The network for 'negative regulation of protein metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of protein metabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
CDC55 Cdc55p 0.645
GLC7 Glc7p 0.477
RTS1 Rts1p 0.361
MAD2 Mad2p 0.332
BCK1 Bck1p 0.304
STI1 Sti1p 0.304
BRE5 Bre5p 0.299
DEF1 Def1p 0.230
BOI1 Boi1p 0.227
PPH21 Pph21p 0.219
PSR2 Psr2p 0.215
CKB1 Ckb1p 0.209
CDC20 Cdc20p 0.207
SIS1 Sis1p 0.192
SLX8 Slx8p 0.188
SIC1 Sic1p 0.182
PPH22 Pph22p 0.155
HTA1 Hta1p 0.153
SWE1 Swe1p 0.144
CDC28 Cdc28p 0.132
DHH1 Dhh1p 0.127
CTF13 Ctf13p 0.125
SSA3 Ssa3p 0.125
NPL3 Npl3p 0.118
MYO5 Myo5p 0.117
MAD3 Mad3p 0.115
SUI3 Sui3p 0.108
HHF2 Hhf2p 0.107
GIS1 Gis1p 0.107
NOP7 Nop7p 0.101
YME1 Yme1p 0.098
CDH1 Cdh1p 0.094
MPT5 Mpt5p 0.093
CRZ1 Crz1p 0.091
ROM2 Rom2p 0.091
STE4 Ste4p 0.088
DED1 Ded1p 0.087
SSA1 Ssa1p 0.087
CAM1 Cam1p 0.085
YBP2 Ybp2p 0.084
FAB1 Fab1p 0.082
RAD23 Rad23p 0.073
SPT16 Spt16p 0.073
CDC25 Cdc25p 0.073
SDS22 Sds22p 0.072
CSE4 Cse4p 0.071
STE20 Ste20p 0.071
EAP1 Eap1p 0.070
TIP41 Tip41p 0.069
KEM1 Kem1p 0.067
NBP2 Nbp2p 0.067
DCP2 Dcp2p 0.067
TSR1 Tsr1p 0.066
WHI2 Whi2p 0.066
MIF2 Mif2p 0.066
COX1 Cox1p 0.065
MDH1 Mdh1p 0.065
KSP1 Ksp1p 0.064
KIP1 Kip1p 0.064
RPS9B Rps9bp 0.063
DSK2 Dsk2p 0.063
DCC1 Dcc1p 0.062
TPD3 Tpd3p 0.062
PHB1 Phb1p 0.062
ADR1 Adr1p 0.062
SOK1 Sok1p 0.061
FKH1 Fkh1p 0.061
NGR1 Ngr1p 0.060
CAK1 Cak1p 0.060
RLM1 Rlm1p 0.060
IMP2' Imp2'p 0.059
HIR1 Hir1p 0.058
ARL3 Arl3p 0.058
SNF1 Snf1p 0.057
GBP2 Gbp2p 0.057
NUG1 Nug1p 0.057
YEL1 Yel1p 0.056
PRP28 Prp28p 0.056
DOP1 Dop1p 0.055
SPT7 Spt7p 0.055
YHB1 Yhb1p 0.055
CTK2 Ctk2p 0.054
MAD1 Mad1p 0.054
TRS65 Trs65p 0.054
KIC1 Kic1p 0.054
IPI1 Ipi1p 0.053
DRS1 Drs1p 0.053
CLN2 Cln2p 0.053
CDC37 Cdc37p 0.052
ULA1 Ula1p 0.052
UBR2 Ubr2p 0.052
YGR054W hypothetical protein 0.052
URN1 Urn1p 0.052
KIN3 Kin3p 0.052
CLB6 Clb6p 0.052
CDC15 Cdc15p 0.052
RRP5 Rrp5p 0.052
YTA12 Yta12p 0.051
TDH2 Tdh2p 0.051
SSE1 Sse1p 0.050
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
mec-2 Protein MEC-2 0.109
mex-5 Protein MEX-5 0.099
egl-44 Protein EGL-44 0.059
ntl-2 Protein NTL-2 0.053
eps-8 Protein EPS-8 0.049
F49C12.9 Protein F49C12.9 0.047
sax-3 Protein SAX-3 0.046
imb-2 Protein IMB-2 0.046
ntl-4 Protein NTL-4 0.045
sma-6 Protein SMA-6 0.045
egg-6 Protein EGG-6 0.043
brp-1 Protein BRP-1 0.042
par-5 Protein PAR-5 0.041
tps-1 Protein TPS-1 0.041
let-502 Protein LET-502 0.037
vab-3 Protein VAB-3 0.037
egl-18 Protein EGL-18 0.036
hlh-30 Protein HLH-30 0.035
ZK507.6 Protein ZK507.6 0.034
lars-1 Protein LARS-1 0.032
csr-1 Protein CSR-1 0.032
spc-1 Protein SPC-1 0.031
pkc-3 Protein PKC-3 0.031
his-45 Protein HIS-45 0.031
his-6 Protein HIS-6 0.030
cbd-1 Protein CBD-1 0.030
ubq-1 Protein UBQ-1 0.030
hpo-32 Protein HPO-32 0.030
F26B1.2 Protein F26B1.2 0.028
mrt-2 Protein MRT-2 0.028
kca-1 Protein KCA-1 0.027
sym-4 Protein SYM-4 0.027
unc-115 Protein UNC-115 0.026
gld-2 Protein GLD-2 0.026
tba-2 Protein TBA-2 0.025
ajm-1 Protein AJM-1 0.025
daf-21 Protein DAF-21 0.025
nhr-34 Protein NHR-34 0.025
gyg-2 Protein GYG-2 0.025
hum-6 Protein HUM-6 0.025
ztf-17 Protein ZTF-17 0.025
mom-2 Protein MOM-2 0.024
egl-27 Protein EGL-27 0.024
K10D6.4 Protein K10D6.4 0.024
gst-36 Protein GST-36 0.024
his-42 Protein HIS-42 0.024
K07B1.7 Protein K07B1.7 0.023
stau-1 Protein STAU-1 0.023
lpd-7 Protein LPD-7 0.023
zen-4 Protein ZEN-4 0.023
C56G2.5 Protein C56G2.5 0.023
itr-1 Protein ITR-1 0.023
ztf-7 Protein ZTF-7 0.023
F49E8.7 Protein F49E8.7 0.023
rpn-6.1 Protein RPN-6.1 0.023
gly-20 Protein GLY-20 0.022
snr-2 Protein SNR-2 0.022
inx-13 Protein INX-13 0.021
unc-9 Protein UNC-9 0.021
nap-1 Protein NAP-1 0.021
pry-1 Protein PRY-1 0.021
gpd-4 Protein GPD-4 0.021
C37H5.5 Protein C37H5.5 0.021
CELE_C17E4.3 Protein C17E4.3 0.021
rpl-4 Protein RPL-4 0.021
mex-3 Protein MEX-3 0.021
mes-3 Protein MES-3 0.021
mml-1 Protein MML-1 0.020
lmn-1 Protein LMN-1 0.020
rpm-1 Protein RPM-1 0.020
ubr-1 Protein UBR-1 0.020
axl-1 Protein AXL-1 0.020
CELE_R11H6.5 Protein R11H6.5 0.020
sek-1 Protein SEK-1 0.020
alg-1 Protein ALG-1 0.020
cgh-1 Protein CGH-1 0.020
ulp-2 Protein ULP-2 0.019
adr-1 Protein ADR-1 0.019
dgk-2 Protein DGK-2 0.019
akt-2 Protein AKT-2 0.019
puf-5 Protein PUF-5 0.019
CELE_F54D5.5 Protein F54D5.5 0.019
F55A12.5 Protein F55A12.5 0.019
puf-6 Protein PUF-6 0.019
lbp-7 Protein LBP-7 0.018
rnp-5 Protein RNP-5 0.018
T28D9.4 Protein T28D9.4 0.018
CELE_C25A1.4 Protein C25A1.4 0.018
atn-1 Protein ATN-1 0.018
zyg-8 Protein ZYG-8 0.018
egl-15 Protein EGL-15 0.018
F18H3.4 Protein F18H3.4 0.018
F57B9.1 Protein F57B9.1 0.018
dep-1 Protein DEP-1 0.018
egl-8 Protein EGL-8 0.018
riok-1 Protein RIOK-1 0.017
swsn-2.2 Protein SWSN-2.2 0.017
par-1 Protein PAR-1 0.017
unc-43 Protein UNC-43 0.017
tbb-2 Protein TBB-2 0.017
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
pcna proliferating cell nuclear antigen 0.270
notch1a notch homolog 1a 0.142
sema3aa semaphorin 3aa 0.113
frem3 Fras1 related extracellular matrix 3 0.091
egr1 early growth response 1 0.068
bcl2l1 bcl2-like 1 0.060
ccnd1 cyclin D1 0.059
ywhabb tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide b 0.056
gadd45ba growth arrest and DNA-damage-inducible, beta a 0.055
brca2 breast cancer 2, early onset 0.050
cxcr4b chemokine (C-X-C motif), receptor 4b 0.050
cx43.4 connexin 43.4 0.046
bmp2b bone morphogenetic protein 2b 0.044
ppp1r12a protein phosphatase 1, regulatory (inhibitor) subunit 12A 0.044
smoc1 SPARC related modular calcium binding 1 0.043
alcama activated leukocyte cell adhesion molecule a 0.041
usp5 ubiquitin specific protease 5 0.038
ccnb1 cyclin B1 0.037
ncl nucleolin 0.037
rarab retinoic acid receptor, alpha b 0.037
fgfr1a fibroblast growth factor receptor 1a 0.037
pax8 paired box gene 8 0.037
pou3f1 POU class 3 homeobox 1 0.036
gli1 GLI-Kruppel family member 1 0.034
spry4 sprouty (Drosophila) homolog 4 0.034
caprin1a cell cycle associated protein 1a 0.032
igf1ra insulin-like growth factor 1a receptor 0.032
sall1a sal-like 1a (Drosophila) 0.032
dab1a disabled homolog 1a (Drosophila) 0.030
mcm5 MCM5 minichromosome maintenance deficient 5 (S. cerevisiae) 0.029
pxn paxillin 0.029
ntn2 netrin 2 0.029
ptch2 patched 2 0.029
stc1l stanniocalcin 1, like 0.029
meis1 myeloid ecotropic viral integration 1 0.029
zgc:195154 zgc:195154 0.028
hsp90a.2 heat shock protein 90-alpha 2 0.028
sox11a SRY-box containing gene 11a 0.028
dld deltaD 0.027
nf1a neurofibromin 1a 0.027
hs6st1a heparan sulfate 6-O-sulfotransferase 1a 0.027
lratb lecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b) 0.025
furina furin (paired basic amino acid cleaving enzyme) a 0.025
zgc:56304 zgc:56304 0.025
sulf2l sulfatase 2, like 0.025
hnrnpk heterogeneous nuclear ribonucleoprotein K 0.024
nfkbiab nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b 0.024
ryk receptor-like tyrosine kinase 0.024
itga5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.024
bactin2 bactin2 0.024
nrg2a neuregulin 2a 0.023
sox11b SRY-box containing gene 11b 0.023
u2af2b U2 small nuclear RNA auxiliary factor 2b 0.023
ptn pleiotrophin 0.023
dusp6 dual specificity phosphatase 6 0.023
med12 mediator of RNA polymerase II transcription, subunit 12 homolog 0.022
mcl1a myeloid cell leukemia sequence 1a 0.022
mdm2 transformed 3T3 cell double minute 2 homolog (mouse) 0.022
mbtps1 membrane-bound transcription factor protease, site 1 0.022
crip2 cysteine-rich protein 2 0.022
shha sonic hedgehog a 0.022
ywhabl tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide like 0.022
rab11fip4a RAB11 family interacting protein 4 (class II) a 0.021
naa50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 0.021
ptpro protein tyrosine phosphatase, receptor type, O 0.021
sox2 SRY-box containing gene 2 0.021
clint1 clathrin interactor 1 0.021
fgg fibrinogen, gamma polypeptide 0.021
tgfb1a transforming growth factor, beta 1a 0.020
bnip3lb BCL2/adenovirus E1B interacting protein 3-like b 0.020
ncapg non-SMC condensin I complex, subunit G 0.020
ascl1a achaete-scute complex-like 1a (Drosophila) 0.020
srsf1a serine/arginine-rich splicing factor 1a 0.020
nog2 noggin 2 0.020
nap1l1 nucleosome assembly protein 1, like 1 0.020
cct8 chaperonin containing TCP1, subunit 8 (theta) 0.020
rhogb ras homolog gene family, member Gb 0.020
mbnl2 muscleblind-like 2 (Drosophila) 0.020
zgc:112211 zgc:112211 0.020
gmnn geminin, DNA replication inhibitor 0.019
eif3s10 eukaryotic translation initiation factor 3, subunit 10 (theta) 0.019
sepw1 selenoprotein W, 1 0.019
col7a1l collagen type VII alpha 1-like 0.019
otpb orthopedia homolog b 0.019
lhx2b LIM homeobox 2b 0.019
cdk8 cyclin-dependent kinase 8 0.018
fabp10a fatty acid binding protein 10a, liver basic 0.018
evx1 even-skipped homeobox 1 0.018
mapk1 mitogen-activated protein kinase 1 0.018
gpr126 G protein-coupled receptor 126 0.018
pak2a p21 (CDKN1A)-activated kinase 2a 0.018
wnt1 wingless-type MMTV integration site family, member 1 0.018
tnfa tumor necrosis factor a (TNF superfamily, member 2) 0.018
acvr1l activin A receptor, type I like 0.018
zgc:86759 zgc:86759 0.018
stac3 SH3 and cysteine rich domain 3 0.018
baxa bcl2-associated X protein, a 0.018
rfng radical fringe homolog (Drosophila) 0.017
etv5b ets variant 5b 0.017
dip2c DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.017
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
Mad Mothers against dpp 0.559
ena enabled 0.504
p53 CG33336 gene product from transcript CG33336-RB 0.500
Egfr Epidermal growth factor receptor 0.438
Ras85D Ras oncogene at 85D 0.412
osk oskar 0.370
drk downstream of receptor kinase 0.330
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.322
lok loki 0.265
CycB Cyclin B 0.257
Rho1 CG8416 gene product from transcript CG8416-RB 0.255
NFAT NFAT homolog 0.242
polo CG12306 gene product from transcript CG12306-RA 0.232
InR Insulin-like receptor 0.216
Cdc42 CG12530 gene product from transcript CG12530-RA 0.211
hts hu li tai shao 0.202
tsh teashirt 0.197
G-oalpha47A G protein oalpha 47A 0.194
rin rasputin 0.169
egh egghead 0.168
foxo forkhead box, sub-group O 0.161
puc puckered 0.158
chico CG5686 gene product from transcript CG5686-RB 0.158
rl rolled 0.146
sax saxophone 0.139
Pgk Phosphoglycerate kinase 0.134
spi spitz 0.133
rpr reaper 0.129
sop string of pearls 0.128
ago archipelago 0.126
Src64B Src oncogene at 64B 0.126
Stim Stromal interaction molecule 0.125
dsh dishevelled 0.124
par-1 CG8201 gene product from transcript CG8201-RA 0.123
rap retina aberrant in pattern 0.121
aux auxillin 0.116
drpr draper 0.115
Akt1 CG4006 gene product from transcript CG4006-RA 0.115
CG5931 CG5931 gene product from transcript CG5931-RA 0.113
ovo CG6824 gene product from transcript CG6824-RE 0.112
CaMKII Calcium/calmodulin-dependent protein kinase II 0.111
dnc dunce 0.109
smt3 CG4494 gene product from transcript CG4494-RA 0.108
pnt pointed 0.105
CG1021 CG1021 gene product from transcript CG1021-RE 0.104
ap apterous 0.104
Thor CG8846 gene product from transcript CG8846-RA 0.104
bsk basket 0.103
Imp IGF-II mRNA-binding protein 0.103
loqs loquacious 0.103
sxc super sex combs 0.102
CSN5 COP9 complex homolog subunit 5 0.101
krz kurtz 0.100
thr three rows 0.100
RanBPM Ran-binding protein M 0.099
Sema-2a CG4700 gene product from transcript CG4700-RC 0.099
enc encore 0.098
Iswi Imitation SWI 0.097
Socs36E Suppressor of cytokine signaling at 36E 0.097
so sine oculis 0.096
twin CG31137 gene product from transcript CG31137-RB 0.096
trx trithorax 0.094
Doa Darkener of apricot 0.092
bam bag of marbles 0.090
Dad Daughters against dpp 0.090
wb wing blister 0.089
Ubx Ultrabithorax 0.088
Gef26 CG9491 gene product from transcript CG9491-RB 0.087
hep hemipterous 0.085
arm armadillo 0.084
hipk homeodomain interacting protein kinase 0.084
tai taiman 0.084
nwk nervous wreck 0.082
msn misshapen 0.082
bel belle 0.081
cact cactus 0.081
sog short gastrulation 0.081
Trim9 CG31721 gene product from transcript CG31721-RB 0.081
trc tricornered 0.081
Stat92E Signal-transducer and activator of transcription protein at 92E 0.080
Snoo Sno oncogene 0.079
mirr mirror 0.078
CG9821 CG9821 gene product from transcript CG9821-RB 0.077
kay kayak 0.077
argos CG4531 gene product from transcript CG4531-RA 0.076
Smr Smrter 0.076
RpS27A Ribosomal protein S27A 0.076
mth methuselah 0.075
brm brahma 0.074
RpII215 RNA polymerase II 215kD subunit 0.073
CG32479 CG32479 gene product from transcript CG32479-RA 0.073
lgs legless 0.073
Sep2 Septin-2 0.073
eya eyes absent 0.073
aret arrest 0.073
CG6361 CG6361 gene product from transcript CG6361-RA 0.073
Cdc37 CG12019 gene product from transcript CG12019-RA 0.072
Smox Smad on X 0.072
Rac1 CG2248 gene product from transcript CG2248-RA 0.072
rho rhomboid 0.072
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 1.000
TP53 tumor protein p53 1.000
GSK3B glycogen synthase kinase 3 beta 1.000
UBC ubiquitin C 0.999
RB1 retinoblastoma 1 0.999
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.999
JUN jun proto-oncogene 0.998
EGFR epidermal growth factor receptor 0.995
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.994
MAPK1 mitogen-activated protein kinase 1 0.991
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.991
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.989
MAPK14 mitogen-activated protein kinase 14 0.989
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.984
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.984
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.983
PRKCZ protein kinase C, zeta 0.981
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.978
DUSP1 dual specificity phosphatase 1 0.978
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.976
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.970
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.969
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.966
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.962
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.958
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.958
XIAP X-linked inhibitor of apoptosis 0.951
APP amyloid beta (A4) precursor protein 0.950
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.937
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.917
BUB1B budding uninhibited by benzimidazoles 1 homolog beta (yeast) 0.913
CREBBP CREB binding protein 0.913
HDAC1 histone deacetylase 1 0.912
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.912
SMAD7 SMAD family member 7 0.907
CAV1 caveolin 1, caveolae protein, 22kDa 0.900
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.899
TNRC6A trinucleotide repeat containing 6A 0.893
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.892
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.891
ANXA1 annexin A1 0.890
SMAD3 SMAD family member 3 0.888
MET met proto-oncogene (hepatocyte growth factor receptor) 0.887
ARRB1 arrestin, beta 1 0.880
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.879
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 0.879
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.876
PABPC1 poly(A) binding protein, cytoplasmic 1 0.866
GHR growth hormone receptor 0.862
SMAD4 SMAD family member 4 0.861
ZNF43 zinc finger protein 43 0.849
ERBB4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) 0.847
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.846
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.825
FAS Fas (TNF receptor superfamily, member 6) 0.824
BCL2L1 BCL2-like 1 0.824
MAP3K7 mitogen-activated protein kinase kinase kinase 7 0.823
RICTOR RPTOR independent companion of MTOR, complex 2 0.823
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.822
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.818
BTRC beta-transducin repeat containing 0.817
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 0.815
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.814
FN1 fibronectin 1 0.814
CUL3 cullin 3 0.810
MYC v-myc myelocytomatosis viral oncogene homolog (avian) 0.805
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.800
GABARAPL2 GABA(A) receptor-associated protein-like 2 0.792
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 0.775
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.774
DAXX death-domain associated protein 0.756
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 0.754
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) 0.753
RIPK2 receptor-interacting serine-threonine kinase 2 0.747
CDC37 cell division cycle 37 homolog (S. cerevisiae) 0.741
RNF11 ring finger protein 11 0.739
PTK2 PTK2 protein tyrosine kinase 2 0.727
IRAK1 interleukin-1 receptor-associated kinase 1 0.727
MAP2K4 mitogen-activated protein kinase kinase 4 0.725
PML promyelocytic leukemia 0.724
SQSTM1 sequestosome 1 0.722
GRB7 growth factor receptor-bound protein 7 0.722
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 0.720
SP1 Sp1 transcription factor 0.718
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.715
LCK lymphocyte-specific protein tyrosine kinase 0.709
ZNF273 zinc finger protein 273 0.703
POU5F1 POU class 5 homeobox 1 0.702
CNOT8 CCR4-NOT transcription complex, subunit 8 0.701
PLCG1 phospholipase C, gamma 1 0.689
RING1 ring finger protein 1 0.686
SORBS3 sorbin and SH3 domain containing 3 0.681
MAPK8 mitogen-activated protein kinase 8 0.680
EPOR erythropoietin receptor 0.679
HTT huntingtin 0.676
SRF serum response factor (c-fos serum response element-binding transcription factor) 0.673
SMAD2 SMAD family member 2 0.670
CNOT6 CCR4-NOT transcription complex, subunit 6 0.661
ITCH itchy E3 ubiquitin protein ligase homolog (mouse) 0.658
FOS FBJ murine osteosarcoma viral oncogene homolog 0.656
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Trp53 transformation related protein 53 1.000
Pten phosphatase and tensin homolog 1.000
Lepr leptin receptor 0.998
Bcl2 B-cell leukemia/lymphoma 2 0.996
Apc adenomatosis polyposis coli 0.990
Stat3 signal transducer and activator of transcription 3 0.986
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.969
Plcg2 phospholipase C, gamma 2 0.960
App amyloid beta (A4) precursor protein 0.945
Rb1 retinoblastoma 1 0.938
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.927
Dusp1 dual specificity phosphatase 1 0.927
Drd2 dopamine receptor D2 0.925
Clock circadian locomotor output cycles kaput 0.924
Ptgs2 prostaglandin-endoperoxide synthase 2 0.920
Skil SKI-like 0.911
Socs1 suppressor of cytokine signaling 1 0.909
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 0.906
Ret ret proto-oncogene 0.904
Emx1 empty spiracles homolog 1 (Drosophila) 0.898
Egfr epidermal growth factor receptor 0.881
Fas Fas (TNF receptor superfamily member 6) 0.881
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.877
Grb2 growth factor receptor bound protein 2 0.868
Per2 period homolog 2 (Drosophila) 0.867
Fos FBJ osteosarcoma oncogene 0.862
Fyn Fyn proto-oncogene 0.862
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.854
Tgfb1 transforming growth factor, beta 1 0.851
Axin1 axin 1 0.850
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.839
Nos3 nitric oxide synthase 3, endothelial cell 0.828
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.819
Jun Jun oncogene 0.815
Csf1 colony stimulating factor 1 (macrophage) 0.814
Smad4 MAD homolog 4 (Drosophila) 0.811
Tnf tumor necrosis factor 0.807
Suz12 suppressor of zeste 12 homolog (Drosophila) 0.807
Smad3 MAD homolog 3 (Drosophila) 0.805
Foxa2 forkhead box A2 0.803
Zeb1 zinc finger E-box binding homeobox 1 0.801
Rara retinoic acid receptor, alpha 0.801
Blnk B-cell linker 0.795
Prnp prion protein 0.792
Arntl aryl hydrocarbon receptor nuclear translocator-like 0.788
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.785
Il6st interleukin 6 signal transducer 0.784
Ctnnb1 catenin (cadherin associated protein), beta 1 0.770
Eif2c2 eukaryotic translation initiation factor 2C, 2 0.768
Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.761
Irf8 interferon regulatory factor 8 0.737
Apoe apolipoprotein E 0.736
Cry2 cryptochrome 2 (photolyase-like) 0.732
Nr3c1 nuclear receptor subfamily 3, group C, member 1 0.731
Dvl2 dishevelled 2, dsh homolog (Drosophila) 0.728
Shh sonic hedgehog 0.724
Timp3 tissue inhibitor of metalloproteinase 3 0.724
Apoa1 apolipoprotein A-I 0.721
Foxp1 forkhead box P1 0.718
Tlr4 toll-like receptor 4 0.710
Irf1 interferon regulatory factor 1 0.707
Junb Jun-B oncogene 0.702
Icos inducible T-cell co-stimulator 0.700
Pax8 paired box gene 8 0.699
Ikzf1 IKAROS family zinc finger 1 0.698
Ptch1 patched homolog 1 0.694
Rxra retinoid X receptor alpha 0.693
Nfkbiz nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.693
Gnai2 guanine nucleotide binding protein (G protein), alpha inhibiting 2 0.690
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.687
Gli2 GLI-Kruppel family member GLI2 0.685
Foxf1a forkhead box F1a 0.683
Socs3 suppressor of cytokine signaling 3 0.682
Lhx3 LIM homeobox protein 3 0.681
Hdac1 histone deacetylase 1 0.675
Elavl1 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) 0.669
Otx2 orthodenticle homolog 2 (Drosophila) 0.668
Spry4 sprouty homolog 4 (Drosophila) 0.666
Ptprc protein tyrosine phosphatase, receptor type, C 0.663
Mdm4 transformed mouse 3T3 cell double minute 4 0.662
Nf1 neurofibromatosis 1 0.651
Ppp2ca protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform 0.644
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.644
Gdnf glial cell line derived neurotrophic factor 0.640
Smad7 MAD homolog 7 (Drosophila) 0.637
Lyz2 lysozyme 2 0.633
Cdk5r1 cyclin-dependent kinase 5, regulatory subunit 1 (p35) 0.631
Onecut1 one cut domain, family member 1 0.630
Thrb thyroid hormone receptor beta 0.627
Lef1 lymphoid enhancer binding factor 1 0.622
Insr insulin receptor 0.619
Nos1 nitric oxide synthase 1, neuronal 0.613
Aim2 absent in melanoma 2 0.612
Cish cytokine inducible SH2-containing protein 0.604
Atf2 activating transcription factor 2 0.601
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.599
Rarg retinoic acid receptor, gamma 0.597
Mndal myeloid nuclear differentiation antigen like 0.596
Vasp vasodilator-stimulated phosphoprotein 0.589
Mdm2 transformed mouse 3T3 cell double minute 2 0.588
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Egr1 early growth response 1 0.276
Apoh apolipoprotein H (beta-2-glycoprotein I) 0.222
Junb jun B proto-oncogene 0.199
Jun Jun oncogene 0.191
C9 complement component 9 0.190
Cdk4 cyclin-dependent kinase 4 0.162
Proc protein C 0.160
Ptms parathymosin 0.154
Gc group specific component 0.153
Ahsg alpha-2-HS-glycoprotein 0.151
Fos FBJ osteosarcoma oncogene 0.146
Hspa1a heat shock 70kD protein 1A 0.146
Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 0.138
Klf9 Kruppel-like factor 9 0.134
Dnajb1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.131
Hsph1 heat shock 105/110 protein 1 0.130
Nfix nuclear factor I/X (CCAAT-binding transcription factor) 0.128
Fga fibrinogen alpha chain 0.126
Dusp1 dual specificity phosphatase 1 0.123
Lgr4 leucine-rich repeat-containing G protein-coupled receptor 4 0.123
Ccnd3 cyclin D3 0.119
Pzp pregnancy-zone protein 0.117
Tcea2 transcription elongation factor A (SII), 2 0.116
Tdo2 tryptophan 2,3-dioxygenase 0.114
Serpina10 serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 0.111
Shc1 SHC (Src homology 2 domain containing) transforming protein 1 0.110
Tgoln1 trans-golgi network protein 0.110
Hp haptoglobin 0.102
Ptgs2 prostaglandin-endoperoxide synthase 2 0.102
Klf4 Kruppel-like factor 4 (gut) 0.099
Thra thyroid hormone receptor alpha 0.099
Rhob ras homolog gene family, member B 0.098
Usf2 upstream transcription factor 2, c-fos interacting 0.096
Fabp1 fatty acid binding protein 1, liver 0.095
Serpind1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 0.094
Nfia nuclear factor I/A 0.093
Agap3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 0.092
Aqp9 aquaporin 9 0.092
Itih4 inter alpha-trypsin inhibitor, heavy chain 4 0.091
Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 0.085
Sirpa signal-regulatory protein alpha 0.085
Dlg1 discs, large homolog 1 (Drosophila) 0.085
Cyp2c13 cytochrome P450, family 2, subfamily c, polypeptide 13 0.084
Serpina3k serine (or cysteine) peptidase inhibitor, clade A, member 3K 0.083
Spp2 secreted phosphoprotein 2 0.083
Selm selenoprotein M 0.082
St8sia3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 0.081
Calcrl calcitonin receptor-like 0.081
Apoa2 apolipoprotein A-II 0.080
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.080
Dnaja4 DnaJ (Hsp40) homolog, subfamily A, member 4 0.080
Mx1 myxovirus (influenza virus) resistance 1 0.078
Sgk1 serum/glucocorticoid regulated kinase 1 0.077
Gjb3 gap junction protein, beta 3 0.076
Rbck1 RanBP-type and C3HC4-type zinc finger containing 1 0.076
Tle4 transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) 0.076
Jak2 Janus kinase 2 0.076
Casp2 caspase 2 0.075
Atp6v1f ATPase, H transporting, lysosomal V1 subunit F 0.074
Myo1b myosin Ib 0.074
Tp53 tumor protein p53 0.073
Dnaja1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.072
Slfn2 schlafen 2 0.072
Pemt phosphatidylethanolamine N-methyltransferase 0.072
Tcfe2a transcription factor E2a 0.072
C4bpa complement component 4 binding protein, alpha 0.070
Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.070
Matk megakaryocyte-associated tyrosine kinase 0.069
Ppm1a protein phosphatase 1A, magnesium dependent, alpha isoform 0.069
Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 0.069
Errfi1 ERBB receptor feedback inhibitor 1 0.067
Napa N-ethylmaleimide-sensitive factor attachment protein, alpha 0.067
Lif leukemia inhibitory factor 0.066
Cngb1 cyclic nucleotide gated channel beta 1 0.065
Eif2b5 eukaryotic translation initiation factor 2B, subunit 5 epsilon 0.065
Apba3 amyloid beta (A4) precursor protein-binding, family A, member 3 0.064
Ambp alpha-1-microglobulin/bikunin precursor 0.063
Hpx hemopexin 0.063
Esr1 estrogen receptor 1 0.063
Ubtf upstream binding transcription factor, RNA polymerase I 0.063
Taok1 TAO kinase 1 0.063
Ifitm3 interferon induced transmembrane protein 3 0.063
Cp ceruloplasmin 0.062
Amh anti-Mullerian hormone 0.062
Ppp2cb protein phosphatase 2, catalytic subunit, beta isoform 0.062
Synpo synaptopodin 0.061
Alb albumin 0.061
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.061
Cfd complement factor D (adipsin) 0.061
Smad1 SMAD family member 1 0.061
Homer1 homer homolog 1 (Drosophila) 0.060
Sycn syncollin 0.060
Mbl1 mannose-binding lectin (protein A) 1 0.060
Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 0.059
Cacna1s calcium channel, voltage-dependent, L type, alpha 1S subunit 0.059
Pgr progesterone receptor 0.059
Gatad1 GATA zinc finger domain containing 1 0.059
Tgfbr2 transforming growth factor, beta receptor II 0.059
Ptch1 patched homolog 1 (Drosophila) 0.058
Ppp1r2 protein phosphatase 1, regulatory (inhibitor) subunit 2 0.058