IMP

Process View

Homo sapiens

22 genes annotated in human

protein activation cascade

A response to a stimulus that consists of a sequential series of modifications to a set of proteins where the product of one reaction acts catalytically in the following reaction. The magnitude of the response is typically amplified at each successive step in the cascade. Modifications typically include proteolysis or covalent modification, and may also include binding events.

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Known genes in the process in human Include functional analogs

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Gene Predictions

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Name	Description	Probability	Func Analog Organism
C1R	complement component 1, r subcomponent	1.000	Human
C1S	complement component 1, s subcomponent	1.000	Human
C3	complement component 3	0.979
FGB	fibrinogen beta chain	0.978	Human
KRT15	keratin 15	0.968
C1QA	complement component 1, q subcomponent, A chain	0.956	Mouse
SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	0.879
TP63	tumor protein p63	0.863
SERPING1	serpin peptidase inhibitor, clade G (C1 inhibitor), member 1	0.838
FGA	fibrinogen alpha chain	0.817
C1QB	complement component 1, q subcomponent, B chain	0.815
KRT19	keratin 19	0.745
KRT17	keratin 17	0.668
C1QC	complement component 1, q subcomponent, C chain	0.579	Zebrafish
TEK	TEK tyrosine kinase, endothelial	0.537
ALB	albumin	0.488
PPL	periplakin	0.446
KRT14	keratin 14	0.440
CFH	complement factor H	0.439	Mouse Rat
PLG	plasminogen	0.392	Human
KRT18	keratin 18	0.387
FGG	fibrinogen gamma chain	0.362
APOE	apolipoprotein E	0.319
CFI	complement factor I	0.313
A2M	alpha-2-macroglobulin	0.312
MASP1	mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)	0.300
DCN	decorin	0.212
HRG	histidine-rich glycoprotein	0.203
SERPINC1	serpin peptidase inhibitor, clade C (antithrombin), member 1	0.181
DMBT1	deleted in malignant brain tumors 1	0.177
F2	coagulation factor II (thrombin)	0.172
APCS	amyloid P component, serum	0.163
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.160
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.157
MASP2	mannan-binding lectin serine peptidase 2	0.155
LPA	lipoprotein, Lp(a)	0.151	Human
KRT6B	keratin 6B	0.139	Human
APOH	apolipoprotein H (beta-2-glycoprotein I)	0.127
C4B	complement component 4B (Chido blood group)	0.124
C19orf50	chromosome 19 open reading frame 50	0.114
RPS6KA6	ribosomal protein S6 kinase, 90kDa, polypeptide 6	0.107
CFHR1	complement factor H-related 1	0.103
ALOX12	arachidonate 12-lipoxygenase	0.103
PLAT	plasminogen activator, tissue	0.102	Human
KNG1	kininogen 1	0.100
CYP2A6	cytochrome P450, family 2, subfamily A, polypeptide 6	0.091
CYP1A2	cytochrome P450, family 1, subfamily A, polypeptide 2	0.086
FCN2	ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin)	0.077
ANGPT2	angiopoietin 2	0.071	Human
HP	haptoglobin	0.070
C8A	complement component 8, alpha polypeptide	0.061
KRT6A	keratin 6A	0.057	Human
LECT2	leukocyte cell-derived chemotaxin 2	0.057
ADH1B	alcohol dehydrogenase 1B (class I), beta polypeptide	0.056
LBP	lipopolysaccharide binding protein	0.054
C7	complement component 7	0.054	Human
C8B	complement component 8, beta polypeptide	0.053	Human
CFB	complement factor B	0.053
DPT	dermatopontin	0.052
RARRES2	retinoic acid receptor responder (tazarotene induced) 2	0.050
CP	ceruloplasmin (ferroxidase)	0.047
CYTB	cytochrome b	0.047
KRT6C	keratin 6C	0.043	Human
SPP2	secreted phosphoprotein 2, 24kDa	0.040
C2	complement component 2	0.038
APOA1	apolipoprotein A-I	0.037
TAT	tyrosine aminotransferase	0.036
SAA4	serum amyloid A4, constitutive	0.036
NNMT	nicotinamide N-methyltransferase	0.036
LRP1	low density lipoprotein receptor-related protein 1	0.035
CFHR2	complement factor H-related 2	0.035
HPX	hemopexin	0.035
KRT2	keratin 2	0.034	Human
C6	complement component 6	0.034	Human Mouse
CTSB	cathepsin B	0.033
HABP2	hyaluronan binding protein 2	0.033	Human
CXCL12	chemokine (C-X-C motif) ligand 12	0.032
KRT9	keratin 9	0.032
C10orf10	chromosome 10 open reading frame 10	0.031
CYP4A11	cytochrome P450, family 4, subfamily A, polypeptide 11	0.030
PPP2R2B	protein phosphatase 2, regulatory subunit B, beta	0.030
CPN1	carboxypeptidase N, polypeptide 1	0.030
C4BPB	complement component 4 binding protein, beta	0.028
PTGDS	prostaglandin D2 synthase 21kDa (brain)	0.028
MBL2	mannose-binding lectin (protein C) 2, soluble	0.027
SERPINF2	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2	0.027	Human
FETUB	fetuin B	0.027
VTN	vitronectin	0.026
CD164	CD164 molecule, sialomucin	0.026
GLYAT	glycine-N-acyltransferase	0.026
EMILIN1	elastin microfibril interfacer 1	0.026
IGF1	insulin-like growth factor 1 (somatomedin C)	0.025
CLU	clusterin	0.024
TRIM29	tripartite motif containing 29	0.023
ITIH1	inter-alpha (globulin) inhibitor H1	0.023
RDH16	retinol dehydrogenase 16 (all-trans)	0.023
EMP1	epithelial membrane protein 1	0.023
PHYH	phytanoyl-CoA 2-hydroxylase	0.022
KRT4	keratin 4	0.022	Human
CCL16	chemokine (C-C motif) ligand 16	0.021
APOF	apolipoprotein F	0.021
COL6A2	collagen, type VI, alpha 2	0.021
CCDC85B	coiled-coil domain containing 85B	0.020
SPRR1A	small proline-rich protein 1A	0.020
LIPC	lipase, hepatic	0.020
PLTP	phospholipid transfer protein	0.020
CFHR4	complement factor H-related 4	0.020
KRT75	keratin 75	0.020	Human
C9	complement component 9	0.019	Human
F9	coagulation factor IX	0.019
PROZ	protein Z, vitamin K-dependent plasma glycoprotein	0.019
SPARCL1	SPARC-like 1 (hevin)	0.019
KRT34	keratin 34	0.018
CYP3A7	cytochrome P450, family 3, subfamily A, polypeptide 7	0.018
AFM	afamin	0.018
KLK10	kallikrein-related peptidase 10	0.018
APOB	apolipoprotein B (including Ag(x) antigen)	0.018
FMO3	flavin containing monooxygenase 3	0.018
F10	coagulation factor X	0.017
FBN1	fibrillin 1	0.017
CPB2	carboxypeptidase B2 (plasma)	0.017
PRELP	proline/arginine-rich end leucine-rich repeat protein	0.017
IFITM2	interferon induced transmembrane protein 2 (1-8D)	0.017
KRT1	keratin 1	0.017
F13B	coagulation factor XIII, B polypeptide	0.017
SLC17A3	solute carrier family 17 (sodium phosphate), member 3	0.017
PGCP	plasma glutamate carboxypeptidase	0.017
APOC4	apolipoprotein C-IV	0.017
CA5A	carbonic anhydrase VA, mitochondrial	0.016
ENPP2	ectonucleotide pyrophosphatase/phosphodiesterase 2	0.016
F11	coagulation factor XI	0.016
S100A6	S100 calcium binding protein A6	0.016
CPN2	carboxypeptidase N, polypeptide 2	0.016
TMEM176A	transmembrane protein 176A	0.016
ITIH2	inter-alpha (globulin) inhibitor H2	0.016
IGFALS	insulin-like growth factor binding protein, acid labile subunit	0.016
DNASE1L3	deoxyribonuclease I-like 3	0.016
PLA2G2A	phospholipase A2, group IIA (platelets, synovial fluid)	0.015
SFTPB	surfactant protein B	0.015
TNXB	tenascin XB	0.015
FBN3	fibrillin 3	0.015
C4BPA	complement component 4 binding protein, alpha	0.015
ITIH4	inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein)	0.015
PAH	phenylalanine hydroxylase	0.015
ORM1	orosomucoid 1	0.014
AGXT	alanine-glyoxylate aminotransferase	0.014
APOC2	apolipoprotein C-II	0.014
TEKT4	tektin 4	0.014
PIK3AP1	phosphoinositide-3-kinase adaptor protein 1	0.014
PCK1	phosphoenolpyruvate carboxykinase 1 (soluble)	0.014
CYP2C8	cytochrome P450, family 2, subfamily C, polypeptide 8	0.014
KRT33B	keratin 33B	0.014
FAM107A	family with sequence similarity 107, member A	0.014
RABGEF1	RAB guanine nucleotide exchange factor (GEF) 1	0.013
PLAUR	plasminogen activator, urokinase receptor	0.013
HAL	histidine ammonia-lyase	0.013
RARRES1	retinoic acid receptor responder (tazarotene induced) 1	0.013
SERPINA5	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5	0.013
PKP1	plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)	0.013
APOC1	apolipoprotein C-I	0.013
ARG1	arginase, liver	0.013
GGT5	gamma-glutamyltransferase 5	0.013
CFD	complement factor D (adipsin)	0.013
SFTPD	surfactant protein D	0.013	Human
CETP	cholesteryl ester transfer protein, plasma	0.013
PLAU	plasminogen activator, urokinase	0.012	Human
HSD11B1	hydroxysteroid (11-beta) dehydrogenase 1	0.012
SLCO2B1	solute carrier organic anion transporter family, member 2B1	0.012
COLEC10	collectin sub-family member 10 (C-type lectin)	0.012	Human
PLA1A	phospholipase A1 member A	0.012
ISLR	immunoglobulin superfamily containing leucine-rich repeat	0.012
PARP4	poly (ADP-ribose) polymerase family, member 4	0.012
HAO1	hydroxyacid oxidase (glycolate oxidase) 1	0.012
MFAP4	microfibrillar-associated protein 4	0.012	Human
SLC10A1	solute carrier family 10 (sodium/bile acid cotransporter family), member 1	0.012
SERPINA6	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6	0.012
ZNF431	zinc finger protein 431	0.012
ECM2	extracellular matrix protein 2, female organ and adipocyte specific	0.011
NR1H4	nuclear receptor subfamily 1, group H, member 4	0.011
TTR	transthyretin	0.011
KRT16	keratin 16	0.011
SLURP1	secreted LY6/PLAUR domain containing 1	0.011
GCGR	glucagon receptor	0.011
AHSG	alpha-2-HS-glycoprotein	0.011
SERPINA3	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3	0.011
DOCK7	dedicator of cytokinesis 7	0.011
LCAT	lecithin-cholesterol acyltransferase	0.011
CSF1R	colony stimulating factor 1 receptor	0.011
CLIC2	chloride intracellular channel 2	0.011
AEBP1	AE binding protein 1	0.011
OLFML3	olfactomedin-like 3	0.011
A1BG	alpha-1-B glycoprotein	0.011
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.011
APOD	apolipoprotein D	0.011
CCL2	chemokine (C-C motif) ligand 2	0.011
CD163	CD163 molecule	0.010
S100A2	S100 calcium binding protein A2	0.010
VCAM1	vascular cell adhesion molecule 1	0.010
CYP8B1	cytochrome P450, family 8, subfamily B, polypeptide 1	0.010
IGFBP4	insulin-like growth factor binding protein 4	0.010
SRPX	sushi-repeat containing protein, X-linked	0.010
C8G	complement component 8, gamma polypeptide	0.010
ABCA6	ATP-binding cassette, sub-family A (ABC1), member 6	0.010
SERPIND1	serpin peptidase inhibitor, clade D (heparin cofactor), member 1	0.010
LY6G6F	lymphocyte antigen 6 complex, locus G6F	0.010