The network for 'double strand break repair via synthesis dependent strand annealing' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

double strand break repair via synthesis dependent strand annealing

SDSA is a major mechanism of double-strand break repair in mitosis which allows for the error-free repair of a double-strand break without the exchange of adjacent sequences. The broken DNA searches for and base pairs with a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template. Newly synthesized DNA is then displaced from the template and anneal with its complement on the other side of the double-strand break.

Name Description Probability Func Analog Organism
SHU1 Shu1p 0.892
PSY3 Psy3p 0.836
SHU2 Shu2p 0.688
RAD55 Rad55p 0.653
CSM2 Csm2p 0.393
RAD51 Rad51p 0.383
TOP3 Top3p 0.276
XRS2 Xrs2p 0.189
RAD54 Rad54p 0.186
SGS1 Sgs1p 0.168
TEL1 Tel1p 0.161
RAD24 Rad24p 0.115
DNA2 Dna2p 0.111
RAD57 Rad57p 0.083
MEC1 Mec1p 0.079
RAD52 Rad52p 0.067
DUN1 Dun1p 0.064
MMS1 Mms1p 0.056
DDC1 Ddc1p 0.050
RAD50 Rad50p 0.048
SLX4 Slx4p 0.047
SRS2 Srs2p 0.040
RAD1 Rad1p 0.039
MMS21 Mms21p 0.039
RAD59 Rad59p 0.035
REV3 Rev3p 0.034
SAE3 Sae3p 0.031
SRD1 Srd1p 0.029
MEI5 Mei5p 0.029
RAD53 Rad53p 0.028
RMI1 Rmi1p 0.028
SPL2 Spl2p 0.026
LEU2 Leu2p 0.025
MMS4 Mms4p 0.025
SIZ1 Siz1p 0.024
YOL038C-A hypothetical protein 0.022
HOP2 Hop2p 0.021
LIF1 Lif1p 0.020
SPO16 Spo16p 0.020
YLR162W hypothetical protein 0.020
ZPS1 Zps1p 0.020
RAD5 Rad5p 0.019
MER1 Mer1p 0.019
YLR264C-A hypothetical protein 0.019
RTT105 Rtt105p 0.019
HXT3 Hxt3p 0.019
MUS81 Mus81p 0.019
ARP10 Arp10p 0.019
RAD18 Rad18p 0.019
HST3 Hst3p 0.018
CUP1-1 Cup1-1p 0.018
YPR157W hypothetical protein 0.018
YBL044W hypothetical protein 0.017
ATP6 Atp6p 0.017
YAR068W hypothetical protein 0.017
RAD10 Rad10p 0.017
GYL1 Gyl1p 0.017
YBR013C hypothetical protein 0.016
YLR042C hypothetical protein 0.016
SLX5 Slx5p 0.016
AUA1 Aua1p 0.015
OPT2 Opt2p 0.015
YOL013W-A hypothetical protein 0.015
MSH4 Msh4p 0.015
REV7 Rev7p 0.015
MLH1 Mlh1p 0.014
PCH2 Pch2p 0.014
YJR120W hypothetical protein 0.014
POL31 Pol31p 0.014
YBR296C-A hypothetical protein 0.014
HPF1 Hpf1p 0.014
YPR096C hypothetical protein 0.014
BSC1 Bsc1p 0.014
FMT1 Fmt1p 0.014
CHA1 Cha1p 0.014
SCM4 Scm4p 0.013
BRN1 Brn1p 0.013
MSH5 Msh5p 0.013
CAR1 Car1p 0.013
DIC1 Dic1p 0.013
ENA5 Ena5p 0.013
IZH4 Izh4p 0.013
RNP1 Rnp1p 0.013
BNA4 Bna4p 0.013
MF(ALPHA)2 Mf(alpha)2p 0.013
YAL064W hypothetical protein 0.013
PHO11 Pho11p 0.013
YNL155W hypothetical protein 0.013
LCL1 Lcl1p 0.013
CPD1 Cpd1p 0.013
YKR075C hypothetical protein 0.012
UPS3 Ups3p 0.012
TYE7 Tye7p 0.012
YPL067C hypothetical protein 0.012
AQY2 Aqy2p 0.012
MFA2 Mfa2p 0.012
BDS1 Bds1p 0.012
ARR2 Arr2p 0.012
YJL160C hypothetical protein 0.012
ARO10 Aro10p 0.012
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
okr okra 0.998
Brca2 Breast cancer 2, early onset homolog 0.997
mus101 mutagen-sensitive 101 0.996
mus205 mutagen-sensitive 205 0.996
rad50 CG6339 gene product from transcript CG6339-RD 0.996
mei-9 meiotic 9 0.993
mus308 mutagen-sensitive 308 0.968
DNApol-eta CG7143 gene product from transcript CG7143-RA 0.956
RecQ5 homolog of RecQ 0.944
mus304 mutagen-sensitive 304 0.911
CG5524 CG5524 gene product from transcript CG5524-RA 0.910
mus201 mutagen-sensitive 201 0.908
mus301 mutagen-sensitive 301 0.860
lok loki 0.858
nbs CG6754 gene product from transcript CG6754-RC 0.840
hay haywire 0.736
spn-B spindle B 0.710
mus309 mutagen-sensitive 309 0.649
RecQ4 CG7487 gene product from transcript CG7487-RA 0.503
tefu telomere fusion 0.427
mei-41 meiotic 41 0.345
mus210 mutagen-sensitive 210 0.279
mus312 mutagen-sensitive 312 0.271
Chrac-14 CG13399 gene product from transcript CG13399-RA 0.247
Irbp Inverted repeat-binding protein 0.240
Rev1 CG12189 gene product from transcript CG12189-RA 0.170
spn-A spindle A 0.156
Smc5 CG32438 gene product from transcript CG32438-RE 0.127
ball ballchen 0.115
p53 CG33336 gene product from transcript CG33336-RB 0.070
Ercc1 CG10215 gene product from transcript CG10215-RA 0.034
Mnn1 Menin 1 0.032
phr photorepair 0.030
gammaTub37C gamma-Tubulin at 37C 0.029
Cdk4 Cyclin-dependent kinase 4 0.026
CG4680 CG4680 gene product from transcript CG4680-RA 0.025
mre11 meiotic recombination 11 0.020
Cenp-C CG31258 gene product from transcript CG31258-RA 0.018
Mcm5 Minichromosome maintenance 5 0.015
spn-D spindle D 0.015
cav caravaggio 0.014
CDC45L CG3658 gene product from transcript CG3658-RA 0.014
stwl stonewall 0.012
Klp3A Kinesin-like protein at 3A 0.012
wisp wispy 0.011
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism