The network for 'regulation of dna dependent dna replication' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of dna dependent dna replication

Any process that modulates the rate, frequency, or extent of DNA-dependent DNA replication, the process in which new strands of DNA are synthesized, using parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands.

Danio rerio
Name Description Probability Func Analog Organism
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
zyg-9 Protein ZYG-9 0.012
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
CG10267 CG10267 gene product from transcript CG10267-RB 0.054
Mcm3 Minichromosome maintenance 3 0.028
tld tolloid 0.020
Mcm2 Minichromosome maintenance 2 0.017
dlp dally-like 0.016
pim pimples 0.016
Rab23 CG2108 gene product from transcript CG2108-RA 0.014
mus101 mutagen-sensitive 101 0.014
luna CG33473 gene product from transcript CG33473-RB 0.013
Slbp Stem-loop binding protein 0.013
mei-9 meiotic 9 0.013
CDC45L CG3658 gene product from transcript CG3658-RA 0.012
piwi CG6122 gene product from transcript CG6122-RA 0.011
Slip1 CG1783 gene product from transcript CG1783-RA 0.011
l(2)dtl lethal-(2)-denticleless 0.010
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
CDK2 cyclin-dependent kinase 2 0.744
RAD21 RAD21 homolog (S. pombe) 0.602
E2F7 E2F transcription factor 7 0.438
SMC1A structural maintenance of chromosomes 1A 0.423
NBN nibrin 0.405
STAG2 stromal antigen 2 0.330
MCM7 minichromosome maintenance complex component 7 0.287
PDS5B PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae) 0.217
E2F8 E2F transcription factor 8 0.203
YY1 YY1 transcription factor 0.195
RPA1 replication protein A1, 70kDa 0.169
BMPR1A bone morphogenetic protein receptor, type IA 0.142
BLM Bloom syndrome, RecQ helicase-like 0.136
TOPBP1 topoisomerase (DNA) II binding protein 1 0.135
WAPAL wings apart-like homolog (Drosophila) 0.129
SMC3 structural maintenance of chromosomes 3 0.107
FANCD2 Fanconi anemia, complementation group D2 0.098
RAD50 RAD50 homolog (S. cerevisiae) 0.097
CPNE6 copine VI (neuronal) 0.073
CCNE1 cyclin E1 0.072
STAG1 stromal antigen 1 0.070
ORC1 origin recognition complex, subunit 1 0.065
SNTA1 syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component) 0.062
ANAPC7 anaphase promoting complex subunit 7 0.060
MRFAP1 Morf4 family associated protein 1 0.060
RBBP4 retinoblastoma binding protein 4 0.053
ARRB1 arrestin, beta 1 0.046
PDS5A PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae) 0.042
BMPR1B bone morphogenetic protein receptor, type IB 0.041
ACTL6A actin-like 6A 0.038
CHEK1 CHK1 checkpoint homolog (S. pombe) 0.033
RAD51 RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) 0.032
BRCA2 breast cancer 2, early onset 0.031
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 0.030
MDC1 mediator of DNA-damage checkpoint 1 0.028
JUN jun proto-oncogene 0.027
HDAC1 histone deacetylase 1 0.027
H2AFX H2A histone family, member X 0.026
CDC6 cell division cycle 6 homolog (S. cerevisiae) 0.026
SSU72 SSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae) 0.026
CNOT1 CCR4-NOT transcription complex, subunit 1 0.026
SKP2 S-phase kinase-associated protein 2 (p45) 0.024
UHRF2 ubiquitin-like with PHD and ring finger domains 2 0.024
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.024
ATM ataxia telangiectasia mutated 0.023
NOG noggin 0.022
ATF2 activating transcription factor 2 0.022
E2F1 E2F transcription factor 1 0.022
MCM6 minichromosome maintenance complex component 6 0.020
RBBP7 retinoblastoma binding protein 7 0.020
CNOT2 CCR4-NOT transcription complex, subunit 2 0.020
KRTAP4-12 keratin associated protein 4-12 0.019
RBL1 retinoblastoma-like 1 (p107) 0.017
MORF4L1 mortality factor 4 like 1 0.017
MCM2 minichromosome maintenance complex component 2 0.016
CDR2 cerebellar degeneration-related protein 2, 62kDa 0.016
WFIKKN1 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 0.016
CDCA5 cell division cycle associated 5 0.016
RB1 retinoblastoma 1 0.016
LARP7 La ribonucleoprotein domain family, member 7 0.015
ACTR5 ARP5 actin-related protein 5 homolog (yeast) 0.015
LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila) 0.015
HEXIM1 hexamethylene bis-acetamide inducible 1 0.015
CCNT1 cyclin T1 0.015
CCDC6 coiled-coil domain containing 6 0.014
FSTL1 follistatin-like 1 0.014
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa 0.013
MCMBP minichromosome maintenance complex binding protein 0.013
NR2E3 nuclear receptor subfamily 2, group E, member 3 0.013
ANAPC4 anaphase promoting complex subunit 4 0.013
MIER3 mesoderm induction early response 1, family member 3 0.013
GTF2I general transcription factor IIi 0.013
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit 0.013
PRMT1 protein arginine methyltransferase 1 0.012
EZH2 enhancer of zeste homolog 2 (Drosophila) 0.012
BCLAF1 BCL2-associated transcription factor 1 0.012
CDC45 cell division cycle 45 homolog (S. cerevisiae) 0.012
TOP1 topoisomerase (DNA) I 0.012
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 0.012
SOCS3 suppressor of cytokine signaling 3 0.012
FANCA Fanconi anemia, complementation group A 0.011
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 0.011
SHPRH SNF2 histone linker PHD RING helicase 0.011
RUVBL1 RuvB-like 1 (E. coli) 0.011
LBR lamin B receptor 0.011
CKS1B CDC28 protein kinase regulatory subunit 1B 0.011
WDR76 WD repeat domain 76 0.011
PSIP1 PC4 and SFRS1 interacting protein 1 0.010
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.010
CUL7 cullin 7 0.010
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Mapk14 mitogen-activated protein kinase 14 0.950
Mecp2 methyl CpG binding protein 2 0.735
Mcm3 minichromosome maintenance deficient 3 (S. cerevisiae) 0.725
Mcm2 minichromosome maintenance deficient 2 mitotin (S. cerevisiae) 0.528
Atf2 activating transcription factor 2 0.486
Ccna2 cyclin A2 0.459
Atm ataxia telangiectasia mutated homolog (human) 0.377
Foxc1 forkhead box C1 0.339
Cdc6 cell division cycle 6 homolog (S. cerevisiae) 0.309
Prc1 protein regulator of cytokinesis 1 0.262
Brca1 breast cancer 1 0.241
Kif11 kinesin family member 11 0.205
Zic3 zinc finger protein of the cerebellum 3 0.174
Pole2 polymerase (DNA directed), epsilon 2 (p59 subunit) 0.169
Stag2 stromal antigen 2 0.167
Mapk8ip3 mitogen-activated protein kinase 8 interacting protein 3 0.158
Cdk4 cyclin-dependent kinase 4 0.154
Ncaph non-SMC condensin I complex, subunit H 0.143
Mapkapk2 MAP kinase-activated protein kinase 2 0.137
Pola1 polymerase (DNA directed), alpha 1 0.107
Mcm7 minichromosome maintenance deficient 7 (S. cerevisiae) 0.103
Mki67 antigen identified by monoclonal antibody Ki 67 0.100
Cdt1 chromatin licensing and DNA replication factor 1 0.099
Cdc20 cell division cycle 20 homolog (S. cerevisiae) 0.097
Tcf19 transcription factor 19 0.095
Ccnb1 cyclin B1 0.094
Rad51ap1 RAD51 associated protein 1 0.092
Mapk11 mitogen-activated protein kinase 11 0.088
Ddx46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 0.086
Cdk1 cyclin-dependent kinase 1 0.079
Cdca7l cell division cycle associated 7 like 0.067
Cdca5 cell division cycle associated 5 0.065
Cdca8 cell division cycle associated 8 0.063
Rock2 Rho-associated coiled-coil containing protein kinase 2 0.061
Bmp7 bone morphogenetic protein 7 0.060
Ctcf CCCTC-binding factor 0.060
Rnf220 ring finger protein 220 0.058
Aurkb aurora kinase B 0.053
Kdm5b lysine (K)-specific demethylase 5B 0.053
Mdm2 transformed mouse 3T3 cell double minute 2 0.051
Ccnb2 cyclin B2 0.050
Suds3 suppressor of defective silencing 3 homolog (S. cerevisiae) 0.049
Ccne1 cyclin E1 0.048
Hells helicase, lymphoid specific 0.045
Dtl denticleless homolog (Drosophila) 0.043
Kif2a kinesin family member 2A 0.043
Asf1b ASF1 anti-silencing function 1 homolog B (S. cerevisiae) 0.039
Dna2 DNA replication helicase 2 homolog (yeast) 0.039
Mobkl1b MOB1, Mps One Binder kinase activator-like 1B (yeast) 0.037
Timeless timeless homolog (Drosophila) 0.037
Orc1 origin recognition complex, subunit 1 0.035
Pds5b PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae) 0.035
Rad50 RAD50 homolog (S. cerevisiae) 0.034
Mcm5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae) 0.033
Mapk8 mitogen-activated protein kinase 8 0.032
Rrm2 ribonucleotide reductase M2 0.032
Mapk1 mitogen-activated protein kinase 1 0.031
Hdac1 histone deacetylase 1 0.031
Rad51 RAD51 homolog (S. cerevisiae) 0.031
Pou5f1 POU domain, class 5, transcription factor 1 0.030
Elavl1 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) 0.030
Cdca7 cell division cycle associated 7 0.030
Smc2 structural maintenance of chromosomes 2 0.029
Otx2 orthodenticle homolog 2 (Drosophila) 0.029
E2f8 E2F transcription factor 8 0.028
Atp11c ATPase, class VI, type 11C 0.028
Kif22 kinesin family member 22 0.028
Plk4 polo-like kinase 4 (Drosophila) 0.025
Brca2 breast cancer 2 0.024
Msh2 mutS homolog 2 (E. coli) 0.024
Plk1 polo-like kinase 1 (Drosophila) 0.024
Nek2 NIMA (never in mitosis gene a)-related expressed kinase 2 0.023
Ccnf cyclin F 0.023
Pold1 polymerase (DNA directed), delta 1, catalytic subunit 0.023
Rad21 RAD21 homolog (S. pombe) 0.023
Trp53 transformation related protein 53 0.022
Lig1 ligase I, DNA, ATP-dependent 0.022
Ttk Ttk protein kinase 0.022
H2afx H2A histone family, member X 0.022
Mis18bp1 MIS18 binding protein 1 0.021
Smc4 structural maintenance of chromosomes 4 0.020
Dyrk1a dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a 0.020
Chek1 checkpoint kinase 1 homolog (S. pombe) 0.020
Kif2c kinesin family member 2C 0.019
Fmr1 fragile X mental retardation syndrome 1 homolog 0.019
Tk1 thymidine kinase 1 0.019
Rbl1 retinoblastoma-like 1 (p107) 0.018
Pds5a PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae) 0.018
Trip13 thyroid hormone receptor interactor 13 0.018
Prkce protein kinase C, epsilon 0.018
Lmnb1 lamin B1 0.017
Zfp644 zinc finger protein 644 0.017
Otud4 OTU domain containing 4 0.017
Kif23 kinesin family member 23 0.017
Mdm4 transformed mouse 3T3 cell double minute 4 0.016
Smc1a structural maintenance of chromosomes 1A 0.016
Sass6 spindle assembly 6 homolog (C. elegans) 0.016
Kif4 kinesin family member 4 0.015
Top2a topoisomerase (DNA) II alpha 0.015
Nbn nibrin 0.015
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Loading network...
Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
RAD53 Rad53p 0.238
MDN1 Mdn1p 0.220
DIA2 Dia2p 0.192
HST1 Hst1p 0.172
ORC3 Orc3p 0.131
PDS5 Pds5p 0.130
YLR455W hypothetical protein 0.116
RAD59 Rad59p 0.115
HSL1 Hsl1p 0.113
AKL1 Akl1p 0.110
CDC14 Cdc14p 0.110
RLF2 Rlf2p 0.108
SNT1 Snt1p 0.106
PDS1 Pds1p 0.096
PTK2 Ptk2p 0.096
SET2 Set2p 0.095
HDA2 Hda2p 0.094
RSC8 Rsc8p 0.085
SDS3 Sds3p 0.085
MRC1 Mrc1p 0.083
SIN3 Sin3p 0.080
CTF18 Ctf18p 0.080
MCM3 Mcm3p 0.078
YLR257W hypothetical protein 0.076
SPT21 Spt21p 0.075
CLB5 Clb5p 0.073
CHD1 Chd1p 0.072
HRK1 Hrk1p 0.072
MCM2 Mcm2p 0.069
CAK1 Cak1p 0.069
CYC8 Cyc8p 0.069
MCM10 Mcm10p 0.068
RAD17 Rad17p 0.067
CKA1 Cka1p 0.065
UME6 Ume6p 0.065
TOP1 Top1p 0.065
DBF4 Dbf4p 0.062
CDC7 Cdc7p 0.061
SUM1 Sum1p 0.060
MCM4 Mcm4p 0.057
ORC2 Orc2p 0.054
RAD50 Rad50p 0.053
MCM7 Mcm7p 0.053
SLD3 Sld3p 0.053
MDS3 Mds3p 0.052
PHO23 Pho23p 0.052
HAL5 Hal5p 0.051
RSC58 Rsc58p 0.051
TOF1 Tof1p 0.051
UME1 Ume1p 0.050
TAX4 Tax4p 0.050
RSC9 Rsc9p 0.049
UTR1 Utr1p 0.048
TCO89 Tco89p 0.048
MSI1 Msi1p 0.047
DOC1 Doc1p 0.047
RGC1 Rgc1p 0.047
RFC1 Rfc1p 0.046
ROD1 Rod1p 0.046
BUB1 Bub1p 0.045
RIF1 Rif1p 0.045
ARP4 Arp4p 0.045
YLR177W hypothetical protein 0.044
UBP10 Ubp10p 0.043
CDH1 Cdh1p 0.042
STH1 Sth1p 0.042
CLB6 Clb6p 0.042
PRI1 Pri1p 0.041
CTI6 Cti6p 0.041
FPK1 Fpk1p 0.040
SWI6 Swi6p 0.040
RSC4 Rsc4p 0.040
SIR3 Sir3p 0.040
RRP14 Rrp14p 0.039
CIK1 Cik1p 0.039
DUN1 Dun1p 0.038
CMK2 Cmk2p 0.038
IMG1 Img1p 0.038
SPT16 Spt16p 0.037
YPL260W hypothetical protein 0.037
RSA4 Rsa4p 0.037
RAD5 Rad5p 0.036
HOP1 Hop1p 0.036
HOT1 Hot1p 0.036
KIN82 Kin82p 0.035
SGV1 Sgv1p 0.035
BIT61 Bit61p 0.035
IES3 Ies3p 0.034
RSC2 Rsc2p 0.034
SAE2 Sae2p 0.034
MMS1 Mms1p 0.034
SIP1 Sip1p 0.034
MKS1 Mks1p 0.033
DNA2 Dna2p 0.033
CDC6 Cdc6p 0.033
ACC1 Acc1p 0.032
MSH6 Msh6p 0.031
NRD1 Nrd1p 0.031
AIM21 Aim21p 0.031
EST2 Est2p 0.030