The network for 'regulation of macromolecule biosynthetic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of macromolecule biosynthetic process

Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

Name Description Probability Func Analog Organism
notch1a notch homolog 1a 0.997
gli1 GLI-Kruppel family member 1 0.996
ntla no tail a 0.995
gata3 GATA-binding protein 3 0.995
shha sonic hedgehog a 0.994
ndr2 nodal-related 2 0.989
spry4 sprouty (Drosophila) homolog 4 0.986
chd chordin 0.985
lft1 lefty1 0.977
klf4 Kruppel-like factor 4 0.972
fgf3 fibroblast growth factor 3 0.970
eomesa eomesodermin homolog a 0.969
dlc deltaC 0.960
otx2 orthodenticle homolog 2 0.959
pcdh18b protocadherin 18b 0.958
rx3 retinal homeobox gene 3 0.957
her6 hairy-related 6 0.945
foxi1 forkhead box I1 0.944
foxa3 forkhead box A3 0.943
nr2e1 nuclear receptor subfamily 2, group E, member 1 0.943
tbx2a T-box gene 2a 0.939
flh floating head 0.936
dlx2a distal-less homeobox gene 2a 0.931
jag2 jagged 2 0.928
otx1b orthodenticle homolog 1b 0.925
bmp4 bone morphogenetic protein 4 0.922
fezf2 FEZ family zinc finger 2 0.919
tal1 T-cell acute lymphocytic leukemia 1 0.917
irf6 interferon regulatory factor 6 0.905
evx1 even-skipped homeobox 1 0.903
snai1a snail homolog 1a (Drosophila) 0.901
fgfr4 fibroblast growth factor receptor 4 0.901
myod1 myogenic differentiation 1 0.900
twist1b twist1b 0.900
otpb orthopedia homolog b 0.899
her7 hairy and enhancer of split related-7 0.898
lhx1a LIM homeobox 1a 0.894
pax6a paired box gene 6a 0.883
etv5b ets variant 5b 0.875
mll myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 0.864
tbx6 T-box gene 6 0.861
lef1 lymphocyte enhancer binding factor 1 0.860
nkx2.2a NK2 transcription factor related 2a 0.860
tll1 tolloid-like 1 0.854
myf5 myogenic factor 5 0.852
neo1 neogenin 1 0.847
fgfr3 fibroblast growth factor receptor 3 0.847
vent ventral expressed homeobox 0.844
six1b sine oculis homeobox homolog 1b 0.840
notch3 notch homolog 3 0.836
tbx16 T-box gene 16 0.831
runx2b runt-related transcription factor 2b 0.831
boc brother of CDO 0.824
hmga1a high mobility group AT-hook 1a 0.821
rasl11b RAS-like, family 11, member B 0.817
fzd8a frizzled homolog 8a 0.816
nfkbiab nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b 0.816
gro2 groucho 2 0.813
dusp6 dual specificity phosphatase 6 0.812
nrg2a neuregulin 2a 0.809
cdkn1c cyclin-dependent kinase inhibitor 1C (p57, Kip2) 0.808
vox ventral homeobox 0.804
mapk1 mitogen-activated protein kinase 1 0.801
crim1 cysteine rich transmembrane BMP regulator 1 (chordin like) 0.801
igf1rb insulin-like growth factor 1b receptor 0.800
axin2 axin 2 (conductin, axil) 0.798
snai1b snail homolog 1b (Drosophila) 0.797
cfl2l cofilin 2, like 0.795
pax2a paired box gene 2a 0.792
vasa vasa homolog 0.790
sox32 SRY-box containing gene 32 0.787
tcf7l2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.785
zic2a zic family member 2 (odd-paired homolog, Drosophila), a 0.784
gbx1 gastrulation brain homeobox 1 0.784
foxa2 forkhead box A2 0.779
brd4 bromodomain containing 4 0.778
cdh1 cadherin 1, epithelial 0.776
spns2 spinster homolog 2 (Drosophila) 0.776
esr2a estrogen receptor 2a 0.772
wnt4a wingless-type MMTV integration site family, member 4a 0.771
whsc1 Wolf-Hirschhorn syndrome candidate 1 0.769
gsc goosecoid 0.762
fzd7a frizzled homolog 7a 0.758
sesn1 sestrin 1 0.756
gro1 groucho 1 0.755
cyp19a1b cytochrome P450, family 19, subfamily A, polypeptide 1b 0.753
emx3 empty spiracles homeobox 3 0.751
mbnl2 muscleblind-like 2 (Drosophila) 0.750
lhx5 LIM homeobox 5 0.745
vegfaa vascular endothelial growth factor Aa 0.736
hp1bp3 heterochromatin protein 1, binding protein 3 0.733
lft2 lefty2 0.731
khdrbs1a KH domain containing, RNA binding, signal transduction associated 1a 0.730
hoxa9a homeo box A9a 0.726
mecom MDS1 and EVI1 complex locus 0.720
raraa retinoic acid receptor, alpha a 0.720
nkx2.1a NK2 homeobox 1a 0.716
wnt10a wingless-type MMTV integration site family, member 10a 0.713
otx1a orthodenticle homolog 1a 0.710
wnt2bb wingless-type MMTV integration site family, member 2Bb 0.706
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
egl-18 Protein EGL-18 0.999
elt-6 Protein ELT-6 0.964
pha-4 Protein PHA-4 0.945
vab-3 Protein VAB-3 0.939
lin-35 Protein LIN-35 0.921
ceh-20 Protein CEH-20 0.912
lin-36 Protein LIN-36 0.788
hbl-1 Protein HBL-1 0.765
fkh-2 Protein FKH-2 0.729
hlh-2 Protein HLH-2 0.724
egl-13 Protein EGL-13 0.689
sas-5 Protein SAS-5 0.659
hcp-3 Protein HCP-3 0.629
D1081.8 Protein D1081.8 0.613
T28F4.1 Protein T28F4.1 0.595
egl-46 Protein EGL-46 0.557
nhr-49 Protein NHR-49 0.549
pry-1 Protein PRY-1 0.545
glp-1 Protein GLP-1 0.534
hlh-1 Protein HLH-1 0.523
his-1 Protein HIS-1 0.521
his-5 Protein HIS-5 0.515
nap-1 Protein NAP-1 0.501
lin-11 Protein LIN-11 0.501
cam-1 Protein CAM-1 0.499
wrm-1 Protein WRM-1 0.477
mig-6 Protein MIG-6 0.464
hsp-1 Protein HSP-1 0.460
F12F6.1 Protein F12F6.1 0.460
mab-5 Protein MAB-5 0.457
cacn-1 Protein CACN-1 0.457
peb-1 Protein PEB-1 0.457
fbf-2 Protein FBF-2 0.456
sna-2 Protein SNA-2 0.451
T28D9.4 Protein T28D9.4 0.446
rsp-1 Protein RSP-1 0.442
his-3 Protein HIS-3 0.434
pdr-1 Protein PDR-1 0.419
plk-3 Protein PLK-3 0.413
his-16 Protein HIS-16 0.412
daf-3 Protein DAF-3 0.412
lin-53 Protein LIN-53 0.411
ten-1 Protein TEN-1 0.411
eya-1 Protein EYA-1 0.407
his-29 Protein HIS-29 0.407
bar-1 Protein BAR-1 0.405
hmg-4 Protein HMG-4 0.403
rpt-2 Protein RPT-2 0.402
R90.1 Protein R90.1 0.398
ztf-2 Protein ZTF-2 0.398
R02F2.7 Protein R02F2.7 0.394
unc-73 Protein UNC-73 0.392
eor-1 Protein EOR-1 0.390
K02D7.1 Protein K02D7.1 0.390
nhr-67 Protein NHR-67 0.387
unc-40 Protein UNC-40 0.382
gop-2 Protein GOP-2 0.380
rad-26 Protein RAD-26 0.380
let-418 Protein LET-418 0.375
nhr-2 Protein NHR-2 0.372
iff-1 Protein IFF-1 0.370
gls-1 Protein GLS-1 0.369
hnd-1 Protein HND-1 0.366
lin-3 Protein LIN-3 0.365
alp-1 Protein ALP-1 0.349
let-60 Protein LET-60 0.348
sma-6 Protein SMA-6 0.346
skp-1 Protein SKP-1 0.338
unc-62 Protein UNC-62 0.337
mdf-2 Protein MDF-2 0.335
tbx-8 Protein TBX-8 0.334
zip-7 Protein ZIP-7 0.332
pqn-44 Protein PQN-44 0.328
pes-1 Protein PES-1 0.326
dcr-1 Protein DCR-1 0.322
cye-1 Protein CYE-1 0.321
snr-4 Protein SNR-4 0.315
his-50 Protein HIS-50 0.315
F10G2.4 Protein F10G2.4 0.314
his-52 Protein HIS-52 0.314
rps-2 Protein RPS-2 0.313
let-502 Protein LET-502 0.311
his-64 Protein HIS-64 0.309
unc-52 Protein UNC-52 0.303
unc-54 Protein UNC-54 0.302
lin-29 Protein LIN-29 0.302
dnj-13 Protein DNJ-13 0.301
F33H1.4 Protein F33H1.4 0.294
hpo-32 Protein HPO-32 0.292
his-24 Protein HIS-24 0.292
bet-1 Protein BET-1 0.288
pqn-59 Protein PQN-59 0.287
his-46 Protein HIS-46 0.286
ras-1 Protein RAS-1 0.286
mep-1 Protein MEP-1 0.286
rme-2 Protein RME-2 0.285
scc-1 Protein SCC-1 0.284
pri-2 Protein PRI-2 0.284
set-1 Protein SET-1 0.283
CELE_Y106G6H.6 Protein Y106G6H.6 0.283
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism