Drosophila melanogaster

147 known processes

Sir2 (Dmel_CG5216)

CG5216 gene product from transcript CG5216-RA

(Aliases: sir2,BEST:LD38188,Dmel\CG5216,CG5216,dSir2,l(2)05326,dSIR2,SIR2,Sir2L,D.mel1,dsir2,dmSRT406,DSir2)

Sir2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
chromatin organization GO:0006325 207 1.000
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.998
chromosome organization GO:0051276 360 0.998
negative regulation of cellular biosynthetic process GO:0031327 277 0.996
negative regulation of rna biosynthetic process GO:1902679 240 0.994
chromatin silencing GO:0006342 76 0.992
histone modification GO:0016570 106 0.992
negative regulation of biosynthetic process GO:0009890 277 0.991
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.988
negative regulation of gene expression epigenetic GO:0045814 77 0.977
chromatin modification GO:0016568 147 0.969
negative regulation of nucleic acid templated transcription GO:1903507 240 0.968
response to organic substance GO:0010033 284 0.968
gene silencing GO:0016458 138 0.967
regulation of gene expression epigenetic GO:0040029 128 0.962
negative regulation of rna metabolic process GO:0051253 251 0.957
negative regulation of gene expression GO:0010629 387 0.955
cellular response to chemical stimulus GO:0070887 199 0.953
Human Mouse
cellular catabolic process GO:0044248 372 0.948
Human Mouse
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.937
intracellular signal transduction GO:0035556 300 0.932
Human Mouse
histone acetylation GO:0016573 38 0.928
negative regulation of cell communication GO:0010648 223 0.927
Human Mouse
negative regulation of cellular metabolic process GO:0031324 382 0.911
regulation of organelle organization GO:0033043 196 0.907
response to oxygen containing compound GO:1901700 200 0.902
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.846
Human Mouse
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.842
Human Mouse
covalent chromatin modification GO:0016569 106 0.840
negative regulation of transcription dna templated GO:0045892 237 0.839
protein acetylation GO:0006473 39 0.815
protein acylation GO:0043543 42 0.815
positive regulation of rna metabolic process GO:0051254 271 0.813
Human Mouse
positive regulation of response to stimulus GO:0048584 323 0.794
negative regulation of signaling GO:0023057 219 0.785
Human Mouse
peptidyl lysine acetylation GO:0018394 39 0.772
positive regulation of cellular biosynthetic process GO:0031328 316 0.771
Human Mouse
peptidyl amino acid modification GO:0018193 105 0.764
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.754
Human Mouse
single organism cellular localization GO:1902580 180 0.745
Human
regulation of cellular response to stress GO:0080135 89 0.744
Human Mouse
muscle structure development GO:0061061 224 0.720
regulation of cell differentiation GO:0045595 302 0.713
Mouse
positive regulation of macromolecule metabolic process GO:0010604 405 0.707
Human Mouse
cell death GO:0008219 279 0.698
positive regulation of nucleic acid templated transcription GO:1903508 266 0.677
Human Mouse
positive regulation of autophagy GO:0010508 21 0.664
Human Mouse
protein localization to organelle GO:0033365 82 0.663
Human
transcription from rna polymerase ii promoter GO:0006366 368 0.662
Human Mouse
growth GO:0040007 359 0.645
Human
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.618
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.606
Human Mouse
positive regulation of organelle organization GO:0010638 65 0.601
Human
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.581
Human Mouse
response to endogenous stimulus GO:0009719 119 0.572
Human Mouse
determination of adult lifespan GO:0008340 137 0.550
regulation of cell cycle process GO:0010564 181 0.547
negative regulation of signal transduction GO:0009968 206 0.547
Human Mouse
intracellular transport GO:0046907 228 0.537
Human
cellular response to dna damage stimulus GO:0006974 223 0.525
Human Mouse
regulation of cell development GO:0060284 215 0.521
protein localization to nucleus GO:0034504 55 0.517
Human
heterocycle catabolic process GO:0046700 166 0.516
Human
negative regulation of neuron death GO:1901215 18 0.513
Mouse
jnk cascade GO:0007254 50 0.512
positive regulation of transcription dna templated GO:0045893 266 0.512
Human Mouse
regionalization GO:0003002 416 0.504
cellular response to starvation GO:0009267 61 0.495
Human Mouse
regulation of apoptotic process GO:0042981 130 0.495
catabolic process GO:0009056 409 0.494
Human Mouse
cellular macromolecule localization GO:0070727 220 0.484
Human
regulation of response to stress GO:0080134 200 0.456
Human Mouse
protein localization to chromatin GO:0071168 3 0.433
response to alcohol GO:0097305 95 0.423
regulation of intracellular signal transduction GO:1902531 236 0.416
Human Mouse
cellular protein localization GO:0034613 160 0.406
Human
internal peptidyl lysine acetylation GO:0018393 38 0.398
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 11 0.392
Human Mouse
cellular response to ionizing radiation GO:0071479 15 0.381
Mouse
regulation of catabolic process GO:0009894 170 0.375
Human Mouse
internal protein amino acid acetylation GO:0006475 38 0.371
cell type specific apoptotic process GO:0097285 38 0.366
Mouse
regulation of chromosome organization GO:0033044 64 0.366
regulation of histone modification GO:0031056 20 0.365
cell migration GO:0016477 238 0.355
cellular protein modification process GO:0006464 438 0.352
response to nitrogen compound GO:1901698 90 0.344
Human Mouse
positive regulation of gene expression GO:0010628 290 0.339
Human Mouse
positive regulation of biosynthetic process GO:0009891 316 0.337
Human Mouse
response to organonitrogen compound GO:0010243 75 0.330
Human Mouse
male gamete generation GO:0048232 201 0.327
Mouse
positive regulation of developmental process GO:0051094 143 0.317
Human
heterochromatin organization GO:0070828 25 0.313
spindle organization GO:0007051 253 0.309
response to organic cyclic compound GO:0014070 89 0.299
Human
regulation of anatomical structure morphogenesis GO:0022603 242 0.289
response to ionizing radiation GO:0010212 32 0.289
Mouse
regulation of cell death GO:0010941 173 0.287
establishment of protein localization GO:0045184 163 0.274
Human
immune response GO:0006955 246 0.266
Human
negative regulation of cell differentiation GO:0045596 143 0.263
Mouse
protein modification process GO:0036211 438 0.263
eye morphogenesis GO:0048592 260 0.258
dna damage checkpoint GO:0000077 78 0.257
regulation of autophagy GO:0010506 62 0.248
Human Mouse
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.248
Human Mouse
peptidyl lysine modification GO:0018205 57 0.248
cellular response to insulin stimulus GO:0032869 28 0.238
Human
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 38 0.236
Mouse
protein targeting GO:0006605 64 0.223
Human
cellular response to nutrient levels GO:0031669 62 0.215
Human Mouse
autophagy GO:0006914 108 0.212
Human Mouse
stress activated mapk cascade GO:0051403 52 0.209
response to lipid GO:0033993 38 0.207
Human
histone h4 k16 acetylation GO:0043984 4 0.205
regulation of stress activated mapk cascade GO:0032872 41 0.203
positive regulation of catabolic process GO:0009896 105 0.203
Human Mouse
regulation of growth GO:0040008 233 0.200
Human
positive regulation of phosphorus metabolic process GO:0010562 139 0.199
Human Mouse
protein complex biogenesis GO:0070271 201 0.199
death GO:0016265 284 0.199
localization of cell GO:0051674 257 0.196
regulation of cellular ketone metabolic process GO:0010565 3 0.193
Mouse
macromolecular complex assembly GO:0065003 256 0.188
regulation of multicellular organismal development GO:2000026 414 0.186
adult behavior GO:0030534 137 0.181
regulation of cellular catabolic process GO:0031329 157 0.181
Human Mouse
organelle fission GO:0048285 340 0.180
cellular macromolecular complex assembly GO:0034622 153 0.176
regulation of protein metabolic process GO:0051246 256 0.174
positive regulation of multicellular organismal process GO:0051240 143 0.168
positive regulation of rna biosynthetic process GO:1902680 266 0.167
Human Mouse
camera type eye morphogenesis GO:0048593 2 0.163
response to extracellular stimulus GO:0009991 116 0.161
response to bacterium GO:0009617 198 0.159
positive regulation of response to external stimulus GO:0032103 44 0.158
Human Mouse
regulation of cellular amino acid metabolic process GO:0006521 0 0.154
response to abiotic stimulus GO:0009628 341 0.154
Human Mouse
regulation of histone acetylation GO:0035065 7 0.152
response to sterol GO:0036314 34 0.151
protein targeting to nucleus GO:0044744 51 0.151
Human
single organism catabolic process GO:0044712 228 0.150
Human Mouse
stress activated protein kinase signaling cascade GO:0031098 55 0.150
regulation of chromatin organization GO:1902275 32 0.147
protein transport GO:0015031 155 0.147
Human
regulation of cell cycle phase transition GO:1901987 130 0.145
regulation of chromatin modification GO:1903308 28 0.144
single organism behavior GO:0044708 391 0.143
purine nucleoside catabolic process GO:0006152 112 0.140
male pronucleus assembly GO:0035039 6 0.139
positive regulation of multicellular organism growth GO:0040018 21 0.138
negative regulation of programmed cell death GO:0043069 72 0.137
Human Mouse
negative regulation of apoptotic process GO:0043066 63 0.132
Human Mouse
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.132
negative regulation of organelle organization GO:0010639 56 0.130
protein localization GO:0008104 284 0.129
Human
regulation of immune system process GO:0002682 176 0.127
Human
eye development GO:0001654 323 0.126
positive regulation of macroautophagy GO:0016239 8 0.125
Human Mouse
regulation of cellular amine metabolic process GO:0033238 3 0.125
organic substance catabolic process GO:1901575 308 0.124
Human
positive regulation of multi organism process GO:0043902 40 0.122
dna packaging GO:0006323 91 0.122
purine ribonucleotide catabolic process GO:0009154 109 0.118
response to other organism GO:0051707 293 0.117
rhythmic process GO:0048511 106 0.116
Human Mouse
cell motility GO:0048870 251 0.115
regulation of phosphorylation GO:0042325 147 0.114
Human Mouse
regulation of jnk cascade GO:0046328 40 0.112
cellular macromolecule catabolic process GO:0044265 136 0.111
Human
purine nucleoside triphosphate metabolic process GO:0009144 119 0.110
regulation of dna metabolic process GO:0051052 34 0.110
Human
regulation of notch signaling pathway GO:0008593 100 0.109
dna metabolic process GO:0006259 227 0.107
Human Mouse
photoreceptor cell differentiation GO:0046530 170 0.106
dna integrity checkpoint GO:0031570 81 0.106
developmental growth GO:0048589 280 0.104
positive regulation of cellular catabolic process GO:0031331 95 0.100
Human Mouse
establishment of localization in cell GO:0051649 402 0.099
Human
epithelial cell differentiation GO:0030855 322 0.098
positive regulation of immune response GO:0050778 63 0.098
Human
stem cell maintenance GO:0019827 67 0.097
cellular response to organic substance GO:0071310 132 0.096
Human Mouse
regulation of programmed cell death GO:0043067 152 0.096
regulation of neuron death GO:1901214 26 0.094
Mouse
nucleoside triphosphate metabolic process GO:0009141 120 0.092
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 65 0.091
Mouse
nucleobase containing compound catabolic process GO:0034655 165 0.090
Human
pigmentation GO:0043473 75 0.090
negative regulation of cellular component organization GO:0051129 108 0.089
chromatin remodeling GO:0006338 72 0.089
Human
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.088
positive regulation of cell communication GO:0010647 250 0.087
Human Mouse
mitotic nuclear division GO:0007067 213 0.087
dendrite morphogenesis GO:0048813 199 0.086
rna catabolic process GO:0006401 37 0.086
regulation of cellular component biogenesis GO:0044087 201 0.086
cellular ketone metabolic process GO:0042180 24 0.085
Mouse
macroautophagy GO:0016236 42 0.085
Human Mouse
positive regulation of antimicrobial peptide biosynthetic process GO:0002807 26 0.082
macromolecule catabolic process GO:0009057 161 0.082
Human
response to external biotic stimulus GO:0043207 293 0.082
embryonic morphogenesis GO:0048598 206 0.081
negative regulation of chromatin silencing GO:0031936 9 0.080
protein complex assembly GO:0006461 200 0.080
regulation of response to external stimulus GO:0032101 115 0.079
Human Mouse
regulation of chromatin silencing GO:0031935 36 0.078
Human
multicellular organism growth GO:0035264 46 0.078
nucleotide catabolic process GO:0009166 109 0.077
regulation of phosphorus metabolic process GO:0051174 210 0.077
Human Mouse
glial cell differentiation GO:0010001 35 0.076
signal transduction by phosphorylation GO:0023014 107 0.075
regulation of stress activated protein kinase signaling cascade GO:0070302 42 0.075
regulation of cell cycle GO:0051726 291 0.074
Human
myotube differentiation GO:0014902 46 0.074
sex differentiation GO:0007548 81 0.073
Mouse
heterochromatin organization involved in chromatin silencing GO:0070868 9 0.073
reproductive structure development GO:0048608 74 0.073
Mouse
establishment of protein localization to organelle GO:0072594 62 0.072
Human
programmed cell death GO:0012501 257 0.072
vesicle mediated transport GO:0016192 381 0.071
response to starvation GO:0042594 97 0.071
Human Mouse
purine ribonucleotide metabolic process GO:0009150 145 0.070
mapk cascade GO:0000165 107 0.069
intracellular protein transport GO:0006886 104 0.069
Human
regulation of multicellular organism growth GO:0040014 40 0.069
purine nucleoside metabolic process GO:0042278 127 0.068
positive regulation of growth GO:0045927 75 0.068
compound eye photoreceptor cell differentiation GO:0001751 140 0.067
amine metabolic process GO:0009308 12 0.066
cell division GO:0051301 248 0.065
camera type eye development GO:0043010 4 0.065
negative regulation of response to stimulus GO:0048585 258 0.064
Human Mouse
stem cell development GO:0048864 79 0.063
regulation of macroautophagy GO:0016241 15 0.061
Human Mouse
regulation of epithelial cell differentiation GO:0030856 4 0.061
regulation of organ morphogenesis GO:2000027 78 0.059
nuclear division GO:0000280 332 0.059
regulation of defense response GO:0031347 102 0.057
apoptotic signaling pathway GO:0097190 27 0.055
Human Mouse
regulation of small gtpase mediated signal transduction GO:0051056 93 0.055
compound eye development GO:0048749 307 0.055
response to virus GO:0009615 28 0.054
neurological system process GO:0050877 358 0.054
epithelial cell development GO:0002064 274 0.054
cellular response to endogenous stimulus GO:0071495 80 0.054
Human Mouse
positive regulation of signal transduction GO:0009967 223 0.054
Human
proteolysis GO:0006508 192 0.053
Human
response to biotic stimulus GO:0009607 294 0.053
embryo development ending in birth or egg hatching GO:0009792 152 0.053
morphogenesis of a branching epithelium GO:0061138 45 0.052
organic substance transport GO:0071702 257 0.052
Human Mouse
regulation of phosphate metabolic process GO:0019220 210 0.052
Human Mouse
protein alkylation GO:0008213 43 0.052
Human
notch signaling pathway GO:0007219 120 0.051
establishment or maintenance of cell polarity GO:0007163 167 0.050
response to ketone GO:1901654 34 0.050
Human
positive regulation of protein metabolic process GO:0051247 128 0.050
Human Mouse
positive regulation of programmed cell death GO:0043068 62 0.050
Human Mouse
response to lipopolysaccharide GO:0032496 4 0.049
endocytosis GO:0006897 310 0.049
cellular protein complex assembly GO:0043623 71 0.048
negative regulation of protein metabolic process GO:0051248 85 0.048
Human
eye photoreceptor cell differentiation GO:0001754 145 0.048
hemopoiesis GO:0030097 46 0.047
purine nucleotide catabolic process GO:0006195 109 0.047
regulation of mapk cascade GO:0043408 92 0.047
phagocytosis GO:0006909 215 0.047
head development GO:0060322 135 0.046
nucleoside catabolic process GO:0009164 112 0.046
purine nucleoside triphosphate catabolic process GO:0009146 108 0.046
defense response GO:0006952 300 0.046
single organism membrane organization GO:0044802 93 0.046
secondary metabolic process GO:0019748 75 0.045
posttranscriptional regulation of gene expression GO:0010608 145 0.045
Mouse
organonitrogen compound catabolic process GO:1901565 128 0.045
positive regulation of phosphate metabolic process GO:0045937 139 0.045
Human Mouse
negative regulation of developmental process GO:0051093 201 0.044
Human Mouse
glycosyl compound catabolic process GO:1901658 112 0.044
columnar cuboidal epithelial cell development GO:0002066 249 0.043
nuclear import GO:0051170 51 0.043
Human
positive regulation of phosphorylation GO:0042327 87 0.043
Human Mouse
central nervous system development GO:0007417 201 0.042
regulation of proteolysis GO:0030162 87 0.042
Human
multi multicellular organism process GO:0044706 123 0.042
behavioral response to ethanol GO:0048149 49 0.042
positive regulation of jun kinase activity GO:0043507 4 0.042
muscle cell differentiation GO:0042692 103 0.041
organophosphate metabolic process GO:0019637 195 0.041
positive regulation of molecular function GO:0044093 136 0.041
Human Mouse
protein dna complex subunit organization GO:0071824 86 0.041
regulation of peptidyl lysine acetylation GO:2000756 7 0.040
syncytium formation by plasma membrane fusion GO:0000768 43 0.040
cellular response to nitrogen compound GO:1901699 51 0.040
Human
positive regulation of response to extracellular stimulus GO:0032106 8 0.040
Human Mouse
immune system development GO:0002520 57 0.039
dna replication GO:0006260 48 0.039
innate immune response GO:0045087 144 0.039
purine ribonucleoside metabolic process GO:0046128 127 0.039
carbohydrate derivative catabolic process GO:1901136 118 0.039
ribonucleoside triphosphate metabolic process GO:0009199 119 0.039
appendage development GO:0048736 401 0.039
organic cyclic compound catabolic process GO:1901361 168 0.038
Human
ribonucleotide catabolic process GO:0009261 109 0.038
cytoplasmic transport GO:0016482 130 0.038
Human
aging GO:0007568 143 0.038
convergent extension GO:0060026 2 0.037
single organism intracellular transport GO:1902582 207 0.037
Human
gliogenesis GO:0042063 80 0.037
single organism nuclear import GO:1902593 51 0.037
Human
organophosphate catabolic process GO:0046434 112 0.037
organonitrogen compound metabolic process GO:1901564 318 0.037
carbohydrate derivative metabolic process GO:1901135 217 0.036
chromatin assembly GO:0031497 48 0.036
regulation of protein modification process GO:0031399 112 0.035
ribonucleotide metabolic process GO:0009259 145 0.035
ribonucleoside triphosphate catabolic process GO:0009203 108 0.035
cell cycle checkpoint GO:0000075 95 0.035
regulation of transport GO:0051049 181 0.035
Human Mouse
positive regulation of mapk cascade GO:0043410 63 0.035
regulation of transforming growth factor beta receptor signaling pathway GO:0017015 6 0.034
Mouse
ras protein signal transduction GO:0007265 88 0.034
tube development GO:0035295 244 0.033
positive regulation of nervous system development GO:0051962 69 0.033
positive regulation of cellular component organization GO:0051130 156 0.033
Human
positive regulation of developmental growth GO:0048639 62 0.032
nucleoside metabolic process GO:0009116 127 0.032
positive regulation of cellular protein metabolic process GO:0032270 118 0.032
Human Mouse
regulation of catalytic activity GO:0050790 185 0.032
Human Mouse
regulation of transcription by chromatin organization GO:0034401 3 0.032
positive regulation of histone acetylation GO:0035066 3 0.032
response to wounding GO:0009611 94 0.031
myoblast fusion GO:0007520 43 0.031
brain development GO:0007420 120 0.031
cell proliferation GO:0008283 299 0.031
Human
cell fate specification GO:0001708 71 0.031
regulation of defense response to virus by host GO:0050691 10 0.031
oxoacid metabolic process GO:0043436 103 0.030
Mouse
macromolecule deacylation GO:0098732 11 0.030
positive regulation of transport GO:0051050 92 0.030
Mouse
negative regulation of cellular protein metabolic process GO:0032269 85 0.030
Human
regulation of developmental pigmentation GO:0048070 24 0.030
ameboidal type cell migration GO:0001667 151 0.029
cellular amino acid metabolic process GO:0006520 61 0.029
muscle organ development GO:0007517 127 0.029
response to transforming growth factor beta GO:0071559 18 0.028
Mouse
digestive system development GO:0055123 149 0.028
protein import into nucleus GO:0006606 51 0.028
Human
cellular response to organic cyclic compound GO:0071407 32 0.028
Human
organic acid metabolic process GO:0006082 103 0.027
Mouse
aromatic compound catabolic process GO:0019439 166 0.027
Human
posttranscriptional gene silencing GO:0016441 46 0.027
response to hormone GO:0009725 45 0.027
Human Mouse
purine containing compound catabolic process GO:0072523 112 0.027
development of primary sexual characteristics GO:0045137 50 0.027
Mouse
organelle assembly GO:0070925 198 0.027
positive regulation of catalytic activity GO:0043085 118 0.026
Human Mouse
compound eye photoreceptor development GO:0042051 78 0.026
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.026
nucleobase containing small molecule metabolic process GO:0055086 174 0.026
carboxylic acid metabolic process GO:0019752 92 0.026
Mouse
cellular response to radiation GO:0071478 52 0.026
Mouse
stem cell differentiation GO:0048863 117 0.025
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 24 0.025
telencephalon development GO:0021537 2 0.025
positive regulation of signaling GO:0023056 243 0.025
Human
positive regulation of intracellular signal transduction GO:1902533 116 0.025
nucleoside triphosphate catabolic process GO:0009143 108 0.025
regulation of jun kinase activity GO:0043506 8 0.025
chromatin mediated maintenance of transcription GO:0048096 7 0.024
neural precursor cell proliferation GO:0061351 75 0.024
developmental pigmentation GO:0048066 68 0.024
cellular protein catabolic process GO:0044257 83 0.023
Human
regulation of apoptotic signaling pathway GO:2001233 10 0.023
Human Mouse
hindbrain development GO:0030902 2 0.023
transforming growth factor beta receptor signaling pathway GO:0007179 16 0.023
Mouse
body morphogenesis GO:0010171 2 0.023
regulation of photoreceptor cell differentiation GO:0046532 34 0.022
cellular amine metabolic process GO:0044106 12 0.022
cellular response to lipid GO:0071396 20 0.022
Human
photoreceptor cell development GO:0042461 96 0.022
negative regulation of multicellular organismal process GO:0051241 142 0.022
sensory organ morphogenesis GO:0090596 260 0.021
gland development GO:0048732 191 0.021
ubiquitin dependent protein catabolic process GO:0006511 78 0.021
Human
imaginal disc derived wing morphogenesis GO:0007476 337 0.021
cellular nitrogen compound catabolic process GO:0044270 165 0.021
Human
apoptotic process GO:0006915 159 0.021
mrna catabolic process GO:0006402 33 0.021
positive regulation of response to biotic stimulus GO:0002833 31 0.021
regulation of immune effector process GO:0002697 52 0.021
enzyme linked receptor protein signaling pathway GO:0007167 179 0.021
Human Mouse
small molecule metabolic process GO:0044281 305 0.021
Mouse
regulation of sequence specific dna binding transcription factor activity GO:0051090 12 0.020
Human
purine ribonucleoside catabolic process GO:0046130 112 0.020
negative regulation of notch signaling pathway GO:0045746 41 0.020
prostaglandin biosynthetic process GO:0001516 1 0.020
Mouse
retina development in camera type eye GO:0060041 4 0.020
cellular response to extracellular stimulus GO:0031668 64 0.020
Human Mouse
immune system process GO:0002376 347 0.020
Human
positive regulation of neurogenesis GO:0050769 41 0.019
response to insulin GO:0032868 29 0.019
Human Mouse
epithelial cell migration GO:0010631 148 0.019
cellular response to oxidative stress GO:0034599 28 0.019
Human
gonad development GO:0008406 50 0.019
Mouse
positive regulation of immune system process GO:0002684 68 0.019
Human
purine containing compound metabolic process GO:0072521 155 0.019
inositol lipid mediated signaling GO:0048017 4 0.018
intrinsic apoptotic signaling pathway GO:0097193 16 0.018
Human Mouse
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 18 0.018
Mouse
atp dependent chromatin remodeling GO:0043044 22 0.018
organ growth GO:0035265 56 0.018
positive regulation of production of molecular mediator of immune response GO:0002702 28 0.018
ribose phosphate metabolic process GO:0019693 145 0.018
wound healing GO:0042060 75 0.018
positive regulation of proteolysis GO:0045862 52 0.018
Human
autophagic vacuole fusion GO:0000046 15 0.017
purine nucleotide metabolic process GO:0006163 146 0.017
positive regulation of cell differentiation GO:0045597 64 0.017
negative regulation of protein processing GO:0010955 31 0.017
regulation of developmental growth GO:0048638 174 0.017
nucleosome positioning GO:0016584 3 0.017
humoral immune response GO:0006959 117 0.017
mitotic spindle organization GO:0007052 220 0.017
dna methylation GO:0006306 4 0.016
dorsal ventral pattern formation GO:0009953 133 0.016
methylation GO:0032259 47 0.016
Human
regulation of nucleocytoplasmic transport GO:0046822 35 0.016
Human
regulation of hydrolase activity GO:0051336 97 0.016
Human
forebrain development GO:0030900 2 0.016
dna methylation or demethylation GO:0044728 4 0.016
pigment metabolic process GO:0042440 84 0.016
regulation of cell morphogenesis GO:0022604 163 0.016
interspecies interaction between organisms GO:0044419 16 0.016
regulation of dna replication GO:0006275 13 0.015
regulation of dna templated transcription in response to stress GO:0043620 4 0.015
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.015
positive regulation of gene expression epigenetic GO:0045815 16 0.015
chromatin assembly or disassembly GO:0006333 52 0.015
regulation of reproductive process GO:2000241 54 0.015
connective tissue development GO:0061448 3 0.015
nurse cell apoptotic process GO:0045476 17 0.015
negative regulation of intracellular signal transduction GO:1902532 57 0.015
Human Mouse
mitotic cell cycle checkpoint GO:0007093 88 0.015
positive regulation of cell cycle GO:0045787 43 0.015
regulation of neuron apoptotic process GO:0043523 16 0.014
compound eye morphogenesis GO:0001745 249 0.014
organelle inheritance GO:0048308 2 0.014
ribonucleoside catabolic process GO:0042454 112 0.014
cellular response to oxygen containing compound GO:1901701 79 0.014
Human
regulation of purine nucleotide metabolic process GO:1900542 62 0.014
regulation of compound eye cone cell fate specification GO:0042682 4 0.014
defense response to bacterium GO:0042742 178 0.014
dendrite development GO:0016358 204 0.014
signal transduction in response to dna damage GO:0042770 3 0.014
Human
mesoderm development GO:0007498 78 0.014
protein catabolic process GO:0030163 101 0.014
Human
anterior posterior pattern specification GO:0009952 136 0.014
tissue morphogenesis GO:0048729 297 0.014
negative regulation of defense response GO:0031348 35 0.014
regulation of phosphatase activity GO:0010921 3 0.014
multi organism reproductive behavior GO:0044705 121 0.014
axis specification GO:0009798 167 0.014
nucleosome organization GO:0034728 59 0.013
regulation of cell motility GO:2000145 23 0.013
regulation of chromatin assembly GO:0010847 9 0.013
modification dependent protein catabolic process GO:0019941 78 0.013
Human
response to peptide GO:1901652 29 0.013
Human Mouse
positive regulation of cell death GO:0010942 69 0.013
Human Mouse
circadian rhythm GO:0007623 105 0.013
Human Mouse
regulation of molecular function GO:0065009 217 0.013
Human Mouse
regulation of localization GO:0032879 275 0.013
Human Mouse
protein kinase b signaling GO:0043491 1 0.013
Human Mouse
dna conformation change GO:0071103 105 0.013
nucleoside phosphate catabolic process GO:1901292 110 0.013
negative regulation of small gtpase mediated signal transduction GO:0051058 13 0.013
mitochondrial membrane organization GO:0007006 3 0.013
membrane organization GO:0061024 112 0.012
icosanoid biosynthetic process GO:0046456 1 0.012
Mouse
positive regulation of cell motility GO:2000147 3 0.012
hematopoietic or lymphoid organ development GO:0048534 57 0.012
positive regulation of cellular amine metabolic process GO:0033240 0 0.012
meiotic cell cycle GO:0051321 171 0.012
response to ethanol GO:0045471 59 0.012
signal transduction by p53 class mediator GO:0072331 6 0.012
Human Mouse
larval development GO:0002164 104 0.012
Worm
regulation of cellular protein metabolic process GO:0032268 243 0.012
reproductive system development GO:0061458 74 0.012
Mouse
bmp signaling pathway GO:0030509 27 0.012
negative regulation of neuron apoptotic process GO:0043524 14 0.012
mitotic dna damage checkpoint GO:0044773 74 0.012
regulation of synaptic plasticity GO:0048167 14 0.012
histone h3 acetylation GO:0043966 11 0.012
Worm
immune response activating signal transduction GO:0002757 2 0.012
negative regulation of intrinsic apoptotic signaling pathway GO:2001243 1 0.012
Human Mouse
cellular response to transforming growth factor beta stimulus GO:0071560 18 0.012
Mouse
regulation of ras protein signal transduction GO:0046578 93 0.011
mitotic sister chromatid segregation GO:0000070 87 0.011

Sir2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.013