protein 2 0.025
Acadl acyl-Coenzyme A dehydrogenase, long-chain 0.025
Ass1 argininosuccinate synthetase 1 0.025
Irf3 interferon regulatory factor 3 0.022
Ak1 adenylate kinase 1 0.022
Acacb acetyl-Coenzyme A carboxylase beta 0.021
Fos FBJ osteosarcoma oncogene 0.020
Pgam1 phosphoglycerate mutase 1 (brain) 0.020
Fbp1 fructose-1,6-bisphosphatase 1 0.018
Nfib nuclear factor I/B 0.018
Cyp3a18 cytochrome P450, family 3, subfamily a, polypeptide 18 0.018
Myh1 myosin, heavy polypeptide 1, skeletal muscle, adult 0.018
Pfkm phosphofructokinase, muscle 0.017
Gstm2 glutathione S-transferase mu 2 0.017
Zbtb20 zinc finger and BTB domain containing 20 0.016
Pdgfb platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.015
Casp2 caspase 2 0.014
Klf4 Kruppel-like factor 4 (gut) 0.014
Btg2 BTG family, member 2 0.013
Mstn myostatin 0.013
Nfia nuclear factor I/A 0.012
Decr1 2,4-dienoyl CoA reductase 1, mitochondrial 0.012
Ppp1r15a protein phosphatase 1, regulatory (inhibitor) subunit 15A 0.012
Slc22a1 solute carrier family 22 (organic cation transporter), member 1 0.012
Hadhb hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit 0.011
LOC100361864 UDP-glucuronosyltransferase 2B3-like 0.011
Nfix nuclear factor I/X (CCAAT-binding transcription factor) 0.011
Ndrg2 N-myc downstream regulated gene 2 0.011
G6pc glucose-6-phosphatase, catalytic subunit 0.011
RGD1305347 similar to RIKEN cDNA 2610528J11 0.011
Rara retinoic acid receptor, alpha 0.011
Kitlg KIT ligand 0.011
A1cf APOBEC1 complementation factor 0.011
Tat tyrosine aminotransferase 0.011
Dio1 deiodinase, iodothyronine, type I 0.011
Slc25a10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 0.011
LOC100366119 Mpv17 transgene, kidney disease mutant-like (predicted)-like 0.011
Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 0.010
Rxrg retinoid X receptor gamma 0.010
Acot12 acyl-CoA thioesterase 12 0.010