The network for 'spindle checkpoint' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

spindle checkpoint

A cell cycle checkpoint that originates from the mitotic or meiotic spindle.

Name Description Probability Func Analog Organism
MAD2 Mad2p 0.813
PPH22 Pph22p 0.807
GLC7 Glc7p 0.789
BUB3 Bub3p 0.782
PPH21 Pph21p 0.701
CDC28 Cdc28p 0.594
TIP41 Tip41p 0.572
BUB2 Bub2p 0.546
CDC20 Cdc20p 0.526
BUB1 Bub1p 0.525
CSE4 Cse4p 0.443
BMH2 Bmh2p 0.402
SIC1 Sic1p 0.399
CTF13 Ctf13p 0.394
BMH1 Bmh1p 0.385
MAD3 Mad3p 0.383
MCM21 Mcm21p 0.354
GIC1 Gic1p 0.346
HTA1 Hta1p 0.313
IML3 Iml3p 0.308
ASE1 Ase1p 0.302
SLI15 Sli15p 0.294
BFA1 Bfa1p 0.269
REG1 Reg1p 0.268
SDS22 Sds22p 0.268
CTF3 Ctf3p 0.227
DAM1 Dam1p 0.225
CKS1 Cks1p 0.207
PCL10 Pcl10p 0.199
DMA2 Dma2p 0.188
NUD1 Nud1p 0.183
SLK19 Slk19p 0.176
KIP1 Kip1p 0.164
CHL4 Chl4p 0.161
RTS1 Rts1p 0.160
FIN1 Fin1p 0.154
NDD1 Ndd1p 0.148
CDC14 Cdc14p 0.146
GIP2 Gip2p 0.143
CBF2 Cbf2p 0.128
CLB4 Clb4p 0.125
KIC1 Kic1p 0.116
CDC6 Cdc6p 0.103
CDC55 Cdc55p 0.103
ORC3 Orc3p 0.099
CLB6 Clb6p 0.095
MCM22 Mcm22p 0.092
MTW1 Mtw1p 0.088
CIN1 Cin1p 0.088
CDC123 Cdc123p 0.087
CLB1 Clb1p 0.083
SKM1 Skm1p 0.081
NBL1 Nbl1p 0.080
PPZ1 Ppz1p 0.079
HTB1 Htb1p 0.079
MSA2 Msa2p 0.078
DMA1 Dma1p 0.075
STE23 Ste23p 0.074
CDC15 Cdc15p 0.070
BIM1 Bim1p 0.070
CLB3 Clb3p 0.066
SGV1 Sgv1p 0.065
CKA1 Cka1p 0.063
DSN1 Dsn1p 0.062
ZDS1 Zds1p 0.062
PSK1 Psk1p 0.061
SPC24 Spc24p 0.061
FRK1 Frk1p 0.058
STE4 Ste4p 0.057
PSY4 Psy4p 0.057
CDH1 Cdh1p 0.056
GLG1 Glg1p 0.055
PIG2 Pig2p 0.055
STU1 Stu1p 0.054
NTO1 Nto1p 0.054
MDM20 Mdm20p 0.052
SWC4 Swc4p 0.052
GAC1 Gac1p 0.051
YIL151C hypothetical protein 0.046
SFI1 Sfi1p 0.045
PTR3 Ptr3p 0.045
KIN1 Kin1p 0.044
MIF2 Mif2p 0.044
CHL1 Chl1p 0.044
YKL075C hypothetical protein 0.043
BUD8 Bud8p 0.041
SOL1 Sol1p 0.041
NSP1 Nsp1p 0.038
CKB2 Ckb2p 0.037
SPC110 Spc110p 0.037
VHS2 Vhs2p 0.037
VIK1 Vik1p 0.036
HST3 Hst3p 0.036
CIN8 Cin8p 0.035
SRD1 Srd1p 0.034
CDC5 Cdc5p 0.034
SKP2 Skp2p 0.034
CAB3 Cab3p 0.033
FMP48 Fmp48p 0.033
SPL2 Spl2p 0.031
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
air-1 Protein AIR-1 0.480
gpr-2 Protein GPR-2 0.125
ZK507.6 Protein ZK507.6 0.102
rnr-1 Protein RNR-1 0.090
C49H3.9 Protein C49H3.9 0.075
cdl-1 Protein CDL-1 0.070
his-42 Protein HIS-42 0.063
R02F11.4 Protein R02F11.4 0.062
pcn-1 Protein PCN-1 0.061
CELE_C24H12.5 Protein C24H12.5 0.059
fzy-1 Protein FZY-1 0.052
cyb-1 Protein CYB-1 0.050
his-45 Protein HIS-45 0.048
air-2 Protein AIR-2 0.046
cyb-2.2 Protein CYB-2.2 0.046
cyb-3 Protein CYB-3 0.042
asd-1 Protein ASD-1 0.041
rga-1 Protein RGA-1 0.041
npp-11 Protein NPP-11 0.040
gly-20 Protein GLY-20 0.039
mex-3 Protein MEX-3 0.039
T08A11.2 Protein T08A11.2 0.037
pri-2 Protein PRI-2 0.037
capg-2 Protein CAPG-2 0.037
mex-5 Protein MEX-5 0.037
lmn-1 Protein LMN-1 0.036
his-6 Protein HIS-6 0.035
imb-2 Protein IMB-2 0.035
dsh-2 Protein DSH-2 0.034
T19H12.2 Protein T19H12.2 0.033
cec-5 Protein CEC-5 0.030
bmk-1 Protein BMK-1 0.029
B0205.9 Protein B0205.9 0.029
sac-1 Protein SAC-1 0.028
T28D9.4 Protein T28D9.4 0.028
B0393.6 Protein B0393.6 0.027
hpo-10 Protein HPO-10 0.027
lin-3 Protein LIN-3 0.027
F25B3.6 Protein F25B3.6 0.027
hcp-1 Protein HCP-1 0.027
rsd-6 Protein RSD-6 0.026
CELE_T03F6.3 Protein T03F6.3 0.026
lst-1 Protein LST-1 0.025
CELE_F14H3.5 Protein F14H3.5 0.025
oma-1 Protein OMA-1 0.025
his-9 Protein HIS-9 0.025
ttll-4 Protein TTLL-4 0.024
CELE_F13E9.1 Protein F13E9.1 0.024
panl-2 Protein PANL-2 0.023
pqn-51 Protein PQN-51 0.022
htz-1 Protein HTZ-1 0.022
T08B2.11 Protein T08B2.11 0.022
kin-19 Protein KIN-19 0.021
spdl-1 Protein SPDL-1 0.021
T12B3.4 Protein T12B3.4 0.020
vps-53 Protein VPS-53 0.020
F12F6.1 Protein F12F6.1 0.020
brc-1 Protein BRC-1 0.019
fli-1 Protein FLI-1 0.019
dpy-26 Protein DPY-26 0.019
mrg-1 Protein MRG-1 0.019
spn-4 Protein SPN-4 0.019
set-1 Protein SET-1 0.018
kin-10 Protein KIN-10 0.018
puf-6 Protein PUF-6 0.018
his-16 Protein HIS-16 0.018
T22C1.1 Protein T22C1.1 0.018
math-33 Protein MATH-33 0.018
F36A2.2 Protein F36A2.2 0.017
scc-1 Protein SCC-1 0.017
zif-1 Protein ZIF-1 0.017
rab-1 Protein RAB-1 0.017
mcm-2 Protein MCM-2 0.017
tba-2 Protein TBA-2 0.016
F15D4.2 Protein F15D4.2 0.016
sas-5 Protein SAS-5 0.016
rnp-7 Protein RNP-7 0.016
clec-88 Protein CLEC-88 0.015
egg-1 Protein EGG-1 0.015
mcm-7 Protein MCM-7 0.015
swsn-6 Protein SWSN-6 0.015
uaf-1 Protein UAF-1 0.015
mcm-3 Protein MCM-3 0.015
klp-19 Protein KLP-19 0.015
ccdc-47 Protein CCDC-47 0.014
ZK1053.4 Protein ZK1053.4 0.014
C41D11.4 Protein C41D11.4 0.014
ppfr-2 Protein PPFR-2 0.014
cks-1 Protein CKS-1 0.014
cul-1 Protein CUL-1 0.014
yif-1 Protein YIF-1 0.014
mat-3 Protein MAT-3 0.014
gck-1 Protein GCK-1 0.014
R144.5 Protein R144.5 0.014
Y59E9AL.4 Protein Y59E9AL.4 0.014
mcm-5 Protein MCM-5 0.014
R11A8.1 Protein R11A8.1 0.014
bath-41 Protein BATH-41 0.014
CELE_C39E9.12 Protein C39E9.12 0.014
cki-2 Protein CKI-2 0.013
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
CycB Cyclin B 0.318
asl asterless 0.142
Cks30A Cyclin-dependent kinase subunit 30A 0.119
CycB3 Cyclin B3 0.069
ncd non-claret disjunctional 0.069
BubR1 Bub1-related kinase 0.063
Mcm10 Sensitized chromosome inheritance modifier 19 0.061
flfl falafel 0.056
mad2 CG17498 gene product from transcript CG17498-RA 0.050
thr three rows 0.039
Sep2 Septin-2 0.035
Cap-G CG34438 gene product from transcript CG34438-RF 0.031
nod no distributive disjunction 0.028
gish gilgamesh 0.028
rux roughex 0.027
bam bag of marbles 0.027
cnn centrosomin 0.027
KP78b CG17216 gene product from transcript CG17216-RB 0.024
mus301 mutagen-sensitive 301 0.024
cdc16 CG6759 gene product from transcript CG6759-RA 0.024
r2d2 CG7138 gene product from transcript CG7138-RB 0.020
Mcm2 Minichromosome maintenance 2 0.020
pie pineapple eye 0.020
tacc transforming acidic coiled-coil protein 0.019
Sgt1 CG9617 gene product from transcript CG9617-RA 0.018
lds lodestar 0.017
ogre optic ganglion reduced 0.017
msb1l CG10364 gene product from transcript CG10364-RA 0.017
MEP-1 CG1244 gene product from transcript CG1244-RG 0.016
I-2 Inhibitor-2 0.016
alphaTub67C alpha-Tubulin at 67C 0.016
CG4887 CG4887 gene product from transcript CG4887-RA 0.015
CG8223 CG8223 gene product from transcript CG8223-RA 0.014
atms antimeros 0.014
mei-9 meiotic 9 0.014
Klp3A Kinesin-like protein at 3A 0.014
SMC2 CG10212 gene product from transcript CG10212-RA 0.014
Hsp83 Heat shock protein 83 0.014
hay haywire 0.014
DNApol-alpha60 DNA polymerase alpha 60kD 0.014
betaTub60D beta-Tubulin at 60D 0.014
CG10722 CG10722 gene product from transcript CG10722-RA 0.013
CycA Cyclin A 0.013
wee CG4488 gene product from transcript CG4488-RA 0.013
wapl wings apart-like 0.012
fzy fizzy 0.012
Sld5 CG14549 gene product from transcript CG14549-RA 0.012
Cat Catalase 0.012
mle maleless 0.012
enok enoki mushroom 0.012
PTP-ER Protein tyrosine phosphatase-ERK/Enhancer of Ras1 0.012
CG3225 CG3225 gene product from transcript CG3225-RA 0.012
Grip75 CG6176 gene product from transcript CG6176-RA 0.011
CG6439 CG6439 gene product from transcript CG6439-RA 0.011
AGO2 Argonaute 2 0.011
betaTub85D beta-Tubulin at 85D 0.011
Vha100-1 CG1709 gene product from transcript CG1709-RF 0.011
cav caravaggio 0.010
tai taiman 0.010
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Homo sapiens
Name Description Probability Func Analog Organism
CDC20 cell division cycle 20 homolog (S. cerevisiae) 0.983
BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) 0.957
BUB1B budding uninhibited by benzimidazoles 1 homolog beta (yeast) 0.918
AURKB aurora kinase B 0.903
H2AFX H2A histone family, member X 0.799
CDC27 cell division cycle 27 homolog (S. cerevisiae) 0.695
BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast) 0.605
CCT8 chaperonin containing TCP1, subunit 8 (theta) 0.486
BRCA2 breast cancer 2, early onset 0.363
ANAPC4 anaphase promoting complex subunit 4 0.357
INCENP inner centromere protein antigens 135/155kDa 0.317
CDCA8 cell division cycle associated 8 0.272
CENPJ centromere protein J 0.266
PLK1 polo-like kinase 1 0.233
CBX5 chromobox homolog 5 0.213
SASS6 spindle assembly 6 homolog (C. elegans) 0.169
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme 0.142
STARD9 StAR-related lipid transfer (START) domain containing 9 0.138
CDT1 chromatin licensing and DNA replication factor 1 0.128
ANAPC7 anaphase promoting complex subunit 7 0.120
C19orf39 chromosome 19 open reading frame 39 0.088
CCT4 chaperonin containing TCP1, subunit 4 (delta) 0.087
FXR2 fragile X mental retardation, autosomal homolog 2 0.081
KIF2C kinesin family member 2C 0.076
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.070
HDAC1 histone deacetylase 1 0.070
TP53BP1 tumor protein p53 binding protein 1 0.065
RAD51 RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) 0.059
CDK1 cyclin-dependent kinase 1 0.058
CDK2 cyclin-dependent kinase 2 0.057
NEK2 NIMA (never in mitosis gene a)-related kinase 2 0.054
CDC23 cell division cycle 23 homolog (S. cerevisiae) 0.053
TROAP trophinin associated protein (tastin) 0.052
MDC1 mediator of DNA-damage checkpoint 1 0.048
ANAPC1 anaphase promoting complex subunit 1 0.048
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.046
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae) 0.044
DOT1L DOT1-like, histone H3 methyltransferase (S. cerevisiae) 0.043
ANAPC5 anaphase promoting complex subunit 5 0.043
RANBP9 RAN binding protein 9 0.043
PBK PDZ binding kinase 0.040
PTTG1 pituitary tumor-transforming 1 0.040
SGOL1 shugoshin-like 1 (S. pombe) 0.039
TOP2A topoisomerase (DNA) II alpha 170kDa 0.037
CDC16 cell division cycle 16 homolog (S. cerevisiae) 0.037
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 0.036
ZW10 ZW10, kinetochore associated, homolog (Drosophila) 0.036
PARP3 poly (ADP-ribose) polymerase family, member 3 0.035
CDC25C cell division cycle 25 homolog C (S. pombe) 0.035
ANAPC11 anaphase promoting complex subunit 11 0.033
UBE2C ubiquitin-conjugating enzyme E2C 0.032
LMNA lamin A/C 0.032
CCNA2 cyclin A2 0.031
TP53 tumor protein p53 0.031
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.030
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.030
GAS2L3 growth arrest-specific 2 like 3 0.029
CEP135 centrosomal protein 135kDa 0.029
MYST1 MYST histone acetyltransferase 1 0.029
HERC2 hect domain and RLD 2 0.028
PRNP prion protein 0.028
TCP1 t-complex 1 0.027
TERF2IP telomeric repeat binding factor 2, interacting protein 0.027
ASH2L ash2 (absent, small, or homeotic)-like (Drosophila) 0.027
PLK4 polo-like kinase 4 0.027
TINF2 TERF1 (TRF1)-interacting nuclear factor 2 0.026
PPP1R9B protein phosphatase 1, regulatory (inhibitor) subunit 9B 0.025
KIF11 kinesin family member 11 0.025
RAD51L1 RAD51-like 1 (S. cerevisiae) 0.025
TRIP13 thyroid hormone receptor interactor 13 0.024
GTSE1 G-2 and S-phase expressed 1 0.023
NASP nuclear autoantigenic sperm protein (histone-binding) 0.023
CENPF centromere protein F, 350/400kDa (mitosin) 0.023
PPME1 protein phosphatase methylesterase 1 0.022
PPP4C protein phosphatase 4, catalytic subunit 0.022
MED1 mediator complex subunit 1 0.022
NKAP NFKB activating protein 0.022
C13orf34 chromosome 13 open reading frame 34 0.022
ATMIN ATM interactor 0.022
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.022
BAG3 BCL2-associated athanogene 3 0.021
CSNK2B casein kinase 2, beta polypeptide 0.021
KPNA3 karyopherin alpha 3 (importin alpha 4) 0.021
KAT5 K(lysine) acetyltransferase 5 0.020
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme 0.020
HUWE1 HECT, UBA and WWE domain containing 1 0.020
HSPB1 heat shock 27kDa protein 1 0.020
GSK3B glycogen synthase kinase 3 beta 0.020
CCNF cyclin F 0.020
PPP2R1B protein phosphatase 2, regulatory subunit A, beta 0.020
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 0.020
HIST1H2AL histone cluster 1, H2al 0.019
HIST1H1E histone cluster 1, H1e 0.019
SGOL2 shugoshin-like 2 (S. pombe) 0.019
AXIN2 axin 2 0.019
PKMYT1 protein kinase, membrane associated tyrosine/threonine 1 0.018
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.018
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.018
HIST1H4F histone cluster 1, H4f 0.018
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.018
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Mus musculus
Name Description Probability Func Analog Organism
Ccnb1 cyclin B1 0.753
Cdk1 cyclin-dependent kinase 1 0.671
Ccnb2 cyclin B2 0.627
Prc1 protein regulator of cytokinesis 1 0.598
Kif20a kinesin family member 20A 0.499
Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.464
Kif22 kinesin family member 22 0.462
Bub1 budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae) 0.200
Dlgap5 discs, large (Drosophila) homolog-associated protein 5 0.185
Kif2c kinesin family member 2C 0.171
Aurka aurora kinase A 0.169
Spag5 sperm associated antigen 5 0.152
Brca2 breast cancer 2 0.140
Trp53 transformation related protein 53 0.137
Ccna2 cyclin A2 0.126
Mki67 antigen identified by monoclonal antibody Ki 67 0.121
Rnf2 ring finger protein 2 0.118
Trim59 tripartite motif-containing 59 0.116
Brca1 breast cancer 1 0.115
Cdca8 cell division cycle associated 8 0.114
Kdm2b lysine (K)-specific demethylase 2B 0.099
Ckap2 cytoskeleton associated protein 2 0.098
C330027C09Rik RIKEN cDNA C330027C09 gene 0.094
Cdkn3 cyclin-dependent kinase inhibitor 3 0.089
Cenpe centromere protein E 0.089
Sgol2 shugoshin-like 2 (S. pombe) 0.087
Ube2c ubiquitin-conjugating enzyme E2C 0.079
Birc5 baculoviral IAP repeat-containing 5 0.072
Nek2 NIMA (never in mitosis gene a)-related expressed kinase 2 0.071
Hmmr hyaluronan mediated motility receptor (RHAMM) 0.071
Ccnf cyclin F 0.065
Ttk Ttk protein kinase 0.065
Top2a topoisomerase (DNA) II alpha 0.061
Cdc20 cell division cycle 20 homolog (S. cerevisiae) 0.060
Cks2 CDC28 protein kinase regulatory subunit 2 0.059
Dtl denticleless homolog (Drosophila) 0.059
Kif4 kinesin family member 4 0.058
Kif23 kinesin family member 23 0.057
Kif11 kinesin family member 11 0.056
Cdc25c cell division cycle 25 homolog C (S. pombe) 0.056
Ncapg non-SMC condensin I complex, subunit G 0.049
Cenpk centromere protein K 0.047
Ect2 ect2 oncogene 0.047
Rpgrip1l Rpgrip1-like 0.045
Ooep oocyte expressed protein homolog (dog) 0.041
Lrrk2 leucine-rich repeat kinase 2 0.039
Mis18bp1 MIS18 binding protein 1 0.034
Racgap1 Rac GTPase-activating protein 1 0.033
Bub1b budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae) 0.032
Aurkb aurora kinase B 0.030
Asf1b ASF1 anti-silencing function 1 homolog B (S. cerevisiae) 0.028
Cep55 centrosomal protein 55 0.028
Ube2t ubiquitin-conjugating enzyme E2T (putative) 0.027
Dna2 DNA replication helicase 2 homolog (yeast) 0.027
Ccdc99 coiled-coil domain containing 99 0.027
Skp1a S-phase kinase-associated protein 1A 0.025
Melk maternal embryonic leucine zipper kinase 0.025
Anln anillin, actin binding protein 0.025
2810417H13Rik RIKEN cDNA 2810417H13 gene 0.025
Ndc80 NDC80 homolog, kinetochore complex component (S. cerevisiae) 0.024
Axin1 axin 1 0.024
Smc4 structural maintenance of chromosomes 4 0.024
Crk v-crk sarcoma virus CT10 oncogene homolog (avian) 0.023
Blm Bloom syndrome, RecQ helicase-like 0.023
Plk4 polo-like kinase 4 (Drosophila) 0.022
Cenpa centromere protein A 0.021
Trp63 transformation related protein 63 0.019
Lin28a lin-28 homolog A (C. elegans) 0.018
Hist1h2bm histone cluster 1, H2bm 0.018
Nasp nuclear autoantigenic sperm protein (histone-binding) 0.018
Sgol1 shugoshin-like 1 (S. pombe) 0.018
Cdk4 cyclin-dependent kinase 4 0.018
Rad51ap1 RAD51 associated protein 1 0.018
Ccne2 cyclin E2 0.016
Cbx1 chromobox homolog 1 (Drosophila HP1 beta) 0.016
Tacc3 transforming, acidic coiled-coil containing protein 3 0.016
Gtse1 G two S phase expressed protein 1 0.015
Sass6 spindle assembly 6 homolog (C. elegans) 0.015
Hmgb2 high mobility group box 2 0.014
E2f8 E2F transcription factor 8 0.014
Gsg2 germ cell-specific gene 2 0.014
Cops7b COP9 (constitutive photomorphogenic) homolog, subunit 7b (Arabidopsis thaliana) 0.014
Stil Scl/Tal1 interrupting locus 0.014
Depdc1a DEP domain containing 1a 0.013
Rbl1 retinoblastoma-like 1 (p107) 0.013
Trip13 thyroid hormone receptor interactor 13 0.013
4632434I11Rik RIKEN cDNA 4632434I11 gene 0.012
H2afz H2A histone family, member Z 0.012
Mdm2 transformed mouse 3T3 cell double minute 2 0.011
Lin9 lin-9 homolog (C. elegans) 0.011
Scaf4 SR-related CTD-associated factor 4 0.010
Mns1 meiosis-specific nuclear structural protein 1 0.010
Pot1a protection of telomeres 1A 0.010
Zfp598 zinc finger protein 598 0.010
Carm1 coactivator-associated arginine methyltransferase 1 0.010
Pgr progesterone receptor 0.010
Csnk2a1 casein kinase 2, alpha 1 polypeptide 0.010
Cenpn centromere protein N 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism