The network for 'negative regulation of leukocyte differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of leukocyte differentiation

Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte differentiation.

Danio rerio
Name Description Probability Func Analog Organism
hhex hematopoietically expressed homeobox 0.289
id1 inhibitor of DNA binding 1 0.276
erbb3b v-erb-b2 erythroblastic leukemia viral oncogene homolog 3b 0.260
ets1a v-ets erythroblastosis virus E26 oncogene homolog 1a 0.244
otx1b orthodenticle homolog 1b 0.238
drl draculin 0.236
wnt8a wingless-type MMTV integration site family, member 8a 0.233
cpox coproporphyrinogen oxidase 0.215
nkx2.5 NK2 transcription factor related 5 0.211
nf1a neurofibromin 1a 0.209
hmgb1b high-mobility group box 1b 0.208
lmo4a LIM domain only 4a 0.204
foxa2 forkhead box A2 0.184
bmp2b bone morphogenetic protein 2b 0.138
bmper BMP binding endothelial regulator 0.124
lft1 lefty1 0.121
mych myelocytomatosis oncogene homolog 0.119
pglyrp6 peptidoglycan recognition protein 6 0.118
foxp1b forkhead box P1b 0.116
crip2 cysteine-rich protein 2 0.112
bcl2l10 BCL2-like 10 (apoptosis facilitator) 0.108
cdx4 caudal type homeo box transcription factor 4 0.107
osr1 odd-skipped related 1 (Drosophila) 0.105
sox2 SRY-box containing gene 2 0.103
hmgb2a high-mobility group box 2a 0.099
sox19b SRY-box containing gene 19b 0.098
fn1 fibronectin 1 0.094
etv2 ets variant gene 2 0.086
prdm1a PR domain containing 1a, with ZNF domain 0.078
rxrga retinoid x receptor, gamma a 0.076
ndr2 nodal-related 2 0.072
raraa retinoic acid receptor, alpha a 0.072
gsc goosecoid 0.064
gata2a GATA-binding protein 2a 0.063
tbx2b T-box 2b 0.062
cxcl12b chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1) 0.062
rbpms2 RNA binding protein with multiple splicing 2 0.062
hmgb1a high-mobility group box 1a 0.058
irf8 interferon regulatory factor 8 0.058
nrarpa notch-regulated ankyrin repeat protein a 0.058
lfng lunatic fringe homolog 0.057
dbx1a developing brain homeobox 1a 0.055
mmp13a matrix metalloproteinase 13a 0.054
cyp26a1 cytochrome P450, subfamily XXVIA, polypeptide 1 0.053
nf1b neurofibromin 1b 0.052
mpx myeloid-specific peroxidase 0.051
bcl2 B-cell leukemia/lymphoma 2 0.051
gsna gelsolin a 0.050
pitx2 paired-like homeodomain transcription factor 2 0.049
tal1 T-cell acute lymphocytic leukemia 1 0.049
hand2 heart and neural crest derivatives expressed transcript 2 0.048
otx2 orthodenticle homolog 2 0.048
angptl2 angiopoietin-like 2 0.048
runx1 runt-related transcription factor 1 0.047
lft2 lefty2 0.047
bambia BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a 0.047
tfr1a transferrin receptor 1a 0.047
aplnrb apelin receptor b 0.046
foxd3 forkhead box D3 0.046
gata1a GATA binding protein 1a 0.045
jag1b jagged 1b 0.045
hoxa2b homeo box A2b 0.044
fev FEV (ETS oncogene family) 0.043
col8a1a collagen, type VIII, alpha 1a 0.042
prrx1a paired related homeobox 1a 0.042
mef2ca myocyte enhancer factor 2ca 0.042
mapk3 mitogen-activated protein kinase 3 0.041
hs3st3b1a heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1a 0.041
znfl2a zinc finger-like gene 2a 0.041
col12a1 collagen, type XII, alpha 1 0.040
pcdh8 protocadherin 8 0.040
rarab retinoic acid receptor, alpha b 0.039
fzd8a frizzled homolog 8a 0.038
cx43 connexin 43 0.038
lef1 lymphocyte enhancer binding factor 1 0.037
wnt11r wingless-type MMTV integration site family, member 11, related 0.037
wu:fb80a07 wu:fb80a07 0.036
gdf6a growth differentiation factor 6a 0.036
dhrs3a dehydrogenase/reductase (SDR family) member 3a 0.036
fzd7b frizzled homolog 7b 0.036
sbno2b strawberry notch homolog 2b 0.034
adora2aa adenosine A2a receptor a 0.034
esd esterase D/formylglutathione hydrolase 0.034
mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.034
cxcl12a chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1) 0.034
anxa11a annexin A11a 0.033
wu:fb58e05 wu:fb58e05 0.033
foxa3 forkhead box A3 0.032
ahcy S-adenosylhomocysteine hydrolase 0.032
hprt1 hypoxanthine phosphoribosyltransferase 1 0.032
znf711 zinc finger protein 711 0.032
slc30a7 solute carrier family 30 (zinc transporter), member 7 0.032
frzb frizzled-related protein 0.031
bmp4 bone morphogenetic protein 4 0.031
foxi3a forkhead box I3a 0.031
mmp14a matrix metalloproteinase 14a (membrane-inserted) 0.030
fli1a friend leukemia integration 1a 0.030
fli1b friend leukemia integration 1b 0.030
sdc2 syndecan 2 0.030
sepp1a selenoprotein P, plasma, 1a 0.030
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
C1QA complement component 1, q subcomponent, A chain 0.998
HLA-C major histocompatibility complex, class I, C 0.996
B2M beta-2-microglobulin 0.986
ZNF43 zinc finger protein 43 0.985
HLA-A major histocompatibility complex, class I, A 0.982
HLA-B major histocompatibility complex, class I, B 0.974
CD80 CD80 molecule 0.883
IL4R interleukin 4 receptor 0.881
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.861
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 0.849
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 0.834
PILRA paired immunoglobin-like type 2 receptor alpha 0.791
HOXB5 homeobox B5 0.787
ZNF253 zinc finger protein 253 0.776
TAL1 T-cell acute lymphocytic leukemia 1 0.731
HLA-E major histocompatibility complex, class I, E 0.726
CD86 CD86 molecule 0.630
BMPR1A bone morphogenetic protein receptor, type IA 0.606
ZNF675 zinc finger protein 675 0.558
HLA-G major histocompatibility complex, class I, G 0.549
CCR5 chemokine (C-C motif) receptor 5 0.535
ZNF273 zinc finger protein 273 0.533
NCOR2 nuclear receptor corepressor 2 0.502
HLA-F major histocompatibility complex, class I, F 0.480
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.470
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.458
HLA-DMA major histocompatibility complex, class II, DM alpha 0.455
CDK6 cyclin-dependent kinase 6 0.435
RXRA retinoid X receptor, alpha 0.424
HOXA10 homeobox A10 0.409
CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 0.403
FSTL1 follistatin-like 1 0.336
CCL4 chemokine (C-C motif) ligand 4 0.311
CCND1 cyclin D1 0.290
EPOR erythropoietin receptor 0.290
RUNX1 runt-related transcription factor 1 0.268
ZNF430 zinc finger protein 430 0.255
ZNF117 zinc finger protein 117 0.252
CXCL9 chemokine (C-X-C motif) ligand 9 0.208
MDFI MyoD family inhibitor 0.207
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 0.198
GRAP2 GRB2-related adaptor protein 2 0.175
CCL2 chemokine (C-C motif) ligand 2 0.170
HOXA7 homeobox A7 0.169
GHR growth hormone receptor 0.165
ZNF91 zinc finger protein 91 0.165
CXCL10 chemokine (C-X-C motif) ligand 10 0.162
TAPBP TAP binding protein (tapasin) 0.158
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 0.151
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin 0.150
HOXA5 homeobox A5 0.150
ZNF93 zinc finger protein 93 0.149
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila) 0.145
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 0.139
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 0.132
ICAM1 intercellular adhesion molecule 1 0.132
BMP2 bone morphogenetic protein 2 0.131
GAB1 GRB2-associated binding protein 1 0.130
ZNF254 zinc finger protein 254 0.128
CCL13 chemokine (C-C motif) ligand 13 0.128
ZNF708 zinc finger protein 708 0.127
C1QC complement component 1, q subcomponent, C chain 0.121
HOXB3 homeobox B3 0.117
SKI v-ski sarcoma viral oncogene homolog (avian) 0.115
CD14 CD14 molecule 0.106
C1QB complement component 1, q subcomponent, B chain 0.105
HOXA11 homeobox A11 0.104
CCL8 chemokine (C-C motif) ligand 8 0.102
CCND3 cyclin D3 0.100
IL4 interleukin 4 0.098
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.098
TUBA1A tubulin, alpha 1a 0.095
HOXB9 homeobox B9 0.094
CCR1 chemokine (C-C motif) receptor 1 0.094
TMEM176B transmembrane protein 176B 0.088
RBBP4 retinoblastoma binding protein 4 0.088
ZNF85 zinc finger protein 85 0.082
IL2RG interleukin 2 receptor, gamma 0.081
ITCH itchy E3 ubiquitin protein ligase homolog (mouse) 0.079
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32) 0.078
PINK1 PTEN induced putative kinase 1 0.077
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.076
ZNF680 zinc finger protein 680 0.075
SH3BP2 SH3-domain binding protein 2 0.075
RARA retinoic acid receptor, alpha 0.071
CCL22 chemokine (C-C motif) ligand 22 0.069
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.067
CCL5 chemokine (C-C motif) ligand 5 0.067
HOXB6 homeobox B6 0.067
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.066
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.063
SIGLEC7 sialic acid binding Ig-like lectin 7 0.059
DDB1 damage-specific DNA binding protein 1, 127kDa 0.057
CCL19 chemokine (C-C motif) ligand 19 0.057
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 0.055
SLAMF1 signaling lymphocytic activation molecule family member 1 0.054
CD40 CD40 molecule, TNF receptor superfamily member 5 0.054
CCR7 chemokine (C-C motif) receptor 7 0.054
HOXB7 homeobox B7 0.054
TYMP thymidine phosphorylase 0.051
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Mus musculus
Name Description Probability Func Analog Organism
Stat3 signal transducer and activator of transcription 3 0.999
Ikzf1 IKAROS family zinc finger 1 0.997
Trp53 transformation related protein 53 0.995
Gli2 GLI-Kruppel family member GLI2 0.994
Igh immunoglobulin heavy chain complex 0.990
Robo1 roundabout homolog 1 (Drosophila) 0.990
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.978
Nf1 neurofibromatosis 1 0.971
Rara retinoic acid receptor, alpha 0.957
Pten phosphatase and tensin homolog 0.954
Fgfr2 fibroblast growth factor receptor 2 0.950
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.933
Zeb1 zinc finger E-box binding homeobox 1 0.926
Sox9 SRY-box containing gene 9 0.925
Rxra retinoid X receptor alpha 0.919
Csf2rb2 colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage) 0.918
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.908
Tgfb1 transforming growth factor, beta 1 0.900
Id3 inhibitor of DNA binding 3 0.887
Foxp3 forkhead box P3 0.876
Bcl3 B-cell leukemia/lymphoma 3 0.860
Jak2 Janus kinase 2 0.829
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.827
Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.806
Id1 inhibitor of DNA binding 1 0.800
Ctnnb1 catenin (cadherin associated protein), beta 1 0.796
Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 0.782
Rb1 retinoblastoma 1 0.773
Fgf10 fibroblast growth factor 10 0.769
Cdkn2c cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 0.760
Pik3ca phosphatidylinositol 3-kinase, catalytic, alpha polypeptide 0.758
Sfpi1 SFFV proviral integration 1 0.748
Il6st interleukin 6 signal transducer 0.727
Trp63 transformation related protein 63 0.710
Slit3 slit homolog 3 (Drosophila) 0.668
Stat6 signal transducer and activator of transcription 6 0.665
Slit2 slit homolog 2 (Drosophila) 0.651
Cd40 CD40 antigen 0.650
Apc adenomatosis polyposis coli 0.649
Ptch1 patched homolog 1 0.646
Notch1 Notch gene homolog 1 (Drosophila) 0.643
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.603
Ptprc protein tyrosine phosphatase, receptor type, C 0.600
Csf1 colony stimulating factor 1 (macrophage) 0.586
Tgfb2 transforming growth factor, beta 2 0.579
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.573
Sfrp2 secreted frizzled-related protein 2 0.563
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.555
Rarg retinoic acid receptor, gamma 0.554
Cbl Casitas B-lineage lymphoma 0.540
Dok1 docking protein 1 0.525
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.520
Irf8 interferon regulatory factor 8 0.519
Robo2 roundabout homolog 2 (Drosophila) 0.517
Kit kit oncogene 0.503
Socs3 suppressor of cytokine signaling 3 0.499
Pax3 paired box gene 3 0.494
Gli3 GLI-Kruppel family member GLI3 0.494
Cd19 CD19 antigen 0.458
Rarb retinoic acid receptor, beta 0.444
Tcf3 transcription factor 3 0.436
Bmp4 bone morphogenetic protein 4 0.427
Chd7 chromodomain helicase DNA binding protein 7 0.405
Tbx2 T-box 2 0.384
Sox10 SRY-box containing gene 10 0.373
Jak3 Janus kinase 3 0.369
Tnf tumor necrosis factor 0.367
H2-DMa histocompatibility 2, class II, locus DMa 0.356
Mdm4 transformed mouse 3T3 cell double minute 4 0.353
Tcirg1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3 0.343
Mdm2 transformed mouse 3T3 cell double minute 2 0.329
Plcg1 phospholipase C, gamma 1 0.323
Twist2 twist homolog 2 (Drosophila) 0.319
Il2rb interleukin 2 receptor, beta chain 0.317
Rag1 recombination activating gene 1 0.306
Erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.297
Cdkn2a cyclin-dependent kinase inhibitor 2A 0.293
Trp73 transformation related protein 73 0.291
Blnk B-cell linker 0.288
Lepr leptin receptor 0.285
Mapk8 mitogen-activated protein kinase 8 0.282
Foxn1 forkhead box N1 0.280
Epor erythropoietin receptor 0.279
Stat2 signal transducer and activator of transcription 2 0.277
Tcra T-cell receptor alpha chain 0.272
Prdm1 PR domain containing 1, with ZNF domain 0.266
Kdr kinase insert domain protein receptor 0.257
Ret ret proto-oncogene 0.253
Gpr97 G protein-coupled receptor 97 0.252
Hhex hematopoietically expressed homeobox 0.247
Icos inducible T-cell co-stimulator 0.239
H2-Aa histocompatibility 2, class II antigen A, alpha 0.239
Msh2 mutS homolog 2 (E. coli) 0.238
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.229
Sorbs3 sorbin and SH3 domain containing 3 0.228
Fgf9 fibroblast growth factor 9 0.224
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.220
Dll1 delta-like 1 (Drosophila) 0.220
Sfrp1 secreted frizzled-related protein 1 0.219
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.218
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Rattus norvegicus
Name Description Probability Func Analog Organism
Rpl15 ribosomal protein L15 0.116
Rps12 ribosomal protein S12 0.111
LOC100362298 ribosomal protein S18-like 0.072
Rps6 ribosomal protein S6 0.064
LOC499782 similar to 60S ribosomal protein L12 0.052
Rps15 ribosomal protein S15 0.048
Rpl5 ribosomal protein L5 0.039
Nme2 non-metastatic cells 2, protein (NM23B) expressed in 0.030
Rpl4 ribosomal protein L4 0.016
Anxa1 annexin A1 0.012
Rpl10a ribosomal protein L10A 0.012
Rpl28 ribosomal protein L28 0.012
Rps7 ribosomal protein S7 0.012
Dhx15 DEAH (Asp-Glu-Ala-His) box polypeptide 15 0.012
Gnb2l1 guanine nucleotide binding protein (G protein), beta polypeptide 2 like 1 0.011
RGD1304704 similar to Hypothetical protein CGI-99 0.011
Tcea1 transcription elongation factor A (SII) 1 0.011
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism