The network for 'intestinal cholesterol absorption' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

intestinal cholesterol absorption

Uptake of cholesterol into the blood by absorption from the small intestine.

Danio rerio
Name Description Probability Func Analog Organism
anxa1a annexin A1a 0.964
krt4 keratin 4 0.602
apoa4 apolipoprotein A-IV 0.579
apoa1 apolipoprotein A-I 0.525
apobl apolipoprotein B, like 0.415
zgc:194131 zgc:194131 0.372
s100a10b S100 calcium binding protein A10b 0.362
anxa2a annexin A2a 0.357
zgc:161979 zgc:161979 0.283
wu:fb18f06 wu:fb18f06 0.268
apob apolipoprotein B 0.218
pkp1 plakophilin 1 0.199
fabp2 fatty acid binding protein 2, intestinal 0.197
fabp1b.1 fatty acid binding protein 1b, tandem duplicate 1 0.177
pla2g12b phospholipase A2, group XIIB 0.126
ctsk cathepsin K 0.125
pvalb9 parvalbumin 9 0.122
tagln2 transgelin 2 0.117
mat1a methionine adenosyltransferase I, alpha 0.116
zgc:193613 zgc:193613 0.104
capns1a calpain, small subunit 1 a 0.103
nfkbiaa nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a 0.094
acsl5 acyl-CoA synthetase long-chain family member 5 0.087
itih2 inter-alpha (globulin) inhibitor H2 0.084
zgc:92533 zgc:92533 0.084
fbp1b fructose-1,6-bisphosphatase 1b 0.082
fgb fibrinogen, B beta polypeptide 0.077
rbp2a retinol binding protein 2a, cellular 0.073
ywhai tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, iota polypeptide 0.071
zgc:66286 zgc:66286 0.069
si:ch211-215l11.5 si:ch211-215l11.5 0.066
lgals2b lectin, galactoside-binding, soluble, 2b 0.061
glud1a glutamate dehydrogenase 1a 0.049
si:dkeyp-113d7.7 si:dkeyp-113d7.7 0.049
zgc:153665 zgc:153665 0.048
pck2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 0.048
b3gnt5a UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5a 0.047
slc27a2 solute carrier family 27 (fatty acid transporter), member 2 0.047
gip gastric inhibitory polypeptide 0.047
ces2 carboxylesterase 2 (intestine, liver) 0.047
si:ch211-105c13.3 si:ch211-105c13.3 0.046
cfb complement factor B 0.044
ahnak AHNAK nucleoprotein 0.044
sepp1b selenoprotein P, plasma, 1b 0.043
zgc:56376 zgc:56376 0.040
smyhc1 slow myosin heavy chain 1 0.038
perp PERP, TP53 apoptosis effector 0.037
gpd1b glycerol-3-phosphate dehydrogenase 1b 0.036
rbpja recombination signal binding protein for immunoglobulin kappa J region a 0.035
stm starmaker 0.034
thy1 Thy-1 cell surface antigen 0.034
fn1b fibronectin 1b 0.034
wu:fk35f04 wu:fk35f04 0.033
agxt2l1 alanine-glyoxylate aminotransferase 2-like 1 0.033
atp1a1a.4 ATPase, Na+/K+ transporting, alpha 1a.4 polypeptide 0.031
lgals3l lectin, galactoside-binding, soluble, 3 (galectin 3)-like 0.031
atp2a2a ATPase, Ca++ transporting, cardiac muscle, slow twitch 2a 0.031
mmp2 matrix metalloproteinase 2 0.031
apoea apolipoprotein Ea 0.030
zgc:91870 zgc:91870 0.030
hadha hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase, alpha subunit 0.029
tpm3 tropomyosin 3 0.029
ckma creatine kinase, muscle a 0.029
nt5c2l1 5'-nucleotidase, cytosolic II, like 1 0.029
aldob aldolase b, fructose-bisphosphate 0.028
gamt guanidinoacetate N-methyltransferase 0.027
anxa5b annexin A5b 0.027
timp2b tissue inhibitor of metalloproteinase 2b 0.026
aqp1a.1 aquaporin 1a, tandem duplicate 1 0.026
tax1bp3 Tax1 (human T-cell leukemia virus type I) binding protein 3 0.026
tpm4 tropomyosin 4 0.026
itm2bb integral membrane protein 2Bb 0.025
zgc:153129 zgc:153129 0.025
pdap1 pdgfa associated protein 1 0.024
hprt1l hypoxanthine phosphoribosyltransferase 1, like 0.024
slc3a2 solute carrier family 3, member 2 0.024
col19a1 collagen, type XIX, alpha 1 0.023
icn ictacalcin 0.023
adh8b alcohol dehydrogenase 8b 0.023
stat3 signal transduction and activation of transcription 3 0.023
casp3a caspase 3, apoptosis-related cysteine protease a 0.022
cnn2 calponin 2 0.022
krt5 keratin 5 0.022
apoc2 apolipoprotein C-II 0.022
s100v2 S100 calcium binding protein V2 0.022
serpinc1 serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1 0.022
cd63 Cd63 antigen 0.021
zgc:92242 zgc:92242 0.021
zgc:55813 zgc:55813 0.021
sdprb serum deprivation response b 0.020
gsnb gelsolin b 0.020
tfa transferrin-a 0.019
ppdpfa pancreatic progenitor cell differentiation and proliferation factor a 0.019
gdpd3 glycerophosphodiester phosphodiesterase domain containing 3 0.019
pabpc4 poly(A) binding protein, cytoplasmic 4 (inducible form) 0.019
slc26a1 solute carrier family 26 (sulfate transporter), member 1 0.019
mxra8a matrix-remodelling associated 8a 0.019
evpl envoplakin 0.019
cfhl4 complement factor H like 4 0.018
psmd12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 0.018
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8 0.647
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 0.591
CAV2 caveolin 2 0.486
S100A10 S100 calcium binding protein A10 0.253
APOC3 apolipoprotein C-III 0.126
PTEN phosphatase and tensin homolog 0.097
PRKCDBP protein kinase C, delta binding protein 0.086
PCSK9 proprotein convertase subtilisin/kexin type 9 0.078
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.076
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.067
ANXA1 annexin A1 0.061
HP haptoglobin 0.054
LCAT lecithin-cholesterol acyltransferase 0.037
EGFR epidermal growth factor receptor 0.037
ALB albumin 0.037
IDI1 isopentenyl-diphosphate delta isomerase 1 0.036
PTPRF protein tyrosine phosphatase, receptor type, F 0.035
FGA fibrinogen alpha chain 0.032
F2R coagulation factor II (thrombin) receptor 0.028
ANXA5 annexin A5 0.022
APOA2 apolipoprotein A-II 0.020
FAS Fas (TNF receptor superfamily, member 6) 0.018
APOC1 apolipoprotein C-I 0.017
APOE apolipoprotein E 0.017
TXNRD1 thioredoxin reductase 1 0.016
TXNDC2 thioredoxin domain containing 2 (spermatozoa) 0.015
PDIA3 protein disulfide isomerase family A, member 3 0.013
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.012
INSIG1 insulin induced gene 1 0.012
TMSB10 thymosin beta 10 0.011
GJA1 gap junction protein, alpha 1, 43kDa 0.011
TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain 0.010
CD59 CD59 molecule, complement regulatory protein 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Pparg peroxisome proliferator activated receptor gamma 0.998
Lepr leptin receptor 0.997
Apoe apolipoprotein E 0.914
Nos3 nitric oxide synthase 3, endothelial cell 0.896
Cav1 caveolin 1, caveolae protein 0.762
Apoa1 apolipoprotein A-I 0.724
Abcg5 ATP-binding cassette, sub-family G (WHITE), member 5 0.621
Nos1 nitric oxide synthase 1, neuronal 0.533
Abca1 ATP-binding cassette, sub-family A (ABC1), member 1 0.465
Ghr growth hormone receptor 0.460
Tlr2 toll-like receptor 2 0.345
Abcg8 ATP-binding cassette, sub-family G (WHITE), member 8 0.252
Lrp1 low density lipoprotein receptor-related protein 1 0.240
Fas Fas (TNF receptor superfamily member 6) 0.191
Gnas GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus 0.188
Cebpa CCAAT/enhancer binding protein (C/EBP), alpha 0.182
Lyz2 lysozyme 2 0.163
Plin1 perilipin 1 0.155
Apob apolipoprotein B 0.150
Scd1 stearoyl-Coenzyme A desaturase 1 0.128
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.113
Cd36 CD36 antigen 0.100
Lpin1 lipin 1 0.099
Col1a1 collagen, type I, alpha 1 0.099
Il1r1 interleukin 1 receptor, type I 0.094
Plg plasminogen 0.088
Ccl2 chemokine (C-C motif) ligand 2 0.081
Fbn1 fibrillin 1 0.079
Aldob aldolase B, fructose-bisphosphate 0.077
S100a10 S100 calcium binding protein A10 (calpactin) 0.076
Tlr4 toll-like receptor 4 0.074
Npc1 Niemann Pick type C1 0.068
Mmp9 matrix metallopeptidase 9 0.061
Adipoq adiponectin, C1Q and collagen domain containing 0.058
Cidec cell death-inducing DFFA-like effector c 0.050
Ldlr low density lipoprotein receptor 0.047
Lep leptin 0.047
Lect2 leukocyte cell-derived chemotaxin 2 0.044
Sycn syncollin 0.039
Nos2 nitric oxide synthase 2, inducible 0.034
Esr1 estrogen receptor 1 (alpha) 0.033
Myd88 myeloid differentiation primary response gene 88 0.031
Ins2 insulin II 0.031
Pnpla2 patatin-like phospholipase domain containing 2 0.030
Esr2 estrogen receptor 2 (beta) 0.028
Gcgr glucagon receptor 0.028
Cdhr5 cadherin-related family member 5 0.026
Pla2g12b phospholipase A2, group XIIB 0.024
Nr1h3 nuclear receptor subfamily 1, group H, member 3 0.023
Hpd 4-hydroxyphenylpyruvic acid dioxygenase 0.023
Zg16 zymogen granule protein 16 0.023
Cd44 CD44 antigen 0.023
Abhd5 abhydrolase domain containing 5 0.022
Spp1 secreted phosphoprotein 1 0.022
Dysf dysferlin 0.021
Vdr vitamin D receptor 0.021
Apoc3 apolipoprotein C-III 0.020
Hnf4a hepatic nuclear factor 4, alpha 0.019
S100a6 S100 calcium binding protein A6 (calcyclin) 0.019
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.019
Slc27a5 solute carrier family 27 (fatty acid transporter), member 5 0.018
Abcc2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 0.018
Apoc4 apolipoprotein C-IV 0.017
Vegfa vascular endothelial growth factor A 0.016
Il10 interleukin 10 0.016
F2 coagulation factor II 0.015
Agtr2 angiotensin II receptor, type 2 0.015
Cideb cell death-inducing DNA fragmentation factor, alpha subunit-like effector B 0.015
Efemp2 epidermal growth factor-containing fibulin-like extracellular matrix protein 2 0.014
Acot12 acyl-CoA thioesterase 12 0.014
Agtr1a angiotensin II receptor, type 1a 0.014
Lmna lamin A 0.013
Irs2 insulin receptor substrate 2 0.013
Fgf21 fibroblast growth factor 21 0.013
Cel carboxyl ester lipase 0.013
Serpinf2 serine (or cysteine) peptidase inhibitor, clade F, member 2 0.013
Igf1 insulin-like growth factor 1 0.012
Nr1i2 nuclear receptor subfamily 1, group I, member 2 0.012
Spp2 secreted phosphoprotein 2 0.012
Ptgs2 prostaglandin-endoperoxide synthase 2 0.012
Pck1 phosphoenolpyruvate carboxykinase 1, cytosolic 0.012
Cyp2d26 cytochrome P450, family 2, subfamily d, polypeptide 26 0.012
Apom apolipoprotein M 0.011
Apoa2 apolipoprotein A-II 0.011
Prlr prolactin receptor 0.011
Ces2a carboxylesterase 2A 0.011
Mogat2 monoacylglycerol O-acyltransferase 2 0.011
Golt1a golgi transport 1 homolog A (S. cerevisiae) 0.011
Lif leukemia inhibitory factor 0.011
Cyp3a25 cytochrome P450, family 3, subfamily a, polypeptide 25 0.010
Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 0.010
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism