IMP

Process View

Homo sapiens

3 genes annotated in human

centrosome separation

The process in which duplicated centrosome components move away from each other. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "centrosome separation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "centrosome separation" (in gray)

Name	Description	Probability	Func Analog Organism
PAFAH1B1	platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)	0.965	Worm Fly
INCENP	inner centromere protein antigens 135/155kDa	0.465
KIF23	kinesin family member 23	0.452
FBXW11	F-box and WD repeat domain containing 11	0.320
BIRC5	baculoviral IAP repeat containing 5	0.318
PPP2R2A	protein phosphatase 2, regulatory subunit B, alpha	0.289
CDCA8	cell division cycle associated 8	0.282
PPP2CA	protein phosphatase 2, catalytic subunit, alpha isozyme	0.279	Worm
PPP2CB	protein phosphatase 2, catalytic subunit, beta isozyme	0.216	Worm
RAD18	RAD18 homolog (S. cerevisiae)	0.215
NDEL1	nudE nuclear distribution gene E homolog (A. nidulans)-like 1	0.212	Mouse
BUB1B	budding uninhibited by benzimidazoles 1 homolog beta (yeast)	0.191
APC	adenomatous polyposis coli	0.185
CLIP1	CAP-GLY domain containing linker protein 1	0.184
MAPK1	mitogen-activated protein kinase 1	0.169
STIL	SCL/TAL1 interrupting locus	0.168
TOP2A	topoisomerase (DNA) II alpha 170kDa	0.161
CHEK2	CHK2 checkpoint homolog (S. pombe)	0.159
GSK3B	glycogen synthase kinase 3 beta	0.158
UBR3	ubiquitin protein ligase E3 component n-recognin 3 (putative)	0.158
CDC25C	cell division cycle 25 homolog C (S. pombe)	0.145
KIF1B	kinesin family member 1B	0.132
PPP2R1B	protein phosphatase 2, regulatory subunit A, beta	0.128
UBR1	ubiquitin protein ligase E3 component n-recognin 1	0.094
CCT8	chaperonin containing TCP1, subunit 8 (theta)	0.089
TROAP	trophinin associated protein (tastin)	0.084
TTK	TTK protein kinase	0.077
RANBP2	RAN binding protein 2	0.074
RACGAP1	Rac GTPase activating protein 1	0.068
LBR	lamin B receptor	0.065
RAD51	RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)	0.063
BTRC	beta-transducin repeat containing	0.062
NEK2	NIMA (never in mitosis gene a)-related kinase 2	0.060
NEURL4	neuralized homolog 4 (Drosophila)	0.059
CLSPN	claspin	0.053
AKAP9	A kinase (PRKA) anchor protein (yotiao) 9	0.052
GAS2L3	growth arrest-specific 2 like 3	0.052
DDX3X	DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked	0.050
PLK1	polo-like kinase 1	0.047
KIF20A	kinesin family member 20A	0.044
KIF2C	kinesin family member 2C	0.043
HDAC1	histone deacetylase 1	0.043
CDK1	cyclin-dependent kinase 1	0.042
CENPJ	centromere protein J	0.042
MAP2K1	mitogen-activated protein kinase kinase 1	0.040
MAPRE1	microtubule-associated protein, RP/EB family, member 1	0.040
SKA1	spindle and kinetochore associated complex subunit 1	0.039
UBE2D1	ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)	0.038
MAP2K4	mitogen-activated protein kinase kinase 4	0.038
CCNF	cyclin F	0.038
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.038
FAM64A	family with sequence similarity 64, member A	0.038
AURKB	aurora kinase B	0.037	Fly
KIF14	kinesin family member 14	0.037
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.036
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.036
CDC27	cell division cycle 27 homolog (S. cerevisiae)	0.035
PPP1R2	protein phosphatase 1, regulatory (inhibitor) subunit 2	0.035
CCNB1	cyclin B1	0.035
DLGAP5	discs, large (Drosophila) homolog-associated protein 5	0.035
TPX2	TPX2, microtubule-associated, homolog (Xenopus laevis)	0.033
CDC20	cell division cycle 20 homolog (S. cerevisiae)	0.033
CENPE	centromere protein E, 312kDa	0.033
YAP1	Yes-associated protein 1	0.033
PPP2R5A	protein phosphatase 2, regulatory subunit B', alpha	0.033
RAB21	RAB21, member RAS oncogene family	0.033
UBE2C	ubiquitin-conjugating enzyme E2C	0.033
BUB1	budding uninhibited by benzimidazoles 1 homolog (yeast)	0.032
TP53	tumor protein p53	0.031
TP53BP2	tumor protein p53 binding protein, 2	0.031
CUL1	cullin 1	0.031
STRN3	striatin, calmodulin binding protein 3	0.031
PPP2R5C	protein phosphatase 2, regulatory subunit B', gamma	0.030
SGOL1	shugoshin-like 1 (S. pombe)	0.029
PPP6C	protein phosphatase 6, catalytic subunit	0.029
CCNB2	cyclin B2	0.028
DTL	denticleless homolog (Drosophila)	0.027
HMMR	hyaluronan-mediated motility receptor (RHAMM)	0.025
SASS6	spindle assembly 6 homolog (C. elegans)	0.024
ZWINT	ZW10 interactor	0.024
PSRC1	proline/serine-rich coiled-coil 1	0.024
CENPF	centromere protein F, 350/400kDa (mitosin)	0.023
CBX5	chromobox homolog 5	0.023
THRAP3	thyroid hormone receptor associated protein 3	0.023
PPP2R2C	protein phosphatase 2, regulatory subunit B, gamma	0.023
TCTEX1D2	Tctex1 domain containing 2	0.022
CP110	CP110 protein	0.021
CCNA2	cyclin A2	0.021
FEM1C	fem-1 homolog c (C. elegans)	0.020
CALM1	calmodulin 1 (phosphorylase kinase, delta)	0.020
MDM4	Mdm4 p53 binding protein homolog (mouse)	0.020
KIAA0930	KIAA0930	0.019
UBE2G1	ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast)	0.018
MPRIP	myosin phosphatase Rho interacting protein	0.018
CDC25A	cell division cycle 25 homolog A (S. pombe)	0.018
PTTG1	pituitary tumor-transforming 1	0.017
SIAH1	seven in absentia homolog 1 (Drosophila)	0.017
PPP2R1A	protein phosphatase 2, regulatory subunit A, alpha	0.017
PPP2R5E	protein phosphatase 2, regulatory subunit B', epsilon isoform	0.017
AXIN2	axin 2	0.017
ERCC6L	excision repair cross-complementing rodent repair deficiency, complementation group 6-like	0.017
CDK17	cyclin-dependent kinase 17	0.017
MKI67	antigen identified by monoclonal antibody Ki-67	0.016
PRKDC	protein kinase, DNA-activated, catalytic polypeptide	0.016
CNOT6	CCR4-NOT transcription complex, subunit 6	0.016
NDC80	NDC80 homolog, kinetochore complex component (S. cerevisiae)	0.016
HJURP	Holliday junction recognition protein	0.015
MARK3	MAP/microtubule affinity-regulating kinase 3	0.014
GAPVD1	GTPase activating protein and VPS9 domains 1	0.014
SKP1	S-phase kinase-associated protein 1	0.014
PFDN1	prefoldin subunit 1	0.014
PPP2R2B	protein phosphatase 2, regulatory subunit B, beta	0.014
AURKA	aurora kinase A	0.014	Mouse
MAPK9	mitogen-activated protein kinase 9	0.014
ARIH1	ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1 (Drosophila)	0.014
BCL2L1	BCL2-like 1	0.014
PLK4	polo-like kinase 4	0.014
ING2	inhibitor of growth family, member 2	0.013
ARPP19	cAMP-regulated phosphoprotein, 19kDa	0.013
DYNC1H1	dynein, cytoplasmic 1, heavy chain 1	0.013
PDE4DIP	phosphodiesterase 4D interacting protein	0.013
ARL15	ADP-ribosylation factor-like 15	0.013
KCNE3	potassium voltage-gated channel, Isk-related family, member 3	0.013
CAB39	calcium binding protein 39	0.013
LATS1	LATS, large tumor suppressor, homolog 1 (Drosophila)	0.013
APTX	aprataxin	0.012
FAM190B	family with sequence similarity 190, member B	0.012
GPSM2	G-protein signaling modulator 2	0.012
PPP2R2D	protein phosphatase 2, regulatory subunit B, delta	0.012
KLC1	kinesin light chain 1	0.012
ARL6IP1	ADP-ribosylation factor-like 6 interacting protein 1	0.012
TIMELESS	timeless homolog (Drosophila)	0.012
SLC9A6	solute carrier family 9 (sodium/hydrogen exchanger), member 6	0.012
STK24	serine/threonine kinase 24	0.012
BAD	BCL2-associated agonist of cell death	0.012
ASPM	asp (abnormal spindle) homolog, microcephaly associated (Drosophila)	0.011
ECT2	epithelial cell transforming sequence 2 oncogene	0.011
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.011
ATP5A1	ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle	0.011
RNF6	ring finger protein (C3H2C3 type) 6	0.011
HMGB2	high mobility group box 2	0.011
BICD2	bicaudal D homolog 2 (Drosophila)	0.011
RALGPS2	Ral GEF with PH domain and SH3 binding motif 2	0.011
WDR48	WD repeat domain 48	0.011
SHOC2	soc-2 suppressor of clear homolog (C. elegans)	0.011
IGBP1	immunoglobulin (CD79A) binding protein 1	0.010
SPC25	SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)	0.010
KIAA1279	KIAA1279	0.010
C22orf39	chromosome 22 open reading frame 39	0.010
PPP1R9B	protein phosphatase 1, regulatory (inhibitor) subunit 9B	0.010
UBE2D3	ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)	0.010
PHLDB2	pleckstrin homology-like domain, family B, member 2	0.010