The network for 'dna dependent dna replication maintenance of fidelity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

dna dependent dna replication maintenance of fidelity

A DNA metabolic process that prevents or corrects errors to ensure that DNA is replicated accurately. Errors can be corrected either by intrinsic DNA polymerase proofreading activity or via mismatch repair.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
MRC1 Mrc1p 0.721
RAD53 Rad53p 0.148
POL2 Pol2p 0.127
DPB11 Dpb11p 0.099
HRK1 Hrk1p 0.097
HSL1 Hsl1p 0.096
CTF4 Ctf4p 0.082
DIA2 Dia2p 0.075
PTK2 Ptk2p 0.071
PPZ1 Ppz1p 0.066
YLR177W hypothetical protein 0.061
PAM1 Pam1p 0.058
SLD5 Sld5p 0.058
EAF1 Eaf1p 0.057
CSM3 Csm3p 0.054
DPB2 Dpb2p 0.053
ACM1 Acm1p 0.050
POL1 Pol1p 0.046
YPL260W hypothetical protein 0.045
CDC9 Cdc9p 0.042
KIN82 Kin82p 0.041
REG1 Reg1p 0.040
FPK1 Fpk1p 0.038
KIN1 Kin1p 0.038
MEC1 Mec1p 0.037
HAC1 Hac1p 0.036
SIA1 Sia1p 0.036
DUN1 Dun1p 0.035
POL12 Pol12p 0.035
YPS1 Yps1p 0.034
NRD1 Nrd1p 0.033
SUR1 Sur1p 0.033
POL32 Pol32p 0.033
YLR257W hypothetical protein 0.032
RAD9 Rad9p 0.031
PRI2 Pri2p 0.030
BMH1 Bmh1p 0.030
SMC6 Smc6p 0.030
HOP1 Hop1p 0.030
MNR2 Mnr2p 0.027
TOF1 Tof1p 0.027
TAX4 Tax4p 0.025
PSF1 Psf1p 0.025
MAM1 Mam1p 0.025
MCM4 Mcm4p 0.024
RRM3 Rrm3p 0.022
YOR385W hypothetical protein 0.022
YMR102C hypothetical protein 0.022
PYC2 Pyc2p 0.021
RAD5 Rad5p 0.021
RGC1 Rgc1p 0.021
ZPS1 Zps1p 0.020
SDS22 Sds22p 0.020
RFA1 Rfa1p 0.020
SAE2 Sae2p 0.019
PAH1 Pah1p 0.019
YNL134C hypothetical protein 0.019
SNF1 Snf1p 0.019
YGR205W hypothetical protein 0.019
SRD1 Srd1p 0.019
MGS1 Mgs1p 0.019
NUR1 Nur1p 0.018
YPL216W hypothetical protein 0.018
RAD55 Rad55p 0.018
HAA1 Haa1p 0.018
KCC4 Kcc4p 0.018
LEU2 Leu2p 0.018
PTI1 Pti1p 0.018
ORC6 Orc6p 0.018
ALY1 Aly1p 0.018
YKR075C hypothetical protein 0.017
YLR162W hypothetical protein 0.017
YNL234W hypothetical protein 0.017
MER1 Mer1p 0.017
STU1 Stu1p 0.017
AZF1 Azf1p 0.017
PSP1 Psp1p 0.017
SLG1 Slg1p 0.017
PBP4 Pbp4p 0.016
SPL2 Spl2p 0.016
PRR2 Prr2p 0.016
VHR1 Vhr1p 0.016
ADR1 Adr1p 0.016
GPB2 Gpb2p 0.016
CDC34 Cdc34p 0.016
TGL4 Tgl4p 0.015
YLR264C-A hypothetical protein 0.015
YOL038C-A hypothetical protein 0.015
OCH1 Och1p 0.015
PDS5 Pds5p 0.015
STE7 Ste7p 0.015
PCH2 Pch2p 0.015
COS111 Cos111p 0.015
NTH2 Nth2p 0.015
SCC2 Scc2p 0.014
POP2 Pop2p 0.014
CPD1 Cpd1p 0.014
ARP10 Arp10p 0.014
APJ1 Apj1p 0.014
HST3 Hst3p 0.014
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
NiPp1 Nuclear inhibitor of Protein phosphatase 1 0.061
Pp1alpha-96A Protein phosphatase 1alpha at 96A 0.023
Pp2A-29B Protein phosphatase 2A at 29B 0.012
MBD-R2 CG10042 gene product from transcript CG10042-RB 0.012
CG5524 CG5524 gene product from transcript CG5524-RA 0.010
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Homo sapiens
Name Description Probability Func Analog Organism
FANCA Fanconi anemia, complementation group A 0.965
BRCA1 breast cancer 1, early onset 0.628
APITD1 apoptosis-inducing, TAF9-like domain 1 0.232
POLD3 polymerase (DNA-directed), delta 3, accessory subunit 0.194
RAD51 RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) 0.151
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae) 0.137
FANCL Fanconi anemia, complementation group L 0.124
THOC2 THO complex 2 0.116
FANCM Fanconi anemia, complementation group M 0.085
BLM Bloom syndrome, RecQ helicase-like 0.060
THOC5 THO complex 5 0.054
CHAF1A chromatin assembly factor 1, subunit A (p150) 0.051
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.048
H2AFX H2A histone family, member X 0.043
MDC1 mediator of DNA-damage checkpoint 1 0.042
RBM8A RNA binding motif protein 8A 0.040
ASF1B ASF1 anti-silencing function 1 homolog B (S. cerevisiae) 0.032
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit 0.028
CNOT1 CCR4-NOT transcription complex, subunit 1 0.027
FANCD2 Fanconi anemia, complementation group D2 0.026
CDT1 chromatin licensing and DNA replication factor 1 0.024
FANCG Fanconi anemia, complementation group G 0.024
NR2E3 nuclear receptor subfamily 2, group E, member 3 0.023
CNOT2 CCR4-NOT transcription complex, subunit 2 0.023
RAD50 RAD50 homolog (S. cerevisiae) 0.022
HEXIM1 hexamethylene bis-acetamide inducible 1 0.021
NBN nibrin 0.021
CCNE1 cyclin E1 0.021
RIF1 RAP1 interacting factor homolog (yeast) 0.020
FBXW7 F-box and WD repeat domain containing 7 0.020
FANCB Fanconi anemia, complementation group B 0.019
RAD52 RAD52 homolog (S. cerevisiae) 0.019
RMI1 RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae) 0.018
ZNF830 zinc finger protein 830 0.018
RPA2 replication protein A2, 32kDa 0.018
STRA13 stimulated by retinoic acid 13 homolog (mouse) 0.015
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3 0.014
CCNT1 cyclin T1 0.013
TOP3A topoisomerase (DNA) III alpha 0.013
ORC1 origin recognition complex, subunit 1 0.013
RPA1 replication protein A1, 70kDa 0.012
ATRIP ATR interacting protein 0.012
NEK1 NIMA (never in mitosis gene a)-related kinase 1 0.012
CHAF1B chromatin assembly factor 1, subunit B (p60) 0.012
RBL1 retinoblastoma-like 1 (p107) 0.012
THOC6 THO complex 6 homolog (Drosophila) 0.011
ATM ataxia telangiectasia mutated 0.011
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.011
CDC45 cell division cycle 45 homolog (S. cerevisiae) 0.011
LIG1 ligase I, DNA, ATP-dependent 0.010
CDK2 cyclin-dependent kinase 2 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Timeless timeless homolog (Drosophila) 0.987
Smc1a structural maintenance of chromosomes 1A 0.941
Brca1 breast cancer 1 0.937
Cdt1 chromatin licensing and DNA replication factor 1 0.744
Brca2 breast cancer 2 0.561
Wdhd1 WD repeat and HMG-box DNA binding protein 1 0.487
Atm ataxia telangiectasia mutated homolog (human) 0.451
Smc3 structural maintenace of chromosomes 3 0.398
Mcm2 minichromosome maintenance deficient 2 mitotin (S. cerevisiae) 0.341
Apc adenomatosis polyposis coli 0.297
Trp53 transformation related protein 53 0.288
Lig1 ligase I, DNA, ATP-dependent 0.274
Mecp2 methyl CpG binding protein 2 0.174
Rad51 RAD51 homolog (S. cerevisiae) 0.172
Rad51ap1 RAD51 associated protein 1 0.168
1500010J02Rik RIKEN cDNA 1500010J02 gene 0.163
Rttn rotatin 0.131
Mcm5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae) 0.126
Chtf18 CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae) 0.115
Mms22l MMS22-like, DNA repair protein 0.113
E2f1 E2F transcription factor 1 0.104
Hmgb1 high mobility group box 1 0.100
Slc22a17 solute carrier family 22 (organic cation transporter), member 17 0.094
Stil Scl/Tal1 interrupting locus 0.092
Ppp1ca protein phosphatase 1, catalytic subunit, alpha isoform 0.092
Clspn claspin homolog (Xenopus laevis) 0.089
Hexim1 hexamethylene bis-acetamide inducible 1 0.086
Rfc1 replication factor C (activator 1) 1 0.079
Srsf9 serine/arginine-rich splicing factor 9 0.077
Pms2 postmeiotic segregation increased 2 (S. cerevisiae) 0.077
Blm Bloom syndrome, RecQ helicase-like 0.076
Dnmt1 DNA methyltransferase (cytosine-5) 1 0.073
Mphosph9 M-phase phosphoprotein 9 0.070
Cspg5 chondroitin sulfate proteoglycan 5 0.068
Cdca7l cell division cycle associated 7 like 0.064
Myc myelocytomatosis oncogene 0.063
Incenp inner centromere protein 0.060
Apbb1 amyloid beta (A4) precursor protein-binding, family B, member 1 0.059
Mybl2 myeloblastosis oncogene-like 2 0.059
Msh2 mutS homolog 2 (E. coli) 0.057
Max Max protein 0.056
Syce2 synaptonemal complex central element protein 2 0.055
Mdm2 transformed mouse 3T3 cell double minute 2 0.055
Lmnb1 lamin B1 0.054
Ung uracil DNA glycosylase 0.052
Mbd4 methyl-CpG binding domain protein 4 0.052
Car11 carbonic anhydrase 11 0.051
Dtl denticleless homolog (Drosophila) 0.051
Eif2a eukaryotic translation initiation factor 2A 0.049
Wdr90 WD repeat domain 90 0.049
Polr2d polymerase (RNA) II (DNA directed) polypeptide D 0.047
Ewsr1 Ewing sarcoma breakpoint region 1 0.046
Mis18bp1 MIS18 binding protein 1 0.044
Ncapd2 non-SMC condensin I complex, subunit D2 0.044
Tsg101 tumor susceptibility gene 101 0.042
Pole2 polymerase (DNA directed), epsilon 2 (p59 subunit) 0.041
Dhfr dihydrofolate reductase 0.041
Smc6 structural maintenance of chromosomes 6 0.041
Pola2 polymerase (DNA directed), alpha 2 0.041
Srrm1 serine/arginine repetitive matrix 1 0.041
Hnrnpl heterogeneous nuclear ribonucleoprotein L 0.040
Ccnd1 cyclin D1 0.040
Fancd2 Fanconi anemia, complementation group D2 0.039
Selm selenoprotein M 0.038
H2afx H2A histone family, member X 0.036
Refbp2 RNA and export factor binding protein 2 0.036
Gins1 GINS complex subunit 1 (Psf1 homolog) 0.036
Camk1g calcium/calmodulin-dependent protein kinase I gamma 0.036
Gng3 guanine nucleotide binding protein (G protein), gamma 3 0.035
Ezh2 enhancer of zeste homolog 2 (Drosophila) 0.035
Rfc2 replication factor C (activator 1) 2 0.035
Srsf2 serine/arginine-rich splicing factor 2 0.035
Ctcf CCCTC-binding factor 0.034
Lrwd1 leucine-rich repeats and WD repeat domain containing 1 0.033
Hnrnpd heterogeneous nuclear ribonucleoprotein D 0.033
Rb1 retinoblastoma 1 0.033
Cdc7 cell division cycle 7 (S. cerevisiae) 0.031
Exo1 exonuclease 1 0.031
Tro trophinin 0.030
4930422G04Rik RIKEN cDNA 4930422G04 gene 0.030
Recql4 RecQ protein-like 4 0.029
Fancm Fanconi anemia, complementation group M 0.029
Creb1 cAMP responsive element binding protein 1 0.029
Mlh1 mutL homolog 1 (E. coli) 0.029
Ddx46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 0.028
Prkar1b protein kinase, cAMP dependent regulatory, type I beta 0.027
Xiap X-linked inhibitor of apoptosis 0.027
4930427A07Rik RIKEN cDNA 4930427A07 gene 0.027
Tcf19 transcription factor 19 0.027
Phf5a PHD finger protein 5A 0.026
Plk1 polo-like kinase 1 (Drosophila) 0.026
Ptges3 prostaglandin E synthase 3 (cytosolic) 0.026
Rad54l RAD54 like (S. cerevisiae) 0.026
Pcna proliferating cell nuclear antigen 0.026
Pask PAS domain containing serine/threonine kinase 0.025
Cenpt centromere protein T 0.025
Chaf1b chromatin assembly factor 1, subunit B (p60) 0.025
Ilf3 interleukin enhancer binding factor 3 0.025
Ncapd3 non-SMC condensin II complex, subunit D3 0.024
Hnrnpa1 heterogeneous nuclear ribonucleoprotein A1 0.024
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Rattus norvegicus
Name Description Probability Func Analog Organism