The network for 'digestion' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

digestion

The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.

Danio rerio
Name Description Probability Func Analog Organism
anxa1b annexin A1b 0.219
adrb2a adrenergic receptor, beta 2a 0.082
fabp2 fatty acid binding protein 2, intestinal 0.067
neurog1 neurogenin 1 0.066
sox9b SRY-box containing gene 9b 0.061
fabp1b.1 fatty acid binding protein 1b, tandem duplicate 1 0.051
ireb2 iron-responsive element binding protein 2 0.043
copb1 coatomer protein complex, subunit beta 1 0.031
hbaa1 hemoglobin alpha adult-1 0.031
zgc:161979 zgc:161979 0.029
st8sia2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 0.027
oprd1b opioid receptor, delta 1b 0.025
trpv6 transient receptor potential cation channel, subfamily V, member 6 0.022
aco1 aconitase 1, soluble 0.021
hoxc8a homeo box C8a 0.021
hnf4a hepatocyte nuclear factor 4, alpha 0.021
apobl apolipoprotein B, like 0.020
mogat2 monoacylglycerol O-acyltransferase 2 0.020
cpa4 carboxypeptidase A4 0.019
zgc:194131 zgc:194131 0.018
krt4 keratin 4 0.018
cyp2y3 cytochrome P450, family 2, subfamily Y, polypeptide 3 0.018
sgpl1 sphingosine-1-phosphate lyase 1 0.018
wls wntless homolog (Drosophila) 0.017
LOC100332193 growth hormone secretagogue receptor type 1-like 0.016
si:dkey-14d8.6 si:dkey-14d8.6 0.016
ptch1 patched 1 0.015
apc adenomatosis polyposis coli 0.015
krt5 keratin 5 0.014
pi4kb phosphatidylinositol 4-kinase, catalytic, beta 0.014
gata5 GATA-binding protein 5 0.013
ak3 adenylate kinase 3 0.013
vim vimentin 0.013
acsl5 acyl-CoA synthetase long-chain family member 5 0.013
myh11a myosin, heavy polypeptide 11, smooth muscle a 0.012
wu:fb18f06 wu:fb18f06 0.012
c6ast3 six-cysteine containing astacin protease 3 0.012
wu:fi18a01 wu:fi18a01 0.012
apoa1 apolipoprotein A-I 0.012
klf4a Kruppel-like transcription factor 4a 0.012
fgf10a fibroblast growth factor 10a 0.012
anxa1a annexin A1a 0.012
stat3 signal transduction and activation of transcription 3 0.012
cx30.3 connexin 30.3 0.012
tax1bp3 Tax1 (human T-cell leukemia virus type I) binding protein 3 0.011
sec31a sec31 homolog A (S. cerevisiae) 0.011
zgc:110409 zgc:110409 0.011
abcc5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 0.011
icn ictacalcin 0.011
LOC568833 claudin-3-like 0.011
atp1a1a.4 ATPase, Na+/K+ transporting, alpha 1a.4 polypeptide 0.011
stk38l serine/threonine kinase 38 like 0.010
zgc:110298 zgc:110298 0.010
pdzk1 PDZ domain containing 1 0.010
sult1st3 sulfotransferase family 1, cytosolic sulfotransferase 3 0.010
sucla2 succinate-CoA ligase, ADP-forming, beta subunit 0.010
htr1aa 5-hydroxytryptamine (serotonin) receptor 1A a 0.010
ompb olfactory marker protein b 0.010
cahz carbonic anhydrase 0.010
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
CG12171 CG12171 gene product from transcript CG12171-RA 0.018
Toll-6 CG7250 gene product from transcript CG7250-RA 0.011
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Homo sapiens
Name Description Probability Func Analog Organism
FGFR2 fibroblast growth factor receptor 2 0.996
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.770
KCNE1 potassium voltage-gated channel, Isk-related family, member 1 0.734
AKR1C2 aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III) 0.615
NCOA1 nuclear receptor coactivator 1 0.548
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 0.546
CAND1 cullin-associated and neddylation-dissociated 1 0.537
AKR1C3 aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) 0.508
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8 0.504
FGF10 fibroblast growth factor 10 0.444
AKR1C1 aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase) 0.427
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit 0.388
FGF1 fibroblast growth factor 1 (acidic) 0.315
RXRA retinoid X receptor, alpha 0.309
CRHR1 corticotropin releasing hormone receptor 1 0.284
S100A10 S100 calcium binding protein A10 0.272
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit 0.260
CD300LD CD300 molecule-like family member d 0.224
TICAM2 toll-like receptor adaptor molecule 2 0.211
COPE coatomer protein complex, subunit epsilon 0.202
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.194
H2AFX H2A histone family, member X 0.181
KLHL3 kelch-like 3 (Drosophila) 0.159
LY96 lymphocyte antigen 96 0.117
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.110
CLNS1A chloride channel, nucleotide-sensitive, 1A 0.109
FGFR1 fibroblast growth factor receptor 1 0.101
TTR transthyretin 0.099
ALB albumin 0.091
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like 0.080
TXN thioredoxin 0.063
OXSR1 oxidative-stress responsive 1 0.062
RUNX1 runt-related transcription factor 1 0.061
CUL5 cullin 5 0.052
MAFA v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian) 0.046
SEC61G Sec61 gamma subunit 0.044
PCSK9 proprotein convertase subtilisin/kexin type 9 0.044
CUL2 cullin 2 0.042
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.042
HP haptoglobin 0.042
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 0.038
ZHX1 zinc fingers and homeoboxes 1 0.038
PRMT2 protein arginine methyltransferase 2 0.038
HR hairless homolog (mouse) 0.036
OPA1 optic atrophy 1 (autosomal dominant) 0.033
GLIS2 GLIS family zinc finger 2 0.033
HMGA1 high mobility group AT-hook 1 0.033
CAV2 caveolin 2 0.032
APOC3 apolipoprotein C-III 0.031
RARA retinoic acid receptor, alpha 0.031
MDFI MyoD family inhibitor 0.031
DMC1 DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast) 0.031
FCRL4 Fc receptor-like 4 0.030
UBXN6 UBX domain protein 6 0.030
LCAT lecithin-cholesterol acyltransferase 0.029
SLC34A1 solute carrier family 34 (sodium phosphate), member 1 0.029
PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit 0.028
MSTO1 misato homolog 1 (Drosophila) 0.028
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.028
HIC1 hypermethylated in cancer 1 0.027
PRODH2 proline dehydrogenase (oxidase) 2 0.026
RIPK2 receptor-interacting serine-threonine kinase 2 0.025
PKD2 polycystic kidney disease 2 (autosomal dominant) 0.024
CCK cholecystokinin 0.024
SLC28A1 solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 0.024
EDF1 endothelial differentiation-related factor 1 0.024
PYDC2 pyrin domain containing 2 0.023
CUL4A cullin 4A 0.023
S100A6 S100 calcium binding protein A6 0.022
TXNDC2 thioredoxin domain containing 2 (spermatozoa) 0.022
SNRPF small nuclear ribonucleoprotein polypeptide F 0.021
FGA fibrinogen alpha chain 0.021
SPOP speckle-type POZ protein 0.021
ADAMTSL4 ADAMTS-like 4 0.020
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase) 0.020
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 0.019
PIGR polymeric immunoglobulin receptor 0.019
TMSB10 thymosin beta 10 0.019
KBTBD7 kelch repeat and BTB (POZ) domain containing 7 0.019
PSEN1 presenilin 1 0.019
ALPI alkaline phosphatase, intestinal 0.019
EMP1 epithelial membrane protein 1 0.018
TFF3 trefoil factor 3 (intestinal) 0.018
FABP1 fatty acid binding protein 1, liver 0.018
ALDOB aldolase B, fructose-bisphosphate 0.018
COPB2 coatomer protein complex, subunit beta 2 (beta prime) 0.018
VPS52 vacuolar protein sorting 52 homolog (S. cerevisiae) 0.018
FGF7 fibroblast growth factor 7 0.018
MUC2 mucin 2, oligomeric mucus/gel-forming 0.017
SLC9A3R1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 0.016
MUC5B mucin 5B, oligomeric mucus/gel-forming 0.016
SLC17A1 solute carrier family 17 (sodium phosphate), member 1 0.016
ANG angiogenin, ribonuclease, RNase A family, 5 0.016
TFF2 trefoil factor 2 0.016
FGF8 fibroblast growth factor 8 (androgen-induced) 0.016
LGALS4 lectin, galactoside-binding, soluble, 4 0.016
TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain 0.015
SLC13A2 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2 0.015
DRD2 dopamine receptor D2 0.015
PDX1 pancreatic and duodenal homeobox 1 0.015
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Mus musculus
Name Description Probability Func Analog Organism
Lep leptin 0.942
Neurod1 neurogenic differentiation 1 0.930
Hand1 heart and neural crest derivatives expressed transcript 1 0.904
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.859
Nos3 nitric oxide synthase 3, endothelial cell 0.828
Drd2 dopamine receptor D2 0.761
Adrb1 adrenergic receptor, beta 1 0.703
Pparg peroxisome proliferator activated receptor gamma 0.679
Nos1 nitric oxide synthase 1, neuronal 0.657
Oprm1 opioid receptor, mu 1 0.583
Cel carboxyl ester lipase 0.544
Kcnj1 potassium inwardly-rectifying channel, subfamily J, member 1 0.542
Npy2r neuropeptide Y receptor Y2 0.521
Hoxd13 homeobox D13 0.517
Shh sonic hedgehog 0.508
Pax6 paired box gene 6 0.497
Apoa1 apolipoprotein A-I 0.497
Kl klotho 0.457
Nr1i3 nuclear receptor subfamily 1, group I, member 3 0.380
Hnf4a hepatic nuclear factor 4, alpha 0.374
Alx3 aristaless-like homeobox 3 0.373
Lepr leptin receptor 0.368
Sycn syncollin 0.361
Tgfb1 transforming growth factor, beta 1 0.352
Chrm1 cholinergic receptor, muscarinic 1, CNS 0.338
Thrb thyroid hormone receptor beta 0.337
Isl1 ISL1 transcription factor, LIM/homeodomain 0.334
Pnpla2 patatin-like phospholipase domain containing 2 0.333
Ptf1a pancreas specific transcription factor, 1a 0.325
Gata4 GATA binding protein 4 0.318
Mogat2 monoacylglycerol O-acyltransferase 2 0.315
Pomc pro-opiomelanocortin-alpha 0.310
Lhx3 LIM homeobox protein 3 0.299
Foxd2 forkhead box D2 0.298
Gnas GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus 0.296
Abcg8 ATP-binding cassette, sub-family G (WHITE), member 8 0.288
Alx4 aristaless-like homeobox 4 0.283
Kcnk4 potassium channel, subfamily K, member 4 0.278
Rxrg retinoid X receptor gamma 0.275
Adra2a adrenergic receptor, alpha 2a 0.259
Slc12a1 solute carrier family 12, member 1 0.247
Sspo SCO-spondin 0.247
Oprk1 opioid receptor, kappa 1 0.238
Cckbr cholecystokinin B receptor 0.225
Tbx15 T-box 15 0.211
Kcnq1 potassium voltage-gated channel, subfamily Q, member 1 0.208
Abcc6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6 0.208
Sox7 SRY-box containing gene 7 0.203
Ppara peroxisome proliferator activated receptor alpha 0.199
Runx2 runt related transcription factor 2 0.196
Vdr vitamin D receptor 0.188
Alx1 ALX homeobox 1 0.187
Sstr1 somatostatin receptor 1 0.181
Trh thyrotropin releasing hormone 0.177
Fgf4 fibroblast growth factor 4 0.173
Onecut1 one cut domain, family member 1 0.172
Slc4a4 solute carrier family 4 (anion exchanger), member 4 0.167
Col1a1 collagen, type I, alpha 1 0.166
Raver2 ribonucleoprotein, PTB-binding 2 0.166
Kcnn1 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1 0.164
Lhx9 LIM homeobox protein 9 0.162
Six3 sine oculis-related homeobox 3 homolog (Drosophila) 0.160
Sst somatostatin 0.159
2210010C04Rik RIKEN cDNA 2210010C04 gene 0.159
Oprd1 opioid receptor, delta 1 0.159
Pdx1 pancreatic and duodenal homeobox 1 0.158
Mecom MDS1 and EVI1 complex locus 0.156
Neurog3 neurogenin 3 0.152
Abcg5 ATP-binding cassette, sub-family G (WHITE), member 5 0.150
Sstr5 somatostatin receptor 5 0.150
Kcnq2 potassium voltage-gated channel, subfamily Q, member 2 0.148
Fgf3 fibroblast growth factor 3 0.147
Agtr2 angiotensin II receptor, type 2 0.147
Prph2 peripherin 2 0.146
Slc5a11 solute carrier family 5 (sodium/glucose cotransporter), member 11 0.146
Tnfrsf11a tumor necrosis factor receptor superfamily, member 11a 0.143
Clcnka chloride channel Ka 0.142
Fshr follicle stimulating hormone receptor 0.139
Apoe apolipoprotein E 0.139
Epor erythropoietin receptor 0.138
Pax3 paired box gene 3 0.138
Six6 sine oculis-related homeobox 6 homolog (Drosophila) 0.138
Npy1r neuropeptide Y receptor Y1 0.137
Tcfap2a transcription factor AP-2, alpha 0.136
Apom apolipoprotein M 0.136
Kcnd1 potassium voltage-gated channel, Shal-related family, member 1 0.134
Iapp islet amyloid polypeptide 0.130
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.130
Zp1 zona pellucida glycoprotein 1 0.129
Slc13a1 solute carrier family 13 (sodium/sulfate symporters), member 1 0.128
Htr4 5 hydroxytryptamine (serotonin) receptor 4 0.125
Lhx6 LIM homeobox protein 6 0.125
Gata6 GATA binding protein 6 0.122
Glra1 glycine receptor, alpha 1 subunit 0.121
Ncoa3 nuclear receptor coactivator 3 0.120
Kcnj5 potassium inwardly-rectifying channel, subfamily J, member 5 0.120
Atoh7 atonal homolog 7 (Drosophila) 0.120
Matn1 matrilin 1, cartilage matrix protein 0.119
Degs2 degenerative spermatocyte homolog 2 (Drosophila), lipid desaturase 0.118
Gabra2 gamma-aminobutyric acid (GABA) A receptor, subunit alpha 2 0.117
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Rattus norvegicus
Name Description Probability Func Analog Organism
Chrna7 cholinergic receptor, nicotinic, alpha 7 0.353
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.148
Slc18a2 solute carrier family 18 (vesicular monoamine), member 2 0.080
Htr6 5-hydroxytryptamine (serotonin) receptor 6 0.064
P2rx2 purinergic receptor P2X, ligand-gated ion channel, 2 0.057
Chst3 carbohydrate (chondroitin 6) sulfotransferase 3 0.054
Olr1078 olfactory receptor 1078 0.052
Cacng4 calcium channel, voltage-dependent, gamma subunit 4 0.052
Grifin galectin-related inter-fiber protein 0.052
Insrr insulin receptor-related receptor 0.051
Mag myelin-associated glycoprotein 0.048
Fam65a family with sequence similarity 65, member A 0.047
Mamdc4 MAM domain containing 4 0.047
Ctsj cathepsin J 0.047
Kif6 kinesin family member 6 0.047
P2rx3 purinergic receptor P2X, ligand-gated ion channel, 3 0.046
Mep1a meprin 1 alpha 0.045
Teddm1 transmembrane epididymal protein 1 0.044
Ppy pancreatic polypeptide 0.043
Btc betacellulin 0.043
Itpkb inositol 1,4,5-trisphosphate 3-kinase B 0.043
Nlrp6 NLR family, pyrin domain containing 6 0.043
Kl Klotho 0.042
Ccbp2 chemokine binding protein 2 0.039
Htr2c 5-hydroxytryptamine (serotonin) receptor 2C 0.038
Cga glycoprotein hormones, alpha polypeptide 0.034
Hrh2 histamine receptor H 2 0.034
Tmem79 transmembrane protein 79 0.034
Klk8 kallikrein related-peptidase 8 0.033
Zg16 zymogen granule protein 16 0.033
Il13 interleukin 13 0.032
Slc8a3 solute carrier family 8 (sodium/calcium exchanger), member 3 0.032
Cartpt CART prepropeptide 0.032
Olr1082 olfactory receptor 1082 0.032
Cyss cystatin S 0.032
Nmbr neuromedin B receptor 0.031
Olr287 olfactory receptor 287 0.031
Hnmt histamine N-methyltransferase 0.030
Gucy2d guanylate cyclase 2d 0.030
Aqp5 aquaporin 5 0.029
Gria4 glutamate receptor, ionotrophic, AMPA 4 0.029
Svs1 seminal vesicle secretory protein 1 0.029
Slc14a2 solute carrier family 14 (urea transporter), member 2 0.029
Slc6a2 solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 0.028
Rho rhodopsin 0.028
Prm3 protamine 3 0.028
Avp arginine vasopressin 0.028
Prss3 protease, serine, 3 0.027
Epha8 Eph receptor A8 0.027
C3ar1 complement component 3a receptor 1 0.026
Pax6 paired box 6 0.026
Prlr prolactin receptor 0.026
Ucp1 uncoupling protein 1 (mitochondrial, proton carrier) 0.026
Wfdc6a WAP four-disulfide core domain 6A 0.025
Ifna1 interferon-alpha 1 0.025
Pnlip pancreatic lipase 0.025
Htr1b 5-hydroxytryptamine (serotonin) receptor 1B 0.024
Scn10a sodium channel, voltage-gated, type X, alpha subunit 0.024
Star steroidogenic acute regulatory protein 0.024
Cnga1 cyclic nucleotide gated channel alpha 1 0.024
Fgfbp1 fibroblast growth factor binding protein 1 0.024
Accn2 amiloride-sensitive cation channel 2, neuronal 0.023
Ivl involucrin 0.023
Kcnmb1 potassium large conductance calcium-activated channel, subfamily M, beta member 1 0.023
Slc30a2 solute carrier family 30 (zinc transporter), member 2 0.022
Ednra endothelin receptor type A 0.022
Ucn urocortin 0.022
Fgf7 fibroblast growth factor 7 0.022
Npy5r neuropeptide Y receptor Y5 0.021
Csn2 casein beta 0.021
Cx3cr1 chemokine (C-X3-C motif) receptor 1 0.021
Upk3bl uroplakin 3B-like 0.021
Tff3 trefoil factor 3, intestinal 0.021
Slco1a1 solute carrier organic anion transporter family, member 1a1 0.021
Psp parotid secretory protein 0.021
Olr1493 olfactory receptor gene Olr1493 0.020
Grm6 glutamate receptor, metabotropic 6 0.020
Trib1 tribbles homolog 1 (Drosophila) 0.020
Htr2b 5-hydroxytryptamine (serotonin) receptor 2B 0.020
Kcnj15 potassium inwardly-rectifying channel, subfamily J, member 15 0.019
Prdx1 peroxiredoxin 1 0.019
Npffr1 neuropeptide FF receptor 1 0.019
Slc22a25 solute carrier family 22, member 25 0.019
Tpbpa trophoblast specific protein alpha 0.019
Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 0.019
Pmfbp1 polyamine modulated factor 1 binding protein 1 0.019
Gabrg1 gamma-aminobutyric acid (GABA) A receptor, gamma 1 0.019
Il12a interleukin 12A 0.019
Smgb neonatal submandibular gland protein B 0.018
Cntn5 contactin 5 0.018
Hsd3b5 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5 0.018
Barhl1 BarH-like homeobox 1 0.018
Gabra5 gamma-aminobutyric acid (GABA) A receptor, alpha 5 0.018
Agtr1a angiotensin II receptor, type 1a 0.018
Mc5r melanocortin 5 receptor 0.018
Naaladl1 N-acetylated alpha-linked acidic dipeptidase-like 1 0.018
Add2 adducin 2 (beta) 0.018
Spink1 serine peptidase inhibitor, Kazal type 1 0.018
Kcnj16 potassium inwardly-rectifying channel, subfamily J, member 16 0.017
Slc28a1 solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 0.017
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism