Drosophila melanogaster

304 known processes

phl (Dmel_CG2845)

pole hole

(Aliases: l(1)2Fe,raf,11-29,raf-1,l(1)raf,DRaf,l(1)ph,RAF,rafl,Phl,D-RAF,DRaf1,Draf,ph,CG2845,C110,Raf/phl,l(1)phl,D-raf1,Draf1,draf,D-raf,l(1)G0475,Raf1,EG:BACH48C10.3,Raf,l(1)polehole,l(1)pole hole,Draf-1,D-Raf,Dmel\CG2845,l(1)polehole/draf,raf1)

phl biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
positive regulation of photoreceptor cell differentiation GO:0046534 12 1.000
axis specification GO:0009798 167 1.000
regionalization GO:0003002 416 0.999
positive regulation of rna metabolic process GO:0051254 271 0.998
growth GO:0040007 359 0.997
regulation of cell cycle GO:0051726 291 0.996
positive regulation of rna biosynthetic process GO:1902680 266 0.996
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.996
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.995
positive regulation of transcription dna templated GO:0045893 266 0.994
eggshell chorion assembly GO:0007306 66 0.993
multicellular organism growth GO:0035264 46 0.993
positive regulation of macromolecule metabolic process GO:0010604 405 0.992
Human Rat
positive regulation of nucleic acid templated transcription GO:1903508 266 0.992
positive regulation of biosynthetic process GO:0009891 316 0.989
positive regulation of nervous system development GO:0051962 69 0.987
open tracheal system development GO:0007424 204 0.986
Fly
negative regulation of mitotic cell cycle GO:0045930 109 0.985
regulation of neuron differentiation GO:0045664 103 0.983
cell cycle phase transition GO:0044770 140 0.982
r3 r4 cell differentiation GO:0048056 12 0.982
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.981
anterior posterior axis specification GO:0009948 109 0.980
eye morphogenesis GO:0048592 260 0.980
blastoderm segmentation GO:0007350 159 0.977
regulation of nervous system development GO:0051960 248 0.977
photoreceptor cell differentiation GO:0046530 170 0.976
columnar cuboidal epithelial cell development GO:0002066 249 0.975
ovarian follicle cell development GO:0030707 248 0.973
cell proliferation GO:0008283 299 0.972
regulation of anatomical structure morphogenesis GO:0022603 242 0.972
Mouse
epithelial cell development GO:0002064 274 0.972
regulation of mitotic cell cycle phase transition GO:1901990 130 0.971
developmental growth GO:0048589 280 0.971
phosphorylation GO:0016310 294 0.970
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.969
chorion containing eggshell formation GO:0007304 105 0.968
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.966
dorsal ventral axis specification ovarian follicular epithelium GO:0008069 13 0.965
response to organic substance GO:0010033 284 0.964
Mouse
regulation of multicellular organismal development GO:2000026 414 0.961
embryonic pattern specification GO:0009880 174 0.960
compound eye development GO:0048749 307 0.959
negative regulation of autophagy GO:0010507 16 0.957
enzyme linked receptor protein signaling pathway GO:0007167 179 0.957
epidermal growth factor receptor signaling pathway GO:0007173 58 0.955
regulation of multicellular organism growth GO:0040014 40 0.945
intracellular signal transduction GO:0035556 300 0.941
tissue morphogenesis GO:0048729 297 0.940
eggshell formation GO:0030703 105 0.936
positive regulation of cellular biosynthetic process GO:0031328 316 0.934
regulation of cell development GO:0060284 215 0.924
development of primary sexual characteristics GO:0045137 50 0.923
positive regulation of multicellular organismal process GO:0051240 143 0.922
regulation of neurogenesis GO:0050767 158 0.921
imaginal disc derived appendage development GO:0048737 399 0.921
eye development GO:0001654 323 0.919
respiratory system development GO:0060541 213 0.914
Fly
regulation of map kinase activity GO:0043405 17 0.913
Rat
regulation of cell cycle phase transition GO:1901987 130 0.912
digestive system development GO:0055123 149 0.910
post embryonic appendage morphogenesis GO:0035120 385 0.910
erbb signaling pathway GO:0038127 58 0.907
negative regulation of cell cycle process GO:0010948 109 0.901
negative regulation of cell cycle GO:0045786 116 0.894
cellular component assembly involved in morphogenesis GO:0010927 151 0.888
cell projection assembly GO:0030031 94 0.885
r3 r4 cell fate commitment GO:0007464 10 0.879
signal transduction by phosphorylation GO:0023014 107 0.877
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.861
germarium derived egg chamber formation GO:0007293 101 0.857
cell migration GO:0016477 238 0.856
regulation of cell differentiation GO:0045595 302 0.852
mitotic cell cycle phase transition GO:0044772 138 0.849
negative regulation of programmed cell death GO:0043069 72 0.841
cell death GO:0008219 279 0.835
embryonic morphogenesis GO:0048598 206 0.835
negative regulation of cellular catabolic process GO:0031330 34 0.834
r7 cell differentiation GO:0045466 43 0.831
compound eye photoreceptor fate commitment GO:0001752 36 0.821
eye antennal disc development GO:0035214 60 0.815
dna metabolic process GO:0006259 227 0.814
eye photoreceptor cell fate commitment GO:0042706 37 0.803
cell cycle g1 s phase transition GO:0044843 31 0.801
cytoplasmic transport GO:0016482 130 0.792
apoptotic process GO:0006915 159 0.792
cell fate specification GO:0001708 71 0.790
Worm
positive regulation of developmental process GO:0051094 143 0.787
cellular catabolic process GO:0044248 372 0.779
regulation of photoreceptor cell differentiation GO:0046532 34 0.777
ras protein signal transduction GO:0007265 88 0.774
positive regulation of developmental growth GO:0048639 62 0.773
single organism cellular localization GO:1902580 180 0.772
positive regulation of gene expression GO:0010628 290 0.770
Human
dorsal appendage formation GO:0046843 47 0.763
regulation of phosphate metabolic process GO:0019220 210 0.750
embryonic axis specification GO:0000578 107 0.749
regulation of intracellular signal transduction GO:1902531 236 0.747
anterior posterior pattern specification GO:0009952 136 0.743
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.742
negative regulation of macroautophagy GO:0016242 6 0.740
regulation of growth GO:0040008 233 0.740
erk1 and erk2 cascade GO:0070371 39 0.739
activation of protein kinase activity GO:0032147 12 0.736
Rat
regulation of response to external stimulus GO:0032101 115 0.736
positive regulation of signaling GO:0023056 243 0.729
positive regulation of cell communication GO:0010647 250 0.724
appendage morphogenesis GO:0035107 397 0.724
death GO:0016265 284 0.723
axon guidance GO:0007411 233 0.723
epithelium migration GO:0090132 148 0.712
cellular response to chemical stimulus GO:0070887 199 0.711
Human Mouse
compound eye morphogenesis GO:0001745 249 0.710
regulation of cellular catabolic process GO:0031329 157 0.705
regulation of cell cycle g1 s phase transition GO:1902806 23 0.702
intermediate filament cytoskeleton organization GO:0045104 1 0.701
Mouse
positive regulation of mapk cascade GO:0043410 63 0.692
digestive tract morphogenesis GO:0048546 127 0.692
dorsal ventral pattern formation GO:0009953 133 0.680
imaginal disc derived appendage morphogenesis GO:0035114 395 0.677
organelle fission GO:0048285 340 0.667
segmentation GO:0035282 207 0.666
muscle cell differentiation GO:0042692 103 0.661
regulation of developmental growth GO:0048638 174 0.658
cellular response to dna damage stimulus GO:0006974 223 0.651
single organism behavior GO:0044708 391 0.650
Mouse
cellular macromolecule localization GO:0070727 220 0.636
regulation of apoptotic process GO:0042981 130 0.622
programmed cell death GO:0012501 257 0.612
regulation of mitotic cell cycle GO:0007346 190 0.612
secretion GO:0046903 109 0.610
Mouse
negative regulation of cell cycle phase transition GO:1901988 103 0.604
cellularization GO:0007349 90 0.601
positive regulation of neurogenesis GO:0050769 41 0.599
photoreceptor cell fate commitment GO:0046552 41 0.592
positive regulation of erk1 and erk2 cascade GO:0070374 36 0.581
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.581
protein catabolic process GO:0030163 101 0.572
Human
negative regulation of response to nutrient levels GO:0032108 6 0.571
male gamete generation GO:0048232 201 0.570
single organism intracellular transport GO:1902582 207 0.564
regulation of immune system process GO:0002682 176 0.556
border follicle cell migration GO:0007298 113 0.555
establishment of ommatidial planar polarity GO:0042067 49 0.552
meiotic cell cycle GO:0051321 171 0.552
regulation of macroautophagy GO:0016241 15 0.546
nucleocytoplasmic transport GO:0006913 72 0.540
neuron fate commitment GO:0048663 50 0.537
aging GO:0007568 143 0.536
Worm
hemocyte differentiation GO:0042386 38 0.531
negative regulation of multicellular organismal process GO:0051241 142 0.525
peptidyl tyrosine phosphorylation GO:0018108 24 0.519
eye antennal disc morphogenesis GO:0007455 34 0.516
wing disc morphogenesis GO:0007472 344 0.507
transcription from rna polymerase ii promoter GO:0006366 368 0.506
zygotic determination of anterior posterior axis embryo GO:0007354 27 0.501
regulation of cellular protein metabolic process GO:0032268 243 0.482
Human Rat
negative regulation of developmental process GO:0051093 201 0.477
Mouse
regulation of cellular amino acid metabolic process GO:0006521 0 0.476
protein modification process GO:0036211 438 0.466
negative regulation of cellular metabolic process GO:0031324 382 0.464
leg disc development GO:0035218 92 0.458
regulation of cell cycle process GO:0010564 181 0.458
malpighian tubule development GO:0072002 64 0.436
torc1 signaling GO:0038202 12 0.436
regulation of protein phosphorylation GO:0001932 64 0.431
Human Rat
mesoderm morphogenesis GO:0048332 22 0.430
positive regulation of catalytic activity GO:0043085 118 0.421
Rat
macromolecule catabolic process GO:0009057 161 0.416
Human
positive regulation of cell differentiation GO:0045597 64 0.413
cellular protein localization GO:0034613 160 0.411
regulation of protein kinase activity GO:0045859 51 0.411
Rat
regulation of kinase activity GO:0043549 53 0.403
Rat
second mitotic wave involved in compound eye morphogenesis GO:0016330 7 0.391
embryonic organ development GO:0048568 50 0.388
malpighian tubule morphogenesis GO:0007443 44 0.379
cellular response to organic substance GO:0071310 132 0.378
Mouse
cellular response to growth factor stimulus GO:0071363 30 0.373
Mouse
regulation of phosphorylation GO:0042325 147 0.373
negative regulation of cell differentiation GO:0045596 143 0.372
Mouse
cell motility GO:0048870 251 0.372
larval lymph gland hemocyte differentiation GO:0035168 11 0.372
protein localization to organelle GO:0033365 82 0.369
localization of cell GO:0051674 257 0.367
cellular protein modification process GO:0006464 438 0.365
epithelial cell differentiation GO:0030855 322 0.365
positive regulation of wnt signaling pathway GO:0030177 25 0.360
dendrite regeneration GO:0031104 2 0.358
positive regulation of molecular function GO:0044093 136 0.357
Rat
digestive tract development GO:0048565 149 0.355
reproductive structure development GO:0048608 74 0.353
positive regulation of protein modification process GO:0031401 58 0.352
Human Rat
chemotaxis GO:0006935 249 0.350
mapk cascade GO:0000165 107 0.348
negative regulation of g1 s transition of mitotic cell cycle GO:2000134 13 0.347
larval lymph gland hemopoiesis GO:0035167 17 0.344
regulation of mapk cascade GO:0043408 92 0.338
maintenance of location GO:0051235 73 0.337
positive regulation of signal transduction GO:0009967 223 0.334
peptidyl tyrosine modification GO:0018212 24 0.325
regulation of gtpase activity GO:0043087 44 0.325
maternal determination of dorsal ventral axis ovarian follicular epithelium soma encoded GO:0008071 1 0.322
oocyte differentiation GO:0009994 145 0.322
nuclear division GO:0000280 332 0.318
establishment of tissue polarity GO:0007164 87 0.318
response to oxygen containing compound GO:1901700 200 0.316
oocyte morphogenesis GO:0048601 3 0.316
organic acid metabolic process GO:0006082 103 0.311
secretion by cell GO:0032940 101 0.305
Mouse
neuron projection guidance GO:0097485 241 0.295
sensory organ morphogenesis GO:0090596 260 0.293
regulation of small gtpase mediated signal transduction GO:0051056 93 0.293
response to endogenous stimulus GO:0009719 119 0.292
small gtpase mediated signal transduction GO:0007264 88 0.289
gtp catabolic process GO:0006184 72 0.288
eye photoreceptor cell differentiation GO:0001754 145 0.288
axon development GO:0061564 297 0.287
regulation of rac protein signal transduction GO:0035020 3 0.287
imaginal disc derived wing vein morphogenesis GO:0008586 44 0.286
regulation of dna metabolic process GO:0051052 34 0.284
regulation of molecular function GO:0065009 217 0.283
Rat
positive regulation of multicellular organism growth GO:0040018 21 0.282
protein localization GO:0008104 284 0.280
regulation of cytoskeleton organization GO:0051493 89 0.278
Mouse
regulation of cell proliferation GO:0042127 163 0.269
cognition GO:0050890 141 0.268
Mouse
organic substance transport GO:0071702 257 0.268
dna packaging GO:0006323 91 0.260
positive regulation of cellular protein metabolic process GO:0032270 118 0.259
Human Rat
establishment of protein localization GO:0045184 163 0.257
axonogenesis GO:0007409 290 0.256
meiotic nuclear envelope disassembly GO:0051078 2 0.256
regulation of cellular component biogenesis GO:0044087 201 0.253
Human Mouse
regulation of planar cell polarity pathway involved in axis elongation GO:2000040 2 0.252
immune system development GO:0002520 57 0.249
regulation of cell proliferation involved in compound eye morphogenesis GO:2000495 2 0.248
prostaglandin biosynthetic process GO:0001516 1 0.246
protein transport GO:0015031 155 0.244
actin cytoskeleton organization GO:0030036 206 0.242
Mouse
photoreceptor cell development GO:0042461 96 0.242
regulation of organ morphogenesis GO:2000027 78 0.242
tube development GO:0035295 244 0.240
regulation of g1 s transition of mitotic cell cycle GO:2000045 23 0.240
hindgut morphogenesis GO:0007442 58 0.237
negative regulation of cell death GO:0060548 81 0.236
regulation of cell projection organization GO:0031344 92 0.236
positive regulation of protein serine threonine kinase activity GO:0071902 15 0.234
Rat
regulation of anatomical structure size GO:0090066 163 0.233
regulation of phosphorus metabolic process GO:0051174 210 0.232
g1 s transition of mitotic cell cycle GO:0000082 31 0.231
response to radiation GO:0009314 155 0.230
Mouse
leg disc morphogenesis GO:0007478 80 0.223
dorsal closure leading edge cell differentiation GO:0046663 2 0.223
compound eye photoreceptor cell differentiation GO:0001751 140 0.221
intracellular transport GO:0046907 228 0.219
regulation of nuclear division GO:0051783 58 0.217
establishment or maintenance of polarity of larval imaginal disc epithelium GO:0016336 3 0.216
icosanoid biosynthetic process GO:0046456 1 0.210
spermatogenesis GO:0007283 200 0.209
positive regulation of protein metabolic process GO:0051247 128 0.208
Human Rat
positive regulation of phosphorus metabolic process GO:0010562 139 0.207
nuclear transport GO:0051169 72 0.203
regulation of sequence specific dna binding transcription factor activity GO:0051090 12 0.202
positive regulation of intracellular signal transduction GO:1902533 116 0.201
connective tissue development GO:0061448 3 0.201
morphogenesis of a polarized epithelium GO:0001738 93 0.200
negative regulation of neurotransmitter secretion GO:0046929 2 0.195
Mouse
negative regulation of response to extracellular stimulus GO:0032105 6 0.189
regulation of protein modification process GO:0031399 112 0.188
Human Rat
regulation of erk1 and erk2 cascade GO:0070372 39 0.187
cellular response to oxygen containing compound GO:1901701 79 0.185
regulation of protein metabolic process GO:0051246 256 0.184
Human Rat
response to abiotic stimulus GO:0009628 341 0.183
Mouse Rat
regulation of erbb signaling pathway GO:1901184 42 0.181
negative regulation of wnt signaling pathway GO:0030178 28 0.178
appendage development GO:0048736 401 0.176
protein phosphorylation GO:0006468 169 0.176
imaginal disc derived wing morphogenesis GO:0007476 337 0.173
autophagy GO:0006914 108 0.173
regulation of protein serine threonine kinase activity GO:0071900 25 0.171
Rat
regulation of notch signaling pathway GO:0008593 100 0.169
oocyte fate commitment GO:0048600 2 0.168
brain development GO:0007420 120 0.164
regulation of immune response GO:0050776 118 0.164
negative regulation of cell communication GO:0010648 223 0.161
positive regulation of cell motility GO:2000147 3 0.161
negative regulation of immune system process GO:0002683 50 0.160
positive regulation of golgi to plasma membrane protein transport GO:0042998 2 0.160
negative regulation of cell development GO:0010721 62 0.158
regulation of cell fate commitment GO:0010453 29 0.158
regulation of cell fate specification GO:0042659 27 0.155
establishment of localization in cell GO:0051649 402 0.154
Mouse
body morphogenesis GO:0010171 2 0.153
positive regulation of phosphate metabolic process GO:0045937 139 0.151
cell cycle checkpoint GO:0000075 95 0.149
regulation of locomotion GO:0040012 42 0.149
Mouse
maternal determination of dorsal ventral axis ovarian follicular epithelium germ line encoded GO:0008070 2 0.148
epithelial cell migration GO:0010631 148 0.148
sex differentiation GO:0007548 81 0.148
muscle structure development GO:0061061 224 0.147
negative regulation of terminal cell fate specification open tracheal system GO:0035155 2 0.146
endodermal cell differentiation GO:0035987 3 0.143
regulation of canonical wnt signaling pathway GO:0060828 15 0.142
gliogenesis GO:0042063 80 0.139
neurological system process GO:0050877 358 0.138
Mouse
defense response GO:0006952 300 0.136
meiotic spindle checkpoint GO:0044779 1 0.136
sister chromatid segregation GO:0000819 92 0.133
negative regulation of apoptotic process GO:0043066 63 0.133
wnt signaling pathway GO:0016055 98 0.133
regulation of rap protein signal transduction GO:0032487 4 0.131
immune response GO:0006955 246 0.129
posttranscriptional regulation of gene expression GO:0010608 145 0.128
gonad development GO:0008406 50 0.127
endocytosis GO:0006897 310 0.127
organophosphate metabolic process GO:0019637 195 0.122
multicellular organismal reproductive behavior GO:0033057 110 0.121
positive regulation of transcription involved in g2 m transition of mitotic cell cycle GO:0090282 1 0.120
taxis GO:0042330 304 0.119
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.118
regulation of ras protein signal transduction GO:0046578 93 0.117
glycerolipid metabolic process GO:0046486 34 0.115
trachea development GO:0060438 29 0.113
regulation of nucleotide catabolic process GO:0030811 48 0.113
specification of segmental identity antennal segment GO:0007383 2 0.111
embryonic hindgut morphogenesis GO:0048619 48 0.110
regulation of cellular response to stress GO:0080135 89 0.109
positive regulation of chromatin silencing at telomere GO:0031940 2 0.109
ribonucleoside catabolic process GO:0042454 112 0.109
striated muscle cell differentiation GO:0051146 90 0.109
negative regulation of dna templated transcription initiation GO:2000143 1 0.108
cellular lipid metabolic process GO:0044255 83 0.108
negative regulation of response to stimulus GO:0048585 258 0.107
dna templated transcriptional start site selection GO:0001173 1 0.107
ovarian follicle cell migration GO:0007297 121 0.105
tube morphogenesis GO:0035239 191 0.105
hindbrain development GO:0030902 2 0.105
hindgut development GO:0061525 58 0.103
rho protein signal transduction GO:0007266 14 0.101
regulation of cell migration GO:0030334 22 0.100
Mouse
regulation of catalytic activity GO:0050790 185 0.100
Rat
formation of primary germ layer GO:0001704 24 0.100
regulation of hemocyte differentiation GO:0045610 22 0.099
organ growth GO:0035265 56 0.098
stem cell fate commitment GO:0048865 25 0.096
regulation of compound eye photoreceptor development GO:0045314 12 0.095
regulation of ran gtpase activity GO:0032316 1 0.093
cuticle development GO:0042335 86 0.093
negative regulation of mitotic anaphase promoting complex activity GO:0060564 2 0.093
positive regulation of map kinase activity GO:0043406 11 0.093
Rat
regulation of centriole replication GO:0046599 2 0.091
regulation of transferase activity GO:0051338 58 0.090
Rat
tripartite regional subdivision GO:0007351 103 0.090
regulation of nucleotide metabolic process GO:0006140 62 0.090
positive regulation of r7 cell differentiation GO:0045678 7 0.089
positive regulation of ribosome biogenesis GO:0090070 3 0.089
actomyosin structure organization GO:0031032 56 0.088
Mouse
multi organism reproductive behavior GO:0044705 121 0.087
cellular response to extracellular stimulus GO:0031668 64 0.086
negative regulation of mrna 3 end processing GO:0031441 3 0.086
regulation of trichome morphogenesis GO:2000039 3 0.085
regulation of autophagy GO:0010506 62 0.085
intracellular protein transport GO:0006886 104 0.084
response to wounding GO:0009611 94 0.084
male meiosis GO:0007140 52 0.083
endodermal cell fate commitment GO:0001711 3 0.083
cell cell signaling involved in cell fate commitment GO:0045168 210 0.083
dormancy process GO:0022611 2 0.083
histone h4 acetylation involved in response to dna damage stimulus GO:2000776 1 0.082
renal system development GO:0072001 72 0.081
anterior head segmentation GO:0035288 3 0.080
cellular response to nutrient levels GO:0031669 62 0.080
notch signaling pathway GO:0007219 120 0.080
positive regulation of protein kinase activity GO:0045860 25 0.079
Rat
positive regulation of ras protein signal transduction GO:0046579 43 0.079
protein complex assembly GO:0006461 200 0.079
Human Mouse
regulation of hematopoietic stem cell differentiation GO:1902036 1 0.078
anterior posterior axis specification follicular epithelium GO:0030714 2 0.078
response to bacterium GO:0009617 198 0.077
negative regulation of rna polymerase ii transcriptional preinitiation complex assembly GO:0017055 1 0.077
dna replication GO:0006260 48 0.077
intermediate filament based process GO:0045103 1 0.077
Mouse
regulation of cell morphogenesis GO:0022604 163 0.077
Mouse
catabolic process GO:0009056 409 0.077
positive regulation of catabolic process GO:0009896 105 0.076
meiotic chromosome movement towards spindle pole GO:0016344 1 0.075
developmental programmed cell death GO:0010623 138 0.075
chromatin modification GO:0016568 147 0.075
regulation of wnt signaling pathway GO:0030111 68 0.073
response to nutrient levels GO:0031667 114 0.073
negative regulation of catabolic process GO:0009895 36 0.071
negative regulation of intracellular signal transduction GO:1902532 57 0.071
negative regulation of transcription initiation from rna polymerase ii promoter GO:0060633 1 0.071
single organism cell adhesion GO:0098602 47 0.071
Mouse
unsaturated fatty acid biosynthetic process GO:0006636 1 0.071
cell aging GO:0007569 2 0.069
dna integrity checkpoint GO:0031570 81 0.068
ribonucleoprotein complex disassembly GO:0032988 1 0.068
terminal region determination GO:0007362 25 0.067
release of cytoplasmic sequestered nf kappab GO:0008588 1 0.067
morphogenesis of an epithelium GO:0002009 276 0.067
positive regulation of protein import into nucleus translocation GO:0033160 2 0.067
response to uv b GO:0010224 1 0.067
compound eye retinal cell programmed cell death GO:0046667 23 0.066
forebrain development GO:0030900 2 0.066
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 4 0.066
mesoderm development GO:0007498 78 0.065
imaginal disc derived leg morphogenesis GO:0007480 80 0.065
regulation of epidermal growth factor receptor signaling pathway GO:0042058 42 0.065
negative regulation of catalytic activity GO:0043086 42 0.064
response to red light GO:0010114 2 0.063
reproductive system development GO:0061458 74 0.063
urogenital system development GO:0001655 72 0.063
negative regulation of ubiquitin protein ligase activity involved in mitotic cell cycle GO:0051436 2 0.063
defense response to bacterium GO:0042742 178 0.062
dna templated transcription elongation GO:0006354 18 0.062
purine containing compound catabolic process GO:0072523 112 0.061
lateral inhibition GO:0046331 206 0.061
magnesium ion homeostasis GO:0010960 1 0.061
positive regulation of stem cell differentiation GO:2000738 3 0.061
positive regulation of neuron differentiation GO:0045666 26 0.060
eye photoreceptor cell development GO:0042462 81 0.060
central nervous system development GO:0007417 201 0.060
positive regulation of cell maturation GO:1903431 2 0.060
cell morphogenesis involved in malpighian tubule morphogenesis GO:0061336 1 0.060
epithelial tube morphogenesis GO:0060562 88 0.059
gastrulation GO:0007369 70 0.059
organ formation GO:0048645 39 0.059
cellular response to starvation GO:0009267 61 0.058
ganglion mother cell fate determination GO:0007402 2 0.058
centripetally migrating follicle cell migration GO:0060269 1 0.057
dorsal vessel heart proper cell fate commitment GO:0035053 2 0.056
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.056
regulation of neuron projection development GO:0010975 69 0.055
trichome morphogenesis GO:0010090 3 0.055
establishment or maintenance of cell polarity GO:0007163 167 0.055
positive regulation of protein phosphorylation GO:0001934 34 0.055
Human Rat
stress activated mapk cascade GO:0051403 52 0.054
heart field specification GO:0003128 0 0.054
protein targeting GO:0006605 64 0.054
regulation of viral entry into host cell GO:0046596 2 0.054
juvenile hormone mediated signaling pathway GO:0035626 3 0.053
chorion containing eggshell pattern formation GO:0030381 11 0.053
nuclear membrane organization GO:0071763 2 0.053
stress activated protein kinase signaling cascade GO:0031098 55 0.053

phl disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.840
Human
cancer DOID:162 0 0.693
Human
organ system cancer DOID:0050686 0 0.456
Human
large intestine cancer DOID:5672 0 0.118
gastrointestinal system cancer DOID:3119 0 0.118
intestinal cancer DOID:10155 0 0.118
colorectal cancer DOID:9256 0 0.118
head and neck cancer DOID:11934 0 0.109
hepatobiliary disease DOID:3118 0 0.103
disease of anatomical entity DOID:7 0 0.103
Human
gastrointestinal system disease DOID:77 0 0.103
liver disease DOID:409 0 0.103
alagille syndrome DOID:9245 0 0.103
organ system benign neoplasm DOID:0060085 0 0.097
pilomatrixoma DOID:5374 0 0.097
hair follicle neoplasm DOID:5375 0 0.097
benign neoplasm DOID:0060072 0 0.097
skin benign neoplasm DOID:3165 0 0.097
integumentary system benign neoplasm DOID:0060121 0 0.097
tuberous sclerosis DOID:13515 0 0.089
artery disease DOID:0050828 0 0.089
vascular disease DOID:178 0 0.089
cardiovascular system disease DOID:1287 0 0.089
Human
aortic disease DOID:520 0 0.089
myopathy DOID:423 0 0.083
Human
muscular disease DOID:0080000 0 0.083
Human
heart disease DOID:114 0 0.083
Human
cardiomyopathy DOID:0050700 0 0.083
Human
intrinsic cardiomyopathy DOID:0060036 0 0.083
Human
arrhythmogenic right ventricular cardiomyopathy DOID:0050431 0 0.083
musculoskeletal system disease DOID:17 0 0.083
Human
muscle tissue disease DOID:66 0 0.083
Human
hajdu cheney syndrome DOID:2736 0 0.078
leopard syndrome DOID:14291 0 0.078
Human
colon cancer DOID:219 0 0.071
disease of metabolism DOID:0014667 0 0.067
hemochromatosis DOID:2352 0 0.067
inherited metabolic disorder DOID:655 0 0.067
metal metabolism disorder DOID:896 0 0.067
female reproductive system disease DOID:229 0 0.066
ovarian disease DOID:1100 0 0.066
reproductive system disease DOID:15 0 0.066
premature ovarian failure DOID:5426 0 0.066
costello syndrome DOID:0050469 0 0.062
myeloma DOID:0070004 0 0.053
hemorrhagic thrombocythemia DOID:2224 0 0.053
chronic myeloproliferative disease DOID:2226 0 0.053
immune system cancer DOID:0060083 0 0.053
hematologic cancer DOID:2531 0 0.053
bone marrow cancer DOID:4960 0 0.053