The network for 'replicative cell aging' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

replicative cell aging

The process associated with progression of the cell from its inception to the end of its lifespan that occurs as the cell continues cycles of growth and division.

Danio rerio
Name Description Probability Func Analog Organism
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit 0.766
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.514
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit 0.452
APLF aprataxin and PNKP like factor 0.430
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit 0.340
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.265
H2AFX H2A histone family, member X 0.255
RAD52 RAD52 homolog (S. cerevisiae) 0.206
RALBP1 ralA binding protein 1 0.167
TERF2IP telomeric repeat binding factor 2, interacting protein 0.136
CHAF1A chromatin assembly factor 1, subunit A (p150) 0.119
PDK1 pyruvate dehydrogenase kinase, isozyme 1 0.115
BLM Bloom syndrome, RecQ helicase-like 0.112
PGAM1 phosphoglycerate mutase 1 (brain) 0.108
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.108
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.107
PPP6R2 protein phosphatase 6, regulatory subunit 2 0.106
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.102
TOP3A topoisomerase (DNA) III alpha 0.096
WRN Werner syndrome, RecQ helicase-like 0.092
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 0.092
STK4 serine/threonine kinase 4 0.086
TERF2 telomeric repeat binding factor 2 0.085
MUS81 MUS81 endonuclease homolog (S. cerevisiae) 0.080
SATB2 SATB homeobox 2 0.075
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4 0.072
CABLES1 Cdk5 and Abl enzyme substrate 1 0.069
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.065
KRT5 keratin 5 0.063
ENO2 enolase 2 (gamma, neuronal) 0.057
TINF2 TERF1 (TRF1)-interacting nuclear factor 2 0.056
PARP1 poly (ADP-ribose) polymerase 1 0.055
NBN nibrin 0.054
TXN thioredoxin 0.049
PGK1 phosphoglycerate kinase 1 0.048
DCLRE1B DNA cross-link repair 1B 0.048
NEK6 NIMA (never in mitosis gene a)-related kinase 6 0.046
RALGDS ral guanine nucleotide dissociation stimulator 0.040
RASSF1 Ras association (RalGDS/AF-6) domain family member 1 0.039
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B 0.037
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 0.036
APTX aprataxin 0.035
SLC39A1 solute carrier family 39 (zinc transporter), member 1 0.035
SLX4 SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae) 0.034
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c 0.033
RASSF5 Ras association (RalGDS/AF-6) domain family member 5 0.032
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit 0.030
SNX18 sorting nexin 18 0.030
ANKRD28 ankyrin repeat domain 28 0.029
RAP1A RAP1A, member of RAS oncogene family 0.028
RIN1 Ras and Rab interactor 1 0.028
TSPAN4 tetraspanin 4 0.027
PAWR PRKC, apoptosis, WT1, regulator 0.027
STARD7 StAR-related lipid transfer (START) domain containing 7 0.027
VDAC1 voltage-dependent anion channel 1 0.027
ABL2 v-abl Abelson murine leukemia viral oncogene homolog 2 0.026
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.026
KRT6C keratin 6C 0.026
UBQLN1 ubiquilin 1 0.025
MAP2K1 mitogen-activated protein kinase kinase 1 0.025
PEBP1 phosphatidylethanolamine binding protein 1 0.025
MRPL27 mitochondrial ribosomal protein L27 0.024
RASSF2 Ras association (RalGDS/AF-6) domain family member 2 0.023
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.023
EME1 essential meiotic endonuclease 1 homolog 1 (S. pombe) 0.023
PEBP4 phosphatidylethanolamine-binding protein 4 0.022
MRPL53 mitochondrial ribosomal protein L53 0.022
GMFB glia maturation factor, beta 0.022
TUBA4A tubulin, alpha 4a 0.021
GABARAPL2 GABA(A) receptor-associated protein-like 2 0.020
NHEJ1 nonhomologous end-joining factor 1 0.020
CD151 CD151 molecule (Raph blood group) 0.020
GCKR glucokinase (hexokinase 4) regulator 0.020
CDV3 CDV3 homolog (mouse) 0.020
S1PR5 sphingosine-1-phosphate receptor 5 0.020
NMNAT1 nicotinamide nucleotide adenylyltransferase 1 0.020
PPIA peptidylprolyl isomerase A (cyclophilin A) 0.020
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.020
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.019
PSEN2 presenilin 2 (Alzheimer disease 4) 0.018
RALB v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein) 0.018
MOBKL1A MOB1, Mps One Binder kinase activator-like 1A (yeast) 0.018
PDE4DIP phosphodiesterase 4D interacting protein 0.018
GADD45G growth arrest and DNA-damage-inducible, gamma 0.017
TP73 tumor protein p73 0.017
CHUK conserved helix-loop-helix ubiquitous kinase 0.017
IGSF21 immunoglobin superfamily, member 21 0.017
TPI1 triosephosphate isomerase 1 0.017
SRI sorcin 0.017
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.016
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa 0.016
ATM ataxia telangiectasia mutated 0.016
TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa 0.016
RAD51 RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) 0.016
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 0.016
FBXO4 F-box protein 4 0.016
ALDOA aldolase A, fructose-bisphosphate 0.015
SIRT1 sirtuin 1 0.015
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa 0.015
SNX9 sorting nexin 9 0.015
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Mus musculus
Name Description Probability Func Analog Organism
Apc adenomatosis polyposis coli 0.032
Prkab1 protein kinase, AMP-activated, beta 1 non-catalytic subunit 0.017
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.017
Trp53 transformation related protein 53 0.016
Grb2 growth factor receptor bound protein 2 0.016
Pik3ca phosphatidylinositol 3-kinase, catalytic, alpha polypeptide 0.015
Egfr epidermal growth factor receptor 0.015
Raf1 v-raf-leukemia viral oncogene 1 0.015
Pten phosphatase and tensin homolog 0.012
Prkaa1 protein kinase, AMP-activated, alpha 1 catalytic subunit 0.012
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.012
Adam17 a disintegrin and metallopeptidase domain 17 0.011
Braf Braf transforming gene 0.011
Nf1 neurofibromatosis 1 0.011
Prkag1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit 0.010
Shc1 src homology 2 domain-containing transforming protein C1 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
SIR2 Sir2p 0.554
MIG1 Mig1p 0.387
CSR2 Csr2p 0.346
MMS22 Mms22p 0.222
DEF1 Def1p 0.209
SNF1 Snf1p 0.206
PHB2 Phb2p 0.182
MDS3 Mds3p 0.176
PHB1 Phb1p 0.167
SIP2 Sip2p 0.158
LAC1 Lac1p 0.152
FOB1 Fob1p 0.148
TOR2 Tor2p 0.139
TOF2 Tof2p 0.130
RFA1 Rfa1p 0.128
YAT1 Yat1p 0.124
MNN9 Mnn9p 0.122
HAL5 Hal5p 0.118
TRA1 Tra1p 0.114
NET1 Net1p 0.112
MOB1 Mob1p 0.111
NDI1 Ndi1p 0.105
CPR1 Cpr1p 0.104
RAS2 Ras2p 0.104
HHO1 Hho1p 0.104
POP2 Pop2p 0.103
HSP78 Hsp78p 0.095
HXT3 Hxt3p 0.092
YTA12 Yta12p 0.092
IRC8 Irc8p 0.091
LAG1 Lag1p 0.091
GIS1 Gis1p 0.091
SIN3 Sin3p 0.090
PEX5 Pex5p 0.085
EXO1 Exo1p 0.084
YKR075C hypothetical protein 0.084
PUT2 Put2p 0.082
AVO1 Avo1p 0.081
DNM1 Dnm1p 0.081
BCY1 Bcy1p 0.081
HST1 Hst1p 0.080
LIP1 Lip1p 0.079
GIS4 Gis4p 0.079
HHT1 Hht1p 0.077
CDC6 Cdc6p 0.076
CRZ1 Crz1p 0.075
YDR026C hypothetical protein 0.074
YPL014W hypothetical protein 0.073
SFG1 Sfg1p 0.073
HOS4 Hos4p 0.072
RAD51 Rad51p 0.072
TRR1 Trr1p 0.070
PHO23 Pho23p 0.068
SLX4 Slx4p 0.066
RPD3 Rpd3p 0.065
TOS3 Tos3p 0.064
ROX1 Rox1p 0.064
RLM1 Rlm1p 0.064
PRR2 Prr2p 0.063
AGP2 Agp2p 0.062
RIM1 Rim1p 0.061
CDC4 Cdc4p 0.061
HXT1 Hxt1p 0.057
ADR1 Adr1p 0.056
YNL194C hypothetical protein 0.056
GPH1 Gph1p 0.056
PUT3 Put3p 0.053
SCH9 Sch9p 0.053
BMH2 Bmh2p 0.053
GLN3 Gln3p 0.052
YKU70 Yku70p 0.051
ICY1 Icy1p 0.051
AHP1 Ahp1p 0.050
YDR506C hypothetical protein 0.050
AFT1 Aft1p 0.049
LYS5 Lys5p 0.049
IRA1 Ira1p 0.049
SNT1 Snt1p 0.049
HXK2 Hxk2p 0.049
ACE2 Ace2p 0.048
YCL042W hypothetical protein 0.047
PEX1 Pex1p 0.047
DNA2 Dna2p 0.046
SOD2 Sod2p 0.046
SNF4 Snf4p 0.046
NUP157 Nup157p 0.045
SAM2 Sam2p 0.045
UGA3 Uga3p 0.045
PET494 Pet494p 0.045
DCS2 Dcs2p 0.044
FPR1 Fpr1p 0.044
GPB2 Gpb2p 0.044
SGF73 Sgf73p 0.043
ALD6 Ald6p 0.043
GPI8 Gpi8p 0.043
GSF2 Gsf2p 0.042
APN1 Apn1p 0.042
CCT2 Cct2p 0.042
GIP2 Gip2p 0.042
YBR235W hypothetical protein 0.042