The network for 'vasculature development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

vasculature development

The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism.

Danio rerio
Name Description Probability Func Analog Organism
kdrl kinase insert domain receptor like 0.999
gata2a GATA-binding protein 2a 0.997
notch3 notch homolog 3 0.995
dll4 delta-like 4 (Drosophila) 0.994
dlc deltaC 0.994
tal1 T-cell acute lymphocytic leukemia 1 0.993
efnb2a ephrin B2a 0.993
ccm2 cerebral cavernous malformation 2 0.990
nrp1a neuropilin 1a 0.988
cdh5 cadherin 5 0.986
edn1 endothelin 1 0.985
fli1a friend leukemia integration 1a 0.985
tbx1 T-box 1 0.984
mib mind bomb 0.984
alcama activated leukocyte cell adhesion molecule a 0.971
dlb deltaB 0.964
traf4a tnf receptor-associated factor 4a 0.960
flt4 fms-related tyrosine kinase 4 0.955
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.949
foxc1a forkhead box C1a 0.946
fn1 fibronectin 1 0.946
cxcr4a chemokine (C-X-C motif) receptor 4a 0.940
vegfc vascular endothelial growth factor c 0.940
etv2 ets variant gene 2 0.939
si:ch211-212m21.5 si:ch211-212m21.5 0.939
runx1 runt-related transcription factor 1 0.935
plcg1 phospholipase C, gamma 1 0.932
dld deltaD 0.928
tie2 endothelium-specific receptor tyrosine kinase 2 0.923
cdx4 caudal type homeo box transcription factor 4 0.921
rargb retinoic acid receptor, gamma b 0.917
erg v-ets erythroblastosis virus E26 oncogene like (avian) 0.916
mpx myeloid-specific peroxidase 0.914
nrp2b neuropilin 2b 0.896
dag1 dystroglycan 1 0.894
tp53 tumor protein p53 0.892
nrarpa notch-regulated ankyrin repeat protein a 0.891
krit1 KRIT1, ankyrin repeat containing 0.891
tbx20 T-box 20 0.888
sox7 SRY-box containing gene 7 0.882
mtp microsomal triglyceride transfer protein 0.872
her9 hairy-related 9 0.860
meis1 myeloid ecotropic viral integration 1 0.858
jag2 jagged 2 0.857
arnt2 aryl hydrocarbon receptor nuclear translocator 2 0.852
sox9b SRY-box containing gene 9b 0.845
fabp11a fatty acid binding protein 11a 0.844
robo4 roundabout homolog 4 0.842
sox2 SRY-box containing gene 2 0.836
fbn2b fibrillin 2b 0.827
plxnd1 plexin D1 0.824
si:ch211-235f6.2 si:ch211-235f6.2 0.822
igf1 insulin-like growth factor 1 0.813
gli2a GLI-Kruppel family member GLI2a 0.808
myf5 myogenic factor 5 0.805
fgfr4 fibroblast growth factor receptor 4 0.800
ptgs1 prostaglandin-endoperoxide synthase 1 0.797
twist1b twist1b 0.797
alcamb activated leukocyte cell adhesion molecule b 0.794
vegfaa vascular endothelial growth factor Aa 0.792
col1a2 collagen, type I, alpha 2 0.787
aplnra apelin receptor a 0.786
sars seryl-tRNA synthetase 0.784
cyp1a cytochrome P450, family 1, subfamily A 0.784
bmp2b bone morphogenetic protein 2b 0.783
gata1a GATA binding protein 1a 0.779
shha sonic hedgehog a 0.777
LOC100000687 signal peptide, CUB and EGF-like domain-containing protein 3-like 0.774
col12a1 collagen, type XII, alpha 1 0.771
fgfrl1a fibroblast growth factor receptor-like 1a 0.763
birc2 baculoviral IAP repeat-containing 2 0.762
notch1b notch homolog 1b 0.761
gng2 guanine nucleotide binding protein (G protein), gamma 2 0.760
pak2a p21 (CDKN1A)-activated kinase 2a 0.752
isl1 islet1 0.751
nr2f2 nuclear receptor subfamily 2, group F, member 2 0.749
lft2 lefty2 0.746
mmp2 matrix metalloproteinase 2 0.744
s1pr2 sphingosine-1-phosphate receptor 2 0.744
rarga retinoic acid receptor gamma a 0.738
lamb1a laminin, beta 1a 0.738
wu:fv91b12 wu:fv91b12 0.734
hspg2 heparan sulfate proteoglycan 2 0.732
fgfrl1b fibroblast growth factor receptor-like 1b 0.724
arhgef7b Rho guanine nucleotide exchange factor (GEF) 7b 0.722
wu:fj39b01 wu:fj39b01 0.722
hey1 hairy/enhancer-of-split related with YRPW motif 1 0.714
vasp vasodilator-stimulated phosphoprotein 0.712
dab2 disabled homolog 2 (Drosophila) 0.707
sema3fa semaphorin 3fa 0.699
sox32 SRY-box containing gene 32 0.694
her7 hairy and enhancer of split related-7 0.693
tbx2a T-box gene 2a 0.691
unc5b unc-5 homolog B (C. elegans) 0.688
ahr2 aryl hydrocarbon receptor 2 0.678
fgfr2 fibroblast growth factor receptor 2 0.675
evx1 even-skipped homeobox 1 0.662
pea3 ETS-domain transcription factor pea3 0.660
fli1b friend leukemia integration 1b 0.660
rxrab retinoid x receptor, alpha b 0.659
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
CREBBP CREB binding protein 1.000
EGFR epidermal growth factor receptor 1.000
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 1.000
SMAD2 SMAD family member 2 0.999
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.999
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.997
VEGFA vascular endothelial growth factor A 0.997
KDR kinase insert domain receptor (a type III receptor tyrosine kinase) 0.996
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.995
YAP1 Yes-associated protein 1 0.994
THBS1 thrombospondin 1 0.992
EP300 E1A binding protein p300 0.992
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.990
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.983
JAG1 jagged 1 0.980
NOTCH1 notch 1 0.977
NRP1 neuropilin 1 0.977
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.976
AR androgen receptor 0.976
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.976
ENG endoglin 0.975
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.974
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.971
FN1 fibronectin 1 0.971
FGFR2 fibroblast growth factor receptor 2 0.965
CTGF connective tissue growth factor 0.965
NOTCH3 notch 3 0.962
FGFR1 fibroblast growth factor receptor 1 0.959
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.955
FAS Fas (TNF receptor superfamily, member 6) 0.952
EGR1 early growth response 1 0.945
CDH5 cadherin 5, type 2 (vascular endothelium) 0.943
ACTB actin, beta 0.940
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.938
CAV1 caveolin 1, caveolae protein, 22kDa 0.934
SMAD1 SMAD family member 1 0.927
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.926
SMAD3 SMAD family member 3 0.923
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.920
PML promyelocytic leukemia 0.917
FOS FBJ murine osteosarcoma viral oncogene homolog 0.916
PAX3 paired box 3 0.913
COL4A1 collagen, type IV, alpha 1 0.907
SIRT1 sirtuin 1 0.907
PARD3 par-3 partitioning defective 3 homolog (C. elegans) 0.906
TEK TEK tyrosine kinase, endothelial 0.905
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.901
FHL2 four and a half LIM domains 2 0.895
MYC v-myc myelocytomatosis viral oncogene homolog (avian) 0.890
COL4A2 collagen, type IV, alpha 2 0.887
COL1A2 collagen, type I, alpha 2 0.872
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.872
HOXB5 homeobox B5 0.854
COL1A1 collagen, type I, alpha 1 0.853
CALD1 caldesmon 1 0.853
TIMP2 TIMP metallopeptidase inhibitor 2 0.848
IL8 interleukin 8 0.843
MEF2C myocyte enhancer factor 2C 0.836
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.826
CTNND1 catenin (cadherin-associated protein), delta 1 0.825
TIMP3 TIMP metallopeptidase inhibitor 3 0.815
PDX1 pancreatic and duodenal homeobox 1 0.813
PLAUR plasminogen activator, urokinase receptor 0.804
COL2A1 collagen, type II, alpha 1 0.801
CAV2 caveolin 2 0.799
DUSP1 dual specificity phosphatase 1 0.799
JUN jun proto-oncogene 0.797
RAMP2 receptor (G protein-coupled) activity modifying protein 2 0.774
SMAD7 SMAD family member 7 0.769
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.763
SKIL SKI-like oncogene 0.756
RUNX1 runt-related transcription factor 1 0.756
RASSF5 Ras association (RalGDS/AF-6) domain family member 5 0.743
CD34 CD34 molecule 0.733
RGS2 regulator of G-protein signaling 2, 24kDa 0.733
TGFBI transforming growth factor, beta-induced, 68kDa 0.733
FOXF1 forkhead box F1 0.727
COL5A1 collagen, type V, alpha 1 0.727
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.726
IL2RB interleukin 2 receptor, beta 0.722
TJP1 tight junction protein 1 (zona occludens 1) 0.720
TCF4 transcription factor 4 0.717
MYOD1 myogenic differentiation 1 0.709
HOXA10 homeobox A10 0.709
IER3 immediate early response 3 0.707
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.705
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.701
CXCL2 chemokine (C-X-C motif) ligand 2 0.698
GJA1 gap junction protein, alpha 1, 43kDa 0.696
TBX2 T-box 2 0.694
EPAS1 endothelial PAS domain protein 1 0.694
SMAD6 SMAD family member 6 0.694
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.690
TAL1 T-cell acute lymphocytic leukemia 1 0.683
PLAU plasminogen activator, urokinase 0.676
KLF4 Kruppel-like factor 4 (gut) 0.675
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.673
PPL periplakin 0.671
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.668
COL3A1 collagen, type III, alpha 1 0.654
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
Ccl2 chemokine (C-C motif) ligand 2 0.824
Utrn utrophin 0.585
Bgn biglycan 0.440
Fos FBJ osteosarcoma oncogene 0.440
Rhoj ras homolog gene family, member J 0.418
Igfbp5 insulin-like growth factor binding protein 5 0.383
Col1a2 collagen, type I, alpha 2 0.376
Kcnj8 potassium inwardly-rectifying channel, subfamily J, member 8 0.333
Ccl4 chemokine (C-C motif) ligand 4 0.326
Fgfr2 fibroblast growth factor receptor 2 0.302
Il1b interleukin 1 beta 0.292
Edn1 endothelin 1 0.290
Trim47 tripartite motif-containing 47 0.270
Nfib nuclear factor I/B 0.267
Zfp36l1 zinc finger protein 36, C3H type-like 1 0.246
A2m alpha-2-macroglobulin 0.240
Dusp1 dual specificity phosphatase 1 0.234
Col1a1 collagen, type I, alpha 1 0.230
Slc10a1 solute carrier family 10 (sodium/bile acid cotransporter family), member 1 0.225
Nr4a3 nuclear receptor subfamily 4, group A, member 3 0.210
Cpxm2 carboxypeptidase X (M14 family), member 2 0.204
Sell selectin L 0.202
Fgfr1 Fibroblast growth factor receptor 1 0.200
Serpine1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.186
Col5a3 collagen, type V, alpha 3 0.186
Fstl1 follistatin-like 1 0.185
Ednrb endothelin receptor type B 0.185
Col5a1 collagen, type V, alpha 1 0.183
Mdfic MyoD family inhibitor domain containing 0.183
Calcrl calcitonin receptor-like 0.182
Id3 inhibitor of DNA binding 3 0.181
Acvrl1 activin A receptor type II-like 1 0.180
Mbl1 mannose-binding lectin (protein A) 1 0.168
Hpx hemopexin 0.165
Trib1 tribbles homolog 1 (Drosophila) 0.160
P2rx1 purinergic receptor P2X, ligand-gated ion channel, 1 0.159
Prok2 prokineticin 2 0.153
Mmp10 matrix metallopeptidase 10 0.151
RGD1564327 similar to integrin alpha 8 0.151
Ccr5 chemokine (C-C motif) receptor 5 0.148
Gulo gulonolactone (L-) oxidase 0.146
Egfl7 EGF-like-domain, multiple 7 0.143
Egr2 early growth response 2 0.142
Il1r1 interleukin 1 receptor, type I 0.142
Vcan versican 0.139
Mmp9 matrix metallopeptidase 9 0.138
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.138
Npr3 natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C) 0.136
Col12a1 collagen, type XII, alpha 1 0.134
Jak1 Janus kinase 1 0.131
Col4a1 collagen, type IV, alpha 1 0.131
Il8rb interleukin 8 receptor, beta 0.131
Csf1 colony stimulating factor 1 (macrophage) 0.130
Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 0.128
Col5a2 collagen, type V, alpha 2 0.127
Fkbp1a FK506 binding protein 1a 0.125
Cmklr1 chemokine-like receptor 1 0.125
Cxcl6 chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) 0.125
Arhgef15 Rho guanine nucleotide exchange factor (GEF) 15 0.125
Has2 hyaluronan synthase 2 0.123
Wisp1 WNT1 inducible signaling pathway protein 1 0.121
Adam7 ADAM metallopeptidase domain 7 0.119
Elk3 ELK3, ETS-domain protein 0.118
Serpina3k serine (or cysteine) peptidase inhibitor, clade A, member 3K 0.117
Cd200r1 CD200 receptor 1 0.115
Htr6 5-hydroxytryptamine (serotonin) receptor 6 0.114
LOC100364212 heterogeneous nuclear ribonucleoprotein K-like 0.113
Anxa4 annexin A4 0.113
Ncr1 natural cytotoxicity triggering receptor 1 0.107
Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N 0.106
Apoh apolipoprotein H (beta-2-glycoprotein I) 0.105
Hspa1a heat shock 70kD protein 1A 0.105
Mmp3 matrix metallopeptidase 3 0.104
Flt1 FMS-related tyrosine kinase 1 0.104
Crisp1 cysteine-rich secretory protein 1 0.097
Fmod fibromodulin 0.096
Pld2 phospholipase D2 0.095
S100a8 S100 calcium binding protein A8 0.095
Wwtr1 WW domain containing transcription regulator 1 0.095
Bglap bone gamma-carboxyglutamate (gla) protein 0.093
Neurl3 neuralized homolog 3 (Drosophila) 0.092
Aebp1 AE binding protein 1 0.092
F13a1 coagulation factor XIII, A1 polypeptide 0.092
Stip1 stress-induced phosphoprotein 1 0.092
Elf1 E74-like factor 1 0.091
Mmp2 matrix metallopeptidase 2 0.091
Plau plasminogen activator, urokinase 0.091
Lamc1 laminin, gamma 1 0.091
Gal galanin prepropeptide 0.090
Twist2 twist homolog 2 (Drosophila) 0.089
Sgk1 serum/glucocorticoid regulated kinase 1 0.088
Spata19 spermatogenesis associated 19 0.088
Alb albumin 0.088
Tgfb3 transforming growth factor, beta 3 0.087
Ccl3 chemokine (C-C motif) ligand 3 0.087
P2ry12 purinergic receptor P2Y, G-protein coupled, 12 0.087
Sox17 SRY (sex determining region Y)-box 17 0.086
Thbd thrombomodulin 0.086
Dab2 disabled homolog 2 (Drosophila) 0.084
Bcl2 B-cell CLL/lymphoma 2 0.083
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism