The network for 'establishment of protein localization' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

establishment of protein localization

The directed movement of a protein to a specific location.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
TIM23 Tim23p 0.999
TOM22 Tom22p 0.997
TOM40 Tom40p 0.991
TOM20 Tom20p 0.989
PEX14 Pex14p 0.988
VPS28 Vps28p 0.987
BMH1 Bmh1p 0.978
TIM17 Tim17p 0.974
NUP116 Nup116p 0.974
NUP145 Nup145p 0.968
TOM70 Tom70p 0.965
VPS4 Vps4p 0.962
TIM44 Tim44p 0.959
NUP49 Nup49p 0.959
VPS21 Vps21p 0.958
PEX13 Pex13p 0.958
HSP82 Hsp82p 0.954
NUP2 Nup2p 0.949
ERV25 Erv25p 0.941
TOM5 Tom5p 0.940
ERP2 Erp2p 0.938
SEC63 Sec63p 0.937
NIC96 Nic96p 0.934
SSC1 Ssc1p 0.933
KAP95 Kap95p 0.931
TIM50 Tim50p 0.930
TIM54 Tim54p 0.930
PEX12 Pex12p 0.925
TIM18 Tim18p 0.922
NSP1 Nsp1p 0.920
PSE1 Pse1p 0.914
PEX2 Pex2p 0.903
PAM18 Pam18p 0.902
SAM35 Sam35p 0.898
YPT1 Ypt1p 0.896
SLT2 Slt2p 0.894
PEP3 Pep3p 0.892
PEX15 Pex15p 0.891
MIM1 Mim1p 0.881
COG6 Cog6p 0.879
VPS36 Vps36p 0.876
PEX5 Pex5p 0.876
STI1 Sti1p 0.872
TIM10 Tim10p 0.869
ATG21 Atg21p 0.865
APL5 Apl5p 0.865
BTN2 Btn2p 0.857
SEC62 Sec62p 0.849
CRM1 Crm1p 0.848
SLG1 Slg1p 0.843
ATG16 Atg16p 0.843
MIA40 Mia40p 0.840
VAM6 Vam6p 0.839
YPT6 Ypt6p 0.834
ERP5 Erp5p 0.826
PEX3 Pex3p 0.819
KAR2 Kar2p 0.817
SAM50 Sam50p 0.817
PEX10 Pex10p 0.817
YPT10 Ypt10p 0.815
CMD1 Cmd1p 0.813
TLG2 Tlg2p 0.813
SNX4 Snx4p 0.804
ATG7 Atg7p 0.798
COG5 Cog5p 0.797
SRP68 Srp68p 0.795
ALO1 Alo1p 0.783
MDM20 Mdm20p 0.778
NPR1 Npr1p 0.774
KAP123 Kap123p 0.764
VPS30 Vps30p 0.753
PEX6 Pex6p 0.750
ATG9 Atg9p 0.750
SRN2 Srn2p 0.749
PEP8 Pep8p 0.748
NUP120 Nup120p 0.746
NUP170 Nup170p 0.745
APM3 Apm3p 0.740
MGE1 Mge1p 0.733
LAS17 Las17p 0.727
LOS1 Los1p 0.724
SRO7 Sro7p 0.723
MON1 Mon1p 0.721
YPT31 Ypt31p 0.719
GLE1 Gle1p 0.718
NUP1 Nup1p 0.716
SEC4 Sec4p 0.711
ATG8 Atg8p 0.709
USA1 Usa1p 0.708
PEP5 Pep5p 0.693
SPA2 Spa2p 0.681
COG8 Cog8p 0.680
TIM13 Tim13p 0.674
YPT7 Ypt7p 0.669
SRP54 Srp54p 0.668
SEC66 Sec66p 0.665
TIM21 Tim21p 0.661
MDY2 Mdy2p 0.661
SIF2 Sif2p 0.654
MYO5 Myo5p 0.653
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
unc-52 Protein UNC-52 0.027
sem-5 Protein SEM-5 0.027
npp-7 Protein NPP-7 0.023
egl-44 Protein EGL-44 0.023
egl-8 Protein EGL-8 0.023
pdi-1 Protein PDI-1 0.021
mpk-1 Protein MPK-1 0.021
unc-108 Protein UNC-108 0.020
chc-1 Protein CHC-1 0.019
sec-23 Protein SEC-23 0.019
hsp-1 Protein HSP-1 0.019
vbh-1 Protein VBH-1 0.019
lin-36 Protein LIN-36 0.018
eftu-2 Protein EFTU-2 0.018
ret-1 Protein RET-1 0.018
klp-7 Protein KLP-7 0.018
acl-14 Protein ACL-14 0.018
par-3 Protein PAR-3 0.018
par-5 Protein PAR-5 0.017
swsn-1 Protein SWSN-1 0.017
let-60 Protein LET-60 0.017
C11E4.6 Protein C11E4.6 0.017
hpo-22 Protein HPO-22 0.017
rpt-3 Protein RPT-3 0.017
pry-1 Protein PRY-1 0.017
rab-5 Protein RAB-5 0.017
CELE_Y59A8A.3 Protein Y59A8A.3 0.017
hum-5 Protein HUM-5 0.017
F44B9.5 Protein F44B9.5 0.017
gei-17 Protein GEI-17 0.017
egl-15 Protein EGL-15 0.016
sma-6 Protein SMA-6 0.016
mat-3 Protein MAT-3 0.016
unc-43 Protein UNC-43 0.016
sqv-4 Protein SQV-4 0.016
R11A8.7 Protein R11A8.7 0.016
syx-17 Protein SYX-17 0.016
unc-44 Protein UNC-44 0.016
mec-2 Protein MEC-2 0.016
rho-1 Protein RHO-1 0.016
C53B4.4 Protein C53B4.4 0.016
skn-1 Protein SKN-1 0.015
hcp-4 Protein HCP-4 0.015
unc-60 Protein UNC-60 0.015
sel-8 Protein SEL-8 0.015
clic-1 Protein CLIC-1 0.015
dnc-2 Protein DNC-2 0.015
dnj-12 Protein DNJ-12 0.015
bub-1 Protein BUB-1 0.015
ubxn-2 Protein UBXN-2 0.015
col-173 Protein COL-173 0.015
F37C4.4 Protein F37C4.4 0.015
hid-1 Protein HID-1 0.015
T09A5.9 Protein T09A5.9 0.014
lmn-1 Protein LMN-1 0.014
ptc-1 Protein PTC-1 0.014
rpn-3 Protein RPN-3 0.014
M03F8.3 Protein M03F8.3 0.014
rme-4 Protein RME-4 0.014
hlh-30 Protein HLH-30 0.014
sys-1 Protein SYS-1 0.014
rab-11.1 Protein RAB-11.1 0.014
ced-7 Protein CED-7 0.014
rpn-1 Protein RPN-1 0.014
cmd-1 Protein CMD-1 0.014
rab-1 Protein RAB-1 0.014
dys-1 Protein DYS-1 0.014
cct-2 Protein CCT-2 0.014
sad-1 Protein SAD-1 0.014
spc-1 Protein SPC-1 0.014
csnk-1 Protein CSNK-1 0.014
csn-6 Protein CSN-6 0.014
unc-9 Protein UNC-9 0.014
pde-2 Protein PDE-2 0.014
his-35 Protein HIS-35 0.014
che-2 Protein CHE-2 0.014
Y71F9AL.17 Protein Y71F9AL.17 0.014
C13B9.3 Protein C13B9.3 0.014
hif-1 Protein HIF-1 0.014
gpb-1 Protein GPB-1 0.014
vav-1 Protein VAV-1 0.014
atn-1 Protein ATN-1 0.014
mom-5 Protein MOM-5 0.014
kin-3 Protein KIN-3 0.014
T20B12.7 Protein T20B12.7 0.014
CELE_T03F6.3 Protein T03F6.3 0.014
daf-14 Protein DAF-14 0.014
unc-112 Protein UNC-112 0.014
imb-2 Protein IMB-2 0.014
nuo-3 Protein NUO-3 0.013
vha-8 Protein VHA-8 0.013
hmg-1.1 Protein HMG-1.1 0.013
mlc-5 Protein MLC-5 0.013
cdc-42 Protein CDC-42 0.013
unc-73 Protein UNC-73 0.013
F42C5.9 Protein F42C5.9 0.013
tbc-9 Protein TBC-9 0.013
cls-2 Protein CLS-2 0.013
hrdl-1 Protein HRDL-1 0.013
che-13 Protein CHE-13 0.013
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
tp53 tumor protein p53 0.057
bmp2b bone morphogenetic protein 2b 0.037
copa coatomer protein complex, subunit alpha 0.024
plcg1 phospholipase C, gamma 1 0.021
cdh1 cadherin 1, epithelial 0.021
anxa1a annexin A1a 0.019
krt4 keratin 4 0.019
pycard PYD and CARD domain containing 0.017
itgb1b.2 integrin, beta 1b.2 0.017
kdrl kinase insert domain receptor like 0.017
mmp2 matrix metalloproteinase 2 0.016
nkx2.2a NK2 transcription factor related 2a 0.015
cnn2 calponin 2 0.015
kif23 kinesin family member 23 0.014
plk1 polo-like kinase 1 (Drosophila) 0.014
llgl2 lethal giant larvae homolog 2 (Drosophila) 0.013
flh floating head 0.013
runx2a runt-related transcription factor 2a 0.013
eif3ha eukaryotic translation initiation factor 3, subunit H, a 0.013
icn ictacalcin 0.012
ahctf1 AT hook containing transcription factor 1 0.012
ywhai tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, iota polypeptide 0.012
gna12 guanine nucleotide binding protein (G protein) alpha 12 0.012
ptenb phosphatase and tensin homolog B (mutated in multiple advanced cancers 1) 0.012
prkcz protein kinase C, zeta 0.012
hspa4a heat shock protein 4a 0.011
mapk3 mitogen-activated protein kinase 3 0.011
scrib scribbled homolog (Drosophila) 0.011
fzd7b frizzled homolog 7b 0.011
col27a1a collagen, type XXVII, alpha 1a 0.011
gdf6a growth differentiation factor 6a 0.011
wls wntless homolog (Drosophila) 0.011
pkd2 polycystic kidney disease 2 0.011
pak2a p21 (CDKN1A)-activated kinase 2a 0.010
nr3c1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.010
cd63 Cd63 antigen 0.010
fgf3 fibroblast growth factor 3 0.010
foxa2 forkhead box A2 0.010
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
Ras85D Ras oncogene at 85D 0.991
dally division abnormally delayed 0.905
Cdc42 CG12530 gene product from transcript CG12530-RA 0.882
Nrx-IV Neurexin IV 0.825
puc puckered 0.766
l(2)gl lethal (2) giant larvae 0.764
dco discs overgrown 0.738
Egfr Epidermal growth factor receptor 0.728
slmb supernumerary limbs 0.695
Mad Mothers against dpp 0.679
cpb capping protein beta 0.676
Akt1 CG4006 gene product from transcript CG4006-RA 0.662
Stat92E Signal-transducer and activator of transcription protein at 92E 0.651
drk downstream of receptor kinase 0.639
TER94 CG2331 gene product from transcript CG2331-RA 0.515
wls wntless 0.492
CdsA CDP diglyceride synthetase 0.482
Moe Moesin 0.465
Rab5 Rab-protein 5 0.454
arm armadillo 0.454
lqf liquid facets 0.432
faf fat facets 0.432
ovo CG6824 gene product from transcript CG6824-RE 0.423
Rac1 CG2248 gene product from transcript CG2248-RA 0.416
wg wingless 0.410
Syx7 Syntaxin 7 0.407
sqh spaghetti squash 0.406
Act5C Actin 5C 0.402
Mer Merlin 0.400
sktl skittles 0.397
Pp4-19C Protein phosphatase 19C 0.396
hyd hyperplastic discs 0.388
pum pumilio 0.384
Khc Kinesin heavy chain 0.361
sina seven in absentia 0.356
lqfR liquid facets-Related 0.354
car carnation 0.352
shn schnurri 0.338
CaMKII Calcium/calmodulin-dependent protein kinase II 0.336
Pp2B-14D Protein phosphatase 2B at 14D 0.327
Amph Amphiphysin 0.325
raps rapsynoid 0.319
Uba1 Ubiquitin activating enzyme 1 0.319
RanGap Ran GTPase activating protein 0.312
Dsp1 Dorsal switch protein 1 0.309
cact cactus 0.295
aop anterior open 0.292
rhea CG6831 gene product from transcript CG6831-RA 0.285
Sir2 CG5216 gene product from transcript CG5216-RA 0.274
Lam Lamin 0.273
trc tricornered 0.271
insc inscuteable 0.267
CG7033 CG7033 gene product from transcript CG7033-RC 0.265
sdt stardust 0.265
chic chickadee 0.258
bs blistered 0.257
phl pole hole 0.257
CG31120 CG31120 gene product from transcript CG31120-RB 0.252
brp bruchpilot 0.250
Hs6st Heparan sulfate 6-O-sulfotransferase 0.249
trbl tribbles 0.247
Lis-1 Lissencephaly-1 0.246
didum dilute class unconventional myosin 0.244
N Notch 0.242
scb scab 0.239
MED6 Mediator complex subunit 6 0.239
baz bazooka 0.238
Rab11 Rab-protein 11 0.232
CG11347 CG11347 gene product from transcript CG11347-RE 0.228
Dat Dopamine N acetyltransferase 0.228
zip zipper 0.227
gammaCop gamma-coatomer protein 0.222
SdhA Succinate dehydrogenase A 0.222
Btk29A Btk family kinase at 29A 0.216
sax saxophone 0.214
Rheb CG1081 gene product from transcript CG1081-RA 0.210
sfl sulfateless 0.206
wit wishful thinking 0.199
BicD Bicaudal D 0.198
PP2A-B' CG7913 gene product from transcript CG7913-RK 0.196
Csp Cysteine string protein 0.196
fs(1)K10 female sterile (1) K10 0.196
rut rutabaga 0.196
fog folded gastrulation 0.196
ninaE neither inactivation nor afterpotential E 0.192
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.191
CycA Cyclin A 0.191
sesB stress-sensitive B 0.189
Fs(2)Ket Female sterile (2) Ketel 0.186
CG12042 CG12042 gene product from transcript CG12042-RA 0.184
trx trithorax 0.183
par-6 CG5884 gene product from transcript CG5884-RA 0.181
Rab7 Rab-protein 7 0.181
emc extra macrochaetae 0.181
alpha-Adaptin CG4260 gene product from transcript CG4260-RA 0.176
pex13 peroxin 13 0.175
pex16 peroxin 16 0.172
wb wing blister 0.172
CG11164 CG11164 gene product from transcript CG11164-RA 0.169
per period 0.169
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Pfn1 profilin 1 0.818
Gria2 glutamate receptor, ionotropic, AMPA 2 0.789
Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 0.761
Tnf tumor necrosis factor (TNF superfamily, member 2) 0.704
Hsph1 heat shock 105/110 protein 1 0.692
Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 0.676
Apbb1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) 0.622
Ppp2r1a protein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform 0.501
Mapk1 mitogen activated protein kinase 1 0.500
Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.452
Ywhaq tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide 0.422
Capza2 capping protein (actin filament) muscle Z-line, alpha 2 0.407
Atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 0.378
Cops7a COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis) 0.376
Ppp2ca protein phosphatase 2, catalytic subunit, alpha isoform 0.375
Canx calnexin 0.375
Actr3 ARP3 actin-related protein 3 homolog (yeast) 0.361
Cd4 Cd4 molecule 0.357
Nrxn1 neurexin 1 0.346
Stip1 stress-induced phosphoprotein 1 0.343
Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.336
Sgta small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha 0.331
Lmna lamin A 0.325
Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.321
Rab11a RAB11a, member RAS oncogene family 0.309
Gdi1 GDP dissociation inhibitor 1 0.303
Fgfr2 fibroblast growth factor receptor 2 0.297
Nckap1 NCK-associated protein 1 0.294
Eef2 eukaryotic translation elongation factor 2 0.291
Trhr2 thyrotropin releasing hormone receptor 2 0.290
Adora3 adenosine A3 receptor 0.289
Ppp3cb protein phosphatase 3, catalytic subunit, beta isoform 0.282
Stxbp1 syntaxin binding protein 1 0.277
Gria3 glutamate receptor, ionotrophic, AMPA 3 0.277
Rhob ras homolog gene family, member B 0.277
Snap25 synaptosomal-associated protein 25 0.275
Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha isoform 0.268
Ubqln1 ubiquilin 1 0.267
Rhoa ras homolog gene family, member A 0.260
Hspa8 heat shock protein 8 0.255
S100a10 S100 calcium binding protein A10 0.255
Syngr2 synaptogyrin 2 0.252
Serpinh1 serine (or cysteine) peptidase inhibitor, clade H, member 1 0.248
Rab6a RAB6A, member RAS oncogene family 0.241
Chrna2 cholinergic receptor, nicotinic, alpha 2 (neuronal) 0.237
Rraga Ras-related GTP binding A 0.233
Snca synuclein, alpha (non A4 component of amyloid precursor) 0.228
Aktip AKT interacting protein 0.228
Hck hemopoietic cell kinase 0.226
Hspd1 heat shock protein 1 (chaperonin) 0.224
Actb actin, beta 0.223
Fkbp1a FK506 binding protein 1a 0.216
Adora2a adenosine A2a receptor 0.215
Ptafr platelet-activating factor receptor 0.214
Nek9 NIMA (never in mitosis gene a)- related kinase 9 0.211
Stx1a syntaxin 1A (brain) 0.211
Ppm1a protein phosphatase 1A, magnesium dependent, alpha isoform 0.205
Gria1 glutamate receptor, ionotropic, AMPA 1 0.204
Klf6 Kruppel-like factor 6 0.202
Pip4k2b phosphatidylinositol-5-phosphate 4-kinase, type II, beta 0.202
Cxcl10 chemokine (C-X-C motif) ligand 10 0.200
Htr7 5-hydroxytryptamine (serotonin) receptor 7 0.194
Anxa5 annexin A5 0.193
Mmp12 matrix metallopeptidase 12 0.192
Pdcl3 phosducin-like 3 0.192
Pdia6 protein disulfide isomerase family A, member 6 0.192
Stx12 syntaxin 12 0.190
Ndfip1 Nedd4 family interacting protein 1 0.190
Glg1 golgi apparatus protein 1 0.187
Stat6 signal transducer and activator of transcription 6 0.187
Msmb microseminoprotein, beta 0.185
Dlgap3 discs, large (Drosophila) homolog-associated protein 3 0.185
Myadm myeloid-associated differentiation marker 0.184
Dnajb1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.182
Sdcbp syndecan binding protein 0.178
Ctse cathepsin E 0.178
Slc12a3 solute carrier family 12 (sodium/chloride transporters), member 3 0.177
Calr calreticulin 0.175
Col5a1 collagen, type V, alpha 1 0.173
Rab3a RAB3A, member RAS oncogene family 0.171
Rara retinoic acid receptor, alpha 0.170
Rap1b RAP1B, member of RAS oncogene family 0.169
Ppp2r2a protein phosphatase 2 (formerly 2A), regulatory subunit B, alpha isoform 0.168
Arf4 ADP-ribosylation factor 4 0.168
Actg1 actin, gamma 1 0.166
Gdi2 GDP dissociation inhibitor 2 0.165
Fkbp4 FK506 binding protein 4 0.165
Gnai1 guanine nucleotide binding protein (G protein), alpha inhibiting 1 0.165
Calcb calcitonin-related polypeptide, beta 0.162
Icam1 intercellular adhesion molecule 1 0.161
Ndfip2 Nedd4 family interacting protein 2 0.161
Grip2 glutamate receptor interacting protein 2 0.160
Tpm3 tropomyosin 3, gamma 0.159
Pdia4 protein disulfide isomerase family A, member 4 0.159
Prkcd protein kinase C, delta 0.157
Zranb2 zinc finger, RAN-binding domain containing 2 0.155
Cd83 CD83 molecule 0.154
Cdk11b cyclin-dependent kinase 11B 0.153
Map3k8 mitogen-activated protein kinase kinase kinase 8 0.153
Hsp90b1 heat shock protein 90, beta, member 1 0.152