IMP

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Homo sapiens

25 genes annotated in human

toll like receptor signaling pathway

Any series of molecular signals generated as a consequence of binding to a toll-like receptor. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "toll like receptor signaling pathway"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "toll like receptor signaling pathway" (in gray)

Name	Description	Probability	Func Analog Organism
IRAK1	interleukin-1 receptor-associated kinase 1	0.995
BIRC3	baculoviral IAP repeat containing 3	0.992
MYD88	myeloid differentiation primary response gene (88)	0.990	Mouse
IRAK2	interleukin-1 receptor-associated kinase 2	0.961	Human
TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	0.911
IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	0.902
TNFAIP3	tumor necrosis factor, alpha-induced protein 3	0.873
TRAF6	TNF receptor-associated factor 6	0.702
TLR4	toll-like receptor 4	0.626	Human Rat
NFKB2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	0.531
S100A1	S100 calcium binding protein A1	0.480	Human
TNIP2	TNFAIP3 interacting protein 2	0.327	Mouse
NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	0.309
S100A14	S100 calcium binding protein A14	0.271
S100A16	S100 calcium binding protein A16	0.249	Human
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.182
TNIP1	TNFAIP3 interacting protein 1	0.142	Mouse
S100B	S100 calcium binding protein B	0.134	Human
PELI3	pellino homolog 3 (Drosophila)	0.134
TICAM2	toll-like receptor adaptor molecule 2	0.127
RXRA	retinoid X receptor, alpha	0.124
S100A6	S100 calcium binding protein A6	0.107
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.104
ESR1	estrogen receptor 1	0.097
MAP3K5	mitogen-activated protein kinase kinase kinase 5	0.092
MAPK14	mitogen-activated protein kinase 14	0.077
REL	v-rel reticuloendotheliosis viral oncogene homolog (avian)	0.074
NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.073	Mouse
RARA	retinoic acid receptor, alpha	0.072	Human
TRAF1	TNF receptor-associated factor 1	0.072
IRAK3	interleukin-1 receptor-associated kinase 3	0.070	Human Mouse
TLR2	toll-like receptor 2	0.064
MAPK1	mitogen-activated protein kinase 1	0.061
MAP3K8	mitogen-activated protein kinase kinase kinase 8	0.061
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.059
NFKBIB	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta	0.057
IRAK4	interleukin-1 receptor-associated kinase 4	0.053
NFKBIE	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon	0.052
BCL3	B-cell CLL/lymphoma 3	0.049
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.046	Human
RELB	v-rel reticuloendotheliosis viral oncogene homolog B	0.042
FKBP4	FK506 binding protein 4, 59kDa	0.039
MAP3K14	mitogen-activated protein kinase kinase kinase 14	0.034
RXRB	retinoid X receptor, beta	0.033
AGER	advanced glycosylation end product-specific receptor	0.033
TICAM1	toll-like receptor adaptor molecule 1	0.032	Mouse
CREBBP	CREB binding protein	0.031
CD14	CD14 molecule	0.030
HSF1	heat shock transcription factor 1	0.030
DUSP1	dual specificity phosphatase 1	0.026
ZC3H12A	zinc finger CCCH-type containing 12A	0.025
S100A8	S100 calcium binding protein A8	0.025
SMS	spermine synthase	0.024
ARRB1	arrestin, beta 1	0.024
TLR1	toll-like receptor 1	0.022	Human
LILRB1	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	0.022
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.022
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.022
TNF	tumor necrosis factor	0.022
MED25	mediator complex subunit 25	0.021
PTAFR	platelet-activating factor receptor	0.020
CLPTM1	cleft lip and palate associated transmembrane protein 1	0.019
CCR2	chemokine (C-C motif) receptor 2	0.019
LILRB2	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	0.019
TRIM34	tripartite motif containing 34	0.018
CCR1	chemokine (C-C motif) receptor 1	0.018
S100P	S100 calcium binding protein P	0.018	Human
IRF8	interferon regulatory factor 8	0.017
IGSF6	immunoglobulin superfamily, member 6	0.017
CD40	CD40 molecule, TNF receptor superfamily member 5	0.017
CARD11	caspase recruitment domain family, member 11	0.017
SPI1	spleen focus forming virus (SFFV) proviral integration oncogene spi1	0.017
PPARA	peroxisome proliferator-activated receptor alpha	0.016
CTLA4	cytotoxic T-lymphocyte-associated protein 4	0.016
TRAF5	TNF receptor-associated factor 5	0.016
YWHAG	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	0.016
MALT1	mucosa associated lymphoid tissue lymphoma translocation gene 1	0.016
NFKBIZ	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta	0.015
FADD	Fas (TNFRSF6)-associated via death domain	0.015
LILRA6	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6	0.015
TXN	thioredoxin	0.015
STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	0.015
LY86	lymphocyte antigen 86	0.014
CYBB	cytochrome b-245, beta polypeptide	0.014
SBF1	SET binding factor 1	0.014
NCOA1	nuclear receptor coactivator 1	0.014
NCOR2	nuclear receptor corepressor 2	0.014
IFNGR1	interferon gamma receptor 1	0.014
HSPB1	heat shock 27kDa protein 1	0.014
NOD2	nucleotide-binding oligomerization domain containing 2	0.014
CASP1	caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)	0.014
LILRB3	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3	0.014
KLHL24	kelch-like 24 (Drosophila)	0.014
PIAS4	protein inhibitor of activated STAT, 4	0.013
IRF7	interferon regulatory factor 7	0.013	Mouse
NELL2	NEL-like 2 (chicken)	0.013
MED1	mediator complex subunit 1	0.013
TRIM21	tripartite motif containing 21	0.013
SIGLEC7	sialic acid binding Ig-like lectin 7	0.012
MS4A6A	membrane-spanning 4-domains, subfamily A, member 6A	0.012
AREG	amphiregulin	0.012
IL1RAP	interleukin 1 receptor accessory protein	0.012
PTPRR	protein tyrosine phosphatase, receptor type, R	0.012
ITGB1BP2	integrin beta 1 binding protein (melusin) 2	0.012
VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	0.012
PILRA	paired immunoglobin-like type 2 receptor alpha	0.011
VNN2	vanin 2	0.011
TRAF3IP1	TNF receptor-associated factor 3 interacting protein 1	0.011
PTPRJ	protein tyrosine phosphatase, receptor type, J	0.011
PELI2	pellino homolog 2 (Drosophila)	0.011
UBE2V1	ubiquitin-conjugating enzyme E2 variant 1	0.011
SMPD1	sphingomyelin phosphodiesterase 1, acid lysosomal	0.011
PRKCZ	protein kinase C, zeta	0.011
HSPH1	heat shock 105kDa/110kDa protein 1	0.011
BRAF	v-raf murine sarcoma viral oncogene homolog B1	0.011
NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	0.011
EIF3C	eukaryotic translation initiation factor 3, subunit C	0.011
STAP2	signal transducing adaptor family member 2	0.011
PTPN7	protein tyrosine phosphatase, non-receptor type 7	0.011
UBE2D3	ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)	0.011
DUSP7	dual specificity phosphatase 7	0.010
GIT2	G protein-coupled receptor kinase interacting ArfGAP 2	0.010
ZRANB1	zinc finger, RAN-binding domain containing 1	0.010	Human
LIMK1	LIM domain kinase 1	0.010
DOCK8	dedicator of cytokinesis 8	0.010
ARHGAP9	Rho GTPase activating protein 9	0.010
RYBP	RING1 and YY1 binding protein	0.010