Drosophila melanogaster

53 known processes

Smg6 (Dmel_CG6369)

CG6369 gene product from transcript CG6369-RA

(Aliases: Dmel\CG6369,SMG6,dSMG6,CG6369)

Smg6 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
positive regulation of cellular biosynthetic process GO:0031328 316 0.262
catabolic process GO:0009056 409 0.207
sperm individualization GO:0007291 48 0.191
regulation of multicellular organismal development GO:2000026 414 0.181
organelle fission GO:0048285 340 0.180
cellular catabolic process GO:0044248 372 0.178
peptide metabolic process GO:0006518 80 0.171
ribose phosphate metabolic process GO:0019693 145 0.154
male meiosis cytokinesis GO:0007112 26 0.150
ion transmembrane transport GO:0034220 122 0.149
response to nutrient levels GO:0031667 114 0.141
cellular macromolecule catabolic process GO:0044265 136 0.129
death GO:0016265 284 0.129
organic substance transport GO:0071702 257 0.129
rhythmic process GO:0048511 106 0.127
organonitrogen compound metabolic process GO:1901564 318 0.126
regulation of multi organism process GO:0043900 131 0.124
spermatid development GO:0007286 98 0.123
nucleus organization GO:0006997 45 0.108
protein modification by small protein conjugation or removal GO:0070647 106 0.108
dna metabolic process GO:0006259 227 0.105
Human
protein localization GO:0008104 284 0.105
ras protein signal transduction GO:0007265 88 0.104
heterocycle catabolic process GO:0046700 166 0.100
regulation of mitotic cell cycle phase transition GO:1901990 130 0.100
modification dependent protein catabolic process GO:0019941 78 0.098
cellular nitrogen compound catabolic process GO:0044270 165 0.097
regulation of small gtpase mediated signal transduction GO:0051056 93 0.097
regulation of nervous system development GO:0051960 248 0.095
response to abiotic stimulus GO:0009628 341 0.095
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.095
proteolysis GO:0006508 192 0.094
nuclear division GO:0000280 332 0.091
negative regulation of signaling GO:0023057 219 0.089
positive regulation of gene expression GO:0010628 290 0.088
establishment of localization in cell GO:0051649 402 0.087
vesicle mediated transport GO:0016192 381 0.085
macromolecule catabolic process GO:0009057 161 0.085
kidney development GO:0001822 3 0.082
protein catabolic process GO:0030163 101 0.081
regulation of gene expression epigenetic GO:0040029 128 0.080
pigmentation GO:0043473 75 0.077
negative regulation of signal transduction GO:0009968 206 0.077
cellular response to uv GO:0034644 12 0.077
cellular amide metabolic process GO:0043603 80 0.077
aromatic compound catabolic process GO:0019439 166 0.075
meiotic cell cycle GO:0051321 171 0.075
transmembrane transport GO:0055085 139 0.074
carbohydrate derivative metabolic process GO:1901135 217 0.074
positive regulation of nucleic acid templated transcription GO:1903508 266 0.074
regulation of ras protein signal transduction GO:0046578 93 0.071
regulation of nuclear division GO:0051783 58 0.068
ubiquitin dependent protein catabolic process GO:0006511 78 0.067
single organism behavior GO:0044708 391 0.066
histone h2a ubiquitination GO:0033522 2 0.065
positive regulation of macromolecule metabolic process GO:0010604 405 0.064
small gtpase mediated signal transduction GO:0007264 88 0.064
regulation of cell differentiation GO:0045595 302 0.064
purine containing compound catabolic process GO:0072523 112 0.062
mitochondrion organization GO:0007005 65 0.062
positive regulation of cysteine type endopeptidase activity GO:2001056 24 0.062
body morphogenesis GO:0010171 2 0.062
secretion GO:0046903 109 0.061
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.060
establishment of organelle localization GO:0051656 122 0.057
cytoplasmic transport GO:0016482 130 0.056
organic acid transport GO:0015849 18 0.055
regulation of localization GO:0032879 275 0.054
dendrite development GO:0016358 204 0.054
dna biosynthetic process GO:0071897 24 0.053
eye pigment metabolic process GO:0042441 33 0.052
response to extracellular stimulus GO:0009991 116 0.052
regulation of transport GO:0051049 181 0.052
negative regulation of cell communication GO:0010648 223 0.052
dna integrity checkpoint GO:0031570 81 0.052
cell cycle phase transition GO:0044770 140 0.051
protein transport GO:0015031 155 0.051
regulation of protein metabolic process GO:0051246 256 0.048
protein localization to organelle GO:0033365 82 0.047
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.047
ion transport GO:0006811 145 0.047
organic substance catabolic process GO:1901575 308 0.047
regulation of cell cycle process GO:0010564 181 0.047
response to starvation GO:0042594 97 0.046
circulatory system development GO:0072359 82 0.046
endocytosis GO:0006897 310 0.046
cell death GO:0008219 279 0.046
intracellular protein transport GO:0006886 104 0.045
organic cyclic compound catabolic process GO:1901361 168 0.045
regulation of protein catabolic process GO:0042176 55 0.045
adult locomotory behavior GO:0008344 76 0.044
embryo development ending in birth or egg hatching GO:0009792 152 0.044
morphogenesis of an epithelium GO:0002009 276 0.044
protein ubiquitination GO:0016567 70 0.043
nucleobase containing small molecule metabolic process GO:0055086 174 0.043
cell division GO:0051301 248 0.043
nucleoside catabolic process GO:0009164 112 0.043
segmentation GO:0035282 207 0.043
meiotic cytokinesis GO:0033206 33 0.042
regulation of cell cycle GO:0051726 291 0.042
nucleoside triphosphate catabolic process GO:0009143 108 0.042
protein complex biogenesis GO:0070271 201 0.042
developmental pigmentation GO:0048066 68 0.042
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.041
cell cycle checkpoint GO:0000075 95 0.041
positive regulation of production of molecular mediator of immune response GO:0002702 28 0.040
cellular protein catabolic process GO:0044257 83 0.040
macromolecular complex disassembly GO:0032984 37 0.040
regulation of cell death GO:0010941 173 0.040
negative regulation of gene expression GO:0010629 387 0.039
eggshell chorion gene amplification GO:0007307 9 0.039
regulation of synapse assembly GO:0051963 94 0.039
posttranscriptional regulation of gene expression GO:0010608 145 0.039
cellular response to extracellular stimulus GO:0031668 64 0.038
regulation of apoptotic process GO:0042981 130 0.038
ribonucleoside triphosphate catabolic process GO:0009203 108 0.038
nucleobase containing compound catabolic process GO:0034655 165 0.038
regionalization GO:0003002 416 0.037
nucleotide metabolic process GO:0009117 161 0.037
cellularization GO:0007349 90 0.037
nucleoside phosphate metabolic process GO:0006753 162 0.036
positive regulation of multicellular organismal process GO:0051240 143 0.036
posttranscriptional gene silencing GO:0016441 46 0.035
positive regulation of biosynthetic process GO:0009891 316 0.035
cellular response to external stimulus GO:0071496 66 0.035
negative regulation of cell cycle phase transition GO:1901988 103 0.035
nucleotide catabolic process GO:0009166 109 0.035
post embryonic appendage morphogenesis GO:0035120 385 0.034
positive regulation of response to stimulus GO:0048584 323 0.034
modification dependent macromolecule catabolic process GO:0043632 79 0.034
regulation of catabolic process GO:0009894 170 0.033
single organism catabolic process GO:0044712 228 0.033
single organism biosynthetic process GO:0044711 206 0.033
regulation of organelle organization GO:0033043 196 0.033
purine nucleoside triphosphate metabolic process GO:0009144 119 0.033
regulation of proteolysis GO:0030162 87 0.032
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.032
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.031
regulation of hydrolase activity GO:0051336 97 0.031
mitotic sister chromatid segregation GO:0000070 87 0.031
response to inorganic substance GO:0010035 44 0.031
regulation of cell development GO:0060284 215 0.031
organophosphate metabolic process GO:0019637 195 0.030
programmed cell death GO:0012501 257 0.030
regulation of mitotic cell cycle GO:0007346 190 0.030
ribonucleoside catabolic process GO:0042454 112 0.030
positive regulation of protein metabolic process GO:0051247 128 0.030
positive regulation of signaling GO:0023056 243 0.030
purine containing compound metabolic process GO:0072521 155 0.029
dendrite morphogenesis GO:0048813 199 0.029
purine nucleoside catabolic process GO:0006152 112 0.029
monocarboxylic acid transport GO:0015718 3 0.029
neurological system process GO:0050877 358 0.029
purine ribonucleoside metabolic process GO:0046128 127 0.029
cellular response to abiotic stimulus GO:0071214 58 0.029
nuclear transport GO:0051169 72 0.029
regulation of programmed cell death GO:0043067 152 0.028
cellular response to dna damage stimulus GO:0006974 223 0.028
urogenital system development GO:0001655 72 0.028
ocellus pigment metabolic process GO:0046158 19 0.028
homeostatic process GO:0042592 199 0.028
Human
dna amplification GO:0006277 11 0.027
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.027
cellular macromolecule localization GO:0070727 220 0.027
imaginal disc derived wing morphogenesis GO:0007476 337 0.027
growth GO:0040007 359 0.027
regulation of cellular component biogenesis GO:0044087 201 0.026
purine nucleoside triphosphate catabolic process GO:0009146 108 0.026
cellular protein localization GO:0034613 160 0.026
synapse organization GO:0050808 196 0.026
purine ribonucleotide catabolic process GO:0009154 109 0.026
biological adhesion GO:0022610 138 0.026
positive regulation of wnt signaling pathway GO:0030177 25 0.026
sister chromatid segregation GO:0000819 92 0.026
regulation of cellular ketone metabolic process GO:0010565 3 0.026
negative regulation of response to stimulus GO:0048585 258 0.025
regulation of synapse structure and activity GO:0050803 128 0.025
protein modification process GO:0036211 438 0.025
positive regulation of transcription dna templated GO:0045893 266 0.025
organonitrogen compound catabolic process GO:1901565 128 0.024
positive regulation of antimicrobial peptide production GO:0002225 28 0.024
gene silencing GO:0016458 138 0.024
regulation of cellular catabolic process GO:0031329 157 0.024
regulation of response to stress GO:0080134 200 0.024
gene silencing by rna GO:0031047 57 0.024
rna phosphodiester bond hydrolysis GO:0090501 17 0.023
mitotic cell cycle checkpoint GO:0007093 88 0.023
negative regulation of developmental process GO:0051093 201 0.023
apoptotic process GO:0006915 159 0.022
small molecule metabolic process GO:0044281 305 0.022
mitotic nuclear division GO:0007067 213 0.022
organonitrogen compound biosynthetic process GO:1901566 117 0.022
regulation of cell shape GO:0008360 113 0.022
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.022
glycosyl compound metabolic process GO:1901657 127 0.022
rna interference GO:0016246 27 0.022
regulation of mitosis GO:0007088 56 0.022
regulation of anatomical structure size GO:0090066 163 0.021
nucleoside triphosphate metabolic process GO:0009141 120 0.021
nucleoside metabolic process GO:0009116 127 0.021
wing disc morphogenesis GO:0007472 344 0.021
regulation of cell cycle phase transition GO:1901987 130 0.020
regulation of phosphatase activity GO:0010921 3 0.020
anion transport GO:0006820 41 0.020
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 18 0.020
positive regulation of phosphate metabolic process GO:0045937 139 0.020
regulation of wnt signaling pathway GO:0030111 68 0.020
negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 4 0.020
mitotic cell cycle phase transition GO:0044772 138 0.019
hemopoiesis GO:0030097 46 0.019
purine nucleoside metabolic process GO:0042278 127 0.019
regulation of gene silencing GO:0060968 63 0.019
response to other organism GO:0051707 293 0.019
regulation of dna repair GO:0006282 5 0.019
negative regulation of biosynthetic process GO:0009890 277 0.019
positive regulation of catalytic activity GO:0043085 118 0.019
molting cycle GO:0042303 56 0.018
regulation of cellular localization GO:0060341 136 0.018
carbohydrate derivative catabolic process GO:1901136 118 0.018
cardiovascular system development GO:0072358 82 0.018
protein complex disassembly GO:0043241 36 0.018
negative regulation of multicellular organismal process GO:0051241 142 0.018
larval development GO:0002164 104 0.018
positive regulation of signal transduction GO:0009967 223 0.018
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 65 0.018
establishment of protein localization to organelle GO:0072594 62 0.018
positive regulation of developmental process GO:0051094 143 0.018
microtubule polymerization or depolymerization GO:0031109 39 0.018
positive regulation of phosphorus metabolic process GO:0010562 139 0.018
meiotic nuclear division GO:0007126 151 0.017
mrna transport GO:0051028 15 0.017
embryonic morphogenesis GO:0048598 206 0.017
positive regulation of hydrolase activity GO:0051345 78 0.017
rna catabolic process GO:0006401 37 0.017
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.017
negative regulation of cellular protein metabolic process GO:0032269 85 0.017
regulation of response to dna damage stimulus GO:2001020 23 0.017
negative regulation of cellular catabolic process GO:0031330 34 0.017
regulation of humoral immune response GO:0002920 51 0.017
positive regulation of cell communication GO:0010647 250 0.017
regulation of cellular protein metabolic process GO:0032268 243 0.016
regulation of meiosis GO:0040020 3 0.016
proteasomal protein catabolic process GO:0010498 59 0.016
eye photoreceptor cell development GO:0042462 81 0.016
imaginal disc derived appendage development GO:0048737 399 0.016
positive regulation of stem cell differentiation GO:2000738 3 0.016
regulation of molecular function GO:0065009 217 0.016
protein modification by small protein removal GO:0070646 28 0.016
cellular protein complex assembly GO:0043623 71 0.016
negative regulation of cell cycle GO:0045786 116 0.016
regulation of cellular response to stress GO:0080135 89 0.016
circadian sleep wake cycle sleep GO:0050802 23 0.016
nucleoside phosphate catabolic process GO:1901292 110 0.016
organic acid metabolic process GO:0006082 103 0.015
protein complex assembly GO:0006461 200 0.015
regulation of neurogenesis GO:0050767 158 0.015
rrna processing GO:0006364 3 0.015
oxoacid metabolic process GO:0043436 103 0.015
microtubule polymerization GO:0046785 15 0.015
inorganic ion transmembrane transport GO:0098660 73 0.015
regulation of cell morphogenesis GO:0022604 163 0.015
regulation of synaptic growth at neuromuscular junction GO:0008582 89 0.014
protein import GO:0017038 55 0.014
phosphorylation GO:0016310 294 0.014
male courtship behavior veined wing extension GO:0048065 22 0.014
translation GO:0006412 69 0.014
response to monosaccharide GO:0034284 4 0.014
positive regulation of catabolic process GO:0009896 105 0.014
metal ion transport GO:0030001 74 0.014
negative regulation of notch signaling pathway GO:0045746 41 0.014
tube development GO:0035295 244 0.014
phagocytosis GO:0006909 215 0.014
cell growth GO:0016049 108 0.014
ribonucleoside triphosphate metabolic process GO:0009199 119 0.014
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.014
organelle assembly GO:0070925 198 0.014
regulation of nucleoside metabolic process GO:0009118 50 0.014
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 44 0.014
positive regulation of transport GO:0051050 92 0.014
positive regulation of apoptotic process GO:0043065 47 0.014
response to hexose GO:0009746 3 0.014
positive regulation of programmed cell death GO:0043068 62 0.014
signal transduction in response to dna damage GO:0042770 3 0.014
circadian rhythm GO:0007623 105 0.014
intracellular protein transmembrane transport GO:0065002 4 0.014
oocyte fate determination GO:0030716 27 0.014
eye pigmentation GO:0048069 43 0.014
neuromuscular junction development GO:0007528 149 0.014
nuclear transcribed mrna catabolic process deadenylation dependent decay GO:0000288 14 0.014
protein modification by small protein conjugation GO:0032446 79 0.013
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 54 0.013
ribonucleotide catabolic process GO:0009261 109 0.013
negative regulation of protein metabolic process GO:0051248 85 0.013
negative regulation of nervous system development GO:0051961 92 0.013
positive regulation of cellular catabolic process GO:0031331 95 0.013
postreplication repair GO:0006301 2 0.013
purine nucleotide metabolic process GO:0006163 146 0.013
antimicrobial peptide production GO:0002775 46 0.013
regulation of translation GO:0006417 56 0.013
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.013
negative regulation of phosphatidylinositol 3 kinase signaling GO:0014067 4 0.013
negative regulation of cellular component organization GO:0051129 108 0.013
positive regulation of insulin receptor signaling pathway GO:0046628 3 0.013
nephron development GO:0072006 3 0.013
eye development GO:0001654 323 0.013
positive regulation of rna biosynthetic process GO:1902680 266 0.013
cellular homeostasis GO:0019725 80 0.013
antimicrobial humoral response GO:0019730 99 0.012
regulation of cell division GO:0051302 72 0.012
dna damage checkpoint GO:0000077 78 0.012
positive regulation of humoral immune response GO:0002922 28 0.012
gliogenesis GO:0042063 80 0.012
carbohydrate metabolic process GO:0005975 82 0.012
humoral immune response GO:0006959 117 0.012
renal system development GO:0072001 72 0.012
dorsal ventral pattern formation GO:0009953 133 0.012
appendage morphogenesis GO:0035107 397 0.012
negative regulation of transferase activity GO:0051348 18 0.012
wnt signaling pathway GO:0016055 98 0.012
single organism nuclear import GO:1902593 51 0.012
gtp metabolic process GO:0046039 72 0.012
cellular response to radiation GO:0071478 52 0.012
regulation of cuticle pigmentation GO:0048079 16 0.012
negative regulation of cellular metabolic process GO:0031324 382 0.012
dna repair GO:0006281 54 0.012
nucleotide excision repair GO:0006289 8 0.011
purine nucleotide catabolic process GO:0006195 109 0.011
regulation of catalytic activity GO:0050790 185 0.011
positive regulation of nervous system development GO:0051962 69 0.011
response to calcium ion GO:0051592 1 0.011
regulation of ras gtpase activity GO:0032318 38 0.011
response to biotic stimulus GO:0009607 294 0.011
glycosyl compound catabolic process GO:1901658 112 0.011
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.011
nucleocytoplasmic transport GO:0006913 72 0.011
adult behavior GO:0030534 137 0.011
single organism intracellular transport GO:1902582 207 0.011
nucleobase containing compound transport GO:0015931 56 0.011
regulation of phosphorus metabolic process GO:0051174 210 0.011
regulation of behavior GO:0050795 75 0.011
cellular macromolecular complex assembly GO:0034622 153 0.011
imaginal disc derived appendage morphogenesis GO:0035114 395 0.011
regulation of circadian rhythm GO:0042752 49 0.011
organophosphate catabolic process GO:0046434 112 0.011
imaginal disc derived wing margin morphogenesis GO:0008587 41 0.011
male gamete generation GO:0048232 201 0.011
response to temperature stimulus GO:0009266 106 0.011
circadian sleep wake cycle process GO:0022410 24 0.011
cell cell signaling involved in cell fate commitment GO:0045168 210 0.010
cellular response to ionizing radiation GO:0071479 15 0.010
regulation of cysteine type endopeptidase activity GO:2000116 27 0.010
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.010
carboxylic acid metabolic process GO:0019752 92 0.010
single organism membrane budding GO:1902591 2 0.010
centrosome organization GO:0051297 163 0.010
embryonic pattern specification GO:0009880 174 0.010
cellular component disassembly GO:0022411 46 0.010
antibacterial peptide production GO:0002778 22 0.010
compound eye photoreceptor cell differentiation GO:0001751 140 0.010
protein processing GO:0016485 68 0.010
negative regulation of mitotic cell cycle GO:0045930 109 0.010
rhythmic behavior GO:0007622 76 0.010
regulation of response to biotic stimulus GO:0002831 63 0.010
reciprocal meiotic recombination GO:0007131 19 0.010
aging GO:0007568 143 0.010
regulation of hemocyte proliferation GO:0035206 37 0.010
nucleus localization GO:0051647 34 0.010
positive regulation of protein transport GO:0051222 37 0.010

Smg6 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
renal tubular transport disease DOID:447 0 0.299
kidney disease DOID:557 0 0.299
disease of anatomical entity DOID:7 0 0.299
urinary system disease DOID:18 0 0.299
central nervous system disease DOID:331 0 0.098
nervous system disease DOID:863 0 0.098
vascular disease DOID:178 0 0.019
cardiovascular system disease DOID:1287 0 0.019
neurodegenerative disease DOID:1289 0 0.013
musculoskeletal system disease DOID:17 0 0.011