The network for 'dna integrity checkpoint' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

dna integrity checkpoint

A cell cycle process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and progresses through signal transduction and ends with cell cycle effector processes.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
RAD53 Rad53p 0.882
GLC7 Glc7p 0.875
POL30 Pol30p 0.599
MRC1 Mrc1p 0.396
RPO26 Rpo26p 0.387
GBP2 Gbp2p 0.371
BUB3 Bub3p 0.299
DPB11 Dpb11p 0.290
DDC1 Ddc1p 0.260
TOR1 Tor1p 0.258
CDC20 Cdc20p 0.215
MEC1 Mec1p 0.211
RAD17 Rad17p 0.210
RGC1 Rgc1p 0.178
RAD27 Rad27p 0.165
SNF1 Snf1p 0.159
CWC2 Cwc2p 0.146
CSM3 Csm3p 0.142
TOF1 Tof1p 0.135
TIP41 Tip41p 0.132
CAK1 Cak1p 0.129
SCS2 Scs2p 0.124
SPT5 Spt5p 0.121
BIM1 Bim1p 0.117
RPB3 Rpb3p 0.116
MCM6 Mcm6p 0.116
PTK2 Ptk2p 0.114
DBF4 Dbf4p 0.113
RAD18 Rad18p 0.110
RPB10 Rpb10p 0.108
DUN1 Dun1p 0.108
PLC1 Plc1p 0.108
MCM4 Mcm4p 0.107
MCM2 Mcm2p 0.105
PPH21 Pph21p 0.099
PPH22 Pph22p 0.098
SLD3 Sld3p 0.093
HTA2 Hta2p 0.090
DPB2 Dpb2p 0.089
NAT1 Nat1p 0.087
HRK1 Hrk1p 0.085
PPZ1 Ppz1p 0.083
POL3 Pol3p 0.082
PSF1 Psf1p 0.078
MAD2 Mad2p 0.074
PAM1 Pam1p 0.073
MPT5 Mpt5p 0.073
HHT2 Hht2p 0.071
SAP4 Sap4p 0.071
RRD1 Rrd1p 0.071
MCM5 Mcm5p 0.069
PEX22 Pex22p 0.067
RTS1 Rts1p 0.066
RPB11 Rpb11p 0.066
CDC37 Cdc37p 0.065
CTF18 Ctf18p 0.064
VAC17 Vac17p 0.064
POL32 Pol32p 0.063
BSC2 Bsc2p 0.062
ZIP1 Zip1p 0.062
MMS22 Mms22p 0.061
CTF8 Ctf8p 0.061
RAD52 Rad52p 0.059
PAP2 Pap2p 0.058
SDC1 Sdc1p 0.057
BUB1 Bub1p 0.056
SRS2 Srs2p 0.056
DCC1 Dcc1p 0.053
MUS81 Mus81p 0.053
SEF1 Sef1p 0.053
FPK1 Fpk1p 0.053
HSL1 Hsl1p 0.052
RAD9 Rad9p 0.050
KIN82 Kin82p 0.050
PDS1 Pds1p 0.050
DSK2 Dsk2p 0.048
THO2 Tho2p 0.048
HTB1 Htb1p 0.048
TCO89 Tco89p 0.047
SUR1 Sur1p 0.047
ACM1 Acm1p 0.047
SWI4 Swi4p 0.047
VHS1 Vhs1p 0.046
HDA2 Hda2p 0.045
CDC6 Cdc6p 0.045
MAD1 Mad1p 0.044
MCM10 Mcm10p 0.043
PDE2 Pde2p 0.043
BMH1 Bmh1p 0.043
ELG1 Elg1p 0.041
RFA2 Rfa2p 0.040
YNL134C hypothetical protein 0.040
MBF1 Mbf1p 0.040
YLR177W hypothetical protein 0.039
LCD1 Lcd1p 0.039
IME2 Ime2p 0.039
SLD2 Sld2p 0.039
PDR15 Pdr15p 0.038
GAL7 Gal7p 0.038
ADE17 Ade17p 0.038
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
ywhabb tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide b 0.128
ccnb1 cyclin B1 0.108
ywhaqb tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b 0.062
cul3a cullin 3a 0.046
snrpd1 small nuclear ribonucleoprotein D1 polypeptide 0.044
mcm5 MCM5 minichromosome maintenance deficient 5 (S. cerevisiae) 0.041
ccnb2 cyclin B2 0.037
cry3 cryptochrome 3 0.037
per2 period homolog 2 (Drosophila) 0.037
id2a inhibitor of DNA binding 2, dominant negative helix-loop-helix protein, a 0.036
zc4h2 zinc finger, C4H2 domain containing 0.034
plk1 polo-like kinase 1 (Drosophila) 0.032
skp2 S-phase kinase-associated protein 2 (p45) 0.032
ccnd1 cyclin D1 0.029
ywhaqa tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide a 0.029
cstf1 cleavage stimulation factor, 3' pre-RNA, subunit 1 0.029
ccna2 cyclin A2 0.026
ywhae1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1 0.026
npat nuclear protein, ataxia-telangiectasia locus 0.026
stmn1b stathmin 1b 0.026
xrcc6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.023
tfam transcription factor A, mitochondrial 0.022
celsr3 cadherin, EGF LAG seven-pass G-type receptor 3 0.021
wdr76 WD repeat domain 76 0.021
smc3 structural maintenance of chromosomes 3 0.021
slbp stem-loop binding protein 0.020
cand1 cullin-associated and neddylation-dissociated 1 0.020
ddb2 damage-specific DNA binding protein 2 0.019
zff9 zinc finger protein 9 0.018
zgc:55701 zgc:55701 0.018
sass6 spindle assembly 6 homolog (C. elegans) 0.018
prdm9 PR domain containing 9 0.018
hirip3 HIRA interacting protein 3 0.017
gtdc1 glycosyltransferase-like domain containing 1 0.016
hat1 histone acetyltransferase 1 0.016
sae1 SUMO1 activating enzyme subunit 1 0.016
kpna3 karyopherin (importin) alpha 3 0.015
ywhai tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, iota polypeptide 0.015
brd2a bromodomain-containing 2a 0.015
ppp4ca protein phosphatase 4 (formerly X), catalytic subunit a 0.015
orc6 origin recognition complex, subunit 6 0.015
zgc:56197 zgc:56197 0.014
anp32a acidic (leucine-rich) nuclear phosphoprotein 32 family, member A 0.014
ube2g2 ubiquitin-conjugating enzyme E2G 2 0.014
cry5 cryptochrome 5 0.014
pif1 PIF1 5'-to-3' DNA helicase homolog (S. cerevisiae) 0.014
mpped2 metallophosphoesterase domain containing 2 0.013
si:dkey-57a22.11 si:dkey-57a22.11 0.013
ywhabl tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide like 0.013
fen1 flap structure-specific endonuclease 1 0.013
rbb4 retinoblastoma binding protein 4 0.013
fzd7a frizzled homolog 7a 0.013
rtkn2 rhotekin 2 0.013
otx1b orthodenticle homolog 1b 0.013
ccnt2a cyclin T2a 0.013
senp3a SUMO1/sentrin/SMT3 specific peptidase 3a 0.013
kif23 kinesin family member 23 0.012
gmnn geminin, DNA replication inhibitor 0.012
wdhd1 WD repeat and HMG-box DNA binding protein 1 0.012
clock3 clock homolog 3 (mouse) 0.012
sumo3a SMT3 suppressor of mif two 3 homolog 3a 0.012
wu:fb54a03 wu:fb54a03 0.012
ccne cyclin E 0.011
nasp nuclear autoantigenic sperm protein (histone-binding) 0.011
zgc:55448 zgc:55448 0.011
aggf1 angiogenic factor with G patch and FHA domains 1 0.011
atrx alpha thalassemia/mental retardation syndrome X-linked homolog (human) 0.011
lrwd1 leucine-rich repeats and WD repeat domain containing 1 0.011
ptmaa prothymosin, alpha a 0.011
zgc:111944 zgc:111944 0.011
morf4l1 mortality factor 4 like 1 0.011
ppp2r5eb protein phosphatase 2, regulatory subunit B', epsilon isoform b 0.011
zgc:101819 zgc:101819 0.011
tubgcp2 tubulin, gamma complex associated protein 2 0.011
dnmt1 DNA (cytosine-5-)-methyltransferase 1 0.011
maea macrophage erythroblast attacher 0.011
rrm1 ribonucleotide reductase M1 polypeptide 0.010
zc3h13 zinc finger CCCH-type containing 13 0.010
wdr18 WD repeat domain 18 0.010
cops3 COP9 constitutive photomorphogenic homolog subunit 3 0.010
aurkb aurora kinase B 0.010
smc1al structural maintenance of chromosomes 1A, like 0.010
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Drosophila melanogaster
Name Description Probability Func Analog Organism
skpA CG16983 gene product from transcript CG16983-RD 0.967
lok loki 0.964
His2Av Histone H2A variant 0.922
pic piccolo 0.872
Rpd3 CG7471 gene product from transcript CG7471-RA 0.851
ssp sunspot 0.850
Iswi Imitation SWI 0.848
eIF4AIII CG7483 gene product from transcript CG7483-RA 0.774
spn-B spindle B 0.718
cdc2c CG10498 gene product from transcript CG10498-RC 0.710
Caf1 Chromatin assembly factor 1 subunit 0.709
mus209 mutagen-sensitive 209 0.674
MED6 Mediator complex subunit 6 0.654
Cap-G CG34438 gene product from transcript CG34438-RF 0.647
Dlic Dynein light intermediate chain 0.640
BRWD3 CG31132 gene product from transcript CG31132-RA 0.639
mus201 mutagen-sensitive 201 0.619
mus205 mutagen-sensitive 205 0.588
p53 CG33336 gene product from transcript CG33336-RB 0.557
CycK Cyclin K 0.509
rad50 CG6339 gene product from transcript CG6339-RD 0.506
scra scraps 0.450
Tip60 CG6121 gene product from transcript CG6121-RA 0.441
CkIIbeta Casein kinase II beta subunit 0.419
Pp2A-29B Protein phosphatase 2A at 29B 0.412
mei-9 meiotic 9 0.373
not non-stop 0.370
CDC45L CG3658 gene product from transcript CG3658-RA 0.369
RanGap Ran GTPase activating protein 0.364
stwl stonewall 0.353
MAGE CG10059 gene product from transcript CG10059-RA 0.347
sxc super sex combs 0.346
Top1 Topoisomerase 1 0.329
Cdc37 CG12019 gene product from transcript CG12019-RA 0.294
key kenny 0.292
Ge-1 CG6181 gene product from transcript CG6181-RA 0.283
Dref DNA replication-related element factor 0.280
Sse Separase 0.277
Mpk2 CG5475 gene product from transcript CG5475-RB 0.272
CG6066 CG6066 gene product from transcript CG6066-RA 0.264
mus309 mutagen-sensitive 309 0.257
CG14641 CG14641 gene product from transcript CG14641-RA 0.255
scny scrawny 0.252
CSN3 COP9 complex homolog subunit 3 0.252
CG10754 CG10754 gene product from transcript CG10754-RA 0.251
wee CG4488 gene product from transcript CG4488-RA 0.243
tefu telomere fusion 0.242
sds22 CG5851 gene product from transcript CG5851-RA 0.238
glu gluon 0.234
M6 CG7540 gene product from transcript CG7540-RA 0.232
eIF-4E Eukaryotic initiation factor 4E 0.232
CG31301 CG31301 gene product from transcript CG31301-RA 0.231
imd immune deficiency 0.226
Bap55 Brahma associated protein 55kD 0.223
aPKC atypical protein kinase C 0.223
CSN1b COP9 complex homolog subunit 1 b 0.219
Vap-33-1 CG5014 gene product from transcript CG5014-RB 0.219
mre11 meiotic recombination 11 0.206
Trf2 TATA box binding protein-related factor 2 0.206
CG10139 CG10139 gene product from transcript CG10139-RA 0.205
MED31 Mediator complex subunit 31 0.204
Adam CG12131 gene product from transcript CG12131-RA 0.204
cdm cadmus 0.202
E2f2 E2F transcription factor 2 0.197
dah discontinuous actin hexagon 0.196
Bj1 Bj1 protein 0.193
Mcm7 Minichromosome maintenance 7 0.193
Klc Kinesin light chain 0.192
Eip63E Ecdysone-induced protein 63E 0.191
Srp54 CG4602 gene product from transcript CG4602-RA 0.188
Ada2b CG9638 gene product from transcript CG9638-RA 0.188
esc extra sexcombs 0.185
CG8159 CG8159 gene product from transcript CG8159-RB 0.184
mei-41 meiotic 41 0.177
DNApol-alpha73 DNA polymerase alpha 73kD 0.176
Mcm3 Minichromosome maintenance 3 0.171
fzy fizzy 0.169
BubR1 Bub1-related kinase 0.165
Caf1-180 CG12109 gene product from transcript CG12109-RB 0.162
lwr lesswright 0.161
alph alphabet 0.161
ari-1 ariadne 0.154
S6kII RPS6-protein kinase-II 0.154
CG17486 CG17486 gene product from transcript CG17486-RB 0.152
Irbp Inverted repeat-binding protein 0.151
Mes2 CG11100 gene product from transcript CG11100-RB 0.151
Uba1 Ubiquitin activating enzyme 1 0.150
U2af50 U2 small nuclear riboprotein auxiliary factor 50 0.149
mus301 mutagen-sensitive 301 0.148
lin19 lin-19-like 0.147
Lnk CG17367 gene product from transcript CG17367-RC 0.147
growl CG14648 gene product from transcript CG14648-RA 0.146
mus304 mutagen-sensitive 304 0.144
dre4 CG1828 gene product from transcript CG1828-RB 0.139
Fer2LCH Ferritin 2 light chain homologue 0.137
CG2924 CG2924 gene product from transcript CG2924-RA 0.136
hay haywire 0.135
Orc2 Origin recognition complex subunit 2 0.135
MTF-1 Metal response element-binding Transcription Factor-1 0.135
Dredd Death related ced-3/Nedd2-like protein 0.134
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Homo sapiens
Name Description Probability Func Analog Organism
TP53 tumor protein p53 1.000
BRCA1 breast cancer 1, early onset 1.000
RB1 retinoblastoma 1 1.000
CUL2 cullin 2 0.999
CDK2 cyclin-dependent kinase 2 0.998
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.997
CHEK1 CHK1 checkpoint homolog (S. pombe) 0.995
E2F1 E2F transcription factor 1 0.989
PCNA proliferating cell nuclear antigen 0.988
COPS5 COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis) 0.983
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.969
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.964
CHEK2 CHK2 checkpoint homolog (S. pombe) 0.960
RAD51 RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) 0.958
PLK1 polo-like kinase 1 0.949
CDK8 cyclin-dependent kinase 8 0.925
SKP2 S-phase kinase-associated protein 2 (p45) 0.908
NBN nibrin 0.905
CLSPN claspin 0.891
MED1 mediator complex subunit 1 0.888
THOC4 THO complex 4 0.865
MCM7 minichromosome maintenance complex component 7 0.839
RAD1 RAD1 homolog (S. pombe) 0.816
MDC1 mediator of DNA-damage checkpoint 1 0.816
RAD50 RAD50 homolog (S. cerevisiae) 0.800
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.789
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.771
CCNA2 cyclin A2 0.757
XIAP X-linked inhibitor of apoptosis 0.744
ATM ataxia telangiectasia mutated 0.721
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma 0.720
JUN jun proto-oncogene 0.698
RBBP8 retinoblastoma binding protein 8 0.696
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.690
MED28 mediator complex subunit 28 0.664
RBL2 retinoblastoma-like 2 (p130) 0.664
BRCC3 BRCA1/BRCA2-containing complex, subunit 3 0.651
RFC2 replication factor C (activator 1) 2, 40kDa 0.650
COPS6 COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis) 0.639
MSH6 mutS homolog 6 (E. coli) 0.618
FOS FBJ murine osteosarcoma viral oncogene homolog 0.617
THOC5 THO complex 5 0.615
RPA2 replication protein A2, 32kDa 0.611
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme 0.596
MAPK6 mitogen-activated protein kinase 6 0.585
CASP2 caspase 2, apoptosis-related cysteine peptidase 0.584
RPA1 replication protein A1, 70kDa 0.583
RBL1 retinoblastoma-like 1 (p107) 0.546
SUMO2 SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae) 0.539
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) 0.526
MAPK14 mitogen-activated protein kinase 14 0.511
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.508
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.499
FANCD2 Fanconi anemia, complementation group D2 0.476
MED6 mediator complex subunit 6 0.466
UIMC1 ubiquitin interaction motif containing 1 0.466
RAD18 RAD18 homolog (S. cerevisiae) 0.453
COPS3 COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis) 0.453
BRCA2 breast cancer 2, early onset 0.446
MSH2 mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) 0.438
BABAM1 BRISC and BRCA1 A complex member 1 0.436
RFC1 replication factor C (activator 1) 1, 145kDa 0.435
RFC5 replication factor C (activator 1) 5, 36.5kDa 0.435
TFDP1 transcription factor Dp-1 0.431
FAM175A family with sequence similarity 175, member A 0.423
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.421
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.415
ORC2 origin recognition complex, subunit 2 0.402
EFTUD2 elongation factor Tu GTP binding domain containing 2 0.402
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae) 0.389
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.386
CCND1 cyclin D1 0.383
CNOT1 CCR4-NOT transcription complex, subunit 1 0.376
CDK6 cyclin-dependent kinase 6 0.357
BRE brain and reproductive organ-expressed (TNFRSF1A modulator) 0.326
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) 0.316
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.313
SIRT1 sirtuin 1 0.311
HIST1H2BG histone cluster 1, H2bg 0.307
IER3 immediate early response 3 0.296
EME1 essential meiotic endonuclease 1 homolog 1 (S. pombe) 0.294
CNOT8 CCR4-NOT transcription complex, subunit 8 0.293
THOC2 THO complex 2 0.293
SLX4 SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae) 0.283
ELAVL1 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) 0.279
POU3F2 POU class 3 homeobox 2 0.278
NEDD8 neural precursor cell expressed, developmentally down-regulated 8 0.275
CDK4 cyclin-dependent kinase 4 0.274
CNOT7 CCR4-NOT transcription complex, subunit 7 0.269
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.263
DDB2 damage-specific DNA binding protein 2, 48kDa 0.263
CDK1 cyclin-dependent kinase 1 0.257
RBX1 ring-box 1, E3 ubiquitin protein ligase 0.255
PPP2R5B protein phosphatase 2, regulatory subunit B', beta 0.255
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) 0.253
COPS4 COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis) 0.249
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 0.243
FADD Fas (TNFRSF6)-associated via death domain 0.240
COPS2 COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis) 0.239
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.230
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Mus musculus
Name Description Probability Func Analog Organism
Trp53 transformation related protein 53 1.000
Cdk4 cyclin-dependent kinase 4 0.993
Mapk14 mitogen-activated protein kinase 14 0.921
Brca1 breast cancer 1 0.917
Pten phosphatase and tensin homolog 0.915
Arntl aryl hydrocarbon receptor nuclear translocator-like 0.855
Rb1 retinoblastoma 1 0.840
Brca2 breast cancer 2 0.832
Mcm3 minichromosome maintenance deficient 3 (S. cerevisiae) 0.809
E2f1 E2F transcription factor 1 0.808
Nbn nibrin 0.780
Clock circadian locomotor output cycles kaput 0.776
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.750
Atm ataxia telangiectasia mutated homolog (human) 0.705
Mcm2 minichromosome maintenance deficient 2 mitotin (S. cerevisiae) 0.643
Per2 period homolog 2 (Drosophila) 0.632
Mdm2 transformed mouse 3T3 cell double minute 2 0.622
Atf2 activating transcription factor 2 0.524
Timeless timeless homolog (Drosophila) 0.515
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.479
Msh2 mutS homolog 2 (E. coli) 0.441
Mdm4 transformed mouse 3T3 cell double minute 4 0.406
Pold1 polymerase (DNA directed), delta 1, catalytic subunit 0.396
Tcf3 transcription factor 3 0.347
Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.326
Ncoa3 nuclear receptor coactivator 3 0.319
Skil SKI-like 0.264
Cry1 cryptochrome 1 (photolyase-like) 0.264
Gtse1 G two S phase expressed protein 1 0.257
Zmym5 zinc finger, MYM-type 5 0.240
Sirt1 sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae) 0.239
Ruvbl2 RuvB-like protein 2 0.207
Elavl1 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) 0.206
Crebbp CREB binding protein 0.199
Mybl2 myeloblastosis oncogene-like 2 0.193
Crk v-crk sarcoma virus CT10 oncogene homolog (avian) 0.192
Mcm5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae) 0.191
Rbl1 retinoblastoma-like 1 (p107) 0.190
Cdk1 cyclin-dependent kinase 1 0.174
Cry2 cryptochrome 2 (photolyase-like) 0.158
Mcm7 minichromosome maintenance deficient 7 (S. cerevisiae) 0.154
H2afx H2A histone family, member X 0.146
Apc adenomatosis polyposis coli 0.146
Lsm2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) 0.136
Cops4 COP9 (constitutive photomorphogenic) homolog, subunit 4 (Arabidopsis thaliana) 0.121
Dicer1 Dicer1, Dcr-1 homolog (Drosophila) 0.118
Tcf19 transcription factor 19 0.115
Mapk8 mitogen-activated protein kinase 8 0.109
Parp1 poly (ADP-ribose) polymerase family, member 1 0.109
Skp1a S-phase kinase-associated protein 1A 0.106
Ccz1 CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae) 0.104
Ccnb1 cyclin B1 0.101
Raf1 v-raf-leukemia viral oncogene 1 0.100
Smad4 MAD homolog 4 (Drosophila) 0.099
Pik3ca phosphatidylinositol 3-kinase, catalytic, alpha polypeptide 0.098
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.097
Cdc20 cell division cycle 20 homolog (S. cerevisiae) 0.097
Gmnn geminin 0.096
Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.095
Ccna2 cyclin A2 0.094
Sp1 trans-acting transcription factor 1 0.092
Rfc3 replication factor C (activator 1) 3 0.091
Cdc6 cell division cycle 6 homolog (S. cerevisiae) 0.088
Ash2l ash2 (absent, small, or homeotic)-like (Drosophila) 0.088
Xpa xeroderma pigmentosum, complementation group A 0.081
Pkm2 pyruvate kinase, muscle 0.077
Cops3 COP9 (constitutive photomorphogenic) homolog, subunit 3 (Arabidopsis thaliana) 0.077
Ccnb2 cyclin B2 0.077
Ccnf cyclin F 0.076
Mlh1 mutL homolog 1 (E. coli) 0.073
Lig1 ligase I, DNA, ATP-dependent 0.073
Eif2c2 eukaryotic translation initiation factor 2C, 2 0.073
Rfc2 replication factor C (activator 1) 2 0.072
Nae1 NEDD8 activating enzyme E1 subunit 1 0.071
Nup85 nucleoporin 85 0.069
Ube3a ubiquitin protein ligase E3A 0.069
Trp73 transformation related protein 73 0.068
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.065
Chaf1b chromatin assembly factor 1, subunit B (p60) 0.065
Gapdh glyceraldehyde-3-phosphate dehydrogenase 0.064
Rad51ap1 RAD51 associated protein 1 0.063
Per1 period homolog 1 (Drosophila) 0.059
Lrrk2 leucine-rich repeat kinase 2 0.058
Sfn stratifin 0.057
Asf1b ASF1 anti-silencing function 1 homolog B (S. cerevisiae) 0.057
Aurkb aurora kinase B 0.055
Pou5f1 POU domain, class 5, transcription factor 1 0.055
Hnrnpf heterogeneous nuclear ribonucleoprotein F 0.054
Hdac1 histone deacetylase 1 0.054
Nono non-POU-domain-containing, octamer binding protein 0.054
Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.053
Daxx Fas death domain-associated protein 0.053
Prc1 protein regulator of cytokinesis 1 0.053
Pdpk1 3-phosphoinositide dependent protein kinase 1 0.052
Cdt1 chromatin licensing and DNA replication factor 1 0.051
Bub1b budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae) 0.050
Orc2 origin recognition complex, subunit 2 0.048
Klf5 Kruppel-like factor 5 0.048
Pcna proliferating cell nuclear antigen 0.048
Cbl Casitas B-lineage lymphoma 0.047
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Rattus norvegicus
Name Description Probability Func Analog Organism
Oaz1 ornithine decarboxylase antizyme 1 0.124
Pcmtd2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 0.044
Pkm2 pyruvate kinase, muscle 0.042
Cdk4 cyclin-dependent kinase 4 0.037
Tcp11l2 t-complex 11 (mouse) like 2 0.035
Snrpa small nuclear ribonucleoprotein polypeptide A 0.035
Top2b topoisomerase (DNA) II beta 0.032
Rbbp7 retinoblastoma binding protein 7 0.032
Kdm1 lysine (K)-specific demethylase 1 0.031
Atp5a1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle 0.031
Tnks2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 0.031
Zfand5 zinc finger, AN1-type domain 5 0.029
Cdc20 cell division cycle 20 homolog (S. cerevisiae) 0.029
Ogt O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) 0.029
Gpi glucose phosphate isomerase 0.028
Snrnp70 small nuclear ribonucleoprotein 70 (U1) 0.028
Xiap X-linked inhibitor of apoptosis 0.028
Tob1 transducer of ErbB-2.1 0.028
Ppp1ca protein phosphatase 1, catalytic subunit, alpha isoform 0.028
Sumo3 SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae) 0.027
Pdp1 pyruvate dehyrogenase phosphatase catalytic subunit 1 0.027
Zfand6 zinc finger, AN1-type domain 6 0.027
Tcf12 transcription factor 12 0.026
Daxx death-domain associated protein 0.026
Pcaf p300/CBP-associated factor 0.025
Mcm5 minichromosome maintenance complex component 5 0.025
Ctxn1 cortexin 1 0.025
Zfp238 zinc finger protein 238 0.024
Stub1 STIP1 homology and U-Box containing protein 1 0.024
Eif4a2 eukaryotic translation initiation factor 4A, isoform 2 0.024
Kif2c kinesin family member 2C 0.024
Troap trophinin associated protein 0.024
Ccnb1 cyclin B1 0.024
Atf2 activating transcription factor 2 0.023
Ube2i ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.023
Mbtps1 membrane-bound transcription factor peptidase, site 1 0.023
Atxn3 ataxin 3 0.023
Spc25 SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae) 0.023
LOC100364212 heterogeneous nuclear ribonucleoprotein K-like 0.022
Pebp1 phosphatidylethanolamine binding protein 1 0.022
Cdca8 cell division cycle associated 8 0.022
Tcfe2a transcription factor E2a 0.022
Mgea5 meningioma expressed antigen 5 (hyaluronidase) 0.022
Gapdh glyceraldehyde-3-phosphate dehydrogenase 0.022
Numb numb homolog (Drosophila) 0.022
Dnaja2 DnaJ (Hsp40) homolog, subfamily A, member 2 0.021
Dlg3 discs, large homolog 3 (Drosophila) 0.021
Ppp1cb protein phosphatase 1, catalytic subunit, beta isoform 0.021
Casp2 caspase 2 0.021
Traf4af1 TRAF4 associated factor 1 0.021
Myo16 myosin XVI 0.021
Usp9x ubiquitin specific peptidase 9, X-linked 0.021
Mov10 Moloney leukemia virus 10 0.020
Chek1 CHK1 checkpoint homolog (S. pombe) 0.020
Mier1 mesoderm induction early response 1 homolog (Xenopus laevis) 0.020
Top2a topoisomerase (DNA) II alpha 0.020
H2afx H2A histone family, member X 0.020
Tle4 transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) 0.020
Cdc42 cell division cycle 42 (GTP binding protein) 0.020
Mxi1 MAX interactor 1 0.020
Rbm18 RNA binding motif protein 18 0.020
Lmnb1 lamin B1 0.019
Tyms thymidylate synthetase 0.019
Atp5b ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide 0.019
Rcc2 regulator of chromosome condensation 2 0.019
Ccni cyclin I 0.019
Slc25a4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 0.019
Rqcd1 rcd1 (required for cell differentiation) homolog 1 (S. pombe) 0.019
Sfrs12 splicing factor, arginine/serine-rich 12 0.019
Gyg1 glycogenin 1 0.019
Srf serum response factor (c-fos serum response element-binding transcription factor) 0.019
Ttc13 tetratricopeptide repeat domain 13 0.019
Acap2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 0.019
Cherp calcium homeostasis endoplasmic reticulum protein 0.019
RGD1561878 similar to mKIAA0978 protein 0.018
Twsg1 twisted gastrulation homolog 1 (Drosophila) 0.018
Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 0.018
Rnasen ribonuclease type III, nuclear 0.018
Ccng2 cyclin G2 0.018
Parp1 poly (ADP-ribose) polymerase 1 0.018
Sesn1 sestrin 1 0.018
Snrpb small nuclear ribonucleoprotein polypeptides B and B1 0.018
Stxbp5 syntaxin binding protein 5 (tomosyn) 0.018
Ccnf cyclin F 0.018
Sdc1 syndecan 1 0.018
Gabarapl2 GABA(A) receptor-associated protein like 2 0.018
Cul3 cullin 3 0.018
Trim47 tripartite motif-containing 47 0.018
Dgka diacylglycerol kinase, alpha 0.018
Mllt6 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 0.018
Lin7c lin-7 homolog C (C. elegans) 0.017
Nol9 nucleolar protein 9 0.017
Mybl2 myeloblastosis oncogene-like 2 0.017
Ccnb2 cyclin B2 0.017
Ldhb lactate dehydrogenase B 0.017
Ilkap integrin-linked kinase-associated serine/threonine phosphatase 2C 0.017
Trim28 tripartite motif-containing 28 0.017
Usp32 ubiquitin specific peptidase 32 0.017
Ptbp1 polypyrimidine tract binding protein 1 0.017
Raf1 v-raf-leukemia viral oncogene 1 0.017