Drosophila melanogaster

16 known processes

Hsp26 (Dmel_CG4183)

Heat shock protein 26

(Aliases: hsp 26,hsp26,26,Dmel\CG4183,26K,HSP26,DmHsp26,small hsp locus 67B,CG4183)

Hsp26 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
behavioral response to starvation GO:0042595 6 0.974
Fly
heat shock mediated polytene chromosome puffing GO:0035080 7 0.785
response to cold GO:0009409 13 0.721
determination of adult lifespan GO:0008340 137 0.709
aging GO:0007568 143 0.597
multicellular organismal aging GO:0010259 140 0.586
response to starvation GO:0042594 97 0.578
Fly
response to heat GO:0009408 63 0.494
Rat Fly
response to temperature stimulus GO:0009266 106 0.487
negative regulation of reactive oxygen species metabolic process GO:2000378 1 0.471
Rat
response to hydrogen peroxide GO:0042542 11 0.466
Mouse Rat
response to nutrient levels GO:0031667 114 0.370
Fly
muscle structure development GO:0061061 224 0.355
Mouse
response to extracellular stimulus GO:0009991 116 0.354
Fly
camera type eye development GO:0043010 4 0.338
Mouse
post embryonic appendage morphogenesis GO:0035120 385 0.324
Fly
regulation of cysteine type endopeptidase activity GO:2000116 27 0.268
Mouse
response to reactive oxygen species GO:0000302 24 0.267
Mouse Rat
negative regulation of cellular metabolic process GO:0031324 382 0.266
Mouse Rat
cellular response to heat GO:0034605 24 0.240
imaginal disc derived wing morphogenesis GO:0007476 337 0.217
Fly
wing disc morphogenesis GO:0007472 344 0.210
Fly
regulation of response to stress GO:0080134 200 0.205
Mouse
programmed cell death GO:0012501 257 0.198
Human Mouse Rat
cellular protein modification process GO:0006464 438 0.189
Mouse
regulation of cellular response to stress GO:0080135 89 0.178
Mouse
response to bacterium GO:0009617 198 0.171
Fly
appendage morphogenesis GO:0035107 397 0.170
Fly
sensory perception GO:0007600 196 0.156
Human
regulation of cell growth GO:0001558 43 0.155
Mouse Rat
response to biotic stimulus GO:0009607 294 0.151
Human Fly
stress activated mapk cascade GO:0051403 52 0.150
Rat
defense response to fungus GO:0050832 48 0.139
Fly
defense response to other organism GO:0098542 225 0.138
Fly
defense response to bacterium GO:0042742 178 0.136
Fly
response to oxidative stress GO:0006979 86 0.134
Mouse Rat Fly
regulation of response to oxidative stress GO:1902882 4 0.133
Mouse
positive regulation of multicellular organismal process GO:0051240 143 0.131
Human Mouse
regulation of proteolysis GO:0030162 87 0.130
Mouse
visual perception GO:0007601 9 0.126
Human
negative regulation of endopeptidase activity GO:0010951 11 0.126
Mouse
response to organic substance GO:0010033 284 0.125
Human Rat
response to other organism GO:0051707 293 0.125
Human Fly
signal transduction by phosphorylation GO:0023014 107 0.120
Rat
response to oxygen containing compound GO:1901700 200 0.118
Mouse Rat
defense response GO:0006952 300 0.115
Fly
protein complex biogenesis GO:0070271 201 0.114
Human Mouse
response to organic cyclic compound GO:0014070 89 0.111
Rat
apoptotic process involved in morphogenesis GO:0060561 3 0.110
Mouse
intracellular transport GO:0046907 228 0.107
Human
peptide metabolic process GO:0006518 80 0.106
imaginal disc derived appendage development GO:0048737 399 0.106
Fly
response to hypoxia GO:0001666 53 0.100
Mouse Fly
regulation of molecular function GO:0065009 217 0.098
Mouse
appendage development GO:0048736 401 0.095
Fly
positive regulation of cellular biosynthetic process GO:0031328 316 0.094
Mouse
cellular response to oxidative stress GO:0034599 28 0.094
Mouse
intracellular signal transduction GO:0035556 300 0.091
Human Mouse Rat
response to alcohol GO:0097305 95 0.089
Rat
apoptotic process GO:0006915 159 0.086
Human Mouse Rat
regulation of growth GO:0040008 233 0.086
Mouse Rat
proteolysis GO:0006508 192 0.085
Mouse
establishment of localization in cell GO:0051649 402 0.082
Human
protein complex assembly GO:0006461 200 0.080
Human Mouse
negative regulation of cellular response to oxidative stress GO:1900408 1 0.077
Mouse
protein processing GO:0016485 68 0.073
Mouse
regulation of cell death GO:0010941 173 0.073
Human Mouse Rat
cellular amine metabolic process GO:0044106 12 0.073
negative regulation of response to stimulus GO:0048585 258 0.073
Mouse
positive regulation of biosynthetic process GO:0009891 316 0.071
Mouse
negative regulation of response to oxidative stress GO:1902883 1 0.070
Mouse
regulation of apoptotic process GO:0042981 130 0.068
Human Mouse Rat
regulation of cellular protein metabolic process GO:0032268 243 0.067
Mouse
microtubule polymerization or depolymerization GO:0031109 39 0.067
Rat
protein phosphorylation GO:0006468 169 0.066
Mouse
death GO:0016265 284 0.064
Human Mouse Rat
cell growth GO:0016049 108 0.064
Mouse Rat
response to endogenous stimulus GO:0009719 119 0.063
Rat
positive regulation of response to stimulus GO:0048584 323 0.062
Human
imaginal disc derived appendage morphogenesis GO:0035114 395 0.059
Fly
oxoacid metabolic process GO:0043436 103 0.059
response to external biotic stimulus GO:0043207 293 0.058
Human Fly
reactive oxygen species metabolic process GO:0072593 22 0.058
Rat
macromolecular complex assembly GO:0065003 256 0.058
Human Mouse
regulation of phosphate metabolic process GO:0019220 210 0.058
Mouse
regulation of multicellular organismal development GO:2000026 414 0.057
Human
negative regulation of phosphorus metabolic process GO:0010563 45 0.056
Mouse
cellular catabolic process GO:0044248 372 0.056
phosphorylation GO:0016310 294 0.055
Mouse Rat
mapk cascade GO:0000165 107 0.055
Rat
catabolic process GO:0009056 409 0.054
cellular amino acid metabolic process GO:0006520 61 0.053
cellular response to ionizing radiation GO:0071479 15 0.052
Human
small molecule metabolic process GO:0044281 305 0.050
negative regulation of apoptotic process GO:0043066 63 0.050
Human Mouse Rat
regulation of reactive oxygen species metabolic process GO:2000377 8 0.049
Rat
regulation of transport GO:0051049 181 0.049
Human
regulation of phosphorylation GO:0042325 147 0.049
Mouse
muscle contraction GO:0006936 13 0.048
Rat
response to abiotic stimulus GO:0009628 341 0.048
organic substance catabolic process GO:1901575 308 0.048
negative regulation of cell communication GO:0010648 223 0.047
Mouse
negative regulation of cell differentiation GO:0045596 143 0.047
sensory perception of light stimulus GO:0050953 12 0.047
Human
regulation of programmed cell death GO:0043067 152 0.047
Human Mouse Rat
negative regulation of cell death GO:0060548 81 0.046
Human Mouse Rat
muscle organ development GO:0007517 127 0.046
Mouse
negative regulation of phosphate metabolic process GO:0045936 45 0.046
Mouse
regulation of catalytic activity GO:0050790 185 0.045
Mouse
forebrain development GO:0030900 2 0.043
regulation of intracellular transport GO:0032386 64 0.043
Human
regulation of hydrolase activity GO:0051336 97 0.042
Mouse
growth GO:0040007 359 0.041
Mouse Rat
response to hormone GO:0009725 45 0.040
Rat
response to decreased oxygen levels GO:0036293 58 0.040
Mouse Fly
regulation of muscle contraction GO:0006937 5 0.040
Rat
regulation of i kappab kinase nf kappab signaling GO:0043122 2 0.039
Mouse
negative regulation of intracellular signal transduction GO:1902532 57 0.039
Mouse
epithelial cell differentiation GO:0030855 322 0.038
Mouse
intrinsic apoptotic signaling pathway GO:0097193 16 0.038
Mouse
negative regulation of phosphorylation GO:0042326 35 0.038
Mouse
protein modification by small protein conjugation or removal GO:0070647 106 0.038
regulation of response to external stimulus GO:0032101 115 0.038
Human
negative regulation of growth GO:0045926 84 0.037
Rat
purine ribonucleoside metabolic process GO:0046128 127 0.036
negative regulation of programmed cell death GO:0043069 72 0.036
Human Mouse Rat
regulation of protein metabolic process GO:0051246 256 0.035
Mouse
negative regulation of catalytic activity GO:0043086 42 0.035
Mouse
negative regulation of cellular protein metabolic process GO:0032269 85 0.035
Mouse
regulation of phosphorus metabolic process GO:0051174 210 0.035
Mouse
regulation of localization GO:0032879 275 0.034
Human
regulation of intracellular signal transduction GO:1902531 236 0.034
Mouse
nitrogen compound transport GO:0071705 85 0.033
organic substance transport GO:0071702 257 0.033
protein localization GO:0008104 284 0.033
response to oxygen levels GO:0070482 59 0.033
Mouse Fly
localization of cell GO:0051674 257 0.033
Human
protein ubiquitination GO:0016567 70 0.032
organonitrogen compound metabolic process GO:1901564 318 0.032
regulation of protein modification process GO:0031399 112 0.030
Mouse
stress activated protein kinase signaling cascade GO:0031098 55 0.030
Rat
cellular protein catabolic process GO:0044257 83 0.030
organophosphate metabolic process GO:0019637 195 0.030
negative regulation of signal transduction GO:0009968 206 0.030
Mouse
muscle system process GO:0003012 21 0.030
Rat
negative regulation of signaling GO:0023057 219 0.029
Mouse
cellular amide metabolic process GO:0043603 80 0.029
regulation of defense response GO:0031347 102 0.029
response to inorganic substance GO:0010035 44 0.029
Mouse Rat
cellular response to gamma radiation GO:0071480 10 0.028
Human
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 25 0.028
Mouse
regulation of system process GO:0044057 36 0.028
Rat
purine nucleoside triphosphate catabolic process GO:0009146 108 0.028
macromolecule catabolic process GO:0009057 161 0.028
amine metabolic process GO:0009308 12 0.027
regulation of cellular amine metabolic process GO:0033238 3 0.027
regulation of autophagy GO:0010506 62 0.027
positive regulation of macromolecule metabolic process GO:0010604 405 0.026
Mouse
negative regulation of transferase activity GO:0051348 18 0.026
Mouse
negative regulation of biosynthetic process GO:0009890 277 0.026
organonitrogen compound biosynthetic process GO:1901566 117 0.026
tissue morphogenesis GO:0048729 297 0.026
modification dependent protein catabolic process GO:0019941 78 0.025
morphogenesis of a branching structure GO:0001763 45 0.025
single organism catabolic process GO:0044712 228 0.025
response to methotrexate GO:0031427 11 0.025
negative regulation of protein phosphorylation GO:0001933 17 0.025
Mouse
autophagy GO:0006914 108 0.024
developmental growth GO:0048589 280 0.024
nucleotide catabolic process GO:0009166 109 0.024
protein transport GO:0015031 155 0.024
actin filament organization GO:0007015 126 0.023
Mouse
phosphatidylethanolamine metabolic process GO:0046337 1 0.023
positive regulation of hydrolase activity GO:0051345 78 0.023
detection of stimulus GO:0051606 156 0.023
negative regulation of kinase activity GO:0033673 16 0.023
Mouse
negative regulation of molecular function GO:0044092 51 0.022
Mouse
limb development GO:0060173 1 0.022
proteasomal protein catabolic process GO:0010498 59 0.022
germ cell migration GO:0008354 43 0.021
positive regulation of cellular catabolic process GO:0031331 95 0.021
morphogenesis of an epithelium GO:0002009 276 0.020
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.020
negative regulation of protein metabolic process GO:0051248 85 0.020
Mouse
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.020
Mouse
regulation of cellular catabolic process GO:0031329 157 0.020
response to lipid GO:0033993 38 0.019
Rat
organic acid metabolic process GO:0006082 103 0.019
positive regulation of cell communication GO:0010647 250 0.019
immune system process GO:0002376 347 0.019
regulation of cell differentiation GO:0045595 302 0.019
ribonucleoside triphosphate metabolic process GO:0009199 119 0.018
cellular macromolecule catabolic process GO:0044265 136 0.018
epithelial cell development GO:0002064 274 0.018
Mouse
columnar cuboidal epithelial cell development GO:0002066 249 0.018
transcription from rna polymerase ii promoter GO:0006366 368 0.018
positive regulation of cysteine type endopeptidase activity GO:2001056 24 0.018
response to fungus GO:0009620 50 0.018
Fly
carboxylic acid metabolic process GO:0019752 92 0.018
regulation of transferase activity GO:0051338 58 0.018
Mouse
regulation of protein kinase activity GO:0045859 51 0.018
Mouse
positive regulation of signaling GO:0023056 243 0.018
regulation of catabolic process GO:0009894 170 0.018
regionalization GO:0003002 416 0.017
nucleoside phosphate catabolic process GO:1901292 110 0.017
amide biosynthetic process GO:0043604 42 0.017
protein modification process GO:0036211 438 0.017
Mouse
protein catabolic process GO:0030163 101 0.017
peptide biosynthetic process GO:0043043 42 0.017
regulation of immune system process GO:0002682 176 0.017
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.017
regulation of nucleotide catabolic process GO:0030811 48 0.017
cellular response to extracellular stimulus GO:0031668 64 0.017
ribonucleoside catabolic process GO:0042454 112 0.017
ribonucleoside triphosphate catabolic process GO:0009203 108 0.017
positive regulation of signal transduction GO:0009967 223 0.017
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.017
retina development in camera type eye GO:0060041 4 0.016
immune response GO:0006955 246 0.016
single organism behavior GO:0044708 391 0.016
cell death GO:0008219 279 0.016
Human Mouse Rat
negative regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043154 2 0.016
Mouse
neurological system process GO:0050877 358 0.016
Human
polytene chromosome puffing GO:0035079 7 0.016
histone modification GO:0016570 106 0.016
response to nitrogen compound GO:1901698 90 0.016
nucleotide metabolic process GO:0009117 161 0.015
somatic muscle development GO:0007525 66 0.015
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.015
regulation of response to biotic stimulus GO:0002831 63 0.015
mitotic nuclear division GO:0007067 213 0.015
response to organonitrogen compound GO:0010243 75 0.015
jak stat cascade GO:0007259 49 0.015
protein oligomerization GO:0051259 16 0.015
Human
positive regulation of catalytic activity GO:0043085 118 0.015
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.015
activation of innate immune response GO:0002218 4 0.015
regulation of production of molecular mediator of immune response GO:0002700 44 0.015
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.015
chromosome organization GO:0051276 360 0.014
connective tissue development GO:0061448 3 0.014
cellular response to dna damage stimulus GO:0006974 223 0.014
negative regulation of developmental process GO:0051093 201 0.014
negative regulation of multicellular organismal process GO:0051241 142 0.014
positive regulation of immune system process GO:0002684 68 0.014
regulation of cellular ketone metabolic process GO:0010565 3 0.014
negative regulation of nucleic acid templated transcription GO:1903507 240 0.014
embryonic development via the syncytial blastoderm GO:0001700 148 0.014
regulation of cellular amide metabolic process GO:0034248 39 0.014
cell motility GO:0048870 251 0.014
Human
carbohydrate derivative biosynthetic process GO:1901137 85 0.014
positive regulation of phosphorus metabolic process GO:0010562 139 0.014
Mouse
negative regulation of transcription dna templated GO:0045892 237 0.014
regulation of multi organism process GO:0043900 131 0.013
modification dependent macromolecule catabolic process GO:0043632 79 0.013
nucleoside phosphate metabolic process GO:0006753 162 0.013
positive regulation of molecular function GO:0044093 136 0.013
nucleoside metabolic process GO:0009116 127 0.013
positive regulation of production of molecular mediator of immune response GO:0002702 28 0.013
heterocycle catabolic process GO:0046700 166 0.013
cellular protein localization GO:0034613 160 0.013
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 54 0.013
protein targeting to nucleus GO:0044744 51 0.013
limb morphogenesis GO:0035108 1 0.013
apoptotic signaling pathway GO:0097190 27 0.013
Mouse
nucleobase containing compound transport GO:0015931 56 0.013
actin filament based process GO:0030029 220 0.013
Mouse
establishment of protein localization GO:0045184 163 0.013
response to acid chemical GO:0001101 25 0.012
ion transport GO:0006811 145 0.012
purine nucleoside triphosphate metabolic process GO:0009144 119 0.012
positive regulation of cellular amine metabolic process GO:0033240 0 0.012
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 4 0.012
aromatic compound catabolic process GO:0019439 166 0.012
regulation of muscle system process GO:0090257 6 0.012
Rat
mitotic spindle organization GO:0007052 220 0.012
histolysis GO:0007559 102 0.012
camera type eye morphogenesis GO:0048593 2 0.012
Mouse
protein alkylation GO:0008213 43 0.012
telencephalon development GO:0021537 2 0.012
regulation of protein phosphorylation GO:0001932 64 0.012
Mouse
respiratory system development GO:0060541 213 0.012
positive regulation of developmental process GO:0051094 143 0.012
Human
epithelial cell migration GO:0010631 148 0.012
Human
negative regulation of peptidase activity GO:0010466 11 0.012
Mouse
ubiquitin dependent protein catabolic process GO:0006511 78 0.012
digestive tract morphogenesis GO:0048546 127 0.012
enzyme linked receptor protein signaling pathway GO:0007167 179 0.012
Human
response to copper ion GO:0046688 4 0.012
carbohydrate derivative metabolic process GO:1901135 217 0.012
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.012
ribose phosphate metabolic process GO:0019693 145 0.012
cellular response to organic substance GO:0071310 132 0.011
Human
cardiovascular system development GO:0072358 82 0.011
Human
tube morphogenesis GO:0035239 191 0.011
regulation of immune response GO:0050776 118 0.011
peptidyl lysine modification GO:0018205 57 0.011
positive regulation of rna metabolic process GO:0051254 271 0.011
guanosine containing compound metabolic process GO:1901068 74 0.011
regulation of cellular amino acid metabolic process GO:0006521 0 0.011
actin cytoskeleton organization GO:0030036 206 0.011
Mouse
muscle cell differentiation GO:0042692 103 0.011
production of molecular mediator of immune response GO:0002440 46 0.011
retina morphogenesis in camera type eye GO:0060042 2 0.011
positive regulation of response to biotic stimulus GO:0002833 31 0.011
gtp metabolic process GO:0046039 72 0.011
negative regulation of protein modification process GO:0031400 29 0.011
Mouse
chaperone mediated protein folding GO:0061077 2 0.011
sulfur compound metabolic process GO:0006790 59 0.011
blastoderm segmentation GO:0007350 159 0.011
antimicrobial humoral response GO:0019730 99 0.011
nuclear division GO:0000280 332 0.011
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 38 0.011
glycosyl compound metabolic process GO:1901657 127 0.011
cellular macromolecular complex assembly GO:0034622 153 0.011
Mouse
endocytosis GO:0006897 310 0.011
pattern recognition receptor signaling pathway GO:0002221 2 0.010
chemotaxis GO:0006935 249 0.010
Human
regulation of protein serine threonine kinase activity GO:0071900 25 0.010
Mouse
protein maturation GO:0051604 71 0.010
Mouse
positive regulation of intracellular signal transduction GO:1902533 116 0.010
regulation of antimicrobial peptide biosynthetic process GO:0002805 38 0.010
spermatogenesis GO:0007283 200 0.010
body morphogenesis GO:0010171 2 0.010
memory GO:0007613 94 0.010
response to hexose GO:0009746 3 0.010
ameboidal type cell migration GO:0001667 151 0.010
Human
positive regulation of catabolic process GO:0009896 105 0.010
nuclear transport GO:0051169 72 0.010
phagocytosis GO:0006909 215 0.010

Hsp26 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
motor neuron disease DOID:231 0 0.973
Human
distal hereditary motor neuropathy DOID:0050582 0 0.973
Human
central nervous system disease DOID:331 0 0.973
Human
disease of anatomical entity DOID:7 0 0.973
Human
motor neuritis DOID:683 0 0.973
Human
neurodegenerative disease DOID:1289 0 0.973
Human
nervous system disease DOID:863 0 0.973
Human
neuromuscular disease DOID:440 0 0.074
Human
charcot marie tooth disease DOID:10595 0 0.074
Human
neuropathy DOID:870 0 0.074
Human
charcot marie tooth disease type 2 DOID:0050539 0 0.051
Human
cardiovascular system disease DOID:1287 0 0.050
Human
musculoskeletal system disease DOID:17 0 0.024
Human
muscular disease DOID:0080000 0 0.023
Human
myopathy DOID:423 0 0.012
Human
heart disease DOID:114 0 0.012
Human
cardiomyopathy DOID:0050700 0 0.012
Human
dilated cardiomyopathy DOID:12930 0 0.012
Human
intrinsic cardiomyopathy DOID:0060036 0 0.012
Human
muscle tissue disease DOID:66 0 0.012
Human