IMP

Process View

Homo sapiens

34 genes annotated in human

regulation of pathway restricted smad protein phosphorylation

Any process that modulates the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of pathway restricted smad protein phosphorylation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of pathway restricted smad protein phosphorylation" (in gray)

Name	Description	Probability	Func Analog Organism
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	1.000	Human
SMURF2	SMAD specific E3 ubiquitin protein ligase 2	1.000
BMP2	bone morphogenetic protein 2	1.000
BMPR1A	bone morphogenetic protein receptor, type IA	1.000
SMAD7	SMAD family member 7	1.000
TGFB1	transforming growth factor, beta 1	0.999
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.999
TGFB3	transforming growth factor, beta 3	0.998	Mouse
SMAD4	SMAD family member 4	0.997	Human Mouse
FSTL1	follistatin-like 1	0.992
TGFBR1	transforming growth factor, beta receptor 1	0.988
BMPR1B	bone morphogenetic protein receptor, type IB	0.987	Human
SMAD1	SMAD family member 1	0.986	Human
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.979
SMAD5	SMAD family member 5	0.973	Human
WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	0.958
ACVR1	activin A receptor, type I	0.922
GDF5	growth differentiation factor 5	0.888	Human
NRP1	neuropilin 1	0.873
SMAD2	SMAD family member 2	0.822	Human
ENG	endoglin	0.790
LRP6	low density lipoprotein receptor-related protein 6	0.787
ZFYVE9	zinc finger, FYVE domain containing 9	0.721
SMAD3	SMAD family member 3	0.707	Human
WFIKKN1	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1	0.701
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.492
SKIL	SKI-like oncogene	0.484
SMAD6	SMAD family member 6	0.464
PSMD11	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11	0.449
ACVR1B	activin A receptor, type IB	0.298	Human Rat Fly
FKBP1A	FK506 binding protein 1A, 12kDa	0.278
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.251
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.246
CXXC5	CXXC finger protein 5	0.236
TGFB2	transforming growth factor, beta 2	0.235	Human
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.222
ACVR2B	activin A receptor, type IIB	0.220	Human
PRKG1	protein kinase, cGMP-dependent, type I	0.213
BMP4	bone morphogenetic protein 4	0.191
FST	follistatin	0.171
ZMYND11	zinc finger, MYND-type containing 11	0.164
NEDD4	neural precursor cell expressed, developmentally down-regulated 4	0.104
SOX7	SRY (sex determining region Y)-box 7	0.100
MAPK8	mitogen-activated protein kinase 8	0.100
ADARB1	adenosine deaminase, RNA-specific, B1	0.098
RBFOX2	RNA binding protein, fox-1 homolog (C. elegans) 2	0.097
THBS1	thrombospondin 1	0.097
FN1	fibronectin 1	0.094
RBFOX1	RNA binding protein, fox-1 homolog (C. elegans) 1	0.084
HEYL	hairy/enhancer-of-split related with YRPW motif-like	0.082
MYO6	myosin VI	0.082
WDYHV1	WDYHV motif containing 1	0.079
ZEB2	zinc finger E-box binding homeobox 2	0.076
RXRA	retinoid X receptor, alpha	0.075
DAZAP2	DAZ associated protein 2	0.067
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	0.066
GRB7	growth factor receptor-bound protein 7	0.058
HOXC8	homeobox C8	0.057
NLK	nemo-like kinase	0.053
MKL2	MKL/myocardin-like 2	0.053
PITX1	paired-like homeodomain 1	0.053
QKI	quaking homolog, KH domain RNA binding (mouse)	0.052
NRP2	neuropilin 2	0.049
PDLIM4	PDZ and LIM domain 4	0.049
VPS24	vacuolar protein sorting 24 homolog (S. cerevisiae)	0.047
COL2A1	collagen, type II, alpha 1	0.047
SMN1	survival of motor neuron 1, telomeric	0.045
VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	0.045
SPG20	spastic paraplegia 20 (Troyer syndrome)	0.044
CSNK2A2	casein kinase 2, alpha prime polypeptide	0.044
RNF11	ring finger protein 11	0.044
NOG	noggin	0.043
TFPI2	tissue factor pathway inhibitor 2	0.043
NEDD9	neural precursor cell expressed, developmentally down-regulated 9	0.042
NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like	0.041
TRAF4	TNF receptor-associated factor 4	0.041
CCDC126	coiled-coil domain containing 126	0.039
ANTXR2	anthrax toxin receptor 2	0.036
FBLN1	fibulin 1	0.035
PHF1	PHD finger protein 1	0.035
ACVR2A	activin A receptor, type IIA	0.034
TGFBR3	transforming growth factor, beta receptor III	0.033	Human
ARHGAP5	Rho GTPase activating protein 5	0.031
SMAD9	SMAD family member 9	0.030
RBMS3	RNA binding motif, single stranded interacting protein 3	0.030
BGN	biglycan	0.029
LRP2	low density lipoprotein receptor-related protein 2	0.029
PMEPA1	prostate transmembrane protein, androgen induced 1	0.029
RHOXF2	Rhox homeobox family, member 2	0.029
DOCK8	dedicator of cytokinesis 8	0.028
POLK	polymerase (DNA directed) kappa	0.028
INHBB	inhibin, beta B	0.026	Human
CTGF	connective tissue growth factor	0.026
FHL2	four and a half LIM domains 2	0.026
PDGFC	platelet derived growth factor C	0.026
WWP2	WW domain containing E3 ubiquitin protein ligase 2	0.025
MED25	mediator complex subunit 25	0.025
PAPPA	pregnancy-associated plasma protein A, pappalysin 1	0.025
FILIP1L	filamin A interacting protein 1-like	0.025
VEGFC	vascular endothelial growth factor C	0.025
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.024
OTX1	orthodenticle homeobox 1	0.024
ZNF71	zinc finger protein 71	0.024
BAMBI	BMP and activin membrane-bound inhibitor homolog (Xenopus laevis)	0.024
STAMBP	STAM binding protein	0.024
DCP1B	DCP1 decapping enzyme homolog B (S. cerevisiae)	0.024
ATXN1	ataxin 1	0.024
EIF2S2	eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa	0.022
INHBA	inhibin, beta A	0.022
FZD7	frizzled homolog 7 (Drosophila)	0.022
MAST4	microtubule associated serine/threonine kinase family member 4	0.022
DEAF1	deformed epidermal autoregulatory factor 1 (Drosophila)	0.022
EYA2	eyes absent homolog 2 (Drosophila)	0.022
PPIL4	peptidylprolyl isomerase (cyclophilin)-like 4	0.022
DVL2	dishevelled, dsh homolog 2 (Drosophila)	0.021
ITGAV	integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)	0.021
SOX21	SRY (sex determining region Y)-box 21	0.021
ATF2	activating transcription factor 2	0.021
ZBED5	zinc finger, BED-type containing 5	0.021
BMP3	bone morphogenetic protein 3	0.021	Human
SCARB2	scavenger receptor class B, member 2	0.021
RNFT1	ring finger protein, transmembrane 1	0.020
GATA2	GATA binding protein 2	0.020
FGF4	fibroblast growth factor 4	0.020
BDNF	brain-derived neurotrophic factor	0.020
FOXF1	forkhead box F1	0.020
CYCS	cytochrome c, somatic	0.020
WWP1	WW domain containing E3 ubiquitin protein ligase 1	0.020
RUNX2	runt-related transcription factor 2	0.020
GDF11	growth differentiation factor 11	0.020	Human
DACH1	dachshund homolog 1 (Drosophila)	0.019
RNF146	ring finger protein 146	0.019
SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	0.019
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.019
AR	androgen receptor	0.019
FOXF2	forkhead box F2	0.019
ICK	intestinal cell (MAK-like) kinase	0.019
GMEB1	glucocorticoid modulatory element binding protein 1	0.019
DCP1A	DCP1 decapping enzyme homolog A (S. cerevisiae)	0.019
MYOC	myocilin, trabecular meshwork inducible glucocorticoid response	0.018
DOCK9	dedicator of cytokinesis 9	0.018
RARA	retinoic acid receptor, alpha	0.018
YY1	YY1 transcription factor	0.018
BMP8B	bone morphogenetic protein 8b	0.018	Human Mouse
SRI	sorcin	0.018
SLIT3	slit homolog 3 (Drosophila)	0.018
SOX5	SRY (sex determining region Y)-box 5	0.018
PSG9	pregnancy specific beta-1-glycoprotein 9	0.018
ACVRL1	activin A receptor type II-like 1	0.017
TIMP3	TIMP metallopeptidase inhibitor 3	0.017
UNC5B	unc-5 homolog B (C. elegans)	0.017
IGSF1	immunoglobulin superfamily, member 1	0.017
SCRT1	scratch homolog 1, zinc finger protein (Drosophila)	0.017
USP15	ubiquitin specific peptidase 15	0.017
SLIT2	slit homolog 2 (Drosophila)	0.017
GDNF	glial cell derived neurotrophic factor	0.016
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.016
NEU4	sialidase 4	0.016
TBC1D1	TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1	0.016
FOXA1	forkhead box A1	0.016
FNDC3B	fibronectin type III domain containing 3B	0.016
LRP12	low density lipoprotein receptor-related protein 12	0.016
MDFI	MyoD family inhibitor	0.015
FOXS1	forkhead box S1	0.015
VASN	vasorin	0.015
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.015
HOXA9	homeobox A9	0.015
ACAN	aggrecan	0.015
SMUG1	single-strand-selective monofunctional uracil-DNA glycosylase 1	0.015
CLU	clusterin	0.015
WNT11	wingless-type MMTV integration site family, member 11	0.015
ST8SIA2	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	0.014
CNN1	calponin 1, basic, smooth muscle	0.014
CARHSP1	calcium regulated heat stable protein 1, 24kDa	0.014
VEGFA	vascular endothelial growth factor A	0.014
BMP6	bone morphogenetic protein 6	0.014
BMP5	bone morphogenetic protein 5	0.014
ACBD3	acyl-CoA binding domain containing 3	0.014
C9orf100	chromosome 9 open reading frame 100	0.014
CRIM1	cysteine rich transmembrane BMP regulator 1 (chordin-like)	0.014
SOX13	SRY (sex determining region Y)-box 13	0.014
CHM	choroideremia (Rab escort protein 1)	0.014
JAG1	jagged 1	0.014
EFNB3	ephrin-B3	0.014
PIAS1	protein inhibitor of activated STAT, 1	0.014
HOXB9	homeobox B9	0.014
VTN	vitronectin	0.014
VAV3	vav 3 guanine nucleotide exchange factor	0.014
MSTN	myostatin	0.014	Human
MTMR4	myotubularin related protein 4	0.014
HAS2	hyaluronan synthase 2	0.013
STX17	syntaxin 17	0.013
PITX2	paired-like homeodomain 2	0.013
EDN1	endothelin 1	0.013
PRRX1	paired related homeobox 1	0.013
DIP2A	DIP2 disco-interacting protein 2 homolog A (Drosophila)	0.013
FCHO2	FCH domain only 2	0.013
DDX24	DEAD (Asp-Glu-Ala-Asp) box polypeptide 24	0.013
C2orf51	chromosome 2 open reading frame 51	0.013
RAMP2	receptor (G protein-coupled) activity modifying protein 2	0.013
RFX1	regulatory factor X, 1 (influences HLA class II expression)	0.013
SCUBE3	signal peptide, CUB domain, EGF-like 3	0.013
PIAS2	protein inhibitor of activated STAT, 2	0.013
SARNP	SAP domain containing ribonucleoprotein	0.013
ENC1	ectodermal-neural cortex 1 (with BTB-like domain)	0.013
TG	thyroglobulin	0.013
ZNF510	zinc finger protein 510	0.013
ARRDC3	arrestin domain containing 3	0.013
C19orf53	chromosome 19 open reading frame 53	0.013
NR0B1	nuclear receptor subfamily 0, group B, member 1	0.013
ITGA2	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	0.013
SLCO2A1	solute carrier organic anion transporter family, member 2A1	0.012
MBNL2	muscleblind-like 2 (Drosophila)	0.012
FGFR1	fibroblast growth factor receptor 1	0.012
MTMR10	myotubularin related protein 10	0.012
TCF21	transcription factor 21	0.012
CHERP	calcium homeostasis endoplasmic reticulum protein	0.012
HS3ST3A1	heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1	0.012
FLNB	filamin B, beta	0.012
ITGA6	integrin, alpha 6	0.012
EFNB2	ephrin-B2	0.012
SOSTDC1	sclerostin domain containing 1	0.012
PFDN2	prefoldin subunit 2	0.012
SP1	Sp1 transcription factor	0.012
ITGB8	integrin, beta 8	0.012
NTN1	netrin 1	0.012
AVPR1B	arginine vasopressin receptor 1B	0.012
RPS6KA6	ribosomal protein S6 kinase, 90kDa, polypeptide 6	0.012
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.012
ASH1L	ash1 (absent, small, or homeotic)-like (Drosophila)	0.011
GPR64	G protein-coupled receptor 64	0.011
COL6A1	collagen, type VI, alpha 1	0.011
ARHGAP29	Rho GTPase activating protein 29	0.011
PCDH7	protocadherin 7	0.011
SOCS5	suppressor of cytokine signaling 5	0.011
ATF7IP	activating transcription factor 7 interacting protein	0.011
STARD13	StAR-related lipid transfer (START) domain containing 13	0.011
FBXL15	F-box and leucine-rich repeat protein 15	0.011
PSME3	proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)	0.011
PTPN12	protein tyrosine phosphatase, non-receptor type 12	0.011
HAND1	heart and neural crest derivatives expressed 1	0.011
KIF5C	kinesin family member 5C	0.011
TNFRSF11B	tumor necrosis factor receptor superfamily, member 11b	0.011
PIAS4	protein inhibitor of activated STAT, 4	0.011
CLDN11	claudin 11	0.011
FOXO3	forkhead box O3	0.011
PTGIS	prostaglandin I2 (prostacyclin) synthase	0.011
KLF7	Kruppel-like factor 7 (ubiquitous)	0.011
WT1	Wilms tumor 1	0.011
SPOCK1	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1	0.011
NT5DC1	5'-nucleotidase domain containing 1	0.011
WNT1	wingless-type MMTV integration site family, member 1	0.011
TSC22D4	TSC22 domain family, member 4	0.011
ZNF75D	zinc finger protein 75D	0.011
ID3	inhibitor of DNA binding 3, dominant negative helix-loop-helix protein	0.011
PRPH2	peripherin 2 (retinal degeneration, slow)	0.011
SSSCA1	Sjogren syndrome/scleroderma autoantigen 1	0.011
TFPI	tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)	0.011
NUAK1	NUAK family, SNF1-like kinase, 1	0.011
DKK3	dickkopf homolog 3 (Xenopus laevis)	0.011
PSG2	pregnancy specific beta-1-glycoprotein 2	0.011
TMEM139	transmembrane protein 139	0.011
CUEDC1	CUE domain containing 1	0.011
FZD4	frizzled homolog 4 (Drosophila)	0.011
CAMSAP1	calmodulin regulated spectrin-associated protein 1	0.011
ZNF581	zinc finger protein 581	0.010
ZC3H10	zinc finger CCCH-type containing 10	0.010
COL13A1	collagen, type XIII, alpha 1	0.010
PTPRG	protein tyrosine phosphatase, receptor type, G	0.010
SHC3	SHC (Src homology 2 domain containing) transforming protein 3	0.010
ZMYM2	zinc finger, MYM-type 2	0.010
FSTL3	follistatin-like 3 (secreted glycoprotein)	0.010
LMBRD2	LMBR1 domain containing 2	0.010
PRKAB2	protein kinase, AMP-activated, beta 2 non-catalytic subunit	0.010
BMP7	bone morphogenetic protein 7	0.010
ASAP2	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2	0.010
GSTM4	glutathione S-transferase mu 4	0.010
NCOA6	nuclear receptor coactivator 6	0.010
NR2F2	nuclear receptor subfamily 2, group F, member 2	0.010
UTRN	utrophin	0.010
FZD10	frizzled homolog 10 (Drosophila)	0.010
TRIM33	tripartite motif containing 33	0.010
IL13RA2	interleukin 13 receptor, alpha 2	0.010
HOOK3	hook homolog 3 (Drosophila)	0.010
RHOBTB3	Rho-related BTB domain containing 3	0.010
SLC16A2	solute carrier family 16, member 2 (monocarboxylic acid transporter 8)	0.010
AMIGO2	adhesion molecule with Ig-like domain 2	0.010