Drosophila melanogaster

115 known processes

vnd (Dmel_CG6172)

ventral nervous system defective

(Aliases: l(1)1Bf,NK2,l(1)EC6,Dmel\CG6172,HDC16822,NK-2,l(1)RC24,l(1)EA142,VND,nk-2,l(1)VA208,l(1)GA122,EG:118B3.1,l(1)VE769,l(1)GA100,vnd/NK-2,Dm-NK2,Nkx2,dNK-2,lab,EC6,Vnd,CG6172)

vnd biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
taxis GO:0042330 304 0.922
axon development GO:0061564 297 0.774
dendrite guidance GO:0070983 21 0.667
axonogenesis GO:0007409 290 0.649
axon guidance GO:0007411 233 0.644
neuron projection guidance GO:0097485 241 0.631
motor neuron axon guidance GO:0008045 58 0.537
regulation of axon extension involved in axon guidance GO:0048841 4 0.427
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.426
salivary gland development GO:0007431 162 0.402
regulation of multicellular organismal development GO:2000026 414 0.342
positive regulation of axonogenesis GO:0050772 2 0.334
negative regulation of gene expression GO:0010629 387 0.310
gland morphogenesis GO:0022612 145 0.289
negative regulation of cellular metabolic process GO:0031324 382 0.280
negative regulation of rna biosynthetic process GO:1902679 240 0.270
exocrine system development GO:0035272 162 0.242
apoptotic process GO:0006915 159 0.220
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.215
negative regulation of biosynthetic process GO:0009890 277 0.204
chemotaxis GO:0006935 249 0.188
embryo development ending in birth or egg hatching GO:0009792 152 0.176
gland development GO:0048732 191 0.158
regulation of protein metabolic process GO:0051246 256 0.151
positive regulation of cell communication GO:0010647 250 0.147
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.146
central nervous system development GO:0007417 201 0.143
ventral cord development GO:0007419 16 0.142
glial cell differentiation GO:0010001 35 0.140
gliogenesis GO:0042063 80 0.138
salivary gland morphogenesis GO:0007435 145 0.136
negative regulation of rna metabolic process GO:0051253 251 0.135
dorsal ventral axon guidance GO:0033563 2 0.132
negative regulation of axon extension GO:0030517 3 0.126
negative regulation of transcription dna templated GO:0045892 237 0.124
morphogenesis of an epithelium GO:0002009 276 0.122
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.119
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.116
multicellular organismal reproductive behavior GO:0033057 110 0.105
regulation of nervous system development GO:0051960 248 0.103
regulation of epithelial cell migration open tracheal system GO:2000274 11 0.102
cardiovascular system development GO:0072358 82 0.101
regulation of axon guidance GO:1902667 10 0.098
cell junction organization GO:0034330 57 0.092
regionalization GO:0003002 416 0.087
regulation of oocyte development GO:0060281 27 0.084
regulation of developmental growth GO:0048638 174 0.082
death GO:0016265 284 0.079
positive regulation of rna metabolic process GO:0051254 271 0.079
neuron recognition GO:0008038 101 0.075
regulation of cell fate commitment GO:0010453 29 0.072
regulation of cellular protein metabolic process GO:0032268 243 0.072
spinal cord development GO:0021510 1 0.071
organelle assembly GO:0070925 198 0.070
head development GO:0060322 135 0.069
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.069
multi organism reproductive behavior GO:0044705 121 0.068
negative regulation of nervous system development GO:0051961 92 0.068
asymmetric cell division GO:0008356 37 0.067
oocyte maturation GO:0001556 3 0.063
body morphogenesis GO:0010171 2 0.062
embryonic pattern specification GO:0009880 174 0.062
reproductive system development GO:0061458 74 0.061
regulation of synapse structure and activity GO:0050803 128 0.061
developmental growth GO:0048589 280 0.061
eye photoreceptor cell differentiation GO:0001754 145 0.061
negative regulation of nucleic acid templated transcription GO:1903507 240 0.061
organic hydroxy compound metabolic process GO:1901615 83 0.060
cardioblast differentiation GO:0010002 20 0.060
response to other organism GO:0051707 293 0.059
reproductive behavior GO:0019098 122 0.059
cell motility GO:0048870 251 0.058
cell junction assembly GO:0034329 42 0.057
negative regulation of cellular biosynthetic process GO:0031327 277 0.056
vesicle mediated transport GO:0016192 381 0.055
regulation of organelle organization GO:0033043 196 0.055
tube development GO:0035295 244 0.054
negative regulation of cell differentiation GO:0045596 143 0.052
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.049
programmed cell death GO:0012501 257 0.048
adult behavior GO:0030534 137 0.047
regulation of localization GO:0032879 275 0.047
proteolysis GO:0006508 192 0.047
skeletal muscle organ development GO:0060538 48 0.046
cardioblast cell fate commitment GO:0042684 14 0.046
positive regulation of biosynthetic process GO:0009891 316 0.046
synapse assembly GO:0007416 143 0.044
axon midline choice point recognition GO:0016199 26 0.043
muscle attachment GO:0016203 36 0.043
cell projection assembly GO:0030031 94 0.042
response to abiotic stimulus GO:0009628 341 0.042
amine metabolic process GO:0009308 12 0.041
axon choice point recognition GO:0016198 26 0.041
regulation of immune system process GO:0002682 176 0.041
cell cell signaling involved in cell fate commitment GO:0045168 210 0.040
cell maturation GO:0048469 144 0.040
tissue morphogenesis GO:0048729 297 0.040
locomotory behavior GO:0007626 176 0.039
transcription from rna polymerase ii promoter GO:0006366 368 0.039
digestive system development GO:0055123 149 0.039
pigment cell differentiation GO:0050931 3 0.039
asymmetric neuroblast division GO:0055059 33 0.039
immune system process GO:0002376 347 0.039
positive regulation of gene expression GO:0010628 290 0.039
regulation of axonogenesis GO:0050770 32 0.039
glial cell migration GO:0008347 31 0.038
neuron fate commitment GO:0048663 50 0.038
oocyte development GO:0048599 124 0.038
determination of muscle attachment site GO:0016204 7 0.038
immune response GO:0006955 246 0.038
multi organism behavior GO:0051705 175 0.038
stem cell fate commitment GO:0048865 25 0.037
negative regulation of growth GO:0045926 84 0.037
negative regulation of cell communication GO:0010648 223 0.037
regulation of anatomical structure morphogenesis GO:0022603 242 0.036
phosphatidylinositol mediated signaling GO:0048015 4 0.036
glial cell development GO:0021782 27 0.036
regulation of apoptotic process GO:0042981 130 0.036
organic substance transport GO:0071702 257 0.035
positive regulation of nucleic acid templated transcription GO:1903508 266 0.035
dendrite development GO:0016358 204 0.035
negative regulation of developmental process GO:0051093 201 0.034
single organism cell adhesion GO:0098602 47 0.033
cell migration GO:0016477 238 0.033
regulation of chromosome organization GO:0033044 64 0.033
localization of cell GO:0051674 257 0.033
regulation of cellular amine metabolic process GO:0033238 3 0.032
cellular catabolic process GO:0044248 372 0.032
positive regulation of developmental growth GO:0048639 62 0.032
negative regulation of chemotaxis GO:0050922 1 0.031
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.031
endocytosis GO:0006897 310 0.031
regulation of cellular component movement GO:0051270 42 0.031
response to biotic stimulus GO:0009607 294 0.031
tube morphogenesis GO:0035239 191 0.030
negative regulation of phosphate metabolic process GO:0045936 45 0.030
positive regulation of signaling GO:0023056 243 0.030
digestive tract morphogenesis GO:0048546 127 0.030
cardiac cell fate commitment GO:0060911 17 0.029
retina morphogenesis in camera type eye GO:0060042 2 0.029
negative regulation of cell development GO:0010721 62 0.029
positive regulation of cellular component organization GO:0051130 156 0.029
rna localization GO:0006403 115 0.029
salivary gland boundary specification GO:0007432 8 0.029
growth GO:0040007 359 0.029
neural precursor cell proliferation GO:0061351 75 0.028
eye photoreceptor cell fate commitment GO:0042706 37 0.028
chromatin remodeling GO:0006338 72 0.028
salivary gland cell autophagic cell death GO:0035071 83 0.028
regulation of cellular component biogenesis GO:0044087 201 0.027
positive regulation of transcription dna templated GO:0045893 266 0.027
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.027
response to nitrogen compound GO:1901698 90 0.027
response to radiation GO:0009314 155 0.027
carboxylic acid metabolic process GO:0019752 92 0.027
carbohydrate derivative biosynthetic process GO:1901137 85 0.026
developmental maturation GO:0021700 172 0.026
male courtship behavior veined wing extension GO:0048065 22 0.026
negative regulation of cellular component organization GO:0051129 108 0.026
telencephalon development GO:0021537 2 0.026
substrate dependent cell migration GO:0006929 3 0.025
positive regulation of macromolecule metabolic process GO:0010604 405 0.025
anatomical structure homeostasis GO:0060249 97 0.025
regulation of response to external stimulus GO:0032101 115 0.025
cellular component assembly involved in morphogenesis GO:0010927 151 0.025
negative regulation of synapse assembly GO:0051964 39 0.025
positive regulation of epithelial cell differentiation GO:0030858 1 0.025
negative regulation of cellular protein metabolic process GO:0032269 85 0.024
regulation of cell projection organization GO:0031344 92 0.024
establishment of glial blood brain barrier GO:0060857 14 0.024
cell death GO:0008219 279 0.024
regulation of protein complex assembly GO:0043254 42 0.024
chromatin modification GO:0016568 147 0.024
regulation of cell division GO:0051302 72 0.024
positive regulation of developmental process GO:0051094 143 0.024
compound eye morphogenesis GO:0001745 249 0.023
regulation of protein modification process GO:0031399 112 0.023
regulation of molecular function GO:0065009 217 0.023
protein phosphorylation GO:0006468 169 0.023
mesenchymal cell differentiation GO:0048762 1 0.023
regulation of cellular localization GO:0060341 136 0.023
muscle tissue morphogenesis GO:0060415 2 0.023
positive regulation of cellular biosynthetic process GO:0031328 316 0.023
positive regulation of cellular protein metabolic process GO:0032270 118 0.023
regulation of cellular amino acid metabolic process GO:0006521 0 0.023
regulation of reproductive process GO:2000241 54 0.022
protein transport GO:0015031 155 0.022
regulation of growth GO:0040008 233 0.022
cell fate determination GO:0001709 91 0.022
negative regulation of phosphorus metabolic process GO:0010563 45 0.022
synaptic target recognition GO:0008039 45 0.022
forebrain development GO:0030900 2 0.022
regulation of proteolysis GO:0030162 87 0.022
regulation of immune response GO:0050776 118 0.022
camera type eye morphogenesis GO:0048593 2 0.021
myofibril assembly GO:0030239 36 0.021
regulation of cellular ketone metabolic process GO:0010565 3 0.021
cellular ketone metabolic process GO:0042180 24 0.021
formation of organ boundary GO:0010160 30 0.021
development of primary sexual characteristics GO:0045137 50 0.021
oocyte differentiation GO:0009994 145 0.021
regulation of notch signaling pathway GO:0008593 100 0.020
heart development GO:0007507 82 0.020
response to organic substance GO:0010033 284 0.020
posttranscriptional regulation of gene expression GO:0010608 145 0.020
pole plasm oskar mrna localization GO:0045451 46 0.020
cellular amine metabolic process GO:0044106 12 0.020
rna processing GO:0006396 147 0.020
cardiac cell fate determination GO:0060913 3 0.020
muscle structure development GO:0061061 224 0.019
nuclear division GO:0000280 332 0.019
regulation of neuron differentiation GO:0045664 103 0.019
response to external biotic stimulus GO:0043207 293 0.019
regulation of chromatin modification GO:1903308 28 0.019
cellular macromolecular complex assembly GO:0034622 153 0.018
circulatory system development GO:0072359 82 0.018
convergent extension GO:0060026 2 0.018
positive regulation of rna biosynthetic process GO:1902680 266 0.018
regulation of phosphorus metabolic process GO:0051174 210 0.018
macromolecular complex assembly GO:0065003 256 0.018
establishment or maintenance of cell polarity GO:0007163 167 0.018
phosphorylation GO:0016310 294 0.018
cell fate specification GO:0001708 71 0.017
mitotic nuclear division GO:0007067 213 0.017
cardiocyte differentiation GO:0035051 29 0.017
lipid metabolic process GO:0006629 121 0.017
actin cytoskeleton organization GO:0030036 206 0.017
central nervous system neuron differentiation GO:0021953 8 0.017
neuroblast division GO:0055057 35 0.017
positive regulation of protein metabolic process GO:0051247 128 0.017
compound eye development GO:0048749 307 0.017
cell recognition GO:0008037 102 0.017
axonal fasciculation GO:0007413 12 0.016
positive regulation of axon guidance GO:1902669 1 0.016
regulation of muscle cell differentiation GO:0051147 8 0.016
regulation of epithelial cell differentiation GO:0030856 4 0.016
imaginal disc derived appendage morphogenesis GO:0035114 395 0.016
negative regulation of multicellular organismal process GO:0051241 142 0.016
hematopoietic or lymphoid organ development GO:0048534 57 0.016
salivary gland histolysis GO:0035070 88 0.016
spindle elongation GO:0051231 83 0.016
regulation of cardiac cell fate specification GO:2000043 8 0.016
muscle cell differentiation GO:0042692 103 0.016
neuron remodeling GO:0016322 29 0.016
regulation of cell development GO:0060284 215 0.015
multi multicellular organism process GO:0044706 123 0.015
regulation of cell proliferation GO:0042127 163 0.015
axon extension involved in axon guidance GO:0048846 10 0.015
protein complex biogenesis GO:0070271 201 0.015
regulation of dendrite development GO:0050773 37 0.015
central complex development GO:0048036 9 0.015
homeostatic process GO:0042592 199 0.015
larval development GO:0002164 104 0.015
maternal determination of anterior posterior axis embryo GO:0008358 74 0.015
regulation of cell morphogenesis involved in differentiation GO:0010769 61 0.015
response to bacterium GO:0009617 198 0.015
ectodermal placode morphogenesis GO:0071697 4 0.015
extrinsic apoptotic signaling pathway GO:0097191 1 0.015
response to alcohol GO:0097305 95 0.015
neuroblast differentiation GO:0014016 29 0.015
response to light stimulus GO:0009416 124 0.014
retinal cone cell differentiation GO:0042670 2 0.014
nephron epithelium development GO:0072009 3 0.014
cellular protein modification process GO:0006464 438 0.014
reproductive structure development GO:0048608 74 0.014
synaptic transmission GO:0007268 288 0.014
sarcomere organization GO:0045214 26 0.014
photoreceptor cell differentiation GO:0046530 170 0.014
regulation of catabolic process GO:0009894 170 0.014
negative regulation of response to stimulus GO:0048585 258 0.014
cardioblast cell fate specification GO:0042685 9 0.014
neuron fate specification GO:0048665 12 0.014
neuron projection extension involved in neuron projection guidance GO:1902284 10 0.014
columnar cuboidal epithelial cell development GO:0002066 249 0.014
kidney epithelium development GO:0072073 3 0.014
ameboidal type cell migration GO:0001667 151 0.013
gastrulation GO:0007369 70 0.013
aging GO:0007568 143 0.013
positive regulation of organelle organization GO:0010638 65 0.013
positive regulation of response to stimulus GO:0048584 323 0.013
regulation of cytoskeleton organization GO:0051493 89 0.013
regulation of cellular catabolic process GO:0031329 157 0.013
jak stat cascade GO:0007259 49 0.013
establishment of localization in cell GO:0051649 402 0.013
regulation of neurogenesis GO:0050767 158 0.013
regulation of cell fate specification GO:0042659 27 0.013
epithelial tube morphogenesis GO:0060562 88 0.013
multicellular organism growth GO:0035264 46 0.012
synapse organization GO:0050808 196 0.012
positive regulation of phosphorus metabolic process GO:0010562 139 0.012
intracellular mrna localization involved in anterior posterior axis specification GO:0060811 53 0.012
roundabout signaling pathway GO:0035385 4 0.012
striated muscle cell differentiation GO:0051146 90 0.012
negative regulation of immune system process GO:0002683 50 0.012
photoreceptor cell axon guidance GO:0072499 23 0.012
protein modification process GO:0036211 438 0.012
eye antennal disc development GO:0035214 60 0.012
negative regulation of response to external stimulus GO:0032102 22 0.012
spermatid differentiation GO:0048515 114 0.012
dendrite morphogenesis GO:0048813 199 0.012
defense response to bacterium GO:0042742 178 0.012
inositol lipid mediated signaling GO:0048017 4 0.012
negative regulation of protein metabolic process GO:0051248 85 0.012
histone methylation GO:0016571 40 0.012
positive regulation of axon extension GO:0045773 2 0.012
chromatin organization GO:0006325 207 0.012
glycoprotein biosynthetic process GO:0009101 41 0.012
regulation of synaptic transmission GO:0050804 69 0.012
regulation of synapse assembly GO:0051963 94 0.012
single organism biosynthetic process GO:0044711 206 0.012
spindle localization GO:0051653 22 0.012
carbohydrate derivative metabolic process GO:1901135 217 0.012
positive regulation of behavior GO:0048520 19 0.012
blastoderm segmentation GO:0007350 159 0.011
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 3 0.011
regulation of pole plasm oskar mrna localization GO:0007317 27 0.011
ectodermal placode development GO:0071696 4 0.011
regulation of multi organism process GO:0043900 131 0.011
cellular response to organic substance GO:0071310 132 0.011
muscle organ development GO:0007517 127 0.011
positive regulation of signal transduction GO:0009967 223 0.011
positive regulation of neurogenesis GO:0050769 41 0.011
brain development GO:0007420 120 0.011
single organism behavior GO:0044708 391 0.011
antennal development GO:0007469 25 0.011
imaginal disc derived appendage development GO:0048737 399 0.011
mesenchymal cell development GO:0014031 1 0.011
single organism intracellular transport GO:1902582 207 0.011
neuronal stem cell division GO:0036445 35 0.011
protein polymerization GO:0051258 42 0.011
muscle organ morphogenesis GO:0048644 7 0.011
neuron apoptotic process GO:0051402 17 0.011
neuroblast fate commitment GO:0014017 19 0.011
regulation of transport GO:0051049 181 0.011
regulation of catalytic activity GO:0050790 185 0.011
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.011
regulation of hemocyte proliferation GO:0035206 37 0.011
cytoplasmic transport GO:0016482 130 0.011
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 25 0.010
lamellipodium organization GO:0097581 21 0.010
negative regulation of catalytic activity GO:0043086 42 0.010
organelle fission GO:0048285 340 0.010
regulation of chromatin organization GO:1902275 32 0.010
phagocytosis GO:0006909 215 0.010
ovulation GO:0030728 4 0.010
positive regulation of cell migration GO:0030335 2 0.010
outflow tract morphogenesis GO:0003151 4 0.010
negative regulation of organelle organization GO:0010639 56 0.010
regulation of hormone levels GO:0010817 40 0.010
anterior posterior pattern specification GO:0009952 136 0.010
cellular macromolecule localization GO:0070727 220 0.010
negative regulation of neuron differentiation GO:0045665 16 0.010
neural retina development GO:0003407 4 0.010
segmentation GO:0035282 207 0.010
spindle organization GO:0007051 253 0.010
cellular amino acid metabolic process GO:0006520 61 0.010
actin filament based process GO:0030029 220 0.010

vnd disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.126
disease of cellular proliferation DOID:14566 0 0.126
waardenburg s syndrome DOID:9258 0 0.057
organ system cancer DOID:0050686 0 0.049
musculoskeletal system cancer DOID:0060100 0 0.048
disease of anatomical entity DOID:7 0 0.032
musculoskeletal system disease DOID:17 0 0.010