Drosophila melanogaster

97 known processes

HDAC6 (Dmel_CG6170)

CG6170 gene product from transcript CG6170-RA

(Aliases: dmHDA404,HDAC2,dHDAC6,dHDAC2,DHDAC2,DmHDAC2,Dmel\CG6170,HDAC,CG6170)

HDAC6 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
synaptic vesicle endocytosis GO:0048488 28 0.694
synaptic transmission GO:0007268 288 0.519
synaptic vesicle transport GO:0048489 50 0.466
signal release GO:0023061 49 0.361
catabolic process GO:0009056 409 0.339
Human
establishment of vesicle localization GO:0051650 51 0.321
establishment of synaptic vesicle localization GO:0097480 50 0.287
vesicle localization GO:0051648 55 0.271
neuromuscular synaptic transmission GO:0007274 67 0.258
single organism cellular localization GO:1902580 180 0.249
synaptic vesicle recycling GO:0036465 28 0.236
organelle localization GO:0051640 148 0.223
Human
cellular catabolic process GO:0044248 372 0.214
Human
synaptic vesicle exocytosis GO:0016079 16 0.209
single organism membrane organization GO:0044802 93 0.178
establishment of organelle localization GO:0051656 122 0.177
organic substance catabolic process GO:1901575 308 0.170
Human
synaptic vesicle localization GO:0097479 53 0.157
nitrogen compound transport GO:0071705 85 0.139
establishment of localization in cell GO:0051649 402 0.137
single organism membrane fusion GO:0044801 42 0.132
regulation of secretion by cell GO:1903530 39 0.129
positive regulation of cell communication GO:0010647 250 0.124
Human
positive regulation of secretion GO:0051047 22 0.121
autophagy GO:0006914 108 0.116
Human
regulation of cellular localization GO:0060341 136 0.114
synapse organization GO:0050808 196 0.113
single organism catabolic process GO:0044712 228 0.111
Human
regulation of secretion GO:0051046 44 0.107
secretion GO:0046903 109 0.101
neuron neuron synaptic transmission GO:0007270 14 0.098
protein complex biogenesis GO:0070271 201 0.097
Human
vesicle fusion GO:0006906 19 0.097
lipid modification GO:0030258 24 0.084
secretion by cell GO:0032940 101 0.082
cellular nitrogen compound catabolic process GO:0044270 165 0.081
organelle fission GO:0048285 340 0.078
membrane organization GO:0061024 112 0.077
regulation of intracellular signal transduction GO:1902531 236 0.075
protein modification process GO:0036211 438 0.072
ion transport GO:0006811 145 0.072
organonitrogen compound metabolic process GO:1901564 318 0.071
positive regulation of exocytosis GO:0045921 4 0.070
neurotransmitter transport GO:0006836 37 0.067
regulation of multi organism process GO:0043900 131 0.066
axon development GO:0061564 297 0.063
aromatic compound catabolic process GO:0019439 166 0.061
macromolecular complex assembly GO:0065003 256 0.060
Human
regulation of transport GO:0051049 181 0.060
single organism behavior GO:0044708 391 0.059
vesicle organization GO:0016050 44 0.059
polyol biosynthetic process GO:0046173 3 0.058
intracellular transport GO:0046907 228 0.058
Human
imaginal disc derived appendage development GO:0048737 399 0.058
vesicle mediated transport GO:0016192 381 0.057
positive regulation of cell migration GO:0030335 2 0.057
Human
small molecule metabolic process GO:0044281 305 0.056
synapse assembly GO:0007416 143 0.055
positive regulation of gene expression GO:0010628 290 0.055
intracellular signal transduction GO:0035556 300 0.055
cell death GO:0008219 279 0.054
Human
regulation of hormone levels GO:0010817 40 0.054
positive regulation of secretion by cell GO:1903532 20 0.052
organic cyclic compound catabolic process GO:1901361 168 0.049
oxidation reduction process GO:0055114 123 0.049
positive regulation of signaling GO:0023056 243 0.048
Human
carbohydrate derivative metabolic process GO:1901135 217 0.047
lipid metabolic process GO:0006629 121 0.047
regulation of neurotransmitter levels GO:0001505 38 0.046
regulation of reproductive process GO:2000241 54 0.046
homeostatic process GO:0042592 199 0.046
membrane fusion GO:0061025 42 0.045
organonitrogen compound catabolic process GO:1901565 128 0.045
oocyte differentiation GO:0009994 145 0.044
ribonucleoside metabolic process GO:0009119 127 0.044
organelle fusion GO:0048284 46 0.044
positive regulation of transport GO:0051050 92 0.044
heterocycle catabolic process GO:0046700 166 0.043
regulation of localization GO:0032879 275 0.043
Human
intracellular protein transport GO:0006886 104 0.043
Human
axonogenesis GO:0007409 290 0.042
nucleobase containing compound catabolic process GO:0034655 165 0.042
epithelial cell development GO:0002064 274 0.040
axon guidance GO:0007411 233 0.040
nucleoside metabolic process GO:0009116 127 0.039
organic substance transport GO:0071702 257 0.039
Human
negative regulation of response to stimulus GO:0048585 258 0.039
cellular lipid metabolic process GO:0044255 83 0.039
response to hormone GO:0009725 45 0.039
Rat
carbohydrate derivative catabolic process GO:1901136 118 0.038
response to organic substance GO:0010033 284 0.038
Human Rat
maintenance of presynaptic active zone structure GO:0048790 8 0.038
response to endogenous stimulus GO:0009719 119 0.038
Rat
endocytosis GO:0006897 310 0.038
purine containing compound catabolic process GO:0072523 112 0.037
phosphatidylinositol phosphorylation GO:0046854 10 0.037
cellular macromolecule localization GO:0070727 220 0.037
Human
nucleotide metabolic process GO:0009117 161 0.037
establishment of protein localization to plasma membrane GO:0090002 9 0.037
organophosphate metabolic process GO:0019637 195 0.036
response to glucose GO:0009749 2 0.036
regulation of cellular component biogenesis GO:0044087 201 0.036
Human
inter male aggressive behavior GO:0002121 60 0.035
protein complex assembly GO:0006461 200 0.035
Human
cell maturation GO:0048469 144 0.034
regulation of vesicle mediated transport GO:0060627 59 0.034
forebrain development GO:0030900 2 0.034
microtubule based transport GO:0010970 42 0.034
regulation of behavior GO:0050795 75 0.034
regulation of multicellular organismal development GO:2000026 414 0.034
developmental programmed cell death GO:0010623 138 0.033
neuron projection guidance GO:0097485 241 0.033
ribonucleoside catabolic process GO:0042454 112 0.033
response to monosaccharide GO:0034284 4 0.033
organic hydroxy compound metabolic process GO:1901615 83 0.033
hindbrain development GO:0030902 2 0.033
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.032
cellular protein modification process GO:0006464 438 0.032
regulation of cell development GO:0060284 215 0.032
regulation of peptide secretion GO:0002791 6 0.032
regulation of synaptic growth at neuromuscular junction GO:0008582 89 0.032
positive regulation of transcription dna templated GO:0045893 266 0.032
regulation of synaptic transmission GO:0050804 69 0.031
developmental maturation GO:0021700 172 0.031
carboxylic acid transport GO:0046942 18 0.031
imaginal disc derived wing morphogenesis GO:0007476 337 0.031
cellular response to hexose stimulus GO:0071331 1 0.031
regulation of excitatory postsynaptic membrane potential GO:0060079 3 0.031
single organism intracellular transport GO:1902582 207 0.031
Human
exocytosis GO:0006887 28 0.030
regulation of synapse organization GO:0050807 110 0.029
oxoacid metabolic process GO:0043436 103 0.029
epithelial cell differentiation GO:0030855 322 0.029
axon cargo transport GO:0008088 29 0.029
gtp catabolic process GO:0006184 72 0.029
cell cell signaling involved in cell fate commitment GO:0045168 210 0.029
purine ribonucleoside metabolic process GO:0046128 127 0.028
cellular macromolecule catabolic process GO:0044265 136 0.028
Human
response to hexose GO:0009746 3 0.028
regulation of immune system process GO:0002682 176 0.027
response to acid chemical GO:0001101 25 0.027
locomotory behavior GO:0007626 176 0.026
feeding behavior GO:0007631 50 0.026
imaginal disc derived appendage morphogenesis GO:0035114 395 0.026
actin filament organization GO:0007015 126 0.026
nucleoside triphosphate metabolic process GO:0009141 120 0.025
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.025
Human
neurotransmitter secretion GO:0007269 35 0.025
cellular response to monosaccharide stimulus GO:0071326 2 0.025
phosphorylation GO:0016310 294 0.025
organic acid metabolic process GO:0006082 103 0.025
purine ribonucleoside catabolic process GO:0046130 112 0.025
compound eye development GO:0048749 307 0.025
carboxylic acid metabolic process GO:0019752 92 0.024
adult locomotory behavior GO:0008344 76 0.024
nucleoside catabolic process GO:0009164 112 0.024
negative regulation of cellular biosynthetic process GO:0031327 277 0.024
Human
organic hydroxy compound biosynthetic process GO:1901617 21 0.024
response to lipid GO:0033993 38 0.024
Rat
positive regulation of cell motility GO:2000147 3 0.024
Human
positive regulation of signal transduction GO:0009967 223 0.024
Human
energy derivation by oxidation of organic compounds GO:0015980 32 0.023
regulation of catabolic process GO:0009894 170 0.023
l glutamate import GO:0051938 1 0.023
positive regulation of response to stimulus GO:0048584 323 0.023
Human
regulation of membrane potential GO:0042391 35 0.023
response to temperature stimulus GO:0009266 106 0.023
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.023
Human
protein localization to plasma membrane GO:0072659 13 0.023
growth GO:0040007 359 0.022
monocarboxylic acid transport GO:0015718 3 0.022
regulation of synaptic vesicle exocytosis GO:2000300 3 0.022
appendage development GO:0048736 401 0.022
neuromuscular junction development GO:0007528 149 0.022
regulation of cellular catabolic process GO:0031329 157 0.022
purine nucleoside metabolic process GO:0042278 127 0.022
central nervous system development GO:0007417 201 0.022
Rat
negative regulation of calcium ion import GO:0090281 2 0.021
response to ketone GO:1901654 34 0.021
Rat
response to abiotic stimulus GO:0009628 341 0.021
mitotic nuclear division GO:0007067 213 0.021
blastoderm segmentation GO:0007350 159 0.021
response to pain GO:0048265 3 0.021
response to oxygen containing compound GO:1901700 200 0.021
Human Rat
learning or memory GO:0007611 141 0.021
appendage morphogenesis GO:0035107 397 0.020
response to nitrogen compound GO:1901698 90 0.020
regulation of insulin secretion GO:0050796 5 0.020
positive regulation of rna biosynthetic process GO:1902680 266 0.020
glycosyl compound metabolic process GO:1901657 127 0.020
generation of precursor metabolites and energy GO:0006091 42 0.020
cognition GO:0050890 141 0.020
negative regulation of cell communication GO:0010648 223 0.020
response to reactive oxygen species GO:0000302 24 0.020
Human
endomembrane system organization GO:0010256 119 0.020
eye development GO:0001654 323 0.020
lateral inhibition GO:0046331 206 0.020
mrna metabolic process GO:0016071 124 0.019
positive regulation of biosynthetic process GO:0009891 316 0.019
Human
morphogenesis of an epithelium GO:0002009 276 0.019
regulation of growth GO:0040008 233 0.019
transmembrane transport GO:0055085 139 0.019
cell migration GO:0016477 238 0.019
Human
amine metabolic process GO:0009308 12 0.019
regulation of synapse structure and activity GO:0050803 128 0.019
regulation of synaptic vesicle transport GO:1902803 10 0.019
macromolecule catabolic process GO:0009057 161 0.019
Human
wing disc morphogenesis GO:0007472 344 0.019
cellular response to carbohydrate stimulus GO:0071322 4 0.019
regulation of exocytosis GO:0017157 6 0.019
positive regulation of intracellular signal transduction GO:1902533 116 0.019
segmentation GO:0035282 207 0.019
nucleobase containing small molecule metabolic process GO:0055086 174 0.019
sulfur compound metabolic process GO:0006790 59 0.018
protein transport GO:0015031 155 0.018
Human
negative regulation of multicellular organismal process GO:0051241 142 0.018
stress activated mapk cascade GO:0051403 52 0.018
negative regulation of insulin secretion GO:0046676 1 0.018
purine nucleoside triphosphate metabolic process GO:0009144 119 0.018
cellular response to organic substance GO:0071310 132 0.018
Human Rat
hyperosmotic salinity response GO:0042538 1 0.018
chemotaxis GO:0006935 249 0.018
cellular protein complex assembly GO:0043623 71 0.017
Human
positive regulation of synaptic transmission GO:0050806 15 0.017
organophosphate catabolic process GO:0046434 112 0.017
cellular macromolecular complex assembly GO:0034622 153 0.017
Human
anatomical structure homeostasis GO:0060249 97 0.017
oocyte anterior posterior axis specification GO:0007314 72 0.017
regulation of steroid metabolic process GO:0019218 2 0.017
detection of stimulus involved in sensory perception GO:0050906 92 0.017
response to organic cyclic compound GO:0014070 89 0.017
Rat
neurological system process GO:0050877 358 0.017
ribonucleoside triphosphate metabolic process GO:0009199 119 0.017
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.017
nuclear division GO:0000280 332 0.017
sensory perception of pain GO:0019233 4 0.017
hormone secretion GO:0046879 7 0.016
cellular carbohydrate metabolic process GO:0044262 22 0.016
ribonucleoside triphosphate catabolic process GO:0009203 108 0.016
columnar cuboidal epithelial cell development GO:0002066 249 0.016
establishment or maintenance of cell polarity GO:0007163 167 0.016
oocyte development GO:0048599 124 0.016
dna packaging GO:0006323 91 0.016
cellular response to starvation GO:0009267 61 0.016
Human
alcohol biosynthetic process GO:0046165 14 0.016
glycosyl compound catabolic process GO:1901658 112 0.016
purine nucleoside catabolic process GO:0006152 112 0.016
positive regulation of cellular biosynthetic process GO:0031328 316 0.016
positive regulation of nucleic acid templated transcription GO:1903508 266 0.016
plasma membrane organization GO:0007009 26 0.016
embryonic pattern specification GO:0009880 174 0.016
negative regulation of gene expression GO:0010629 387 0.016
Human
sensory perception of chemical stimulus GO:0007606 116 0.016
organonitrogen compound biosynthetic process GO:1901566 117 0.016
protein phosphorylation GO:0006468 169 0.016
organic anion transport GO:0015711 28 0.016
response to inorganic substance GO:0010035 44 0.015
Human
multi organism reproductive behavior GO:0044705 121 0.015
phagocytosis GO:0006909 215 0.015
associative learning GO:0008306 65 0.015
regulation of system process GO:0044057 36 0.015
synaptic transmission glutamatergic GO:0035249 7 0.015
purine ribonucleotide metabolic process GO:0009150 145 0.015
regulation of cell substrate adhesion GO:0010810 2 0.015
negative regulation of peptide secretion GO:0002792 1 0.015
steroid biosynthetic process GO:0006694 16 0.015
defense response to gram negative bacterium GO:0050829 94 0.015
germarium derived egg chamber formation GO:0007293 101 0.015
regulation of cell cycle GO:0051726 291 0.015
ovarian follicle cell development GO:0030707 248 0.015
regulation of autophagy GO:0010506 62 0.015
proteolysis GO:0006508 192 0.015
Human
immune system process GO:0002376 347 0.015
carbohydrate metabolic process GO:0005975 82 0.015
ameboidal type cell migration GO:0001667 151 0.015
Human
phenol containing compound metabolic process GO:0018958 57 0.015
cellular ketone metabolic process GO:0042180 24 0.015
stress activated protein kinase signaling cascade GO:0031098 55 0.015
pyridine containing compound metabolic process GO:0072524 3 0.015
transcription from rna polymerase ii promoter GO:0006366 368 0.015
Human
response to mechanical stimulus GO:0009612 28 0.014
gland development GO:0048732 191 0.014
meiotic nuclear division GO:0007126 151 0.014
kidney development GO:0001822 3 0.014
ribonucleotide metabolic process GO:0009259 145 0.014
organic acid transport GO:0015849 18 0.014
heart process GO:0003015 37 0.014
monocarboxylic acid metabolic process GO:0032787 29 0.014
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.014
positive regulation of cellular catabolic process GO:0031331 95 0.014
defense response GO:0006952 300 0.014
single organism carbohydrate metabolic process GO:0044723 72 0.014
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.014
Human
microtubule based movement GO:0007018 51 0.014
protein localization to membrane GO:0072657 19 0.014
positive regulation of catabolic process GO:0009896 105 0.014
cytoplasmic transport GO:0016482 130 0.014
response to lipopolysaccharide GO:0032496 4 0.014
purine containing compound metabolic process GO:0072521 155 0.013
negative regulation of biosynthetic process GO:0009890 277 0.013
Human
positive regulation of macromolecule metabolic process GO:0010604 405 0.013
Human
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.013
Human
anion transport GO:0006820 41 0.013
single organism biosynthetic process GO:0044711 206 0.013
cellular response to mechanical stimulus GO:0071260 2 0.013
response to organonitrogen compound GO:0010243 75 0.013
negative regulation of programmed cell death GO:0043069 72 0.013
body morphogenesis GO:0010171 2 0.013
positive regulation of rna metabolic process GO:0051254 271 0.013
regulation of response to stress GO:0080134 200 0.013
Human
developmental growth GO:0048589 280 0.013
death GO:0016265 284 0.013
Human
regulation of cellular ketone metabolic process GO:0010565 3 0.013
negative regulation of phosphatidylinositol 3 kinase signaling GO:0014067 4 0.013
regulation of peptide hormone secretion GO:0090276 5 0.013
purine nucleotide catabolic process GO:0006195 109 0.013
tube morphogenesis GO:0035239 191 0.012
synaptic vesicle fusion to presynaptic membrane GO:0031629 7 0.012
regulation of cellular amine metabolic process GO:0033238 3 0.012
negative regulation of signal transduction GO:0009968 206 0.012
regionalization GO:0003002 416 0.012
mitotic cell cycle phase transition GO:0044772 138 0.012
detection of chemical stimulus involved in sensory perception GO:0050907 75 0.012
cellular response to endogenous stimulus GO:0071495 80 0.012
Rat
spindle assembly GO:0051225 80 0.012
taxis GO:0042330 304 0.012
tissue morphogenesis GO:0048729 297 0.012
pole plasm mrna localization GO:0019094 49 0.012
positive regulation of mapk cascade GO:0043410 63 0.012
negative regulation of cell differentiation GO:0045596 143 0.012
embryonic development via the syncytial blastoderm GO:0001700 148 0.012
regulation of cellular response to stress GO:0080135 89 0.012
Human
regulation of immune response GO:0050776 118 0.012
sensory organ morphogenesis GO:0090596 260 0.012
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.012
regulation of cellular protein metabolic process GO:0032268 243 0.012
Human
digestive tract morphogenesis GO:0048546 127 0.012
positive regulation of autophagy GO:0010508 21 0.012
response to organophosphorus GO:0046683 2 0.012
molting cycle chitin based cuticle GO:0007591 56 0.012
telencephalon development GO:0021537 2 0.012
detection of chemical stimulus GO:0009593 93 0.012
cellular response to external stimulus GO:0071496 66 0.012
Human
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.012
anterograde synaptic vesicle transport GO:0048490 3 0.012
salivary gland histolysis GO:0035070 88 0.012
cellular amine metabolic process GO:0044106 12 0.012
regulation of phosphorus metabolic process GO:0051174 210 0.012
cellular homeostasis GO:0019725 80 0.011
hematopoietic progenitor cell differentiation GO:0002244 1 0.011
establishment of protein localization GO:0045184 163 0.011
Human
pyridine nucleotide metabolic process GO:0019362 2 0.011
programmed cell death GO:0012501 257 0.011
Human
positive regulation of synaptic transmission glutamatergic GO:0051968 3 0.011
post golgi vesicle mediated transport GO:0006892 11 0.011
cellular response to oxygen containing compound GO:1901701 79 0.011
Human
regulation of cell morphogenesis involved in differentiation GO:0010769 61 0.011
peptide metabolic process GO:0006518 80 0.011
small molecule biosynthetic process GO:0044283 37 0.011
response to alcohol GO:0097305 95 0.011
Rat
jnk cascade GO:0007254 50 0.011
positive regulation of jun kinase activity GO:0043507 4 0.011
cellular protein localization GO:0034613 160 0.011
Human
regulation of anatomical structure morphogenesis GO:0022603 242 0.011
mitotic chromosome condensation GO:0007076 22 0.011
regulation of organelle organization GO:0033043 196 0.011
histolysis GO:0007559 102 0.011
response to radiation GO:0009314 155 0.011
response to copper ion GO:0046688 4 0.011
regulation of phosphorylation GO:0042325 147 0.011
localization of cell GO:0051674 257 0.011
Human
anion homeostasis GO:0055081 3 0.011
positive regulation of cell development GO:0010720 61 0.011
steroid catabolic process GO:0006706 1 0.011
response to calcium ion GO:0051592 1 0.011
enzyme linked receptor protein signaling pathway GO:0007167 179 0.011
glycerolipid metabolic process GO:0046486 34 0.011
regulation of cell maturation GO:1903429 27 0.011
regulation of programmed cell death GO:0043067 152 0.011
Human
oocyte construction GO:0007308 112 0.011
toxin metabolic process GO:0009404 2 0.011
camera type eye morphogenesis GO:0048593 2 0.011
metal ion transport GO:0030001 74 0.011
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.011
sensory perception GO:0007600 196 0.011
peptidyl amino acid modification GO:0018193 105 0.011
Human
protein targeting GO:0006605 64 0.011
maternal determination of anterior posterior axis embryo GO:0008358 74 0.011
regulation of cell death GO:0010941 173 0.010
Human
respiratory system development GO:0060541 213 0.010
rna catabolic process GO:0006401 37 0.010
camera type eye development GO:0043010 4 0.010
brain development GO:0007420 120 0.010
regulation of mapk cascade GO:0043408 92 0.010
dendrite morphogenesis GO:0048813 199 0.010
response to heat GO:0009408 63 0.010
establishment of protein localization to membrane GO:0090150 11 0.010
protein localization GO:0008104 284 0.010
Human
ras protein signal transduction GO:0007265 88 0.010
purine nucleotide metabolic process GO:0006163 146 0.010
nicotinamide nucleotide metabolic process GO:0046496 2 0.010
positive regulation of hormone secretion GO:0046887 4 0.010
epithelium migration GO:0090132 148 0.010
Human
actin filament based process GO:0030029 220 0.010
sensory perception of smell GO:0007608 80 0.010

HDAC6 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.072
disease of metabolism DOID:0014667 0 0.063
inherited metabolic disorder DOID:655 0 0.063
nervous system disease DOID:863 0 0.030
central nervous system disease DOID:331 0 0.027
neurodegenerative disease DOID:1289 0 0.025
vascular disease DOID:178 0 0.017
cardiovascular system disease DOID:1287 0 0.017
cancer DOID:162 0 0.013
disease of cellular proliferation DOID:14566 0 0.013
organ system cancer DOID:0050686 0 0.010