IMP

Process View

Homo sapiens

24 genes annotated in human

skeletal muscle tissue development

The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "skeletal muscle tissue development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "skeletal muscle tissue development" (in gray)

Name	Description	Probability	Func Analog Organism
SRF	serum response factor (c-fos serum response element-binding transcription factor)	0.752
ESR1	estrogen receptor 1	0.578
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.577
FHL2	four and a half LIM domains 2	0.575
JAG1	jagged 1	0.502
JUN	jun proto-oncogene	0.460
FLNA	filamin A, alpha	0.414
HDAC4	histone deacetylase 4	0.246	Mouse
EGFR	epidermal growth factor receptor	0.212
CAV1	caveolin 1, caveolae protein, 22kDa	0.200	Mouse
IGF2	insulin-like growth factor 2 (somatomedin A)	0.192
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.161
AR	androgen receptor	0.158
CEBPB	CCAAT/enhancer binding protein (C/EBP), beta	0.154
SMAD3	SMAD family member 3	0.153
HNRNPH1	heterogeneous nuclear ribonucleoprotein H1 (H)	0.150
NKX2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.148
FN1	fibronectin 1	0.131
MEF2C	myocyte enhancer factor 2C	0.128
RBPMS	RNA binding protein with multiple splicing	0.127
FBLN1	fibulin 1	0.127
POU5F1	POU class 5 homeobox 1	0.121
PAX3	paired box 3	0.117
SMAD2	SMAD family member 2	0.112
NCOR2	nuclear receptor corepressor 2	0.101
APP	amyloid beta (A4) precursor protein	0.099
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.099
NOTCH1	notch 1	0.087
MYH7B	myosin, heavy chain 7B, cardiac muscle, beta	0.084
DDX5	DEAD (Asp-Glu-Ala-Asp) box polypeptide 5	0.068	Human Mouse
ATF3	activating transcription factor 3	0.068	Mouse
MYOD1	myogenic differentiation 1	0.067	Zebrafish Mouse
EP300	E1A binding protein p300	0.060	Mouse
SPTBN1	spectrin, beta, non-erythrocytic 1	0.058
JUNB	jun B proto-oncogene	0.058
BCL6	B-cell CLL/lymphoma 6	0.053
FSTL1	follistatin-like 1	0.051
DMD	dystrophin	0.051	Mouse
TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	0.049
TCF4	transcription factor 4	0.048
CSRP3	cysteine and glycine-rich protein 3 (cardiac LIM protein)	0.048
MEF2A	myocyte enhancer factor 2A	0.046	Human Fly
TTN	titin	0.045
GSK3B	glycogen synthase kinase 3 beta	0.045
BMPR1A	bone morphogenetic protein receptor, type IA	0.045
TRIM63	tripartite motif containing 63	0.043
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.041
ID1	inhibitor of DNA binding 1, dominant negative helix-loop-helix protein	0.040
DBP	D site of albumin promoter (albumin D-box) binding protein	0.040
SP1	Sp1 transcription factor	0.039
PARVA	parvin, alpha	0.038
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.038
FOS	FBJ murine osteosarcoma viral oncogene homolog	0.038	Mouse
EGR3	early growth response 3	0.038
TNNI1	troponin I type 1 (skeletal, slow)	0.036
NOTCH3	notch 3	0.036	Human Fly
DAG1	dystroglycan 1 (dystrophin-associated glycoprotein 1)	0.036	Zebrafish
SIRT1	sirtuin 1	0.036
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.035
COL6A1	collagen, type VI, alpha 1	0.035
LOX	lysyl oxidase	0.035
NFIL3	nuclear factor, interleukin 3 regulated	0.035
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.035
NR4A2	nuclear receptor subfamily 4, group A, member 2	0.034
EGR1	early growth response 1	0.034	Mouse
NR4A3	nuclear receptor subfamily 4, group A, member 3	0.034
FYN	FYN oncogene related to SRC, FGR, YES	0.033
BCL2L1	BCL2-like 1	0.032
ACTA2	actin, alpha 2, smooth muscle, aorta	0.032
MAPT	microtubule-associated protein tau	0.032
SMURF2	SMAD specific E3 ubiquitin protein ligase 2	0.032
NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	0.032
COL1A1	collagen, type I, alpha 1	0.032
FBN1	fibrillin 1	0.032
ATP2A1	ATPase, Ca++ transporting, cardiac muscle, fast twitch 1	0.031
CREBBP	CREB binding protein	0.031
PTEN	phosphatase and tensin homolog	0.030
GSN	gelsolin	0.030
LAMB1	laminin, beta 1	0.030
JUND	jun D proto-oncogene	0.029
ESR2	estrogen receptor 2 (ER beta)	0.029
SMAD4	SMAD family member 4	0.028
RB1	retinoblastoma 1	0.028	Mouse
EGR2	early growth response 2	0.028	Mouse
SMAD9	SMAD family member 9	0.028
FADD	Fas (TNFRSF6)-associated via death domain	0.028
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.028
PSEN1	presenilin 1	0.028
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.027
NCOA3	nuclear receptor coactivator 3	0.024
PPP3R1	protein phosphatase 3, regulatory subunit B, alpha	0.024
FOSB	FBJ murine osteosarcoma viral oncogene homolog B	0.024
LRP6	low density lipoprotein receptor-related protein 6	0.024
INO80B	INO80 complex subunit B	0.024
ZFP36	zinc finger protein 36, C3H type, homolog (mouse)	0.023
COL4A3	collagen, type IV, alpha 3 (Goodpasture antigen)	0.023
COL4A6	collagen, type IV, alpha 6	0.023	Fly
DTNA	dystrobrevin, alpha	0.022
DUSP1	dual specificity phosphatase 1	0.022
TESK1	testis-specific kinase 1	0.021
ANXA2	annexin A2	0.021
MAPK8	mitogen-activated protein kinase 8	0.021
COL4A5	collagen, type IV, alpha 5	0.021	Fly
RANBP9	RAN binding protein 9	0.021
YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.021
RBFOX2	RNA binding protein, fox-1 homolog (C. elegans) 2	0.021
TBX1	T-box 1	0.021	Human
PTRF	polymerase I and transcript release factor	0.021
FLNC	filamin C, gamma	0.020
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.020
LTA	lymphotoxin alpha (TNF superfamily, member 1)	0.020
CTGF	connective tissue growth factor	0.020
MTMR12	myotubularin related protein 12	0.020
UTRN	utrophin	0.020
SPRY2	sprouty homolog 2 (Drosophila)	0.019
CASP10	caspase 10, apoptosis-related cysteine peptidase	0.019
ITSN1	intersectin 1 (SH3 domain protein)	0.019
SETD8	SET domain containing (lysine methyltransferase) 8	0.019
PTCH1	patched 1	0.019
AHR	aryl hydrocarbon receptor	0.019
SPECC1L	sperm antigen with calponin homology and coiled-coil domains 1-like	0.019
SOX10	SRY (sex determining region Y)-box 10	0.019
HIPK2	homeodomain interacting protein kinase 2	0.018
GATA4	GATA binding protein 4	0.018
MYL9	myosin, light chain 9, regulatory	0.018
CXCL11	chemokine (C-X-C motif) ligand 11	0.018
VCL	vinculin	0.018
ONECUT1	one cut homeobox 1	0.018
ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	0.018
CLOCK	clock homolog (mouse)	0.018
EPAS1	endothelial PAS domain protein 1	0.018
FAM46A	family with sequence similarity 46, member A	0.018
ATP2B1	ATPase, Ca++ transporting, plasma membrane 1	0.017
FAS	Fas (TNF receptor superfamily, member 6)	0.017
CDX2	caudal type homeobox 2	0.017
TNNC1	troponin C type 1 (slow)	0.017
ENG	endoglin	0.017
FOXC1	forkhead box C1	0.017	Human
CEBPD	CCAAT/enhancer binding protein (C/EBP), delta	0.017
HIC1	hypermethylated in cancer 1	0.017
DLL1	delta-like 1 (Drosophila)	0.016
TCAP	titin-cap (telethonin)	0.016
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.016	Mouse
ITGB4	integrin, beta 4	0.016
SF1	splicing factor 1	0.016
IGF1R	insulin-like growth factor 1 receptor	0.016
IQGAP1	IQ motif containing GTPase activating protein 1	0.016
ACTN3	actinin, alpha 3	0.016
LBX1	ladybird homeobox 1	0.015	Fly
ZNF512B	zinc finger protein 512B	0.015
KCNA5	potassium voltage-gated channel, shaker-related subfamily, member 5	0.015
IER2	immediate early response 2	0.015
LCK	lymphocyte-specific protein tyrosine kinase	0.015
NPM1	nucleophosmin (nucleolar phosphoprotein B23, numatrin)	0.015
CKM	creatine kinase, muscle	0.015
RGS2	regulator of G-protein signaling 2, 24kDa	0.015
TIMP1	TIMP metallopeptidase inhibitor 1	0.015
NR2E3	nuclear receptor subfamily 2, group E, member 3	0.015
NEB	nebulin	0.015
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.014
BARX1	BARX homeobox 1	0.014
AHNAK	AHNAK nucleoprotein	0.014
KLF6	Kruppel-like factor 6	0.014
HSPG2	heparan sulfate proteoglycan 2	0.014
TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.014	Mouse
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.014
HOXD9	homeobox D9	0.014	Mouse
PTPRF	protein tyrosine phosphatase, receptor type, F	0.014
RANBP2	RAN binding protein 2	0.014
ARRDC3	arrestin domain containing 3	0.014
COASY	CoA synthase	0.013
DTNB	dystrobrevin, beta	0.013
SIM2	single-minded homolog 2 (Drosophila)	0.013
MATR3	matrin 3	0.013
MSN	moesin	0.013
RET	ret proto-oncogene	0.013	Zebrafish
TNFRSF10A	tumor necrosis factor receptor superfamily, member 10a	0.013
CNOT8	CCR4-NOT transcription complex, subunit 8	0.013
CHRNA1	cholinergic receptor, nicotinic, alpha 1 (muscle)	0.013
QKI	quaking homolog, KH domain RNA binding (mouse)	0.013	Zebrafish
EIF3H	eukaryotic translation initiation factor 3, subunit H	0.013
WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	0.013
HPCAL4	hippocalcin like 4	0.013
HDAC9	histone deacetylase 9	0.013	Mouse
CRIM1	cysteine rich transmembrane BMP regulator 1 (chordin-like)	0.013
PBX1	pre-B-cell leukemia homeobox 1	0.013
FUNDC2	FUN14 domain containing 2	0.013
SH2B2	SH2B adaptor protein 2	0.013
BTG2	BTG family, member 2	0.013	Human Mouse
IGFBP3	insulin-like growth factor binding protein 3	0.013
BGN	biglycan	0.013
ZEB2	zinc finger E-box binding homeobox 2	0.013
H3F3C	H3 histone, family 3C	0.013
ACTA1	actin, alpha 1, skeletal muscle	0.013	Mouse
GATAD2B	GATA zinc finger domain containing 2B	0.012
TFAP2A	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)	0.012
LDB3	LIM domain binding 3	0.012
TNKS2	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2	0.012
ROCK1	Rho-associated, coiled-coil containing protein kinase 1	0.012
MYL2	myosin, light chain 2, regulatory, cardiac, slow	0.012
MYH7	myosin, heavy chain 7, cardiac muscle, beta	0.012
COL4A2	collagen, type IV, alpha 2	0.012
TNNT2	troponin T type 2 (cardiac)	0.012
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.012
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.012
CYR61	cysteine-rich, angiogenic inducer, 61	0.012
SIX2	SIX homeobox 2	0.012
LMNA	lamin A/C	0.011
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.011
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.011	Human Mouse
MEN1	multiple endocrine neoplasia I	0.011
PAX7	paired box 7	0.011	Mouse
HOXD12	homeobox D12	0.011
VIP	vasoactive intestinal peptide	0.011
SMAD1	SMAD family member 1	0.011
POU3F2	POU class 3 homeobox 2	0.011
HIPK3	homeodomain interacting protein kinase 3	0.011
LMOD1	leiomodin 1 (smooth muscle)	0.011
NFIX	nuclear factor I/X (CCAAT-binding transcription factor)	0.011
ELN	elastin	0.011	Mouse
KLF9	Kruppel-like factor 9	0.011
NGFR	nerve growth factor receptor	0.011	Rat
S100A10	S100 calcium binding protein A10	0.011
FZD8	frizzled homolog 8 (Drosophila)	0.011
ITGAV	integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)	0.011
JAG2	jagged 2	0.011
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.011
SGCA	sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)	0.011
SOX9	SRY (sex determining region Y)-box 9	0.011	Mouse
CAV2	caveolin 2	0.011	Mouse
HES1	hairy and enhancer of split 1, (Drosophila)	0.010
ERBB2IP	erbb2 interacting protein	0.010
NAP1L1	nucleosome assembly protein 1-like 1	0.010
NID1	nidogen 1	0.010
CDK5R1	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	0.010
SKIL	SKI-like oncogene	0.010
HEY1	hairy/enhancer-of-split related with YRPW motif 1	0.010
PITX2	paired-like homeodomain 2	0.010	Mouse
FOXA2	forkhead box A2	0.010	Human
F2R	coagulation factor II (thrombin) receptor	0.010
LAMC1	laminin, gamma 1 (formerly LAMB2)	0.010	Zebrafish
ZC3H12A	zinc finger CCCH-type containing 12A	0.010
NOV	nephroblastoma overexpressed gene	0.010
DDIT4	DNA-damage-inducible transcript 4	0.010