The network for 'cardiac cell fate commitment' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cardiac cell fate commitment

The commitment of cells to specific cardiac cell fates and their capacity to differentiate into cardiac cells. Cardiac cells are cells that comprise the organ which pumps blood through the circulatory system.

Danio rerio
Name Description Probability Func Analog Organism
neo1 neogenin 1 0.982
gata6 GATA-binding protein 6 0.941
notch3 notch homolog 3 0.925
etv2 ets variant gene 2 0.884
tbx5a T-box 5a 0.873
wnt2bb wingless-type MMTV integration site family, member 2Bb 0.867
tbx20 T-box 20 0.845
mespb mesoderm posterior b 0.843
spaw southpaw 0.808
kdrl kinase insert domain receptor like 0.792
nr2f2 nuclear receptor subfamily 2, group F, member 2 0.781
flt4 fms-related tyrosine kinase 4 0.763
robo3 roundabout homolog 3 0.752
wnt1 wingless-type MMTV integration site family, member 1 0.709
jag2 jagged 2 0.708
tal1 T-cell acute lymphocytic leukemia 1 0.642
cdh2 cadherin 2, neuronal 0.627
dcc deleted in colorectal carcinoma 0.619
yap1 Yes-associated protein 1 0.606
hnf1ba HNF1 homeobox Ba 0.542
sox7 SRY-box containing gene 7 0.523
nr2f1a nuclear receptor subfamily 2, group F, member 1a 0.523
hoxa11a homeo box A11a 0.463
robo1 roundabout homolog 1 0.431
hey2 hairy/enhancer-of-split related with YRPW motif 2 0.397
has2 hyaluronan synthase 2 0.383
wt1a wilms tumor 1a 0.368
gata2a GATA-binding protein 2a 0.367
osr2 odd-skipped related 2 (Drosophila) 0.367
si:ch211-235f6.2 si:ch211-235f6.2 0.360
her7 hairy and enhancer of split related-7 0.347
mespa mesoderm posterior a 0.347
wnt3 wingless-type MMTV integration site family, member 3 0.346
irx1a iroquois homeobox protein 1, a 0.342
tie1 endothelium-specific receptor tyrosine kinase 1 0.329
lft1 lefty1 0.328
tbx1 T-box 1 0.316
gli1 GLI-Kruppel family member 1 0.311
fli1a friend leukemia integration 1a 0.298
wnt4a wingless-type MMTV integration site family, member 4a 0.298
tp73 tumor protein p73 0.292
pcdh8 protocadherin 8 0.289
tbx2a T-box gene 2a 0.288
pax2a paired box gene 2a 0.280
pcdh10b protocadherin 10b 0.265
tbx6 T-box gene 6 0.263
fn1 fibronectin 1 0.252
arnt2 aryl hydrocarbon receptor nuclear translocator 2 0.252
nfatc1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 0.251
tbx2b T-box 2b 0.240
mef2cb myocyte enhancer factor 2cb 0.232
znf703 zinc finger protein 703 0.230
cdh5 cadherin 5 0.227
nrp1a neuropilin 1a 0.221
lft2 lefty2 0.221
hey1 hairy/enhancer-of-split related with YRPW motif 1 0.214
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.207
rbfox2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.204
irx5a iroquois homeobox protein 5a 0.204
gata4 GATA-binding protein 4 0.204
sox17 SRY-box containing gene 17 0.203
olig2 oligodendrocyte lineage transcription factor 2 0.196
sim1a single-minded homolog 1a (Drosophila) 0.183
hhex hematopoietically expressed homeobox 0.182
axin2 axin 2 (conductin, axil) 0.180
jag1b jagged 1b 0.178
otx2 orthodenticle homolog 2 0.175
irx1b iroquois homeobox protein 1, b 0.172
dag1 dystroglycan 1 0.163
aplnrb apelin receptor b 0.161
isl2a islet2a 0.158
fzd7a frizzled homolog 7a 0.157
gro2 groucho 2 0.156
fli1b friend leukemia integration 1b 0.156
pax6a paired box gene 6a 0.155
waca WW domain containing adaptor with coiled-coil a 0.155
gbx2 gastrulation brain homeo box 2 0.153
igf1rb insulin-like growth factor 1b receptor 0.151
hnf1bb HNF1 homeobox Bb 0.151
elk4 ELK4, ETS-domain protein 0.149
her1 hairy-related 1 0.149
tll1 tolloid-like 1 0.148
foxc1a forkhead box C1a 0.148
vegfaa vascular endothelial growth factor Aa 0.148
tcf7l2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.148
prox1 prospero-related homeobox gene 1 0.146
ncs1a neuronal calcium sensor 1a 0.139
lhx2b LIM homeobox 2b 0.137
nkx2.5 NK2 transcription factor related 5 0.136
unc5b unc-5 homolog B (C. elegans) 0.134
rfx2 regulatory factor X, 2 (influences HLA class II expression) 0.132
ptprsa protein tyrosine phosphatase, receptor type, s, a 0.131
dld deltaD 0.120
rgma RGM domain family, member A 0.119
wnt2ba wingless-type MMTV integration site family, member 2Ba 0.118
six3a sine oculis homeobox homolog 3a 0.115
gng2 guanine nucleotide binding protein (G protein), gamma 2 0.113
ef1 ETS-related factor1 0.112
pbx4 pre-B-cell leukemia transcription factor 4 0.110
ascl1a achaete-scute complex-like 1a (Drosophila) 0.108
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
sli slit 0.960
Ubx Ultrabithorax 0.943
en engrailed 0.887
wg wingless 0.878
InR Insulin-like receptor 0.812
ush u-shaped 0.802
zfh1 Zn finger homeodomain 1 0.770
Ser Serrate 0.736
stumps CG31317 gene product from transcript CG31317-RC 0.704
slp1 sloppy paired 1 0.703
lea leak 0.697
tin tinman 0.678
robo roundabout 0.616
Mad Mothers against dpp 0.600
rib ribbon 0.593
shn schnurri 0.560
twi twist 0.547
mid midline 0.540
csw corkscrew 0.484
Egfr Epidermal growth factor receptor 0.442
hh hedgehog 0.432
hep hemipterous 0.430
dpp decapentaplegic 0.402
arm armadillo 0.390
numb CG3779 gene product from transcript CG3779-RB 0.358
dsh dishevelled 0.358
robo3 CG5423 gene product from transcript CG5423-RA 0.337
abd-A abdominal A 0.300
Dad Daughters against dpp 0.298
Kr Kruppel 0.286
dac dachshund 0.258
Tl Toll 0.214
Doc2 Dorsocross2 0.202
disco disconnected 0.202
sens senseless 0.201
pan pangolin 0.197
ci cubitus interruptus 0.176
shi shibire 0.150
dally division abnormally delayed 0.142
bab2 CG9102 gene product from transcript CG9102-RA 0.140
hkb huckebein 0.139
mam mastermind 0.137
hth homothorax 0.136
lab labial 0.135
HLH54F CG5005 gene product from transcript CG5005-RA 0.134
nkd naked cuticle 0.131
sqz squeeze 0.125
htl heartless 0.115
eve even skipped 0.114
emc extra macrochaetae 0.111
nej nejire 0.107
slou slouch 0.105
kn knot 0.105
run runt 0.100
tld tolloid 0.094
raw CG12437 gene product from transcript CG12437-RB 0.090
fkh fork head 0.089
aop anterior open 0.087
gsb gooseberry 0.083
bin biniou 0.083
pnr pannier 0.083
fz frizzled 0.081
sog short gastrulation 0.080
insc inscuteable 0.079
nos nanos 0.078
Notum CG13076 gene product from transcript CG13076-RB 0.078
pdm2 POU domain protein 2 0.076
tll tailless 0.073
vvl ventral veins lacking 0.072
G-oalpha47A G protein oalpha 47A 0.071
Antp Antennapedia 0.071
spdo sanpodo 0.070
brk brinker 0.069
comm commissureless 0.069
slp2 sloppy paired 2 0.067
C15 CG7937 gene product from transcript CG7937-RA 0.067
rho rhomboid 0.064
Hand CG18144 gene product from transcript CG18144-RA 0.064
scw screw 0.061
salm spalt major 0.061
fas faint sausage 0.059
nau nautilus 0.058
CG14869 CG14869 gene product from transcript CG14869-RB 0.056
al aristaless 0.056
ftz fushi tarazu 0.056
mys myospheroid 0.055
kirre kin of irre 0.052
mask multiple ankyrin repeats single KH domain 0.051
put punt 0.050
nmo nemo 0.050
spen split ends 0.050
sob sister of odd and bowl 0.049
nub nubbin 0.049
Dll Distal-less 0.048
wb wing blister 0.048
grn grain 0.046
Lim3 CG10699 gene product from transcript CG10699-RB 0.044
fz2 frizzled 2 0.044
kkv krotzkopf verkehrt 0.042
l(2)gl lethal (2) giant larvae 0.042
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Homo sapiens
Name Description Probability Func Analog Organism
JAG1 jagged 1 0.981
NOTCH1 notch 1 0.867
FOXD3 forkhead box D3 0.858
PAX3 paired box 3 0.759
POU3F2 POU class 3 homeobox 2 0.653
SP1 Sp1 transcription factor 0.635
POU5F1 POU class 5 homeobox 1 0.619
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.618
DVL3 dishevelled, dsh homolog 3 (Drosophila) 0.524
SMAD7 SMAD family member 7 0.424
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.363
BMP2 bone morphogenetic protein 2 0.360
TBX5 T-box 5 0.321
FKBP1A FK506 binding protein 1A, 12kDa 0.309
TGFB1 transforming growth factor, beta 1 0.305
DVL1 dishevelled, dsh homolog 1 (Drosophila) 0.243
NOTCH3 notch 3 0.226
LRP6 low density lipoprotein receptor-related protein 6 0.186
SOX10 SRY (sex determining region Y)-box 10 0.156
GATA4 GATA binding protein 4 0.114
SOX2 SRY (sex determining region Y)-box 2 0.083
WWP2 WW domain containing E3 ubiquitin protein ligase 2 0.064
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.055
MAML1 mastermind-like 1 (Drosophila) 0.054
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.054
ENG endoglin 0.049
WT1 Wilms tumor 1 0.041
DLL1 delta-like 1 (Drosophila) 0.039
ACVR1 activin A receptor, type I 0.036
LRRK2 leucine-rich repeat kinase 2 0.035
POU3F3 POU class 3 homeobox 3 0.034
APC adenomatous polyposis coli 0.033
BHLHE23 basic helix-loop-helix family, member e23 0.032
JUN jun proto-oncogene 0.031
AXIN1 axin 1 0.030
FSTL1 follistatin-like 1 0.030
CSNK1E casein kinase 1, epsilon 0.029
SOX1 SRY (sex determining region Y)-box 1 0.029
FZD1 frizzled homolog 1 (Drosophila) 0.028
GDF5 growth differentiation factor 5 0.028
FOXC2 forkhead box C2 (MFH-1, mesenchyme forkhead 1) 0.026
SNIP1 Smad nuclear interacting protein 1 0.024
FGF3 fibroblast growth factor 3 0.024
SFRP5 secreted frizzled-related protein 5 0.024
PRKG1 protein kinase, cGMP-dependent, type I 0.024
OTP orthopedia homeobox 0.023
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.022
TBX2 T-box 2 0.021
AR androgen receptor 0.021
BMPR1A bone morphogenetic protein receptor, type IA 0.021
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.021
MEOX2 mesenchyme homeobox 2 0.020
FAM46A family with sequence similarity 46, member A 0.020
NR5A1 nuclear receptor subfamily 5, group A, member 1 0.020
LBX1 ladybird homeobox 1 0.020
FGF8 fibroblast growth factor 8 (androgen-induced) 0.019
LMX1A LIM homeobox transcription factor 1, alpha 0.019
JAG2 jagged 2 0.018
CTNNBIP1 catenin, beta interacting protein 1 0.017
FGF18 fibroblast growth factor 18 0.017
HCFC1 host cell factor C1 (VP16-accessory protein) 0.017
CPE carboxypeptidase E 0.017
DAXX death-domain associated protein 0.016
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.016
SOX21 SRY (sex determining region Y)-box 21 0.016
GBX2 gastrulation brain homeobox 2 0.016
PDX1 pancreatic and duodenal homeobox 1 0.016
LHX5 LIM homeobox 5 0.015
CEP164 centrosomal protein 164kDa 0.015
NEUROG3 neurogenin 3 0.014
LHX3 LIM homeobox 3 0.014
BMP4 bone morphogenetic protein 4 0.014
TGFB3 transforming growth factor, beta 3 0.014
FOXE1 forkhead box E1 (thyroid transcription factor 2) 0.014
GATA5 GATA binding protein 5 0.014
WNT1 wingless-type MMTV integration site family, member 1 0.014
RAX retina and anterior neural fold homeobox 0.014
HIC1 hypermethylated in cancer 1 0.013
TWIST2 twist homolog 2 (Drosophila) 0.013
TLX2 T-cell leukemia homeobox 2 0.013
HOXB13 homeobox B13 0.012
CTNND1 catenin (cadherin-associated protein), delta 1 0.012
TBX1 T-box 1 0.012
MARCKSL1 MARCKS-like 1 0.012
NPAS1 neuronal PAS domain protein 1 0.012
TP73 tumor protein p73 0.011
SLC6A2 solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 0.011
RFWD2 ring finger and WD repeat domain 2 0.011
DLX4 distal-less homeobox 4 0.011
POU3F1 POU class 3 homeobox 1 0.011
PAX6 paired box 6 0.011
LHX1 LIM homeobox 1 0.011
PAX7 paired box 7 0.010
ST8SIA2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 0.010
ATXN1L ataxin 1-like 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Shh sonic hedgehog 1.000
Fgf8 fibroblast growth factor 8 0.994
Otx2 orthodenticle homolog 2 (Drosophila) 0.993
Gli3 GLI-Kruppel family member GLI3 0.987
Pax3 paired box gene 3 0.985
Vangl2 vang-like 2 (van gogh, Drosophila) 0.981
Pitx2 paired-like homeodomain transcription factor 2 0.974
Pax2 paired box gene 2 0.966
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.965
Sox9 SRY-box containing gene 9 0.956
Tbx3 T-box 3 0.946
Fgfr2 fibroblast growth factor receptor 2 0.946
Lhx1 LIM homeobox protein 1 0.933
Ctnnb1 catenin (cadherin associated protein), beta 1 0.932
Gata4 GATA binding protein 4 0.924
Foxc1 forkhead box C1 0.908
Hand1 heart and neural crest derivatives expressed transcript 1 0.894
Hand2 heart and neural crest derivatives expressed transcript 2 0.887
Sox2 SRY-box containing gene 2 0.825
Gli2 GLI-Kruppel family member GLI2 0.820
Pou5f1 POU domain, class 5, transcription factor 1 0.742
Pax6 paired box gene 6 0.698
Emx1 empty spiracles homolog 1 (Drosophila) 0.683
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.662
Pitx1 paired-like homeodomain transcription factor 1 0.658
Foxc2 forkhead box C2 0.627
Emx2 empty spiracles homolog 2 (Drosophila) 0.624
Fgfr1 fibroblast growth factor receptor 1 0.618
Alx4 aristaless-like homeobox 4 0.602
Tcfap2a transcription factor AP-2, alpha 0.583
Isl1 ISL1 transcription factor, LIM/homeodomain 0.560
Pten phosphatase and tensin homolog 0.547
Bmp4 bone morphogenetic protein 4 0.543
Wnt3a wingless-related MMTV integration site 3A 0.513
Wt1 Wilms tumor 1 homolog 0.501
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.453
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.420
Meox2 mesenchyme homeobox 2 0.370
Notch1 Notch gene homolog 1 (Drosophila) 0.340
Tgfb2 transforming growth factor, beta 2 0.323
Lmx1a LIM homeobox transcription factor 1 alpha 0.311
Rxra retinoid X receptor alpha 0.300
Gata6 GATA binding protein 6 0.286
Hoxa1 homeobox A1 0.275
Nog noggin 0.252
Chd7 chromodomain helicase DNA binding protein 7 0.223
Fgf10 fibroblast growth factor 10 0.221
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.218
Robo1 roundabout homolog 1 (Drosophila) 0.211
Pou3f3 POU domain, class 3, transcription factor 3 0.200
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.193
Sox11 SRY-box containing gene 11 0.190
Dll4 delta-like 4 (Drosophila) 0.190
Lhx9 LIM homeobox protein 9 0.189
Nos3 nitric oxide synthase 3, endothelial cell 0.183
Msx1 homeobox, msh-like 1 0.176
Rarg retinoic acid receptor, gamma 0.173
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.172
Hoxd13 homeobox D13 0.164
Tbx1 T-box 1 0.158
Hoxa13 homeobox A13 0.158
Nodal nodal 0.153
Vegfa vascular endothelial growth factor A 0.146
Vangl1 vang-like 1 (van gogh, Drosophila) 0.141
Sall4 sal-like 4 (Drosophila) 0.139
Jag1 jagged 1 0.135
She src homology 2 domain-containing transforming protein E 0.134
Wnt6 wingless-related MMTV integration site 6 0.132
Foxg1 forkhead box G1 0.125
Pax8 paired box gene 8 0.123
Hspg2 perlecan (heparan sulfate proteoglycan 2) 0.120
En1 engrailed 1 0.119
Alx3 aristaless-like homeobox 3 0.118
Lmx1b LIM homeobox transcription factor 1 beta 0.116
Prrx1 paired related homeobox 1 0.113
Fgfr3 fibroblast growth factor receptor 3 0.111
Otx1 orthodenticle homolog 1 (Drosophila) 0.110
Gbx2 gastrulation brain homeobox 2 0.106
Mesp1 mesoderm posterior 1 0.103
Smad6 MAD homolog 6 (Drosophila) 0.099
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.094
Apc adenomatosis polyposis coli 0.092
Gdnf glial cell line derived neurotrophic factor 0.089
Cldn5 claudin 5 0.089
Rara retinoic acid receptor, alpha 0.089
Lef1 lymphoid enhancer binding factor 1 0.084
Dlx5 distal-less homeobox 5 0.082
Hes1 hairy and enhancer of split 1 (Drosophila) 0.080
Sall3 sal-like 3 (Drosophila) 0.075
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.068
Egr2 early growth response 2 0.063
Ngfr nerve growth factor receptor (TNFR superfamily, member 16) 0.063
Atoh7 atonal homolog 7 (Drosophila) 0.062
Ntf3 neurotrophin 3 0.061
Sox3 SRY-box containing gene 3 0.061
Nkx2-3 NK2 transcription factor related, locus 3 (Drosophila) 0.060
Zeb1 zinc finger E-box binding homeobox 1 0.058
Igdcc3 immunoglobulin superfamily, DCC subclass, member 3 0.058
Arx aristaless related homeobox 0.057
Amhr2 anti-Mullerian hormone type 2 receptor 0.055
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism