Drosophila melanogaster

23 known processes

skl (Dmel_CG13701)

sickle

(Aliases: BcDNA:RE14076,meph,veto,Dmel\CG13701,Skl,CG13701)

skl biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
salt aversion GO:0035199 3 0.145
sensory perception of chemical stimulus GO:0007606 116 0.124
response to abiotic stimulus GO:0009628 341 0.114
stem cell development GO:0048864 79 0.113
respiratory system development GO:0060541 213 0.104
connective tissue development GO:0061448 3 0.087
salivary gland morphogenesis GO:0007435 145 0.085
gland morphogenesis GO:0022612 145 0.078
response to organic substance GO:0010033 284 0.071
regulation of execution phase of apoptosis GO:1900117 5 0.069
notch signaling pathway GO:0007219 120 0.068
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 23 0.067
regulation of programmed cell death GO:0043067 152 0.063
exocrine system development GO:0035272 162 0.063
positive regulation of endopeptidase activity GO:0010950 26 0.062
salivary gland development GO:0007431 162 0.061
regulation of cell death GO:0010941 173 0.061
regulation of endopeptidase activity GO:0052548 36 0.056
transcription from rna polymerase ii promoter GO:0006366 368 0.055
regulation of apoptotic process GO:0042981 130 0.055
cell death GO:0008219 279 0.054
organonitrogen compound metabolic process GO:1901564 318 0.054
proteolysis GO:0006508 192 0.054
regulation of response to stress GO:0080134 200 0.053
eye development GO:0001654 323 0.053
localization of cell GO:0051674 257 0.051
positive regulation of peptidase activity GO:0010952 29 0.051
defense response GO:0006952 300 0.050
axon development GO:0061564 297 0.050
positive regulation of cysteine type endopeptidase activity GO:2001056 24 0.047
developmental programmed cell death GO:0010623 138 0.047
single organism behavior GO:0044708 391 0.046
synaptic transmission GO:0007268 288 0.046
cellular catabolic process GO:0044248 372 0.045
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.045
negative regulation of programmed cell death GO:0043069 72 0.044
eye photoreceptor cell differentiation GO:0001754 145 0.042
cell proliferation GO:0008283 299 0.042
axonogenesis GO:0007409 290 0.042
intracellular signal transduction GO:0035556 300 0.041
protein localization GO:0008104 284 0.041
innate immune response GO:0045087 144 0.040
response to extracellular stimulus GO:0009991 116 0.039
negative regulation of rna metabolic process GO:0051253 251 0.037
response to hypoxia GO:0001666 53 0.036
negative regulation of cell death GO:0060548 81 0.035
positive regulation of proteolysis GO:0045862 52 0.035
cellular response to chemical stimulus GO:0070887 199 0.035
negative regulation of cellular metabolic process GO:0031324 382 0.034
negative regulation of neuron death GO:1901215 18 0.034
response to alcohol GO:0097305 95 0.033
catabolic process GO:0009056 409 0.033
gland development GO:0048732 191 0.033
phenol containing compound metabolic process GO:0018958 57 0.033
negative regulation of biosynthetic process GO:0009890 277 0.032
cell recognition GO:0008037 102 0.031
pigment metabolic process GO:0042440 84 0.031
synapse organization GO:0050808 196 0.031
rhabdomere development GO:0042052 38 0.031
feeding behavior GO:0007631 50 0.031
neuron death GO:0070997 27 0.031
execution phase of apoptosis GO:0097194 7 0.030
open tracheal system development GO:0007424 204 0.030
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.030
response to external biotic stimulus GO:0043207 293 0.030
response to ionizing radiation GO:0010212 32 0.030
regulation of cysteine type endopeptidase activity GO:2000116 27 0.030
regulation of anatomical structure morphogenesis GO:0022603 242 0.029
negative regulation of cell communication GO:0010648 223 0.029
neuron apoptotic process GO:0051402 17 0.029
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.028
protein modification process GO:0036211 438 0.028
central nervous system development GO:0007417 201 0.028
organic substance transport GO:0071702 257 0.028
death GO:0016265 284 0.028
autophagy GO:0006914 108 0.028
response to bacterium GO:0009617 198 0.027
brain development GO:0007420 120 0.027
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 25 0.027
regulation of cell proliferation GO:0042127 163 0.027
positive regulation of protein metabolic process GO:0051247 128 0.027
negative regulation of apoptotic process GO:0043066 63 0.027
establishment or maintenance of cell polarity GO:0007163 167 0.027
monocarboxylic acid transport GO:0015718 3 0.026
organic acid metabolic process GO:0006082 103 0.026
nephron development GO:0072006 3 0.026
cell division GO:0051301 248 0.026
eye morphogenesis GO:0048592 260 0.026
regulation of response to extracellular stimulus GO:0032104 18 0.026
regulation of neuron death GO:1901214 26 0.026
response to biotic stimulus GO:0009607 294 0.025
stem cell differentiation GO:0048863 117 0.025
humoral immune response GO:0006959 117 0.025
aromatic compound catabolic process GO:0019439 166 0.025
secondary metabolic process GO:0019748 75 0.025
intracellular transport GO:0046907 228 0.025
regulation of cell cycle GO:0051726 291 0.024
sensory perception of smell GO:0007608 80 0.024
regulation of proteolysis GO:0030162 87 0.024
endocytosis GO:0006897 310 0.024
regulation of localization GO:0032879 275 0.024
positive regulation of response to stimulus GO:0048584 323 0.024
regulation of intracellular signal transduction GO:1902531 236 0.024
organic substance catabolic process GO:1901575 308 0.024
peripheral nervous system development GO:0007422 52 0.024
cell type specific apoptotic process GO:0097285 38 0.024
larval behavior GO:0030537 42 0.023
melanization defense response GO:0035006 45 0.023
single organism carbohydrate metabolic process GO:0044723 72 0.023
cellular response to starvation GO:0009267 61 0.023
negative regulation of response to stimulus GO:0048585 258 0.022
negative regulation of nucleic acid templated transcription GO:1903507 240 0.022
regulation of peptidase activity GO:0052547 39 0.022
methylation GO:0032259 47 0.021
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.021
anatomical structure homeostasis GO:0060249 97 0.021
negative regulation of rna biosynthetic process GO:1902679 240 0.021
modification dependent protein catabolic process GO:0019941 78 0.021
programmed cell death GO:0012501 257 0.021
peptide metabolic process GO:0006518 80 0.021
response to lipopolysaccharide GO:0032496 4 0.021
sensory perception of salty taste GO:0050914 3 0.021
negative regulation of transcription dna templated GO:0045892 237 0.021
compound eye development GO:0048749 307 0.021
apoptotic process GO:0006915 159 0.021
ion transport GO:0006811 145 0.020
adult behavior GO:0030534 137 0.020
regulation of cellular amide metabolic process GO:0034248 39 0.020
regulation of cellular component biogenesis GO:0044087 201 0.020
neuromuscular junction development GO:0007528 149 0.020
stem cell maintenance GO:0019827 67 0.020
regulation of protein metabolic process GO:0051246 256 0.020
ectopic germ cell programmed cell death GO:0035234 8 0.020
vesicle mediated transport GO:0016192 381 0.020
single organism catabolic process GO:0044712 228 0.020
negative regulation of signal transduction GO:0009968 206 0.020
regulation of response to external stimulus GO:0032101 115 0.020
cell cell adhesion GO:0098609 26 0.020
negative regulation of gene expression GO:0010629 387 0.020
chromatin modification GO:0016568 147 0.019
positive regulation of cell communication GO:0010647 250 0.019
positive regulation of hydrolase activity GO:0051345 78 0.019
synaptic target recognition GO:0008039 45 0.019
covalent chromatin modification GO:0016569 106 0.019
cellular response to organic substance GO:0071310 132 0.019
response to oxygen containing compound GO:1901700 200 0.019
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 16 0.019
macroautophagy GO:0016236 42 0.019
regulation of cellular amine metabolic process GO:0033238 3 0.019
regulation of multicellular organismal development GO:2000026 414 0.019
antimicrobial peptide production GO:0002775 46 0.018
regulation of organ morphogenesis GO:2000027 78 0.018
regulation of developmental growth GO:0048638 174 0.018
immune response regulating signaling pathway GO:0002764 2 0.018
response to radiation GO:0009314 155 0.018
positive regulation of defense response to bacterium GO:1900426 23 0.018
cellular protein modification process GO:0006464 438 0.018
positive regulation of cellular protein metabolic process GO:0032270 118 0.018
neuron recognition GO:0008038 101 0.018
production of molecular mediator of immune response GO:0002440 46 0.018
circadian rhythm GO:0007623 105 0.018
defense response to gram negative bacterium GO:0050829 94 0.018
chaeta development GO:0022416 97 0.018
regulation of synapse structure and activity GO:0050803 128 0.018
biological adhesion GO:0022610 138 0.018
retina development in camera type eye GO:0060041 4 0.018
melanin metabolic process GO:0006582 47 0.018
homeostatic process GO:0042592 199 0.018
cellular amino acid metabolic process GO:0006520 61 0.017
small molecule metabolic process GO:0044281 305 0.017
organelle assembly GO:0070925 198 0.017
establishment of protein localization GO:0045184 163 0.017
kidney development GO:0001822 3 0.017
taxis GO:0042330 304 0.017
r3 r4 cell differentiation GO:0048056 12 0.017
tissue death GO:0016271 102 0.017
phagocytosis GO:0006909 215 0.017
regulation of immune response GO:0050776 118 0.017
protein modification by small protein conjugation or removal GO:0070647 106 0.017
regulation of cellular response to stress GO:0080135 89 0.017
negative regulation of signaling GO:0023057 219 0.017
positive regulation of cell migration GO:0030335 2 0.017
cilium assembly GO:0042384 38 0.017
mesenchymal cell development GO:0014031 1 0.017
regulation of defense response GO:0031347 102 0.017
eye photoreceptor cell development GO:0042462 81 0.017
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.017
nucleobase containing compound catabolic process GO:0034655 165 0.017
intracellular protein transport GO:0006886 104 0.017
compound eye photoreceptor cell differentiation GO:0001751 140 0.017
immune system process GO:0002376 347 0.016
regulation of neuron apoptotic process GO:0043523 16 0.016
defense response to bacterium GO:0042742 178 0.016
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.016
response to oxygen levels GO:0070482 59 0.016
positive regulation of compound eye retinal cell programmed cell death GO:0046672 9 0.016
regionalization GO:0003002 416 0.016
regulation of notch signaling pathway GO:0008593 100 0.016
chromosome organization GO:0051276 360 0.016
regulation of catabolic process GO:0009894 170 0.016
synapse assembly GO:0007416 143 0.016
photoreceptor cell differentiation GO:0046530 170 0.016
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.015
autophagic cell death GO:0048102 83 0.015
positive regulation of cell motility GO:2000147 3 0.015
cellular protein catabolic process GO:0044257 83 0.015
response to other organism GO:0051707 293 0.015
larval locomotory behavior GO:0008345 27 0.015
hormone catabolic process GO:0042447 3 0.015
tube development GO:0035295 244 0.015
positive regulation of cellular catabolic process GO:0031331 95 0.015
developmental growth GO:0048589 280 0.015
positive regulation of response to extracellular stimulus GO:0032106 8 0.015
pattern recognition receptor signaling pathway GO:0002221 2 0.015
regulation of i kappab kinase nf kappab signaling GO:0043122 2 0.015
sensory organ morphogenesis GO:0090596 260 0.015
mrna processing GO:0006397 104 0.014
growth GO:0040007 359 0.014
nuclear division GO:0000280 332 0.014
regulation of hydrolase activity GO:0051336 97 0.014
regulation of humoral immune response GO:0002920 51 0.014
positive regulation of autophagy GO:0010508 21 0.014
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 11 0.014
regulation of growth GO:0040008 233 0.014
negative regulation of cell differentiation GO:0045596 143 0.014
defense response to other organism GO:0098542 225 0.014
forebrain development GO:0030900 2 0.014
regulation of response to biotic stimulus GO:0002831 63 0.014
organic hydroxy compound metabolic process GO:1901615 83 0.014
positive regulation of retinal cell programmed cell death GO:0046670 9 0.014
regulation of production of molecular mediator of immune response GO:0002700 44 0.014
establishment of localization in cell GO:0051649 402 0.014
heterocycle catabolic process GO:0046700 166 0.014
histone modification GO:0016570 106 0.014
positive regulation of macroautophagy GO:0016239 8 0.014
protein transport GO:0015031 155 0.014
compound eye photoreceptor development GO:0042051 78 0.014
neuromuscular synaptic transmission GO:0007274 67 0.014
camera type eye development GO:0043010 4 0.014
innate immune response activating signal transduction GO:0002758 2 0.014
cell migration GO:0016477 238 0.014
positive regulation of immune response GO:0050778 63 0.014
salivary gland histolysis GO:0035070 88 0.014
mrna metabolic process GO:0016071 124 0.014
mitotic spindle organization GO:0007052 220 0.014
single organism intracellular transport GO:1902582 207 0.013
positive regulation of cell proliferation GO:0008284 47 0.013
regulation of cell substrate adhesion GO:0010810 2 0.013
regulation of organ growth GO:0046620 42 0.013
gene silencing GO:0016458 138 0.013
regulation of multicellular organism growth GO:0040014 40 0.013
immune effector process GO:0002252 98 0.013
cellular ketone metabolic process GO:0042180 24 0.013
multi organism reproductive behavior GO:0044705 121 0.013
carboxylic acid metabolic process GO:0019752 92 0.013
extrinsic apoptotic signaling pathway GO:0097191 1 0.013
molting cycle process GO:0022404 29 0.013
response to endogenous stimulus GO:0009719 119 0.013
oxoacid metabolic process GO:0043436 103 0.013
spindle organization GO:0007051 253 0.013
sperm individualization GO:0007291 48 0.013
protein heterooligomerization GO:0051291 4 0.013
organ growth GO:0035265 56 0.013
mapk cascade GO:0000165 107 0.013
antimicrobial humoral response GO:0019730 99 0.013
apoptotic process involved in development GO:1902742 20 0.013
limb development GO:0060173 1 0.013
histolysis GO:0007559 102 0.013
behavioral response to ethanol GO:0048149 49 0.013
endomembrane system organization GO:0010256 119 0.013
immune response activating signal transduction GO:0002757 2 0.013
negative regulation of notch signaling pathway GO:0045746 41 0.013
positive regulation of catalytic activity GO:0043085 118 0.013
negative regulation of cellular biosynthetic process GO:0031327 277 0.013
positive regulation of developmental process GO:0051094 143 0.013
cell motility GO:0048870 251 0.013
cellularization GO:0007349 90 0.013
response to nutrient levels GO:0031667 114 0.013
regulation of retinal cell programmed cell death GO:0046668 18 0.013
cellular response to dna damage stimulus GO:0006974 223 0.013
negative regulation of multicellular organismal process GO:0051241 142 0.012
salivary gland cell autophagic cell death GO:0035071 83 0.012
spermatogenesis GO:0007283 200 0.012
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.012
regulation of synapse assembly GO:0051963 94 0.012
positive regulation of nucleic acid templated transcription GO:1903508 266 0.012
regulation of compound eye retinal cell programmed cell death GO:0046669 18 0.012
response to virus GO:0009615 28 0.012
cell cycle phase transition GO:0044770 140 0.012
nucleobase containing small molecule metabolic process GO:0055086 174 0.012
tripartite regional subdivision GO:0007351 103 0.012
positive regulation of response to nutrient levels GO:0032109 8 0.012
regulation of cellular protein metabolic process GO:0032268 243 0.012
amide biosynthetic process GO:0043604 42 0.012
developmental maturation GO:0021700 172 0.012
positive regulation of intracellular signal transduction GO:1902533 116 0.012
response to starvation GO:0042594 97 0.012
male gamete generation GO:0048232 201 0.012
response to glucose GO:0009749 2 0.012
organic cyclic compound catabolic process GO:1901361 168 0.012
protein maturation GO:0051604 71 0.012
cell maturation GO:0048469 144 0.012
regulation of synaptic transmission GO:0050804 69 0.012
macromolecule methylation GO:0043414 45 0.012
sensory perception of taste GO:0050909 25 0.012
regulation of immune effector process GO:0002697 52 0.012
protein phosphorylation GO:0006468 169 0.012
peripheral nervous system neuron development GO:0048935 8 0.012
nucleus organization GO:0006997 45 0.012
positive regulation of apoptotic signaling pathway GO:2001235 4 0.012
dendrite morphogenesis GO:0048813 199 0.012
negative regulation of neuron apoptotic process GO:0043524 14 0.011
retinal cell programmed cell death GO:0046666 25 0.011
compound eye morphogenesis GO:0001745 249 0.011
response to sterol GO:0036314 34 0.011
spermatid development GO:0007286 98 0.011
nitrogen compound transport GO:0071705 85 0.011
compound eye retinal cell programmed cell death GO:0046667 23 0.011
cellular amide metabolic process GO:0043603 80 0.011
lateral inhibition GO:0046331 206 0.011
imaginal disc derived appendage development GO:0048737 399 0.011
serotonin receptor signaling pathway GO:0007210 5 0.011
photoreceptor cell development GO:0042461 96 0.011
regulation of mitotic cell cycle GO:0007346 190 0.011
regulation of transport GO:0051049 181 0.011
larval midgut histolysis GO:0035069 22 0.011
regulation of tube architecture open tracheal system GO:0035152 68 0.011
circadian sleep wake cycle GO:0042745 28 0.011
rna splicing via transesterification reactions GO:0000375 73 0.011
carbohydrate derivative metabolic process GO:1901135 217 0.011
nephron epithelium development GO:0072009 3 0.011
positive regulation of phosphorus metabolic process GO:0010562 139 0.011
amino sugar catabolic process GO:0046348 3 0.011
regulation of catalytic activity GO:0050790 185 0.011
positive regulation of phosphate metabolic process GO:0045937 139 0.011
circadian sleep wake cycle sleep GO:0050802 23 0.011
regulation of cell motility GO:2000145 23 0.011
acid secretion GO:0046717 1 0.011
positive regulation of catabolic process GO:0009896 105 0.011
cell adhesion GO:0007155 136 0.011
regulation of circadian rhythm GO:0042752 49 0.011
response to hexose GO:0009746 3 0.011
hindbrain development GO:0030902 2 0.010
immune response GO:0006955 246 0.010
activation of cysteine type endopeptidase activity GO:0097202 17 0.010
mitotic spindle elongation GO:0000022 81 0.010
embryonic pattern specification GO:0009880 174 0.010
protein alkylation GO:0008213 43 0.010
organonitrogen compound biosynthetic process GO:1901566 117 0.010
positive regulation of multicellular organismal process GO:0051240 143 0.010
signal transduction by phosphorylation GO:0023014 107 0.010
positive regulation of humoral immune response GO:0002922 28 0.010
purine containing compound catabolic process GO:0072523 112 0.010
vitamin biosynthetic process GO:0009110 1 0.010
macromolecule catabolic process GO:0009057 161 0.010
alternative mrna splicing via spliceosome GO:0000380 60 0.010
cellular response to nutrient levels GO:0031669 62 0.010
molting cycle chitin based cuticle GO:0007591 56 0.010

skl disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.076
musculoskeletal system disease DOID:17 0 0.076
bone development disease DOID:0080006 0 0.057
bone disease DOID:0080001 0 0.057
connective tissue disease DOID:65 0 0.057
nervous system disease DOID:863 0 0.017
urinary system disease DOID:18 0 0.015
sensory system disease DOID:0050155 0 0.011