IMP

Process View

Homo sapiens

21 genes annotated in human

actin nucleation

The initial step in the formation of an actin filament, in which actin monomers combine to form a new filament. Nucleation is slow relative to the subsequent addition of more monomers to extend the filament.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in human Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "actin nucleation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "actin nucleation" (in gray)

Name	Description	Probability	Func Analog Organism
GAS7	growth arrest-specific 7	1.000
ARPC5	actin related protein 2/3 complex, subunit 5, 16kDa	0.996
ARPC3	actin related protein 2/3 complex, subunit 3, 21kDa	0.996
ARPC2	actin related protein 2/3 complex, subunit 2, 34kDa	0.996
ACTR3	ARP3 actin-related protein 3 homolog (yeast)	0.986
ACTR2	ARP2 actin-related protein 2 homolog (yeast)	0.984
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.962
FASLG	Fas ligand (TNF superfamily, member 6)	0.916
CAP1	CAP, adenylate cyclase-associated protein 1 (yeast)	0.916
DAAM1	dishevelled associated activator of morphogenesis 1	0.865
ARPC1B	actin related protein 2/3 complex, subunit 1B, 41kDa	0.854
WAS	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	0.845	Yeast Fly
GRB2	growth factor receptor-bound protein 2	0.776
DNM2	dynamin 2	0.733
IQGAP1	IQ motif containing GTPase activating protein 1	0.722	Human
CTTN	cortactin	0.663
ARPC4	actin related protein 2/3 complex, subunit 4, 20kDa	0.635
NCKAP1	NCK-associated protein 1	0.564
WASF1	WAS protein family, member 1	0.514
BAIAP2	BAI1-associated protein 2	0.507
WASL	Wiskott-Aldrich syndrome-like	0.504	Yeast Fly
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.491
FMR1	fragile X mental retardation 1	0.469
TPM4	tropomyosin 4	0.441
TRIM39	tripartite motif containing 39	0.391	Human
SORBS3	sorbin and SH3 domain containing 3	0.332
MED15	mediator complex subunit 15	0.306
TRIM5	tripartite motif containing 5	0.293	Human
PFDN1	prefoldin subunit 1	0.267
ZNF263	zinc finger protein 263	0.265
TRIP10	thyroid hormone receptor interactor 10	0.236	Fly
CYFIP2	cytoplasmic FMR1 interacting protein 2	0.228	Human
ADAM19	ADAM metallopeptidase domain 19	0.224
WIPF1	WAS/WASL interacting protein family, member 1	0.207
UBE2D4	ubiquitin-conjugating enzyme E2D 4 (putative)	0.192
PACSIN2	protein kinase C and casein kinase substrate in neurons 2	0.165	Yeast
ABI2	abl-interactor 2	0.157
ITSN1	intersectin 1 (SH3 domain protein)	0.144
ARHGDIA	Rho GDP dissociation inhibitor (GDI) alpha	0.138
WDR1	WD repeat domain 1	0.127
IFI16	interferon, gamma-inducible protein 16	0.122
PSTPIP1	proline-serine-threonine phosphatase interacting protein 1	0.107
UBE2D1	ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)	0.102
RBCK1	RanBP-type and C3HC4-type zinc finger containing 1	0.099
FMNL1	formin-like 1	0.088
PACSIN1	protein kinase C and casein kinase substrate in neurons 1	0.086	Yeast
COTL1	coactosin-like 1 (Dictyostelium)	0.086
ABI1	abl-interactor 1	0.079	Human
CYFIP1	cytoplasmic FMR1 interacting protein 1	0.076
NCKIPSD	NCK interacting protein with SH3 domain	0.071
GNB1	guanine nucleotide binding protein (G protein), beta polypeptide 1	0.069
MYH9	myosin, heavy chain 9, non-muscle	0.066
TRIM32	tripartite motif containing 32	0.061
CAPZB	capping protein (actin filament) muscle Z-line, beta	0.055
TRIM21	tripartite motif containing 21	0.054	Human
PFN1	profilin 1	0.053
MAP3K11	mitogen-activated protein kinase kinase kinase 11	0.052
EPS8	epidermal growth factor receptor pathway substrate 8	0.051
TNK2	tyrosine kinase, non-receptor, 2	0.048
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.047
CORO1C	coronin, actin binding protein, 1C	0.044	Human Yeast
CYTH2	cytohesin 2	0.044
TNKS	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase	0.039
WASF2	WAS protein family, member 2	0.039	Human
SNX9	sorting nexin 9	0.039
PARD6G	par-6 partitioning defective 6 homolog gamma (C. elegans)	0.038
ZNF473	zinc finger protein 473	0.038
TRIM26	tripartite motif containing 26	0.037
KIAA0408	KIAA0408	0.036
UBE2V1	ubiquitin-conjugating enzyme E2 variant 1	0.034
PRLHR	prolactin releasing hormone receptor	0.034
ARPC1A	actin related protein 2/3 complex, subunit 1A, 41kDa	0.032
RHOA	ras homolog gene family, member A	0.032
VCL	vinculin	0.031
PICALM	phosphatidylinositol binding clathrin assembly protein	0.031
BECN1	beclin 1, autophagy related	0.030
PARD6B	par-6 partitioning defective 6 homolog beta (C. elegans)	0.030
PRKCG	protein kinase C, gamma	0.030
TRIM34	tripartite motif containing 34	0.029
MYL12B	myosin, light chain 12B, regulatory	0.029
NCKAP1L	NCK-associated protein 1-like	0.029	Human
TRIM43	tripartite motif containing 43	0.028
SLC6A3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.028
DIAPH1	diaphanous homolog 1 (Drosophila)	0.025	Fly
MSN	moesin	0.025
CFL1	cofilin 1 (non-muscle)	0.025
RAC1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	0.024
UBE2U	ubiquitin-conjugating enzyme E2U (putative)	0.024
DAPK1	death-associated protein kinase 1	0.024
FLNA	filamin A, alpha	0.022
ACTB	actin, beta	0.022
TRIM8	tripartite motif containing 8	0.021
PAK2	p21 protein (Cdc42/Rac)-activated kinase 2	0.021
ATXN7L3	ataxin 7-like 3	0.021
MLLT6	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6	0.021
FNBP1	formin binding protein 1	0.020	Fly
ZNRF1	zinc and ring finger 1	0.020
PAK4	p21 protein (Cdc42/Rac)-activated kinase 4	0.020
DTNBP1	dystrobrevin binding protein 1	0.020
CDC34	cell division cycle 34 homolog (S. cerevisiae)	0.020
VASP	vasodilator-stimulated phosphoprotein	0.020
LGALS1	lectin, galactoside-binding, soluble, 1	0.019
RALB	v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)	0.019
IRF2	interferon regulatory factor 2	0.019
MCOLN1	mucolipin 1	0.018
ACTA1	actin, alpha 1, skeletal muscle	0.018
FMNL2	formin-like 2	0.018
PAK7	p21 protein (Cdc42/Rac)-activated kinase 7	0.018
UBE2D3	ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)	0.018
TRIM41	tripartite motif containing 41	0.017	Human
LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	0.017
ARIH2	ariadne homolog 2 (Drosophila)	0.017
C4orf14	chromosome 4 open reading frame 14	0.017
MSH5	mutS homolog 5 (E. coli)	0.017
DNM1	dynamin 1	0.017
ZBTB8A	zinc finger and BTB domain containing 8A	0.017
UBE2J1	ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast)	0.017
SP100	SP100 nuclear antigen	0.017
ACCN2	amiloride-sensitive cation channel 2, neuronal	0.017
PRKAA1	protein kinase, AMP-activated, alpha 1 catalytic subunit	0.016
BTK	Bruton agammaglobulinemia tyrosine kinase	0.016
TMOD3	tropomodulin 3 (ubiquitous)	0.016
LASP1	LIM and SH3 protein 1	0.016
RAC2	ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)	0.016
CBLB	Cas-Br-M (murine) ecotropic retroviral transforming sequence b	0.016
ANLN	anillin, actin binding protein	0.016
HOMER3	homer homolog 3 (Drosophila)	0.015
TRIM17	tripartite motif containing 17	0.015	Human
GIT2	G protein-coupled receptor kinase interacting ArfGAP 2	0.015
NMI	N-myc (and STAT) interactor	0.015
MYO1E	myosin IE	0.015
OAS1	2',5'-oligoadenylate synthetase 1, 40/46kDa	0.015
TAGLN2	transgelin 2	0.015
ARHGAP1	Rho GTPase activating protein 1	0.015
RNF126	ring finger protein 126	0.015
ARF6	ADP-ribosylation factor 6	0.015
ARRB1	arrestin, beta 1	0.014
ARPC5L	actin related protein 2/3 complex, subunit 5-like	0.014	Human Worm
PAK1	p21 protein (Cdc42/Rac)-activated kinase 1	0.014
ANXA4	annexin A4	0.014
ARHGAP17	Rho GTPase activating protein 17	0.014
RIPK3	receptor-interacting serine-threonine kinase 3	0.014
PACSIN3	protein kinase C and casein kinase substrate in neurons 3	0.014
ROD1	ROD1 regulator of differentiation 1 (S. pombe)	0.014
RAB35	RAB35, member RAS oncogene family	0.013
RNF5	ring finger protein 5	0.013
CIC	capicua homolog (Drosophila)	0.013
TRIM35	tripartite motif containing 35	0.013
GNAI3	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	0.012
SP110	SP110 nuclear body protein	0.012
GNGT2	guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2	0.012
LRRK2	leucine-rich repeat kinase 2	0.012
CORO1A	coronin, actin binding protein, 1A	0.012
TRIM63	tripartite motif containing 63	0.012
ARHGAP4	Rho GTPase activating protein 4	0.012
CDC42EP2	CDC42 effector protein (Rho GTPase binding) 2	0.011
UBE2Z	ubiquitin-conjugating enzyme E2Z	0.011
TAB3	TGF-beta activated kinase 1/MAP3K7 binding protein 3	0.011
PARD6A	par-6 partitioning defective 6 homolog alpha (C. elegans)	0.011
SREBF1	sterol regulatory element binding transcription factor 1	0.011
TEX11	testis expressed 11	0.011
C3orf10	chromosome 3 open reading frame 10	0.011
TRIM4	tripartite motif containing 4	0.011	Human
DDX60	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	0.011
USP4	ubiquitin specific peptidase 4 (proto-oncogene)	0.011
MKRN3	makorin ring finger protein 3	0.011
STAU1	staufen, RNA binding protein, homolog 1 (Drosophila)	0.011
TPD52L2	tumor protein D52-like 2	0.011
IQGAP2	IQ motif containing GTPase activating protein 2	0.010
RNF4	ring finger protein 4	0.010