The network for 'negative regulation of proteolysis involved in cellular protein catabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of proteolysis involved in cellular protein catabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of proteolysis involved in cellular protein catabolic process.

Name Description Probability Func Analog Organism
MAD2 Mad2p 0.702
CDC20 Cdc20p 0.535
CDC55 Cdc55p 0.501
PPH22 Pph22p 0.480
PPH21 Pph21p 0.441
SLI15 Sli15p 0.432
HHF2 Hhf2p 0.324
MAD1 Mad1p 0.310
BUB1 Bub1p 0.308
CHL4 Chl4p 0.297
RTS1 Rts1p 0.266
MAD3 Mad3p 0.258
PPZ1 Ppz1p 0.204
YPI1 Ypi1p 0.192
CTF3 Ctf3p 0.187
NBL1 Nbl1p 0.173
GIP2 Gip2p 0.168
KIP1 Kip1p 0.163
CTF13 Ctf13p 0.163
BUB3 Bub3p 0.140
SLK19 Slk19p 0.119
ECO1 Eco1p 0.109
IML3 Iml3p 0.104
MTW1 Mtw1p 0.100
PIG2 Pig2p 0.098
TID3 Tid3p 0.067
DSN1 Dsn1p 0.058
SDS22 Sds22p 0.057
FMP48 Fmp48p 0.056
CIN8 Cin8p 0.053
ZDS1 Zds1p 0.053
CHL1 Chl1p 0.052
TIP41 Tip41p 0.048
CSL4 Csl4p 0.046
GLC7 Glc7p 0.045
PCL10 Pcl10p 0.045
MLC1 Mlc1p 0.044
CDC28 Cdc28p 0.043
CSE4 Cse4p 0.043
SKP1 Skp1p 0.041
PTI1 Pti1p 0.039
MCM21 Mcm21p 0.039
RAD23 Rad23p 0.038
CBF1 Cbf1p 0.038
SPC110 Spc110p 0.037
SPC24 Spc24p 0.037
RPT6 Rpt6p 0.037
GLG1 Glg1p 0.037
YML053C hypothetical protein 0.035
VIK1 Vik1p 0.034
STU1 Stu1p 0.034
NSL1 Nsl1p 0.034
STD1 Std1p 0.033
UFD2 Ufd2p 0.032
CBF2 Cbf2p 0.032
RPT1 Rpt1p 0.032
SPT15 Spt15p 0.030
YIL151C hypothetical protein 0.030
SPO12 Spo12p 0.029
TOR2 Tor2p 0.029
MIF2 Mif2p 0.029
YLR264C-A hypothetical protein 0.028
TPD3 Tpd3p 0.028
GSY1 Gsy1p 0.028
RAD53 Rad53p 0.028
STB2 Stb2p 0.027
TAF6 Taf6p 0.027
SRD1 Srd1p 0.027
YLR162W hypothetical protein 0.026
YOL038C-A hypothetical protein 0.026
LEU2 Leu2p 0.025
PSK1 Psk1p 0.025
YNL144C hypothetical protein 0.025
PRS2 Prs2p 0.025
RPN14 Rpn14p 0.025
NDD1 Ndd1p 0.025
MCM22 Mcm22p 0.025
TPI1 Tpi1p 0.025
TAF10 Taf10p 0.024
SPL2 Spl2p 0.024
SPO14 Spo14p 0.024
HST3 Hst3p 0.024
HIR1 Hir1p 0.023
SKM1 Skm1p 0.023
ADH2 Adh2p 0.023
CHA1 Cha1p 0.023
SUR1 Sur1p 0.023
YBR296C-A hypothetical protein 0.023
WSS1 Wss1p 0.023
RPT2 Rpt2p 0.023
MER1 Mer1p 0.023
NTO1 Nto1p 0.022
VHS3 Vhs3p 0.022
CIN1 Cin1p 0.022
RPT4 Rpt4p 0.022
HTB1 Htb1p 0.022
RAD54 Rad54p 0.022
YIR035C hypothetical protein 0.022
BCK2 Bck2p 0.022
MF(ALPHA)2 Mf(alpha)2p 0.022
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
spdl-1 Protein SPDL-1 0.025
imb-2 Protein IMB-2 0.023
asd-1 Protein ASD-1 0.022
rga-1 Protein RGA-1 0.021
let-502 Protein LET-502 0.020
ani-1 Protein ANI-1 0.018
his-6 Protein HIS-6 0.017
tba-2 Protein TBA-2 0.017
spk-1 Protein SPK-1 0.017
his-32 Protein HIS-32 0.016
ZK507.6 Protein ZK507.6 0.016
his-45 Protein HIS-45 0.016
uaf-1 Protein UAF-1 0.015
T22C1.1 Protein T22C1.1 0.015
his-42 Protein HIS-42 0.015
rnr-1 Protein RNR-1 0.014
rsd-6 Protein RSD-6 0.014
tba-1 Protein TBA-1 0.014
icp-1 Protein ICP-1 0.014
ubq-1 Protein UBQ-1 0.014
math-33 Protein MATH-33 0.014
wrb-1 Protein WRB-1 0.014
F44E2.8 Protein F44E2.8 0.013
E01A2.2 Protein E01A2.2 0.013
lmn-1 Protein LMN-1 0.013
exos-1 Protein EXOS-1 0.013
npp-11 Protein NPP-11 0.013
goa-1 Protein GOA-1 0.013
pac-1 Protein PAC-1 0.013
gpr-2 Protein GPR-2 0.013
mel-11 Protein MEL-11 0.013
ntl-4 Protein NTL-4 0.013
lin-53 Protein LIN-53 0.013
C49H3.9 Protein C49H3.9 0.013
F33D11.10 Protein F33D11.10 0.012
W09D10.1 Protein W09D10.1 0.012
szy-20 Protein SZY-20 0.012
htz-1 Protein HTZ-1 0.012
R11A8.7 Protein R11A8.7 0.012
rpt-5 Protein RPT-5 0.012
hat-1 Protein HAT-1 0.012
CELE_R11H6.2 Protein R11H6.2 0.012
mcm-2 Protein MCM-2 0.012
air-2 Protein AIR-2 0.012
lin-23 Protein LIN-23 0.012
his-64 Protein HIS-64 0.012
F12F6.1 Protein F12F6.1 0.011
knl-3 Protein KNL-3 0.011
csn-5 Protein CSN-5 0.011
pcn-1 Protein PCN-1 0.011
hcp-1 Protein HCP-1 0.011
rpn-6.1 Protein RPN-6.1 0.011
F25B3.6 Protein F25B3.6 0.011
F31D4.2 Protein F31D4.2 0.011
hpo-10 Protein HPO-10 0.011
abu-13 Protein ABU-13 0.011
npl-4.1 Protein NPL-4.1 0.011
gpr-1 Protein GPR-1 0.011
cyb-1 Protein CYB-1 0.011
csn-4 Protein CSN-4 0.011
cids-2 Protein CIDS-2 0.011
T22F3.2 Protein T22F3.2 0.011
bmk-1 Protein BMK-1 0.011
CELE_C24H12.5 Protein C24H12.5 0.011
F28C10.3 Protein F28C10.3 0.011
cul-1 Protein CUL-1 0.011
H03E18.1 Protein H03E18.1 0.011
ptp-3 Protein PTP-3 0.011
hgrs-1 Protein HGRS-1 0.010
CELE_ZK1025.3 Protein ZK1025.3 0.010
Y55F3BR.8 Protein Y55F3BR.8 0.010
csc-1 Protein CSC-1 0.010
rnp-5 Protein RNP-5 0.010
snr-2 Protein SNR-2 0.010
T19C3.2 Protein T19C3.2 0.010
hmp-1 Protein HMP-1 0.010
air-1 Protein AIR-1 0.010
prp-21 Protein PRP-21 0.010
mes-6 Protein MES-6 0.010
sax-3 Protein SAX-3 0.010
T12B3.4 Protein T12B3.4 0.010
rfl-1 Protein RFL-1 0.010
hda-3 Protein HDA-3 0.010
lin-49 Protein LIN-49 0.010
R07B1.5 Protein R07B1.5 0.010
T23B3.1 Protein T23B3.1 0.010
CELE_F52C6.3 Protein F52C6.3 0.010
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Pp1-87B Protein phosphatase 1 at 87B 0.153
CSN5 COP9 complex homolog subunit 5 0.101
Egfr Epidermal growth factor receptor 0.083
asl asterless 0.057
ncd non-claret disjunctional 0.051
B52 CG10851 gene product from transcript CG10851-RB 0.046
fzy fizzy 0.034
hh hedgehog 0.028
Iswi Imitation SWI 0.028
CycA Cyclin A 0.027
gsb gooseberry 0.026
brm brahma 0.025
Doa Darkener of apricot 0.025
CSN4 COP9 complex homolog subunit 4 0.024
Sep2 Septin-2 0.023
CycB Cyclin B 0.023
Ras85D Ras oncogene at 85D 0.022
Nup153 Nucleoporin 153 0.022
Cks30A Cyclin-dependent kinase subunit 30A 0.022
CycB3 Cyclin B3 0.021
Bap55 Brahma associated protein 55kD 0.020
rux roughex 0.018
CSN6 COP9 complex homolog subunit 6 0.018
RanGap Ran GTPase activating protein 0.018
CG6540 CG6540 gene product from transcript CG6540-RA 0.018
hyd hyperplastic discs 0.017
bam bag of marbles 0.017
Cul-3 Cullin-3 0.016
CG4030 CG4030 gene product from transcript CG4030-RA 0.016
MED6 Mediator complex subunit 6 0.015
Cap-G CG34438 gene product from transcript CG34438-RF 0.015
flfl falafel 0.014
lgs legless 0.014
borr borealin-related 0.014
png pan gu 0.014
Dref DNA replication-related element factor 0.013
dpp decapentaplegic 0.013
Syx13 Syntaxin 13 0.013
CG8223 CG8223 gene product from transcript CG8223-RA 0.013
tld tolloid 0.013
ci cubitus interruptus 0.013
gammaTub23C gamma-Tubulin at 23C 0.012
jar jaguar 0.012
sle slender lobes 0.012
cdc2 CG5363 gene product from transcript CG5363-RA 0.011
CSN7 COP9 complex homolog subunit 7 0.011
Incenp Inner centromere protein 0.011
wg wingless 0.011
cutlet CG33122 gene product from transcript CG33122-RA 0.011
noi noisette 0.011
sno strawberry notch 0.011
spn-D spindle D 0.011
KP78b CG17216 gene product from transcript CG17216-RB 0.011
edl ETS-domain lacking 0.010
Psa Puromycin sensitive aminopeptidase 0.010
arm armadillo 0.010
smo smoothened 0.010
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Homo sapiens
Name Description Probability Func Analog Organism
BUB1B budding uninhibited by benzimidazoles 1 homolog beta (yeast) 0.938
ANAPC4 anaphase promoting complex subunit 4 0.653
ANAPC7 anaphase promoting complex subunit 7 0.423
CDC27 cell division cycle 27 homolog (S. cerevisiae) 0.392
BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) 0.363
RB1 retinoblastoma 1 0.299
BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast) 0.227
ANAPC5 anaphase promoting complex subunit 5 0.196
CDK2 cyclin-dependent kinase 2 0.162
CCT8 chaperonin containing TCP1, subunit 8 (theta) 0.152
DAXX death-domain associated protein 0.141
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.127
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.126
TP53 tumor protein p53 0.121
BRCA2 breast cancer 2, early onset 0.119
CCNA2 cyclin A2 0.112
CHAF1A chromatin assembly factor 1, subunit A (p150) 0.106
CD2BP2 CD2 (cytoplasmic tail) binding protein 2 0.104
ZNF263 zinc finger protein 263 0.086
PSEN1 presenilin 1 0.078
TRIM39 tripartite motif containing 39 0.075
ASF1A ASF1 anti-silencing function 1 homolog A (S. cerevisiae) 0.072
HIPK2 homeodomain interacting protein kinase 2 0.072
GABARAPL1 GABA(A) receptor-associated protein like 1 0.069
SMAD2 SMAD family member 2 0.061
SYVN1 synovial apoptosis inhibitor 1, synoviolin 0.060
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 0.059
TPBG trophoblast glycoprotein 0.058
CCNB1 cyclin B1 0.058
PPP2R1B protein phosphatase 2, regulatory subunit A, beta 0.053
RAD51 RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) 0.052
DOT1L DOT1-like, histone H3 methyltransferase (S. cerevisiae) 0.051
CDC20 cell division cycle 20 homolog (S. cerevisiae) 0.051
FXR2 fragile X mental retardation, autosomal homolog 2 0.049
MAP1LC3A microtubule-associated protein 1 light chain 3 alpha 0.049
MED15 mediator complex subunit 15 0.046
TRAF6 TNF receptor-associated factor 6 0.046
NBR1 neighbor of BRCA1 gene 1 0.045
ARIH2 ariadne homolog 2 (Drosophila) 0.044
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.044
UBE2D4 ubiquitin-conjugating enzyme E2D 4 (putative) 0.043
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 0.042
BAG2 BCL2-associated athanogene 2 0.042
C19orf39 chromosome 19 open reading frame 39 0.042
GFI1B growth factor independent 1B transcription repressor 0.041
CBX1 chromobox homolog 1 0.041
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 0.039
CASC5 cancer susceptibility candidate 5 0.039
CREBBP CREB binding protein 0.039
PLK1 polo-like kinase 1 0.039
SQSTM1 sequestosome 1 0.038
SKP2 S-phase kinase-associated protein 2 (p45) 0.038
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.037
CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 0.036
ZNF207 zinc finger protein 207 0.034
OTUB1 OTU domain, ubiquitin aldehyde binding 1 0.034
CKS1B CDC28 protein kinase regulatory subunit 1B 0.034
STX5 syntaxin 5 0.034
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.032
VCP valosin containing protein 0.032
CDC6 cell division cycle 6 homolog (S. cerevisiae) 0.032
CCND1 cyclin D1 0.032
TOR1A torsin family 1, member A (torsin A) 0.032
ANAPC11 anaphase promoting complex subunit 11 0.031
GABARAPL2 GABA(A) receptor-associated protein-like 2 0.031
MED1 mediator complex subunit 1 0.030
COPS8 COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis) 0.030
UHRF2 ubiquitin-like with PHD and ring finger domains 2 0.030
MDC1 mediator of DNA-damage checkpoint 1 0.029
GABARAP GABA(A) receptor-associated protein 0.029
HUWE1 HECT, UBA and WWE domain containing 1 0.029
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme 0.028
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.028
TP53BP1 tumor protein p53 binding protein 1 0.028
MLLT6 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 0.028
BIRC5 baculoviral IAP repeat containing 5 0.027
TOR1AIP2 torsin A interacting protein 2 0.027
TYRP1 tyrosinase-related protein 1 0.027
FLNB filamin B, beta 0.026
SP100 SP100 nuclear antigen 0.026
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 0.026
CDC37 cell division cycle 37 homolog (S. cerevisiae) 0.026
MYST1 MYST histone acetyltransferase 1 0.026
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme 0.025
CBX5 chromobox homolog 5 0.025
FAS Fas (TNF receptor superfamily, member 6) 0.025
SRI sorcin 0.024
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.024
LMNA lamin A/C 0.024
ATMIN ATM interactor 0.024
PSEN2 presenilin 2 (Alzheimer disease 4) 0.024
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 0.024
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 0.024
BTBD2 BTB (POZ) domain containing 2 0.023
UBC ubiquitin C 0.023
BCL2L1 BCL2-like 1 0.023
FANCD2 Fanconi anemia, complementation group D2 0.023
TRIM32 tripartite motif containing 32 0.023
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 0.023
TERF2IP telomeric repeat binding factor 2, interacting protein 0.022
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Mus musculus
Name Description Probability Func Analog Organism
Trp53 transformation related protein 53 0.986
Gli3 GLI-Kruppel family member GLI3 0.718
Pax2 paired box gene 2 0.661
Ctnnb1 catenin (cadherin associated protein), beta 1 0.618
Fgfr2 fibroblast growth factor receptor 2 0.607
Foxc1 forkhead box C1 0.483
Rb1 retinoblastoma 1 0.473
Cdk1 cyclin-dependent kinase 1 0.383
Wnt3a wingless-related MMTV integration site 3A 0.332
Shh sonic hedgehog 0.304
Lhx1 LIM homeobox protein 1 0.273
Notch1 Notch gene homolog 1 (Drosophila) 0.260
Ccnb1 cyclin B1 0.254
Gli2 GLI-Kruppel family member GLI2 0.253
Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.250
Ncoa3 nuclear receptor coactivator 3 0.248
Pten phosphatase and tensin homolog 0.235
Bmp7 bone morphogenetic protein 7 0.194
Kif22 kinesin family member 22 0.158
Ccne1 cyclin E1 0.158
Emx2 empty spiracles homolog 2 (Drosophila) 0.152
Sox9 SRY-box containing gene 9 0.146
Skil SKI-like 0.145
Bmp4 bone morphogenetic protein 4 0.142
Mdm2 transformed mouse 3T3 cell double minute 2 0.140
Cdk2 cyclin-dependent kinase 2 0.136
Ccna2 cyclin A2 0.126
Ptch1 patched homolog 1 0.122
Emx1 empty spiracles homolog 1 (Drosophila) 0.121
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.120
Ccnb2 cyclin B2 0.115
Setdb1 SET domain, bifurcated 1 0.115
Pax8 paired box gene 8 0.111
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.108
Birc5 baculoviral IAP repeat-containing 5 0.105
Trp73 transformation related protein 73 0.104
Notch2 Notch gene homolog 2 (Drosophila) 0.096
Pthlh parathyroid hormone-like peptide 0.095
Socs1 suppressor of cytokine signaling 1 0.084
Prc1 protein regulator of cytokinesis 1 0.081
Ncstn nicastrin 0.080
Sgol2 shugoshin-like 2 (S. pombe) 0.079
Lrp6 low density lipoprotein receptor-related protein 6 0.078
C330027C09Rik RIKEN cDNA C330027C09 gene 0.077
Wnt4 wingless-related MMTV integration site 4 0.077
Otx2 orthodenticle homolog 2 (Drosophila) 0.077
Smo smoothened homolog (Drosophila) 0.076
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.072
Ccne2 cyclin E2 0.071
Nuf2 NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae) 0.070
Rarb retinoic acid receptor, beta 0.066
Otx1 orthodenticle homolog 1 (Drosophila) 0.064
Cdca8 cell division cycle associated 8 0.064
Efna4 ephrin A4 0.064
Daxx Fas death domain-associated protein 0.063
Kif20a kinesin family member 20A 0.063
Amhr2 anti-Mullerian hormone type 2 receptor 0.063
Fgf8 fibroblast growth factor 8 0.061
Hoxd13 homeobox D13 0.060
Asf1b ASF1 anti-silencing function 1 homolog B (S. cerevisiae) 0.059
Sgol1 shugoshin-like 1 (S. pombe) 0.058
T brachyury 0.058
Tbx1 T-box 1 0.057
Lin9 lin-9 homolog (C. elegans) 0.056
Usp1 ubiquitin specific peptidase 1 0.055
Naa38 N(alpha)-acetyltransferase 38, NatC auxiliary subunit 0.055
Spag5 sperm associated antigen 5 0.053
Fgfr3 fibroblast growth factor receptor 3 0.051
Aimp1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 0.049
Hmgb2 high mobility group box 2 0.047
Pcna proliferating cell nuclear antigen 0.046
Ube2c ubiquitin-conjugating enzyme E2C 0.046
Cks2 CDC28 protein kinase regulatory subunit 2 0.046
Wnt1 wingless-related MMTV integration site 1 0.046
Kl klotho 0.046
Cbx1 chromobox homolog 1 (Drosophila HP1 beta) 0.043
Zfp219 zinc finger protein 219 0.041
Cops4 COP9 (constitutive photomorphogenic) homolog, subunit 4 (Arabidopsis thaliana) 0.041
Gdnf glial cell line derived neurotrophic factor 0.040
Col2a1 collagen, type II, alpha 1 0.040
Rarg retinoic acid receptor, gamma 0.039
Pax3 paired box gene 3 0.038
Bcl2 B-cell leukemia/lymphoma 2 0.038
Suz12 suppressor of zeste 12 homolog (Drosophila) 0.038
Fzd10 frizzled homolog 10 (Drosophila) 0.038
Fgfr1 fibroblast growth factor receptor 1 0.037
Ar androgen receptor 0.037
Msx2 homeobox, msh-like 2 0.036
Ooep oocyte expressed protein homolog (dog) 0.035
Trp63 transformation related protein 63 0.035
En1 engrailed 1 0.034
Mki67 antigen identified by monoclonal antibody Ki 67 0.034
Nog noggin 0.033
Arid1b AT rich interactive domain 1B (SWI-like) 0.033
Smc4 structural maintenance of chromosomes 4 0.033
Msx1 homeobox, msh-like 1 0.033
Mdm4 transformed mouse 3T3 cell double minute 4 0.033
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.032
Hmmr hyaluronan mediated motility receptor (RHAMM) 0.032
Braf Braf transforming gene 0.031
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Rattus norvegicus
Name Description Probability Func Analog Organism