The network for 'proteolysis involved in cellular protein catabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

proteolysis involved in cellular protein catabolic process

The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
CDC48 Cdc48p 1.000
PRE1 Pre1p 1.000
RPT1 Rpt1p 0.999
RAD23 Rad23p 0.999
RPT6 Rpt6p 0.998
ECM29 Ecm29p 0.992
RPN10 Rpn10p 0.992
RPT2 Rpt2p 0.987
RPT4 Rpt4p 0.977
RPN11 Rpn11p 0.970
PRE10 Pre10p 0.968
RPN12 Rpn12p 0.967
RPT3 Rpt3p 0.965
OTU1 Otu1p 0.964
PRE2 Pre2p 0.963
PPH22 Pph22p 0.957
HRD1 Hrd1p 0.948
MND2 Mnd2p 0.944
MAD2 Mad2p 0.944
KAR2 Kar2p 0.943
PUP2 Pup2p 0.941
FYV10 Fyv10p 0.940
CDC53 Cdc53p 0.938
UBC4 Ubc4p 0.920
SKP1 Skp1p 0.916
RPN3 Rpn3p 0.900
UFD2 Ufd2p 0.897
VPS36 Vps36p 0.885
DSK2 Dsk2p 0.882
CDC20 Cdc20p 0.874
PRE4 Pre4p 0.872
UFD4 Ufd4p 0.869
PUP1 Pup1p 0.868
UBP3 Ubp3p 0.864
UBR1 Ubr1p 0.861
CDC23 Cdc23p 0.860
RPN9 Rpn9p 0.858
PRE6 Pre6p 0.857
MGR1 Mgr1p 0.857
SHP1 Shp1p 0.849
RPT5 Rpt5p 0.847
RPN8 Rpn8p 0.841
DOC1 Doc1p 0.840
UBP6 Ubp6p 0.836
RPN2 Rpn2p 0.830
APC5 Apc5p 0.824
CDC16 Cdc16p 0.819
APC2 Apc2p 0.817
CDC27 Cdc27p 0.802
VID30 Vid30p 0.792
SWM1 Swm1p 0.790
HRD3 Hrd3p 0.784
PRE9 Pre9p 0.782
PRE7 Pre7p 0.777
LAG2 Lag2p 0.776
NPL4 Npl4p 0.763
RPN6 Rpn6p 0.744
CDC4 Cdc4p 0.743
UBA1 Uba1p 0.718
PPH21 Pph21p 0.700
GID7 Gid7p 0.696
UFD1 Ufd1p 0.693
MAD3 Mad3p 0.677
RKR1 Rkr1p 0.676
ELC1 Elc1p 0.662
APC4 Apc4p 0.658
CDC26 Cdc26p 0.656
DER1 Der1p 0.655
APC1 Apc1p 0.644
CTF13 Ctf13p 0.639
PRE8 Pre8p 0.624
UBX3 Ubx3p 0.609
RPN1 Rpn1p 0.602
UBC13 Ubc13p 0.590
RPN7 Rpn7p 0.584
UBX4 Ubx4p 0.579
DOA1 Doa1p 0.570
PRE5 Pre5p 0.561
BRE5 Bre5p 0.551
MCM21 Mcm21p 0.551
SCL1 Scl1p 0.546
USA1 Usa1p 0.537
PRE3 Pre3p 0.530
YDJ1 Ydj1p 0.523
VPS27 Vps27p 0.516
PUP3 Pup3p 0.515
RMD5 Rmd5p 0.510
SGT2 Sgt2p 0.504
DFM1 Dfm1p 0.495
MOH1 Moh1p 0.491
UBC7 Ubc7p 0.491
MET30 Met30p 0.490
HRT1 Hrt1p 0.489
HSM3 Hsm3p 0.485
PMT1 Pmt1p 0.484
MNR2 Mnr2p 0.479
YDR306C hypothetical protein 0.477
RPN13 Rpn13p 0.476
SSM4 Ssm4p 0.476
RTS1 Rts1p 0.473
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
rpt-2 Protein RPT-2 0.856
rpt-3 Protein RPT-3 0.773
rpn-7 Protein RPN-7 0.771
imb-2 Protein IMB-2 0.679
rpn-12 Protein RPN-12 0.666
rpt-5 Protein RPT-5 0.641
rpn-3 Protein RPN-3 0.632
pas-4 Protein PAS-4 0.566
pbs-5 Protein PBS-5 0.543
rpn-6.1 Protein RPN-6.1 0.532
app-1 Protein APP-1 0.426
rod-1 Protein ROD-1 0.346
hgrs-1 Protein HGRS-1 0.338
cul-1 Protein CUL-1 0.336
pbs-6 Protein PBS-6 0.313
rpn-2 Protein RPN-2 0.304
pas-2 Protein PAS-2 0.276
stam-1 Protein STAM-1 0.262
rnr-1 Protein RNR-1 0.244
npl-4.2 Protein NPL-4.2 0.244
npl-4.1 Protein NPL-4.1 0.244
E04D5.1 Protein E04D5.1 0.234
pas-1 Protein PAS-1 0.227
cdc-48.2 Protein CDC-48.2 0.225
tba-2 Protein TBA-2 0.221
pas-6 Protein PAS-6 0.221
rpn-10 Protein RPN-10 0.216
pbs-3 Protein PBS-3 0.209
pbs-2 Protein PBS-2 0.189
rpn-5 Protein RPN-5 0.169
pbs-1 Protein PBS-1 0.152
mig-5 Protein MIG-5 0.149
bub-1 Protein BUB-1 0.149
rpt-4 Protein RPT-4 0.145
ima-2 Protein IMA-2 0.137
zyg-1 Protein ZYG-1 0.126
mat-3 Protein MAT-3 0.124
egl-18 Protein EGL-18 0.123
D1081.8 Protein D1081.8 0.122
syx-17 Protein SYX-17 0.116
rpl-11.1 Protein RPL-11.1 0.108
rpn-9 Protein RPN-9 0.106
zen-4 Protein ZEN-4 0.099
daf-21 Protein DAF-21 0.098
C31E10.6 Protein C31E10.6 0.098
Y54E5A.7 Protein Y54E5A.7 0.095
R11A8.7 Protein R11A8.7 0.093
taf-5 Protein TAF-5 0.088
pbs-7 Protein PBS-7 0.088
hda-1 Protein HDA-1 0.086
rad-26 Protein RAD-26 0.085
syx-5 Protein SYX-5 0.084
klp-16 Protein KLP-16 0.084
ZK180.6 Protein ZK180.6 0.078
T22F3.2 Protein T22F3.2 0.076
crt-1 Protein CRT-1 0.072
pas-5 Protein PAS-5 0.070
T08A11.2 Protein T08A11.2 0.070
rbg-1 Protein RBG-1 0.069
his-6 Protein HIS-6 0.068
CELE_C24H12.5 Protein C24H12.5 0.068
rpn-1 Protein RPN-1 0.068
CELE_R102.5 Protein R102.5 0.066
cpr-4 Protein CPR-4 0.065
R186.3 Protein R186.3 0.064
smc-3 Protein SMC-3 0.062
mom-2 Protein MOM-2 0.062
ZK1055.7 Protein ZK1055.7 0.062
pup-2 Protein PUP-2 0.061
F46F11.6 Protein F46F11.6 0.060
rpt-1 Protein RPT-1 0.059
ung-1 Protein UNG-1 0.058
sym-4 Protein SYM-4 0.056
CELE_T10C6.6 Protein T10C6.6 0.054
ubc-3 Protein UBC-3 0.054
dli-1 Protein DLI-1 0.054
pbs-4 Protein PBS-4 0.053
tag-353 Protein TAG-353 0.053
sel-12 Protein SEL-12 0.053
snr-4 Protein SNR-4 0.052
pas-7 Protein PAS-7 0.052
mel-26 Protein MEL-26 0.051
B0454.9 Protein B0454.9 0.050
hrp-1 Protein HRP-1 0.050
mex-5 Protein MEX-5 0.050
ZK507.6 Protein ZK507.6 0.049
K08E3.5 Protein K08E3.5 0.048
pcn-1 Protein PCN-1 0.047
rfc-2 Protein RFC-2 0.047
CELE_C39E9.11 Protein C39E9.11 0.047
sur-2 Protein SUR-2 0.046
skr-1 Protein SKR-1 0.045
Y110A7A.6 Protein Y110A7A.6 0.044
usp-14 Protein USP-14 0.044
ztf-7 Protein ZTF-7 0.044
dsh-2 Protein DSH-2 0.044
dlc-1 Protein DLC-1 0.044
goa-1 Protein GOA-1 0.043
asb-1 Protein ASB-1 0.043
sel-2 Protein SEL-2 0.043
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
psmb1 proteasome (prosome, macropain) subunit, beta type, 1 0.968
psma6a proteasome (prosome, macropain) subunit, alpha type, 6a 0.958
psmd12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 0.919
psmc5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 0.900
psmb4 proteasome (prosome, macropain) subunit, beta type, 4 0.894
psmd6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 0.881
psmc4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 0.829
psmc2 proteasome (prosome, macropain) 26S subunit, ATPase 2 0.813
hspa4b heat shock protein 4b 0.772
psma8 proteasome (prosome, macropain) subunit, alpha type, 8 0.754
psmc6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 0.714
ccnb1 cyclin B1 0.702
zgc:92775 zgc:92775 0.695
psmd4b proteasome (prosome, macropain) 26S subunit, non-ATPase, 4b 0.690
zgc:86903 zgc:86903 0.671
psmb5 proteasome (prosome, macropain) subunit, beta type, 5 0.656
ctsc cathepsin C 0.626
ddx42 DEAD (Asp-Glu-Ala-Asp) box polypeptide 42 0.585
ywhabb tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide b 0.551
plk1 polo-like kinase 1 (Drosophila) 0.544
ctsk cathepsin K 0.534
hspa5 heat shock protein 5 0.524
adrm1b adhesion regulating molecule 1b 0.524
psmd11a proteasome (prosome, macropain) 216S subunit, non-ATPase, 11a 0.513
wnt4a wingless-type MMTV integration site family, member 4a 0.499
gro2 groucho 2 0.492
kif23 kinesin family member 23 0.488
usp5 ubiquitin specific protease 5 0.471
psmb7 proteasome (prosome, macropain) subunit, beta type, 7 0.458
psmb3 proteasome (prosome, macropain) subunit, beta type, 3 0.455
exoc3 exocyst complex component 3 0.455
psma4 proteasome (prosome, macropain) subunit, alpha type, 4 0.454
psmc1b proteasome (prosome, macropain) 26S subunit, ATPase, 1b 0.441
psmd11b proteasome (prosome, macropain) 216S subunit, non-ATPase, 11b 0.436
ved ventrally expressed dharma/bozozok antagonist 0.431
psmd8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 0.403
aurkb aurora kinase B 0.377
vcp valosin containing protein 0.369
xbp1 X-box binding protein 1 0.367
eif4h eukaryotic translation initiation factor 4h 0.363
ctsz cathepsin Z 0.359
baxa bcl2-associated X protein, a 0.359
runx2a runt-related transcription factor 2a 0.353
nploc4 nuclear protein localization 4 homolog (S. cerevisiae) 0.346
lancl1 LanC antibiotic synthetase component C-like 1 (bacterial) 0.345
si:ch211-239j15.4 si:ch211-239j15.4 0.331
zgc:64051 zgc:64051 0.330
zgc:73111 zgc:73111 0.324
LOC100330405 transmembrane protein 176B-like 0.308
tia1l cytotoxic granule-associated RNA binding protein 1, like 0.307
max myc-associated factor X 0.307
psmb2 proteasome (prosome, macropain) subunit, beta type, 2 0.306
snai1a snail homolog 1a (Drosophila) 0.305
bsdc1 BSD domain containing 1 0.303
psmd3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 0.301
cdc20 cell division cycle 20 homolog 0.300
psmd13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 0.300
akt2 v-akt murine thymoma viral oncogene homolog 2 0.290
rangap1 Ran GTPase activating protein 1 0.289
zgc:110116 zgc:110116 0.284
bc2 putative breast adenocarcinoma marker 0.281
rae1 RAE1 RNA export 1 homolog (S. pombe) 0.279
ip6k2 inositol hexaphosphate kinase 2 0.276
prkrir protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor) 0.276
ccnb2 cyclin B2 0.275
rplp0 ribosomal protein, large, P0 0.268
zgc:92765 zgc:92765 0.267
rqcd1 RCD1 required for cell differentiation1 homolog (S. pombe) 0.266
ihha Indian hedgehog homolog a 0.262
psma2 proteasome (prosome, macropain) subunit, alpha type, 2 0.260
mcts1 malignant T cell amplified sequence 1 0.259
hyou1 hypoxia up-regulated 1 0.258
psap prosaposin 0.258
gps1 G protein pathway suppressor 1 0.252
ctsd cathepsin D 0.251
snx3 sorting nexin 3 0.247
hsp90b1 heat shock protein 90, beta (grp94), member 1 0.238
ube2g2 ubiquitin-conjugating enzyme E2G 2 0.233
usp14 ubiquitin specific protease 14 (tRNA-guanine transglycosylase) 0.231
psma1 proteasome (prosome, macropain) subunit, alpha type, 1 0.231
ck2b casein kinase 2 beta 0.227
racgap1 Rac GTPase-activating protein 1 0.225
dnm1l dynamin 1-like 0.225
zgc:55683 zgc:55683 0.224
kpna4 karyopherin alpha 4 (importin alpha 3) 0.223
cand1 cullin-associated and neddylation-dissociated 1 0.223
psmc1a proteasome (prosome, macropain) 26S subunit, ATPase, 1a 0.222
faf2 Fas associated factor family member 2 0.221
flii flightless I homolog (Drosophila) 0.221
syvn1 synovial apoptosis inhibitor 1, synoviolin 0.220
supt5h suppressor of Ty 5 homolog (S. cerevisiae) 0.220
gna13a guanine nucleotide binding protein (G protein), alpha 13a 0.219
ctsba cathepsin B, a 0.219
zgc:92139 zgc:92139 0.216
ccna2 cyclin A2 0.213
cdt1 chromatin licensing and DNA replication factor 1 0.211
fmnl2b formin-like 2b 0.211
sox32 SRY-box containing gene 32 0.208
zgc:158603 zgc:158603 0.205
cul2 cullin 2 0.205
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
tefu telomere fusion 0.980
Prosbeta2 Proteasome beta2 subunit 0.953
CG12321 CG12321 gene product from transcript CG12321-RA 0.948
Ras85D Ras oncogene at 85D 0.889
Rpn9 CG10230 gene product from transcript CG10230-RB 0.863
Rpt1 CG1341 gene product from transcript CG1341-RA 0.852
CycB Cyclin B 0.812
Rpt3 CG16916 gene product from transcript CG16916-RA 0.809
Pros29 Proteasome 29kD subunit 0.752
Pros28.1 Proteasome 28kD subunit 1 0.705
nej nejire 0.621
Mov34 CG3416 gene product from transcript CG3416-RA 0.616
Nipped-A CG33554 gene product from transcript CG33554-RE 0.597
Rpt4 CG3455 gene product from transcript CG3455-RA 0.594
Rpn2 CG11888 gene product from transcript CG11888-RA 0.549
dco discs overgrown 0.539
Hsp83 Heat shock protein 83 0.538
Prosbeta3 Proteasome beta3 subunit 0.530
Rpn1 CG7762 gene product from transcript CG7762-RA 0.530
Pros26.4 Proteasome 26S subunit subunit 4 ATPase 0.526
Vap-33-1 CG5014 gene product from transcript CG5014-RB 0.479
brm brahma 0.453
betaTub56D beta-Tubulin at 56D 0.443
CG13349 CG13349 gene product from transcript CG13349-RA 0.441
Pros54 Proteasome 54kD subunit 0.433
Prosbeta1 Proteasome beta1 subunit 0.416
Vps25 Vacuolar protein sorting 25 0.415
ncd non-claret disjunctional 0.409
slmb supernumerary limbs 0.403
RagA CG11968 gene product from transcript CG11968-RA 0.391
Prosbeta5 Proteasome beta5 subunit 0.378
pr-set7 CG3307 gene product from transcript CG3307-RC 0.375
CG5555 CG5555 gene product from transcript CG5555-RA 0.366
Incenp Inner centromere protein 0.361
Rpn5 CG1100 gene product from transcript CG1100-RA 0.342
Rpn6 Proteasome p44.5 subunit 0.333
Tip60 CG6121 gene product from transcript CG6121-RA 0.329
Fcp1 CG12252 gene product from transcript CG12252-RA 0.306
smo smoothened 0.303
Prosalpha5 Proteasome alpha5 subunit 0.294
Akt1 CG4006 gene product from transcript CG4006-RA 0.294
Tbp-1 Tat-binding protein-1 0.290
skpA CG16983 gene product from transcript CG16983-RD 0.290
yki yorkie 0.279
Rpn12 CG4157 gene product from transcript CG4157-RA 0.274
CG32581 CG32581 gene product from transcript CG32581-RB 0.274
Rpn3 Regulatory particle non-ATPase 3 0.267
Top1 Topoisomerase 1 0.265
msps mini spindles 0.244
Rpn11 CG18174 gene product from transcript CG18174-RA 0.239
gwl greatwall 0.231
CycD Cyclin D 0.231
RYBP Ring and YY1 Binding Protein 0.228
Rpd3 CG7471 gene product from transcript CG7471-RA 0.227
ago archipelago 0.222
Rpn7 CG5378 gene product from transcript CG5378-RA 0.221
Pp1-87B Protein phosphatase 1 at 87B 0.211
Psa Puromycin sensitive aminopeptidase 0.211
lqf liquid facets 0.211
step steppke 0.209
hpo hippo 0.208
RhoGEF2 CG9635 gene product from transcript CG9635-RF 0.208
Caf1 Chromatin assembly factor 1 subunit 0.201
Cap-G CG34438 gene product from transcript CG34438-RF 0.201
asp abnormal spindle 0.200
CG8979 CG8979 gene product from transcript CG8979-RC 0.198
lsn larsen 0.194
CSN3 COP9 complex homolog subunit 3 0.187
Prosbeta7 Proteasome beta7 subunit 0.186
pan pangolin 0.174
Act5C Actin 5C 0.171
dhd deadhead 0.171
Mgat1 UDP-GlcNAc:a-3-D-mannoside-beta-1,2-N-acetylglucosaminyltransferase I 0.170
CycG Cyclin G 0.167
Tak1 TGF-beta activated kinase 1 0.166
Rheb CG1081 gene product from transcript CG1081-RA 0.165
cal1 chromosome alignment defect 1 0.162
CycE Cyclin E 0.158
ttv tout-velu 0.157
Uch Ubiquitin carboxy-terminal hydrolase 0.156
Su(H) Suppressor of Hairless 0.154
Mad Mothers against dpp 0.151
fzy fizzy 0.150
CSN8 COP9 complex homolog subunit 8 0.149
Ube3a Ubiquitin protein ligase E3A 0.147
Pros35 Proteasome 35kD subunit 0.146
Sara Smad anchor for receptor activation 0.145
Pros26 Proteasome 26kD subunit 0.144
UbcD2 Ubiquitin conjugating enzyme 2 0.143
polo CG12306 gene product from transcript CG12306-RA 0.142
wdb widerborst 0.142
CG4673 CG4673 gene product from transcript CG4673-RB 0.139
TSG101 tumor suppressor protein 101 0.137
ash2 absent, small, or homeotic discs 2 0.133
krz kurtz 0.133
lin19 lin-19-like 0.133
Rad23 CG1836 gene product from transcript CG1836-RB 0.133
CG9135 CG9135 gene product from transcript CG9135-RB 0.132
yrt yurt 0.131
Tab2 TAK1-associated binding protein 2 0.131
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
UBC ubiquitin C 1.000
UBE2D3 ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast) 1.000
UBE2D2 ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast) 1.000
XIAP X-linked inhibitor of apoptosis 1.000
RNF11 ring finger protein 11 1.000
UBE2D1 ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast) 1.000
TP53 tumor protein p53 1.000
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 1.000
VCP valosin containing protein 0.999
UBE2N ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast) 0.999
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.998
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 0.998
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.998
TRAF6 TNF receptor-associated factor 6 0.997
SKP1 S-phase kinase-associated protein 1 0.996
CDC27 cell division cycle 27 homolog (S. cerevisiae) 0.996
BUB1B budding uninhibited by benzimidazoles 1 homolog beta (yeast) 0.993
RB1 retinoblastoma 1 0.993
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 0.993
CDC20 cell division cycle 20 homolog (S. cerevisiae) 0.992
BTRC beta-transducin repeat containing 0.991
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.991
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 0.991
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.989
RBX1 ring-box 1, E3 ubiquitin protein ligase 0.988
ATXN3 ataxin 3 0.987
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.987
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2 0.985
BIRC2 baculoviral IAP repeat containing 2 0.984
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.983
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.982
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2 0.980
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6 0.978
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2 0.977
PTK2 PTK2 protein tyrosine kinase 2 0.977
CCNB1 cyclin B1 0.975
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 0.974
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.974
CUL3 cullin 3 0.973
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 0.972
ANAPC4 anaphase promoting complex subunit 4 0.971
SMAD4 SMAD family member 4 0.970
RNF111 ring finger protein 111 0.970
UBQLN1 ubiquilin 1 0.969
TRIM39 tripartite motif containing 39 0.967
CDK2 cyclin-dependent kinase 2 0.967
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.965
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.964
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1 0.961
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3 0.955
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 0.954
SQSTM1 sequestosome 1 0.951
ADRM1 adhesion regulating molecule 1 0.950
UBE3A ubiquitin protein ligase E3A 0.950
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 0.948
SMAD2 SMAD family member 2 0.948
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) 0.946
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.944
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.941
POMP proteasome maturation protein 0.941
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.933
FBXW11 F-box and WD repeat domain containing 11 0.932
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.929
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5 0.928
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 0.924
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 0.923
CCNA2 cyclin A2 0.918
SYVN1 synovial apoptosis inhibitor 1, synoviolin 0.916
RNF126 ring finger protein 126 0.912
RNF5 ring finger protein 5 0.908
OTUB1 OTU domain, ubiquitin aldehyde binding 1 0.902
MDM4 Mdm4 p53 binding protein homolog (mouse) 0.900
ZNRF1 zinc and ring finger 1 0.893
CUL1 cullin 1 0.893
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.892
COPS5 COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis) 0.891
ANAPC7 anaphase promoting complex subunit 7 0.889
PLK1 polo-like kinase 1 0.889
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase 0.880
ANAPC11 anaphase promoting complex subunit 11 0.873
MARCH7 membrane-associated ring finger (C3HC4) 7 0.868
FAF2 Fas associated factor family member 2 0.865
CUL2 cullin 2 0.864
CDC5L CDC5 cell division cycle 5-like (S. pombe) 0.863
PDCD6IP programmed cell death 6 interacting protein 0.861
GSK3B glycogen synthase kinase 3 beta 0.861
HSPA8 heat shock 70kDa protein 8 0.852
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 0.851
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 0.845
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.837
TCEB1 transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C) 0.828
SIAH1 seven in absentia homolog 1 (Drosophila) 0.825
FBXO5 F-box protein 5 0.823
UBXN7 UBX domain protein 7 0.820
UBE2H ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast) 0.813
SKP2 S-phase kinase-associated protein 2 (p45) 0.810
DERL1 Der1-like domain family, member 1 0.805
PJA2 praja ring finger 2 0.798
MYC v-myc myelocytomatosis viral oncogene homolog (avian) 0.798
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4 0.793
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Ctnnb1 catenin (cadherin associated protein), beta 1 1.000
Trp53 transformation related protein 53 1.000
Axin1 axin 1 1.000
Psen1 presenilin 1 0.999
Per2 period homolog 2 (Drosophila) 0.998
Vcp valosin containing protein 0.992
Clock circadian locomotor output cycles kaput 0.990
Akt1 thymoma viral proto-oncogene 1 0.989
Map3k7 mitogen-activated protein kinase kinase kinase 7 0.989
Ncoa3 nuclear receptor coactivator 3 0.989
Gsk3b glycogen synthase kinase 3 beta 0.985
Pten phosphatase and tensin homolog 0.985
Usp9x ubiquitin specific peptidase 9, X chromosome 0.976
Psmb7 proteasome (prosome, macropain) subunit, beta type 7 0.965
Nedd4 neural precursor cell expressed, developmentally down-regulated 4 0.959
Fgfr1 fibroblast growth factor receptor 1 0.955
Cul3 cullin 3 0.951
Psma7 proteasome (prosome, macropain) subunit, alpha type 7 0.941
Apc adenomatosis polyposis coli 0.934
Ncstn nicastrin 0.934
Psmb6 proteasome (prosome, macropain) subunit, beta type 6 0.929
Mdm2 transformed mouse 3T3 cell double minute 2 0.929
Traf6 TNF receptor-associated factor 6 0.927
Psma3 proteasome (prosome, macropain) subunit, alpha type 3 0.906
Smad7 MAD homolog 7 (Drosophila) 0.898
Cdk1 cyclin-dependent kinase 1 0.892
Skp1a S-phase kinase-associated protein 1A 0.887
Psmd4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 0.871
Ccnb1 cyclin B1 0.870
Skil SKI-like 0.853
Psma5 proteasome (prosome, macropain) subunit, alpha type 5 0.851
Psmc2 proteasome (prosome, macropain) 26S subunit, ATPase 2 0.838
Psma1 proteasome (prosome, macropain) subunit, alpha type 1 0.826
Aamp angio-associated migratory protein 0.819
App amyloid beta (A4) precursor protein 0.812
Mgea5 meningioma expressed antigen 5 (hyaluronidase) 0.812
Mbd3 methyl-CpG binding domain protein 3 0.807
Cyld cylindromatosis (turban tumor syndrome) 0.806
Dyrk1a dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a 0.806
Manf mesencephalic astrocyte-derived neurotrophic factor 0.801
Mdm4 transformed mouse 3T3 cell double minute 4 0.800
Ube2g1 ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, C. elegans) 0.791
Psma2 proteasome (prosome, macropain) subunit, alpha type 2 0.760
Bag6 BCL2-associated athanogene 6 0.758
Pomp proteasome maturation protein 0.750
Psmc3 proteasome (prosome, macropain) 26S subunit, ATPase 3 0.750
Cops5 COP9 (constitutive photomorphogenic) homolog, subunit 5 (Arabidopsis thaliana) 0.744
Ccne1 cyclin E1 0.721
Ube2d3 ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast) 0.717
Vhl von Hippel-Lindau tumor suppressor 0.709
Prc1 protein regulator of cytokinesis 1 0.700
Pax8 paired box gene 8 0.697
Agap3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 0.695
Psma4 proteasome (prosome, macropain) subunit, alpha type 4 0.695
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.688
Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 0.671
Sqstm1 sequestosome 1 0.649
Bcl2 B-cell leukemia/lymphoma 2 0.646
Kpna1 karyopherin (importin) alpha 1 0.645
Csnk1g2 casein kinase 1, gamma 2 0.635
Stat3 signal transducer and activator of transcription 3 0.630
Glrx3 glutaredoxin 3 0.616
Ehmt2 euchromatic histone lysine N-methyltransferase 2 0.614
Gli3 GLI-Kruppel family member GLI3 0.611
Psme4 proteasome (prosome, macropain) activator subunit 4 0.603
Add1 adducin 1 (alpha) 0.599
Yap1 yes-associated protein 1 0.599
Ahr aryl-hydrocarbon receptor 0.593
Tax1bp1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.592
Arrb1 arrestin, beta 1 0.590
Hif1a hypoxia inducible factor 1, alpha subunit 0.590
Pparg peroxisome proliferator activated receptor gamma 0.589
H2afz H2A histone family, member Z 0.586
Rnf111 ring finger 111 0.586
Ikbkg inhibitor of kappaB kinase gamma 0.584
Ubc ubiquitin C 0.581
Rnf19a ring finger protein 19A 0.579
Mapk8 mitogen-activated protein kinase 8 0.578
Ski ski sarcoma viral oncogene homolog (avian) 0.573
Kpna3 karyopherin (importin) alpha 3 0.571
Tab3 TGF-beta activated kinase 1/MAP3K7 binding protein 3 0.569
Brca1 breast cancer 1 0.566
Grin2b glutamate receptor, ionotropic, NMDA2B (epsilon 2) 0.564
Rbl2 retinoblastoma-like 2 0.562
Cul4a cullin 4A 0.558
Amfr autocrine motility factor receptor 0.557
Arntl aryl hydrocarbon receptor nuclear translocator-like 0.556
Adrm1 adhesion regulating molecule 1 0.553
Birc5 baculoviral IAP repeat-containing 5 0.552
Ranbp9 RAN binding protein 9 0.551
Thra thyroid hormone receptor alpha 0.550
Gli2 GLI-Kruppel family member GLI2 0.537
Wdr26 WD repeat domain 26 0.533
Arrb2 arrestin, beta 2 0.533
Mllt1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 0.530
Sirt1 sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae) 0.525
Notch1 Notch gene homolog 1 (Drosophila) 0.517
Psmc5 protease (prosome, macropain) 26S subunit, ATPase 5 0.517
Map3k1 mitogen-activated protein kinase kinase kinase 1 0.516
Fzr1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.515
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Psma5 proteasome (prosome, macropain) subunit, alpha type 5 0.987
Psmb3 proteasome (prosome, macropain) subunit, beta type 3 0.943
Psma4 proteasome (prosome, macropain) subunit, alpha type 4 0.902
Psma3 proteasome (prosome, macropain) subunit, alpha type 3 0.900
Psmc1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 0.710
Dnaja2 DnaJ (Hsp40) homolog, subfamily A, member 2 0.694
Psmc2 proteasome (prosome, macropain) 26S subunit, ATPase 2 0.687
Psma7 proteasome (prosome, macropain) subunit, alpha type 7 0.600
Psmb6 proteasome (prosome, macropain) subunit, beta type 6 0.550
Ppp1cb protein phosphatase 1, catalytic subunit, beta isoform 0.536
Eef2 eukaryotic translation elongation factor 2 0.392
Psmc4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 0.364
Dnaja1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.358
Zfand5 zinc finger, AN1-type domain 5 0.300
Psmb2 proteasome (prosome, macropain) subunit, beta type 2 0.272
Psmd6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 0.270
Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 0.245
Psme2 proteasome (prosome, macropain) activator subunit 2 0.234
Psmb7 proteasome (prosome, macropain) subunit, beta type 7 0.204
Dctn4 dynactin 4 0.194
Dnajb11 DnaJ (Hsp40) homolog, subfamily B, member 11 0.189
Psmb5 proteasome (prosome, macropain) subunit, beta type 5 0.188
Csnk1d casein kinase 1, delta 0.180
Psma6 proteasome (prosome, macropain) subunit, alpha type 6 0.172
Rpn2 ribophorin II 0.157
Dnajb9 DnaJ (Hsp40) homolog, subfamily B, member 9 0.150
Rab11a RAB11a, member RAS oncogene family 0.140
Jtb jumping translocation breakpoint 0.136
Psmd13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 0.127
Vcp valosin-containing protein 0.124
Pdia4 protein disulfide isomerase family A, member 4 0.122
Psma2 proteasome (prosome, macropain) subunit, alpha type 2 0.122
Syngr2 synaptogyrin 2 0.113
Psmc5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 0.110
Dbp D site of albumin promoter (albumin D-box) binding protein 0.104
Psmd4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 0.103
Magi2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.103
Psmb8 proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) 0.100
Psmb10 proteasome (prosome, macropain) subunit, beta type 10 0.100
Cdc20 cell division cycle 20 homolog (S. cerevisiae) 0.096
Hsph1 heat shock 105/110 protein 1 0.093
P4hb prolyl 4-hydroxylase, beta polypeptide 0.090
Traf4af1 TRAF4 associated factor 1 0.085
Psmb4 proteasome (prosome, macropain) subunit, beta type 4 0.082
Psmd7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 0.080
Cnbp CCHC-type zinc finger, nucleic acid binding protein 0.075
Manf mesencephalic astrocyte-derived neurotrophic factor 0.075
Txnl1 thioredoxin-like 1 0.074
Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 0.073
Prdx1 peroxiredoxin 1 0.073
Cltc clathrin, heavy chain (Hc) 0.072
Psmd3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 0.071
Dusp11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) 0.070
Psmb1 proteasome (prosome, macropain) subunit, beta type 1 0.069
Ptges3 prostaglandin E synthase 3 (cytosolic) 0.069
Hprt1 hypoxanthine phosphoribosyltransferase 1 0.069
Ypel5 yippee-like 5 (Drosophila) 0.068
Hspa5 heat shock protein 5 0.067
Nudt3 nudix (nucleoside diphosphate linked moiety X)-type motif 3 0.064
Ccnb1 cyclin B1 0.063
Usp47 ubiquitin specific peptidase 47 0.060
Rab21 RAB21, member RAS oncogene family 0.058
Hspe1 heat shock protein 1 (chaperonin 10) 0.058
Tax1bp1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.058
Ppp1r2 protein phosphatase 1, regulatory (inhibitor) subunit 2 0.057
Psmd1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 0.056
Lman1 lectin, mannose-binding, 1 0.055
Cand1 cullin-associated and neddylation-dissociated 1 0.054
Cops2 COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis) 0.054
Rbbp7 retinoblastoma binding protein 7 0.053
Psma1 proteasome (prosome, macropain) subunit, alpha type 1 0.052
Plk1 polo-like kinase 1 (Drosophila) 0.052
Mgat2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase 0.051
Rfc1 replication factor C (activator 1) 1 0.050
Creld2 cysteine-rich with EGF-like domains 2 0.050
Lamp2 lysosomal-associated membrane protein 2 0.048
Cast calpastatin 0.048
Cenpi centromere protein I 0.047
Calr calreticulin 0.046
Tcf12 transcription factor 12 0.045
Ubc ubiquitin C 0.045
Kars lysyl-tRNA synthetase 0.044
Wdr26 WD repeat domain 26 0.043
Cmtm6 CKLF-like MARVEL transmembrane domain containing 6 0.043
Pkn2 protein kinase N2 0.042
Tle4 transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) 0.041
Sec61a1 Sec61 alpha 1 subunit (S. cerevisiae) 0.041
Mdm2 Mdm2 p53 binding protein homolog (mouse) 0.041
Ube2d3 ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast) 0.039
Senp2 Sumo1/sentrin/SMT3 specific peptidase 2 0.038
Foxm1 forkhead box M1 0.038
Usp15 ubiquitin specific peptidase 15 0.037
Grasp GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein 0.036
Sdf2l1 stromal cell-derived factor 2-like 1 0.036
Dlg1 discs, large homolog 1 (Drosophila) 0.035
Cdc37 cell division cycle 37 homolog (S. cerevisiae) 0.034
Eif2s2 eukaryotic translation initiation factor 2, subunit 2 beta 0.034
Vapa VAMP (vesicle-associated membrane protein)-associated protein A 0.034
Serp1 stress-associated endoplasmic reticulum protein 1 0.033
Taok1 TAO kinase 1 0.032