The network for 'heterocycle biosynthetic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

heterocycle biosynthetic process

The chemical reactions and pathways resulting in the formation of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings).

Name Description Probability Func Analog Organism
bmp2b bone morphogenetic protein 2b 0.995
pitx3 paired-like homeodomain transcription factor 3 0.989
tbx18 T-box 18 0.988
gli1 GLI-Kruppel family member 1 0.987
ndr2 nodal-related 2 0.985
smyhc1 slow myosin heavy chain 1 0.983
pcna proliferating cell nuclear antigen 0.983
tbx20 T-box 20 0.983
foxa2 forkhead box A2 0.982
notch1a notch homolog 1a 0.976
foxi1 forkhead box I1 0.975
kdrl kinase insert domain receptor like 0.964
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.962
etv2 ets variant gene 2 0.961
whsc1 Wolf-Hirschhorn syndrome candidate 1 0.960
tal1 T-cell acute lymphocytic leukemia 1 0.958
mll myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 0.955
dlx5a distal-less homeobox gene 5a 0.954
klf4 Kruppel-like factor 4 0.953
foxd3 forkhead box D3 0.951
snai1a snail homolog 1a (Drosophila) 0.944
fgf3 fibroblast growth factor 3 0.943
pcdh18b protocadherin 18b 0.939
gata6 GATA-binding protein 6 0.938
her8a hairy-related 8a 0.938
egr1 early growth response 1 0.934
otx1b orthodenticle homolog 1b 0.931
spry4 sprouty (Drosophila) homolog 4 0.924
hnf1ba HNF1 homeobox Ba 0.921
sox17 SRY-box containing gene 17 0.916
boc brother of CDO 0.907
pax3a paired box gene 3a 0.907
eomesa eomesodermin homolog a 0.904
fezf2 FEZ family zinc finger 2 0.903
oxtl oxytocin-like 0.903
cdkn1c cyclin-dependent kinase inhibitor 1C (p57, Kip2) 0.902
lef1 lymphocyte enhancer binding factor 1 0.898
her7 hairy and enhancer of split related-7 0.898
mespa mesoderm posterior a 0.894
otpa orthopedia homolog a 0.887
twist3 twist3 0.887
rxrbb retinoid x receptor, beta b 0.881
otx2 orthodenticle homolog 2 0.871
robo3 roundabout homolog 3 0.866
sox32 SRY-box containing gene 32 0.866
esr2a estrogen receptor 2a 0.864
dlx2a distal-less homeobox gene 2a 0.859
bmp4 bone morphogenetic protein 4 0.858
runx2b runt-related transcription factor 2b 0.856
brd4 bromodomain containing 4 0.855
cry1a cryptochrome 1a 0.854
ptf1a pancreas specific transcription factor, 1a 0.853
snai1b snail homolog 1b (Drosophila) 0.849
gpr126 G protein-coupled receptor 126 0.848
dld deltaD 0.848
shhb sonic hedgehog b 0.846
lhx5 LIM homeobox 5 0.837
emx3 empty spiracles homeobox 3 0.837
lft1 lefty1 0.834
per2 period homolog 2 (Drosophila) 0.823
nr2e1 nuclear receptor subfamily 2, group E, member 1 0.818
zic1 zic family member 1 (odd-paired homolog, Drosophila) 0.816
irx4b iroquois homeobox protein 4b 0.815
olfm2 olfactomedin 2 0.810
nanos3 nanos homolog 3 0.810
tll1 tolloid-like 1 0.809
nkx2.5 NK2 transcription factor related 5 0.803
rargb retinoic acid receptor, gamma b 0.799
pitx2 paired-like homeodomain transcription factor 2 0.785
hoxd4a homeo box D4a 0.774
atoh1b atonal homolog 1b 0.773
oprm1 opioid receptor, mu 1 0.773
nrg2a neuregulin 2a 0.771
foxj1a forkhead box J1a 0.763
pax8 paired box gene 8 0.759
six1b sine oculis homeobox homolog 1b 0.758
rx3 retinal homeobox gene 3 0.758
brd2a bromodomain-containing 2a 0.756
mecom MDS1 and EVI1 complex locus 0.754
foxa3 forkhead box A3 0.754
mab21l2 mab-21-like 2 0.752
runx2a runt-related transcription factor 2a 0.747
mstnb myostatin b 0.746
raraa retinoic acid receptor, alpha a 0.745
chd chordin 0.744
ar androgen receptor 0.740
ascl1a achaete-scute complex-like 1a (Drosophila) 0.738
dlc deltaC 0.737
zic2b zic family member 2 (odd-paired homolog, Drosophila) b 0.735
hand2 heart and neural crest derivatives expressed transcript 2 0.732
isl1 islet1 0.729
ntn1a netrin 1a 0.729
cav1 caveolin 1 0.729
prox1 prospero-related homeobox gene 1 0.727
clock clock 0.725
sox7 SRY-box containing gene 7 0.722
mcm5 MCM5 minichromosome maintenance deficient 5 (S. cerevisiae) 0.718
rarab retinoic acid receptor, alpha b 0.718
loxl2b lysyl oxidase-like 2b 0.715
fzd7a frizzled homolog 7a 0.712
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
egl-18 Protein EGL-18 0.998
nhr-49 Protein NHR-49 0.983
elt-6 Protein ELT-6 0.978
hlh-2 Protein HLH-2 0.934
pha-4 Protein PHA-4 0.929
nhr-67 Protein NHR-67 0.923
nhr-2 Protein NHR-2 0.889
cnd-1 Protein CND-1 0.848
npp-2 Protein NPP-2 0.846
ceh-20 Protein CEH-20 0.844
fkh-2 Protein FKH-2 0.840
dlk-1 Protein DLK-1 0.750
hda-2 Protein HDA-2 0.746
let-502 Protein LET-502 0.736
mep-1 Protein MEP-1 0.717
vab-3 Protein VAB-3 0.704
egl-46 Protein EGL-46 0.699
srgp-1 Protein SRGP-1 0.699
F39B2.1 Protein F39B2.1 0.693
zip-7 Protein ZIP-7 0.686
rad-26 Protein RAD-26 0.686
wrm-1 Protein WRM-1 0.678
ten-1 Protein TEN-1 0.677
egl-13 Protein EGL-13 0.671
daf-14 Protein DAF-14 0.671
lin-35 Protein LIN-35 0.667
his-16 Protein HIS-16 0.666
set-2 Protein SET-2 0.656
npp-19 Protein NPP-19 0.653
bet-1 Protein BET-1 0.635
ztf-2 Protein ZTF-2 0.624
R07E4.5 Protein R07E4.5 0.606
his-1 Protein HIS-1 0.604
his-64 Protein HIS-64 0.597
skp-1 Protein SKP-1 0.589
npp-7 Protein NPP-7 0.585
cam-1 Protein CAM-1 0.581
egl-27 Protein EGL-27 0.549
hcp-3 Protein HCP-3 0.547
smp-1 Protein SMP-1 0.544
cfim-2 Protein CFIM-2 0.533
nhr-6 Protein NHR-6 0.530
patr-1 Protein PATR-1 0.530
T28F4.1 Protein T28F4.1 0.518
pop-1 Protein POP-1 0.514
F53F10.2 Protein F53F10.2 0.501
rpb-11 Protein RPB-11 0.497
mab-5 Protein MAB-5 0.491
ceh-27 Protein CEH-27 0.489
sma-6 Protein SMA-6 0.483
pmk-1 Protein PMK-1 0.482
peb-1 Protein PEB-1 0.476
gei-4 Protein GEI-4 0.468
pkg-1 Protein PKG-1 0.466
scc-1 Protein SCC-1 0.465
flh-2 Protein FLH-2 0.465
daf-1 Protein DAF-1 0.458
hif-1 Protein HIF-1 0.452
lin-11 Protein LIN-11 0.451
ida-1 Protein IDA-1 0.442
ceh-32 Protein CEH-32 0.441
eya-1 Protein EYA-1 0.439
attf-2 Protein ATTF-2 0.432
lin-36 Protein LIN-36 0.429
Y48E1A.1 Protein Y48E1A.1 0.429
his-61 Protein HIS-61 0.426
hlh-1 Protein HLH-1 0.426
daf-11 Protein DAF-11 0.419
unc-83 Protein UNC-83 0.416
lin-17 Protein LIN-17 0.416
plk-3 Protein PLK-3 0.407
mls-2 Protein MLS-2 0.403
pbrm-1 Protein PBRM-1 0.403
sams-4 Protein SAMS-4 0.400
lin-29 Protein LIN-29 0.399
F40F4.7 Protein F40F4.7 0.398
imb-2 Protein IMB-2 0.397
unc-62 Protein UNC-62 0.388
isw-1 Protein ISW-1 0.385
mat-3 Protein MAT-3 0.383
T09B4.5 Protein T09B4.5 0.382
tag-260 Protein TAG-260 0.377
his-38 Protein HIS-38 0.377
rsp-1 Protein RSP-1 0.375
klp-16 Protein KLP-16 0.374
myo-3 Protein MYO-3 0.374
lin-66 Protein LIN-66 0.371
cpt-1 Protein CPT-1 0.367
sur-2 Protein SUR-2 0.365
his-3 Protein HIS-3 0.361
rpn-1 Protein RPN-1 0.360
unc-73 Protein UNC-73 0.357
ogt-1 Protein OGT-1 0.357
zyg-9 Protein ZYG-9 0.356
rpt-3 Protein RPT-3 0.355
emb-5 Protein EMB-5 0.354
mix-1 Protein MIX-1 0.353
apr-1 Protein APR-1 0.353
sma-9 Protein SMA-9 0.352
lin-2 Protein LIN-2 0.352
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism