The network for 'establishment of protein localization to vacuole' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

establishment of protein localization to vacuole

The directed movement of a protein to a specific location in a vacuole.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
VPS21 Vps21p 0.997
VPS28 Vps28p 0.991
ATG9 Atg9p 0.986
ATG7 Atg7p 0.980
VPS41 Vps41p 0.978
APL5 Apl5p 0.961
VPS36 Vps36p 0.959
LSB3 Lsb3p 0.957
COG5 Cog5p 0.943
ATG12 Atg12p 0.931
ATG3 Atg3p 0.927
COG7 Cog7p 0.927
VPS35 Vps35p 0.926
COG6 Cog6p 0.925
COG8 Cog8p 0.917
SRN2 Srn2p 0.893
YPT6 Ypt6p 0.879
BRO1 Bro1p 0.872
ATG4 Atg4p 0.825
VPS4 Vps4p 0.808
COG4 Cog4p 0.806
VPS20 Vps20p 0.788
VPS3 Vps3p 0.775
APL6 Apl6p 0.762
ATG20 Atg20p 0.728
YPT52 Ypt52p 0.704
SNX4 Snx4p 0.702
VPS30 Vps30p 0.696
ATG1 Atg1p 0.687
COG1 Cog1p 0.678
COG3 Cog3p 0.678
YPT7 Ypt7p 0.661
ATG23 Atg23p 0.650
ATG13 Atg13p 0.650
ATG21 Atg21p 0.637
ATG10 Atg10p 0.583
PEP3 Pep3p 0.562
VAM7 Vam7p 0.547
ATG26 Atg26p 0.531
VPS52 Vps52p 0.514
BSD2 Bsd2p 0.508
VTI1 Vti1p 0.505
ATG14 Atg14p 0.503
MON1 Mon1p 0.484
VAM6 Vam6p 0.470
ATG11 Atg11p 0.462
APM3 Apm3p 0.425
TRS85 Trs85p 0.401
PEP1 Pep1p 0.382
PEP5 Pep5p 0.371
TLG2 Tlg2p 0.366
DID4 Did4p 0.364
STP22 Stp22p 0.351
HSV2 Hsv2p 0.346
VPS16 Vps16p 0.335
VPS13 Vps13p 0.322
VPS8 Vps8p 0.311
VPS17 Vps17p 0.287
ATG29 Atg29p 0.286
ATG16 Atg16p 0.281
PEP8 Pep8p 0.279
ATG5 Atg5p 0.276
RIM21 Rim21p 0.276
ATG8 Atg8p 0.270
ECM21 Ecm21p 0.269
VPS38 Vps38p 0.260
YPT53 Ypt53p 0.258
GYL1 Gyl1p 0.243
BPT1 Bpt1p 0.227
SNF8 Snf8p 0.220
RAV1 Rav1p 0.214
IST1 Ist1p 0.209
YPR091C hypothetical protein 0.195
COT1 Cot1p 0.190
VPS9 Vps9p 0.185
CMP2 Cmp2p 0.184
ATG19 Atg19p 0.182
CSR2 Csr2p 0.181
MON2 Mon2p 0.178
LSB1 Lsb1p 0.177
CNB1 Cnb1p 0.175
SLG1 Slg1p 0.166
ATG17 Atg17p 0.160
ATG27 Atg27p 0.160
VPS60 Vps60p 0.159
VMA8 Vma8p 0.156
ASI1 Asi1p 0.154
VPS5 Vps5p 0.147
RGP1 Rgp1p 0.144
CCZ1 Ccz1p 0.144
YJL185C hypothetical protein 0.137
BBC1 Bbc1p 0.134
SYS1 Sys1p 0.134
VMA16 Vma16p 0.133
PHO84 Pho84p 0.132
VPS24 Vps24p 0.131
SLA2 Sla2p 0.131
VTA1 Vta1p 0.125
VPS33 Vps33p 0.124
COG2 Cog2p 0.123
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
atp6v1f ATPase, H+ transporting, V1 subunit F 0.358
paqr8 progestin and adipoQ receptor family member VIII 0.202
zgc:73134 zgc:73134 0.087
atp6v0d1 ATPase, H+ transporting, V0 subunit D isoform 1 0.063
creb3l3l cAMP responsive element binding protein 3-like 3 like 0.060
rab5aa RAB5A, member RAS oncogene family, a 0.054
arhgdia Rho GDP dissociation inhibitor (GDI) alpha 0.052
cltca clathrin, heavy polypeptide a (Hc) 0.046
atp6v1e1b ATPase, H+ transporting, lysosomal, V1 subunit E isoform 1b 0.045
zgc:77849 zgc:77849 0.043
sdf4 stromal cell derived factor 4 0.042
atp6v1d ATPase, H+ transporting, V1 subunit D and ATPase, H+ transporting, V1 subunit D 0.040
snx5 sorting nexin 5 0.040
cyp17a1 cytochrome P450, family 17, subfamily A, polypeptide 1 0.033
scamp2 secretory carrier membrane protein 2 0.032
lhb luteinizing hormone, beta polypeptide 0.031
vps35 vacuolar protein sorting 35 (yeast) 0.030
pfn2 profilin 2 0.029
si:dkey-181m9.9 si:dkey-181m9.9 0.028
stambpa STAM binding protein a 0.027
clcn7 chloride channel 7 0.027
vps26bl vacuolar protein sorting 26 homolog B, like 0.026
syap1 synapse associated protein 1 0.024
gdf9 growth differentiation factor 9 0.024
rab7 RAB7, member RAS oncogene family 0.023
LOC559201 similar to Neuromedin-K receptor (NKR) (Neurokinin B receptor) (NK-3 receptor) (NK-3R) (Tachykinin receptor 3) 0.023
jak1 Janus kinase 1 0.023
vps28 vacuolar protein sorting 28 (yeast) 0.023
maff v-maf musculoaponeurotic fibrosarcoma oncogene homolog f (avian) 0.023
atp6ap2 ATPase, H+ transporting, lysosomal accessory protein 2 0.022
inhbab inhibin, beta Ab 0.022
rab5ab RAB5A, member RAS oncogene family, b 0.021
ikbkg inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.021
nanos3 nanos homolog 3 0.021
bsdc1 BSD domain containing 1 0.021
gabarapa GABA(A) receptor-associated protein a 0.021
gdi2 GDP dissociation inhibitor 2 0.021
rspo1 R-spondin homolog (Xenopus laevis) 0.020
zgc:55671 zgc:55671 0.020
uck2a uridine-cytidine kinase 2a 0.019
wipi1 WD repeat domain, phosphoinositide interacting 1 0.019
kop askopos 0.019
atp6v1c1a ATPase, H+ transporting, lysosomal, V1 subunit C, isoform 1a 0.019
zgc:152984 zgc:152984 0.018
LOC569642 hypothetical protein LOC569642 0.018
sbf1 SET binding factor 1 0.018
arih2 ariadne homolog 2 (Drosophila) 0.017
cpne1 copine I 0.017
plekha3 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 3 0.017
arcn1l archain 1 like 0.017
pafah1b3 platelet-activating factor acetylhydrolase, isoform Ib, gamma subunit 0.016
ddx6 DEAD (Asp-Glu-Ala-Asp) box polypeptide 6 0.016
atf4b2 activating transcription factor 4b2 0.016
cldn2 claudin 2 0.016
iqgap1 IQ motif containing GTPase activating protein 1 0.016
slc30a5 solute carrier family 30 (zinc transporter), member 5 0.015
yipf4 Yip1 domain family, member 4 0.015
ndfip1 Nedd4 family interacting protein 1 0.015
sass6 spindle assembly 6 homolog (C. elegans) 0.015
LOC555482 tachykinin receptor 3-like 0.015
apg3l APG3 autophagy 3-like 0.015
arid4a AT rich interactive domain 4A (RBP1-like) 0.015
capza1a capping protein (actin filament) muscle Z-line, alpha 1a 0.015
tmem9b TMEM9 domain family, member B 0.014
phf20b PHD finger protein 20, b 0.014
tm9sf2 transmembrane 9 superfamily member 2 0.014
tmem129 transmembrane protein 129 0.014
kiss2 kisspeptin 2 0.014
mtmr6 myotubularin related protein 6 0.014
zgc:114097 zgc:114097 0.014
tpsn tapasin 0.014
ftsjd1 FtsJ methyltransferase domain containing 1 0.014
brap BRCA1 associated protein 0.014
letm1 leucine zipper-EF-hand containing transmembrane protein 1 0.014
fshb follicle stimulating hormone, beta polypeptide 0.014
rab2a RAB2A, member RAS oncogene family 0.014
slc7a6os solute carrier family 7, member 6 opposite strand 0.013
tpd52l2b tumor protein D52-like 2b 0.013
zgc:113121 zgc:113121 0.013
tbc1d15 TBC1 domain family, member 15 0.013
aktip akt interacting protein 0.013
arpc4l actin related protein 2/3 complex, subunit 4, like 0.013
zgc:56010 zgc:56010 0.013
spns1 spinster homolog 1 (Drosophila) 0.013
chic2 cysteine-rich hydrophobic domain 2 0.013
arpc5a actin related protein 2/3 complex, subunit 5A 0.013
igf3 insulin-like growth factor 3 0.013
ppme1 protein phosphatase methylesterase 1 0.013
cln6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant 0.013
zgc:152900 zgc:152900 0.013
vipar vps33b interacting protein, apical-basolateral polarity regulator 0.013
nedd1 neural precursor cell expressed, developmentally down-regulated 1 0.012
zgc:64161 zgc:64161 0.012
zgc:77817 zgc:77817 0.012
pik3c3 phosphoinositide-3-kinase, class 3 0.012
piga phosphatidylinositol glycan anchor biosynthesis, class A 0.012
LOC559976 similar to glutamate receptor, ionotropic, NMDA2B (epsilon 2) 0.012
tmem199 transmembrane protein 199 0.012
gosr1 golgi SNAP receptor complex member 1 0.012
ube2q2 ubiquitin-conjugating enzyme E2Q family member 2 0.012
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.550
GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1 0.429
RNF11 ring finger protein 11 0.403
SQSTM1 sequestosome 1 0.133
ATG3 ATG3 autophagy related 3 homolog (S. cerevisiae) 0.128
WWP1 WW domain containing E3 ubiquitin protein ligase 1 0.081
EEA1 early endosome antigen 1 0.062
RABEP1 rabaptin, RAB GTPase binding effector protein 1 0.040
ATG7 ATG7 autophagy related 7 homolog (S. cerevisiae) 0.038
SNF8 SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae) 0.031
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.027
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.025
NEDD4 neural precursor cell expressed, developmentally down-regulated 4 0.023
ANKRD13A ankyrin repeat domain 13A 0.023
SORT1 sortilin 1 0.020
GABARAP GABA(A) receptor-associated protein 0.018
SMAD4 SMAD family member 4 0.018
LRRK2 leucine-rich repeat kinase 2 0.015
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa 0.014
ATG12 ATG12 autophagy related 12 homolog (S. cerevisiae) 0.014
GABARAPL2 GABA(A) receptor-associated protein-like 2 0.014
TSG101 tumor susceptibility gene 101 0.013
ELL elongation factor RNA polymerase II 0.013
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.012
TMED2 transmembrane emp24 domain trafficking protein 2 0.012
WASL Wiskott-Aldrich syndrome-like 0.012
WWP2 WW domain containing E3 ubiquitin protein ligase 2 0.011
RAB6A RAB6A, member RAS oncogene family 0.010
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Atg12 autophagy-related 12 (yeast) 0.596
Chmp1b chromatin modifying protein 1B 0.248
Stx7 syntaxin 7 0.155
Tax1bp1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.153
Rnf11 ring finger protein 11 0.123
8430410K20Rik RIKEN cDNA 8430410K20 gene 0.122
Rnf103 ring finger protein 103 0.096
Sec23a SEC23A (S. cerevisiae) 0.092
Grb10 growth factor receptor bound protein 10 0.084
Lyst lysosomal trafficking regulator 0.076
Axin1 axin 1 0.073
Pldn pallidin 0.070
Ghr growth hormone receptor 0.062
Tbx3 T-box 3 0.060
Rbbp9 retinoblastoma binding protein 9 0.054
Gsk3b glycogen synthase kinase 3 beta 0.054
Hps4 Hermansky-Pudlak syndrome 4 homolog (human) 0.051
Ctnnb1 catenin (cadherin associated protein), beta 1 0.051
Dram2 VDNA-damage regulated autophagy modulator 2 0.050
Rab27a RAB27A, member RAS oncogene family 0.049
Stam2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 0.049
Ndfip1 Nedd4 family interacting protein 1 0.046
Chm choroidermia 0.044
Shd src homology 2 domain-containing transforming protein D 0.044
Traf6 TNF receptor-associated factor 6 0.042
Lrrk2 leucine-rich repeat kinase 2 0.042
Hps1 Hermansky-Pudlak syndrome 1 homolog (human) 0.041
Pdcl phosducin-like 0.039
Ripk1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.039
Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 0.037
Fpgt fucose-1-phosphate guanylyltransferase 0.037
Dnajb9 DnaJ (Hsp40) homolog, subfamily B, member 9 0.036
Atp6ap2 ATPase, H+ transporting, lysosomal accessory protein 2 0.036
Samd4b sterile alpha motif domain containing 4B 0.036
Syap1 synapse associated protein 1 0.036
Lysmd3 LysM, putative peptidoglycan-binding, domain containing 3 0.036
Kit kit oncogene 0.035
Rab1 RAB1, member RAS oncogene family 0.034
T brachyury 0.034
Hps5 Hermansky-Pudlak syndrome 5 homolog (human) 0.033
Mobkl3 MOB1, Mps One Binder kinase activator-like 3 (yeast) 0.033
Apoe apolipoprotein E 0.033
Rab33b RAB33B, member of RAS oncogene family 0.032
Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 0.032
Ar androgen receptor 0.032
Csgalnact2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 0.031
Dmxl1 Dmx-like 1 0.031
Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.030
Dpy19l4 dpy-19-like 4 (C. elegans) 0.030
Crtc3 CREB regulated transcription coactivator 3 0.030
Rnf115 ring finger protein 115 0.030
Lrp6 low density lipoprotein receptor-related protein 6 0.029
Sos2 son of sevenless homolog 2 (Drosophila) 0.029
Traf2 TNF receptor-associated factor 2 0.029
C78339 expressed sequence C78339 0.028
Chuk conserved helix-loop-helix ubiquitous kinase 0.028
Klhl2 kelch-like 2, Mayven (Drosophila) 0.028
Tmem33 transmembrane protein 33 0.028
Blnk B-cell linker 0.028
Lrp5 low density lipoprotein receptor-related protein 5 0.028
Adamts1 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1 0.028
Rragc Ras-related GTP binding C 0.026
Tmem30a transmembrane protein 30A 0.026
Gga2 golgi associated, gamma adaptin ear containing, ARF binding protein 2 0.026
Pofut1 protein O-fucosyltransferase 1 0.026
Inha inhibin alpha 0.026
Hdlbp high density lipoprotein (HDL) binding protein 0.026
Mitf microphthalmia-associated transcription factor 0.025
Lamp2 lysosomal-associated membrane protein 2 0.025
Gjb2 gap junction protein, beta 2 0.025
Asah1 N-acylsphingosine amidohydrolase 1 0.025
Fshr follicle stimulating hormone receptor 0.025
Dynlt1b dynein light chain Tctex-type 1D 0.025
Nipsnap3b nipsnap homolog 3B (C. elegans) 0.024
Tmx3 thioredoxin-related transmembrane protein 3 0.024
Kcnj10 potassium inwardly-rectifying channel, subfamily J, member 10 0.024
Gtf2i general transcription factor II I 0.023
Zfp758 zinc finger protein 758 0.023
Stxbp3a syntaxin binding protein 3A 0.023
Fam18b family with sequence similarity 18, member B 0.023
Pnpla8 patatin-like phospholipase domain containing 8 0.023
Esr1 estrogen receptor 1 (alpha) 0.023
Mesdc2 mesoderm development candidate 2 0.023
Pdcd10 programmed cell death 10 0.023
Fabp4 fatty acid binding protein 4, adipocyte 0.022
Sertad2 SERTA domain containing 2 0.022
Pls3 plastin 3 (T-isoform) 0.022
Cttn cortactin 0.022
Actr3 ARP3 actin-related protein 3 homolog (yeast) 0.022
Prkcd protein kinase C, delta 0.022
Dynlt3 dynein light chain Tctex-type 3 0.022
Mark4 MAP/microtubule affinity-regulating kinase 4 0.021
Wbp2 WW domain binding protein 2 0.021
Mocs1 molybdenum cofactor synthesis 1 0.021
Prrg2 proline-rich Gla (G-carboxyglutamic acid) polypeptide 2 0.021
Slc12a6 solute carrier family 12, member 6 0.021
Clock circadian locomotor output cycles kaput 0.021
Bmp7 bone morphogenetic protein 7 0.021
Pmepa1 prostate transmembrane protein, androgen induced 1 0.020
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.020
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Rattus norvegicus
Name Description Probability Func Analog Organism