The network for 'negative regulation of dna metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of dna metabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
MRC1 Mrc1p 0.585
RAD53 Rad53p 0.569
STN1 Stn1p 0.413
DIA2 Dia2p 0.368
BDF1 Bdf1p 0.326
SNT1 Snt1p 0.282
MEC1 Mec1p 0.279
RAD54 Rad54p 0.251
PTK2 Ptk2p 0.241
RAD59 Rad59p 0.197
SRS2 Srs2p 0.168
RAD24 Rad24p 0.167
PIL1 Pil1p 0.161
RAD52 Rad52p 0.147
SKO1 Sko1p 0.147
RED1 Red1p 0.137
RRM3 Rrm3p 0.136
TOF2 Tof2p 0.129
ZDS1 Zds1p 0.126
UME6 Ume6p 0.110
VID22 Vid22p 0.110
YPL260W hypothetical protein 0.103
SPT8 Spt8p 0.100
YLR177W hypothetical protein 0.099
SEF1 Sef1p 0.096
TEN1 Ten1p 0.096
HOP1 Hop1p 0.091
DCC1 Dcc1p 0.089
SIN3 Sin3p 0.087
RAD1 Rad1p 0.083
AKL1 Akl1p 0.082
RMI1 Rmi1p 0.081
ESF1 Esf1p 0.080
CDC13 Cdc13p 0.079
MMS1 Mms1p 0.078
ROD1 Rod1p 0.076
DUN1 Dun1p 0.076
MAG1 Mag1p 0.074
NUP157 Nup157p 0.071
RTF1 Rtf1p 0.066
HPR1 Hpr1p 0.066
YPL014W hypothetical protein 0.066
MCM4 Mcm4p 0.066
FMP48 Fmp48p 0.064
CKA1 Cka1p 0.064
CMK2 Cmk2p 0.063
NET1 Net1p 0.062
CDC4 Cdc4p 0.061
SWI3 Swi3p 0.060
PDS1 Pds1p 0.060
CTF18 Ctf18p 0.058
YLR257W hypothetical protein 0.058
RAD5 Rad5p 0.057
RTS1 Rts1p 0.057
POL30 Pol30p 0.057
SUV3 Suv3p 0.056
HHO1 Hho1p 0.055
SIR2 Sir2p 0.053
SAE2 Sae2p 0.053
MSH3 Msh3p 0.053
SCH9 Sch9p 0.052
IRC8 Irc8p 0.052
STP1 Stp1p 0.051
HDA2 Hda2p 0.051
SIF2 Sif2p 0.051
PIR1 Pir1p 0.050
KCS1 Kcs1p 0.048
POL1 Pol1p 0.048
SET3 Set3p 0.047
DNA2 Dna2p 0.046
RAD30 Rad30p 0.045
SIC1 Sic1p 0.045
MSH6 Msh6p 0.045
SDS3 Sds3p 0.045
DBP10 Dbp10p 0.043
PAM1 Pam1p 0.043
RPL5 Rpl5p 0.042
RFA2 Rfa2p 0.041
MSI1 Msi1p 0.041
SMC6 Smc6p 0.041
EST2 Est2p 0.041
SKI8 Ski8p 0.041
TAX4 Tax4p 0.041
NRD1 Nrd1p 0.040
HOS4 Hos4p 0.040
PRI1 Pri1p 0.040
RAD51 Rad51p 0.040
RAD27 Rad27p 0.040
MGS1 Mgs1p 0.039
PRP43 Prp43p 0.039
CDC7 Cdc7p 0.039
YPK1 Ypk1p 0.039
YCS4 Ycs4p 0.038
HST3 Hst3p 0.037
ADR1 Adr1p 0.036
DSE3 Dse3p 0.036
XRS2 Xrs2p 0.035
YOL131W hypothetical protein 0.035
EST1 Est1p 0.035
YNL134C hypothetical protein 0.035
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
zgc:64114 zgc:64114 0.157
pds5b PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae) 0.132
mybl2 myeloblastosis oncogene-like 2 0.130
zgc:110113 zgc:110113 0.118
rnf17 ring finger protein 17 0.116
anp32a acidic (leucine-rich) nuclear phosphoprotein 32 family, member A 0.098
slc2a10 solute carrier family 2 (facilitated glucose transporter), member 10 0.096
myst2 MYST histone acetyltransferase 2 0.095
plagx pleiomorphic adenoma gene X 0.091
msh2 mutS homolog 2 (E. coli) 0.087
gpia glucose phosphate isomerase a 0.077
vsx2 visual system homeobox 2 0.067
hspb11 heat shock protein, alpha-crystallin-related, b11 0.067
usp1 ubiquitin specific protease 1 0.067
dnmt1 DNA (cytosine-5-)-methyltransferase 1 0.065
dyx1c1 dyslexia susceptibility 1 candidate 1 0.065
recql5 RecQ protein-like 5 0.065
rfx2 regulatory factor X, 2 (influences HLA class II expression) 0.063
si:ch211-57k11.10 si:ch211-57k11.10 0.061
hirip3 HIRA interacting protein 3 0.060
hp1bp3 heterochromatin protein 1, binding protein 3 0.059
esco2 establishment of cohesion 1 homolog 2 0.059
mcm5 MCM5 minichromosome maintenance deficient 5 (S. cerevisiae) 0.059
blm Bloom syndrome 0.059
crh corticotropin releasing hormone 0.058
itgb1b.2 integrin, beta 1b.2 0.056
slc12a3 solute carrier family 12 (sodium/chloride transporters), member 3 0.055
smc3 structural maintenance of chromosomes 3 0.054
col14a1 collagen, type XIV, alpha 1 0.053
si:dkey-228g21.4 si:dkey-228g21.4 0.051
tnfa tumor necrosis factor a (TNF superfamily, member 2) 0.050
sid4 secreted immunoglobulin domain 4 0.049
vasa vasa homolog 0.049
eif3c eukaryotic translation initiation factor 3, subunit C 0.049
elavl2 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B) 0.048
sephs1 selenophosphate synthetase 1 0.048
LOC100003330 melanocortin-2 receptor accessory protein 2-like 0.048
arpp19a cAMP-regulated phosphoprotein 19a 0.048
ahctf1 AT hook containing transcription factor 1 0.047
mapk1 mitogen-activated protein kinase 1 0.047
rpsa ribosomal protein SA 0.047
smc2 structural maintenance of chromosomes 2 0.047
tra2b transformer 2 beta homolog (Drosophila) 0.045
slc4a2a solute carrier family 4, anion exchanger, member 2a 0.044
hdac8 histone deacetylase 8 0.044
srsf4 serine/arginine-rich splicing factor 4 0.044
slc6a4a solute carrier family 6 (neurotransmitter transporter, serotonin), member 4A 0.044
zgc:101782 zgc:101782 0.043
itgb1b.1 integrin, beta 1b.1 0.043
ephb4b eph receptor B4b 0.043
cbx5 chromobox homolog 5 (HP1 alpha homolog, Drosophila) 0.042
camk2n2 calcium/calmodulin-dependent protein kinase II inhibitor 2 0.042
bmpr2a bone morphogenetic protein receptor, type II a (serine/threonine kinase) 0.042
stmn4 stathmin-like 4 0.042
ptger4b prostaglandin E receptor 4 (subtype EP4) b 0.042
col4a6 collagen, type IV, alpha 6 0.042
ca15b carbonic anhydrase XV b 0.042
sh3gl1b SH3-domain GRB2-like 1b 0.041
rpl13 ribosomal protein L13 0.041
si:ch211-157f15.3 si:ch211-157f15.3 0.041
nr0b1 nuclear receptor subfamily 0, group B, member 1 0.041
esr1 estrogen receptor 1 0.041
ash2l ash2 (absent, small, or homeotic)-like (Drosophila) 0.041
cbx1a chromobox homolog 1a (HP1 beta homolog Drosophila) 0.041
eif3d eukaryotic translation initiation factor 3, subunit D 0.041
mical2b microtubule associated monoxygenase, calponin and LIM domain containing 2b 0.040
sass6 spindle assembly 6 homolog (C. elegans) 0.039
whsc1 Wolf-Hirschhorn syndrome candidate 1 0.039
smc1al structural maintenance of chromosomes 1A, like 0.039
igfbp1a insulin-like growth factor binding protein 1a 0.039
zgc:92664 zgc:92664 0.039
igf2b insulin-like growth factor 2b 0.039
nap1l1 nucleosome assembly protein 1, like 1 0.039
cx45.6 connexin 45.6 0.038
hamp1 hepcidin antimicrobial peptide 1 0.038
zgc:101737 zgc:101737 0.038
eve1 even-skipped-like1 0.038
gins2 GINS complex subunit 2 0.038
nasp nuclear autoantigenic sperm protein (histone-binding) 0.038
pola1 polymerase (DNA directed), alpha 1 0.037
zgc:103482 zgc:103482 0.037
msh6 mutS homolog 6 (E. coli) 0.037
nr3c1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.037
chat choline acetyltransferase 0.036
tcf7l1a transcription factor 7-like 1a (T-cell specific, HMG-box) 0.036
nanos3 nanos homolog 3 0.036
trpm6 transient receptor potential cation channel, subfamily M, member 6 0.036
mef2a myocyte enhancer factor 2a 0.036
col10a1 collagen, type X, alpha 1 0.036
eef1g eukaryotic translation elongation factor 1 gamma 0.036
rpl3 ribosomal protein L3 0.035
ezh2 enhancer of zeste homolog 2 (Drosophila) 0.035
pou1f1 POU domain, class 1, transcription factor 1 0.035
LOC100150924 DNA polymerase subunit gamma-1-like 0.035
pola2 polymerase (DNA directed), alpha 2 0.035
rpa1 replication protein A1 0.035
hat1 histone acetyltransferase 1 0.035
frem3 Fras1 related extracellular matrix 3 0.034
palb2 partner and localizer of BRCA2 0.034
zgc:85939 zgc:85939 0.034
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Drosophila melanogaster
Name Description Probability Func Analog Organism
dap dacapo 0.419
png pan gu 0.145
mip120 Myb-interacting protein 120 0.143
lok loki 0.106
ex expanded 0.044
tefu telomere fusion 0.040
Dp DP transcription factor 0.039
vas vasa 0.036
mei-9 meiotic 9 0.036
rad50 CG6339 gene product from transcript CG6339-RD 0.035
CG9772 CG9772 gene product from transcript CG9772-RB 0.031
cutlet CG33122 gene product from transcript CG33122-RA 0.031
babo baboon 0.030
E2f2 E2F transcription factor 2 0.029
mus209 mutagen-sensitive 209 0.029
pim pimples 0.028
piwi CG6122 gene product from transcript CG6122-RA 0.027
sti sticky 0.027
p53 CG33336 gene product from transcript CG33336-RB 0.026
mus304 mutagen-sensitive 304 0.025
orb oo18 RNA-binding protein 0.024
dmt dalmatian 0.024
cdc2 CG5363 gene product from transcript CG5363-RA 0.024
ash2 absent, small, or homeotic discs 2 0.023
fzy fizzy 0.023
imd immune deficiency 0.023
DNApol-eta CG7143 gene product from transcript CG7143-RA 0.020
CG4680 CG4680 gene product from transcript CG4680-RA 0.019
Slbp Stem-loop binding protein 0.018
Med Medea 0.018
PSR phosphatidylserine receptor 0.018
mus205 mutagen-sensitive 205 0.018
CG17273 CG17273 gene product from transcript CG17273-RA 0.017
CycJ Cyclin J 0.017
swa swallow 0.017
pie pineapple eye 0.017
gammaTub37C gamma-Tubulin at 37C 0.017
Df31 Decondensation factor 31 0.017
Rbf Retinoblastoma-family protein 0.016
su(f) suppressor of forked 0.016
Mad Mothers against dpp 0.016
Tl Toll 0.016
Mcm7 Minichromosome maintenance 7 0.015
plu plutonium 0.014
nbs CG6754 gene product from transcript CG6754-RC 0.014
armi armitage 0.014
E(var)3-9 Enhancer of variegation 3-9 0.014
AGO2 Argonaute 2 0.014
Traf4 TNF-receptor-associated factor 4 0.014
cin cinnamon 0.014
tin tinman 0.013
byn brachyenteron 0.013
Dhc64C Dynein heavy chain 64C 0.013
rept reptin 0.013
tos tosca 0.013
Cdk4 Cyclin-dependent kinase 4 0.012
MED19 Mediator complex subunit 19 0.012
DNApol-alpha73 DNA polymerase alpha 73kD 0.012
zpg zero population growth 0.012
CDC45L CG3658 gene product from transcript CG3658-RA 0.012
cdc2c CG10498 gene product from transcript CG10498-RC 0.012
CG10414 CG10414 gene product from transcript CG10414-RA 0.012
hh hedgehog 0.012
CG5524 CG5524 gene product from transcript CG5524-RA 0.012
esg escargot 0.012
Klp3A Kinesin-like protein at 3A 0.012
Smc5 CG32438 gene product from transcript CG32438-RE 0.011
slo slowpoke 0.011
CG10990 CG10990 gene product from transcript CG10990-RB 0.011
ro rough 0.011
Rab23 CG2108 gene product from transcript CG2108-RA 0.011
Orc6 Origin recognition complex subunit 6 0.011
abo abnormal oocyte 0.010
kin17 CG5649 gene product from transcript CG5649-RA 0.010
Cks30A Cyclin-dependent kinase subunit 30A 0.010
Dref DNA replication-related element factor 0.010
spn-A spindle A 0.010
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Homo sapiens
Name Description Probability Func Analog Organism
TERF2 telomeric repeat binding factor 2 0.966
RAD21 RAD21 homolog (S. pombe) 0.961
MSH2 mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) 0.950
SLX4 SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae) 0.949
CDK2 cyclin-dependent kinase 2 0.937
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.928
BRCA1 breast cancer 1, early onset 0.918
RB1 retinoblastoma 1 0.915
STAG1 stromal antigen 1 0.908
C1QA complement component 1, q subcomponent, A chain 0.906
CHEK1 CHK1 checkpoint homolog (S. pombe) 0.824
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 0.800
PCNA proliferating cell nuclear antigen 0.746
WRN Werner syndrome, RecQ helicase-like 0.676
MSH6 mutS homolog 6 (E. coli) 0.651
RBBP8 retinoblastoma binding protein 8 0.575
WAPAL wings apart-like homolog (Drosophila) 0.570
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.543
UBC ubiquitin C 0.465
FKBP1A FK506 binding protein 1A, 12kDa 0.430
BLM Bloom syndrome, RecQ helicase-like 0.391
TERF1 telomeric repeat binding factor (NIMA-interacting) 1 0.389
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.381
RPA1 replication protein A1, 70kDa 0.375
RAD1 RAD1 homolog (S. pombe) 0.368
E2F1 E2F transcription factor 1 0.361
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.348
BMP2 bone morphogenetic protein 2 0.319
BRCA2 breast cancer 2, early onset 0.312
CBX5 chromobox homolog 5 0.304
C1QC complement component 1, q subcomponent, C chain 0.302
SMC1A structural maintenance of chromosomes 1A 0.293
PDS5A PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae) 0.272
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.259
SKP2 S-phase kinase-associated protein 2 (p45) 0.257
SH3KBP1 SH3-domain kinase binding protein 1 0.255
FANCD2 Fanconi anemia, complementation group D2 0.249
PARP1 poly (ADP-ribose) polymerase 1 0.248
C1QB complement component 1, q subcomponent, B chain 0.246
PDS5B PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae) 0.239
SMC3 structural maintenance of chromosomes 3 0.224
TGFB1 transforming growth factor, beta 1 0.224
ORC2 origin recognition complex, subunit 2 0.223
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) 0.219
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.218
PRMT6 protein arginine methyltransferase 6 0.202
ENG endoglin 0.197
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.194
CHAF1A chromatin assembly factor 1, subunit A (p150) 0.193
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1 0.188
CCNE1 cyclin E1 0.174
BTG1 B-cell translocation gene 1, anti-proliferative 0.170
RAD51 RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) 0.157
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.156
RFC1 replication factor C (activator 1) 1, 145kDa 0.153
SCHIP1 schwannomin interacting protein 1 0.151
GNLY granulysin 0.137
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.135
CNOT8 CCR4-NOT transcription complex, subunit 8 0.128
STAG2 stromal antigen 2 0.125
CD44 CD44 molecule (Indian blood group) 0.116
PRF1 perforin 1 (pore forming protein) 0.115
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.115
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like 0.113
ATR ataxia telangiectasia and Rad3 related 0.113
IQGAP1 IQ motif containing GTPase activating protein 1 0.104
HIST1H3B histone cluster 1, H3b 0.102
RIF1 RAP1 interacting factor homolog (yeast) 0.100
TOPBP1 topoisomerase (DNA) II binding protein 1 0.099
ACD adrenocortical dysplasia homolog (mouse) 0.099
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 0.097
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) 0.095
INO80B INO80 complex subunit B 0.093
MAFA v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian) 0.091
RHOA ras homolog gene family, member A 0.084
IPO4 importin 4 0.083
TGFB3 transforming growth factor, beta 3 0.082
CCNA2 cyclin A2 0.081
NIPBL Nipped-B homolog (Drosophila) 0.081
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae) 0.075
RAD9A RAD9 homolog A (S. pombe) 0.074
RBBP4 retinoblastoma binding protein 4 0.072
INSR insulin receptor 0.072
TGFBR1 transforming growth factor, beta receptor 1 0.071
CLTC clathrin, heavy chain (Hc) 0.069
CNOT2 CCR4-NOT transcription complex, subunit 2 0.067
SETD8 SET domain containing (lysine methyltransferase) 8 0.067
H2AFX H2A histone family, member X 0.064
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae) 0.064
JUN jun proto-oncogene 0.063
PNKP polynucleotide kinase 3'-phosphatase 0.063
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 0.062
CNOT1 CCR4-NOT transcription complex, subunit 1 0.062
NR2E3 nuclear receptor subfamily 2, group E, member 3 0.061
MAPK14 mitogen-activated protein kinase 14 0.060
SMAD7 SMAD family member 7 0.060
HLTF helicase-like transcription factor 0.060
MAGEA2 melanoma antigen family A, 2 0.060
CBX3 chromobox homolog 3 0.059
FANCI Fanconi anemia, complementation group I 0.058
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
Junb jun B proto-oncogene 0.012