Drosophila melanogaster

119 known processes

Ire1 (Dmel_CG4583)

Inositol-requiring enzyme-1

(Aliases: dIRE1,Dmel\CG4583,dire-1,ire-1,CG4583,IRE1,Ire-1,IRE-like,Ire)

Ire1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
growth GO:0040007 359 0.119
autophagy GO:0006914 108 0.081
regulation of developmental growth GO:0048638 174 0.066
small molecule metabolic process GO:0044281 305 0.062
regionalization GO:0003002 416 0.061
organonitrogen compound metabolic process GO:1901564 318 0.058
eye morphogenesis GO:0048592 260 0.055
compound eye development GO:0048749 307 0.055
negative regulation of developmental growth GO:0048640 64 0.051
homeostatic process GO:0042592 199 0.050
cellular catabolic process GO:0044248 372 0.048
compound eye morphogenesis GO:0001745 249 0.044
sensory organ morphogenesis GO:0090596 260 0.043
negative regulation of growth GO:0045926 84 0.041
positive regulation of signaling GO:0023056 243 0.040
eye development GO:0001654 323 0.040
death GO:0016265 284 0.040
nucleobase containing compound catabolic process GO:0034655 165 0.039
organic substance transport GO:0071702 257 0.037
ion transmembrane transport GO:0034220 122 0.036
organelle assembly GO:0070925 198 0.035
cellular macromolecular complex assembly GO:0034622 153 0.034
macromolecular complex assembly GO:0065003 256 0.034
ribonucleoside triphosphate metabolic process GO:0009199 119 0.034
cell death GO:0008219 279 0.033
spindle organization GO:0007051 253 0.033
regulation of phosphorus metabolic process GO:0051174 210 0.033
negative regulation of developmental process GO:0051093 201 0.032
catabolic process GO:0009056 409 0.032
developmental growth GO:0048589 280 0.032
connective tissue development GO:0061448 3 0.032
positive regulation of response to stimulus GO:0048584 323 0.031
vesicle mediated transport GO:0016192 381 0.031
regulation of multicellular organismal development GO:2000026 414 0.030
regulation of response to stress GO:0080134 200 0.030
camera type eye development GO:0043010 4 0.030
response to bacterium GO:0009617 198 0.030
ribonucleoside triphosphate catabolic process GO:0009203 108 0.030
protein complex assembly GO:0006461 200 0.029
single organism biosynthetic process GO:0044711 206 0.029
organic cyclic compound catabolic process GO:1901361 168 0.029
positive regulation of cell communication GO:0010647 250 0.028
positive regulation of signal transduction GO:0009967 223 0.028
phagocytosis GO:0006909 215 0.027
enzyme linked receptor protein signaling pathway GO:0007167 179 0.027
regulation of catabolic process GO:0009894 170 0.026
heterocycle catabolic process GO:0046700 166 0.026
cellular nitrogen compound catabolic process GO:0044270 165 0.026
positive regulation of catabolic process GO:0009896 105 0.026
regulation of intracellular signal transduction GO:1902531 236 0.025
nucleobase containing small molecule metabolic process GO:0055086 174 0.025
ribonucleotide metabolic process GO:0009259 145 0.025
cation homeostasis GO:0055080 51 0.025
carboxylic acid metabolic process GO:0019752 92 0.025
glycosyl compound catabolic process GO:1901658 112 0.025
adult behavior GO:0030534 137 0.025
intracellular signal transduction GO:0035556 300 0.024
programmed cell death GO:0012501 257 0.024
negative regulation of multicellular organismal process GO:0051241 142 0.023
positive regulation of cellular biosynthetic process GO:0031328 316 0.023
neurological system process GO:0050877 358 0.023
organic acid metabolic process GO:0006082 103 0.022
multicellular organismal aging GO:0010259 140 0.022
regulation of neurogenesis GO:0050767 158 0.022
organophosphate metabolic process GO:0019637 195 0.022
single organism behavior GO:0044708 391 0.022
defense response to gram negative bacterium GO:0050829 94 0.022
endomembrane system organization GO:0010256 119 0.022
transmembrane transport GO:0055085 139 0.022
cholesterol transport GO:0030301 2 0.022
regulation of cellular catabolic process GO:0031329 157 0.022
regulation of notch signaling pathway GO:0008593 100 0.022
regulation of growth GO:0040008 233 0.022
nitrogen compound transport GO:0071705 85 0.022
immune response GO:0006955 246 0.022
regulation of stress activated mapk cascade GO:0032872 41 0.021
nucleoside phosphate metabolic process GO:0006753 162 0.021
lateral inhibition GO:0046331 206 0.021
small gtpase mediated signal transduction GO:0007264 88 0.020
apoptotic process GO:0006915 159 0.020
regulation of phosphate metabolic process GO:0019220 210 0.020
response to monosaccharide GO:0034284 4 0.020
body morphogenesis GO:0010171 2 0.020
rna processing GO:0006396 147 0.020
ribonucleoside metabolic process GO:0009119 127 0.020
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.020
aromatic compound catabolic process GO:0019439 166 0.020
single organism catabolic process GO:0044712 228 0.020
regulation of molecular function GO:0065009 217 0.020
regulation of localization GO:0032879 275 0.020
ras protein signal transduction GO:0007265 88 0.020
positive regulation of intracellular signal transduction GO:1902533 116 0.020
ribonucleotide catabolic process GO:0009261 109 0.020
mitotic g2 m transition checkpoint GO:0044818 70 0.020
positive regulation of molecular function GO:0044093 136 0.019
segmentation GO:0035282 207 0.019
response to external biotic stimulus GO:0043207 293 0.019
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.019
protein complex biogenesis GO:0070271 201 0.019
cellular lipid metabolic process GO:0044255 83 0.019
cell proliferation GO:0008283 299 0.019
epithelial cell development GO:0002064 274 0.019
regulation of programmed cell death GO:0043067 152 0.019
oxoacid metabolic process GO:0043436 103 0.018
biological adhesion GO:0022610 138 0.018
ribose phosphate metabolic process GO:0019693 145 0.018
embryonic morphogenesis GO:0048598 206 0.018
negative regulation of nervous system development GO:0051961 92 0.018
regulation of phosphorylation GO:0042325 147 0.018
purine nucleoside triphosphate catabolic process GO:0009146 108 0.018
regulation of cell cycle phase transition GO:1901987 130 0.018
camera type eye morphogenesis GO:0048593 2 0.018
lipid metabolic process GO:0006629 121 0.018
nucleoside metabolic process GO:0009116 127 0.018
defense response to bacterium GO:0042742 178 0.017
glycosyl compound metabolic process GO:1901657 127 0.017
nucleoside catabolic process GO:0009164 112 0.017
positive regulation of phosphate metabolic process GO:0045937 139 0.017
regulation of i kappab kinase nf kappab signaling GO:0043122 2 0.017
positive regulation of phosphorus metabolic process GO:0010562 139 0.017
developmental maturation GO:0021700 172 0.017
aging GO:0007568 143 0.017
male gamete generation GO:0048232 201 0.017
ion transport GO:0006811 145 0.017
positive regulation of transcription dna templated GO:0045893 266 0.017
regulation of synapse assembly GO:0051963 94 0.017
anterior posterior pattern specification GO:0009952 136 0.017
establishment of localization in cell GO:0051649 402 0.017
ovarian follicle cell development GO:0030707 248 0.017
regulation of transport GO:0051049 181 0.016
purine ribonucleotide metabolic process GO:0009150 145 0.016
single organism intracellular transport GO:1902582 207 0.016
muscle organ development GO:0007517 127 0.016
carbohydrate derivative catabolic process GO:1901136 118 0.016
blastoderm segmentation GO:0007350 159 0.016
cation transport GO:0006812 110 0.016
monocarboxylic acid transport GO:0015718 3 0.016
multi multicellular organism process GO:0044706 123 0.016
nucleoside phosphate catabolic process GO:1901292 110 0.016
mrna metabolic process GO:0016071 124 0.016
stress activated mapk cascade GO:0051403 52 0.016
cell adhesion GO:0007155 136 0.016
positive regulation of biosynthetic process GO:0009891 316 0.016
cellular component assembly involved in morphogenesis GO:0010927 151 0.016
imaginal disc derived wing morphogenesis GO:0007476 337 0.015
defense response to other organism GO:0098542 225 0.015
open tracheal system development GO:0007424 204 0.015
nucleotide catabolic process GO:0009166 109 0.015
regulation of cell proliferation GO:0042127 163 0.015
establishment of protein localization GO:0045184 163 0.015
imaginal disc derived appendage development GO:0048737 399 0.015
membrane organization GO:0061024 112 0.015
purine nucleotide metabolic process GO:0006163 146 0.015
positive regulation of cellular catabolic process GO:0031331 95 0.015
response to extracellular stimulus GO:0009991 116 0.015
positive regulation of mapk cascade GO:0043410 63 0.015
mesenchymal cell differentiation GO:0048762 1 0.015
morphogenesis of a polarized epithelium GO:0001738 93 0.015
regulation of defense response GO:0031347 102 0.015
single organism cell adhesion GO:0098602 47 0.015
purine nucleoside catabolic process GO:0006152 112 0.015
purine nucleotide catabolic process GO:0006195 109 0.015
phosphorylation GO:0016310 294 0.015
notch signaling pathway GO:0007219 120 0.015
regulation of stress activated protein kinase signaling cascade GO:0070302 42 0.015
columnar cuboidal epithelial cell development GO:0002066 249 0.015
regulation of cellular component size GO:0032535 98 0.014
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.014
synaptic growth at neuromuscular junction GO:0051124 119 0.014
mitotic spindle organization GO:0007052 220 0.014
muscle structure development GO:0061061 224 0.014
developmental programmed cell death GO:0010623 138 0.014
histolysis GO:0007559 102 0.014
neuromuscular junction development GO:0007528 149 0.014
positive regulation of macromolecule metabolic process GO:0010604 405 0.014
protein localization GO:0008104 284 0.014
regulation of cellular response to stress GO:0080135 89 0.014
establishment of rna localization GO:0051236 47 0.014
endocytosis GO:0006897 310 0.014
carbohydrate derivative metabolic process GO:1901135 217 0.014
regulation of jnk cascade GO:0046328 40 0.014
organic substance catabolic process GO:1901575 308 0.014
spermatogenesis GO:0007283 200 0.014
cellular macromolecule localization GO:0070727 220 0.014
g2 dna damage checkpoint GO:0031572 69 0.014
mesenchymal cell development GO:0014031 1 0.014
organonitrogen compound catabolic process GO:1901565 128 0.014
purine containing compound metabolic process GO:0072521 155 0.014
locomotory behavior GO:0007626 176 0.014
cellular protein complex assembly GO:0043623 71 0.014
ameboidal type cell migration GO:0001667 151 0.014
regulation of apoptotic process GO:0042981 130 0.014
positive regulation of phosphorylation GO:0042327 87 0.014
positive regulation of rna biosynthetic process GO:1902680 266 0.014
proteolysis GO:0006508 192 0.014
mrna processing GO:0006397 104 0.014
positive regulation of stem cell differentiation GO:2000738 3 0.013
cytoplasmic transport GO:0016482 130 0.013
protein transport GO:0015031 155 0.013
organophosphate catabolic process GO:0046434 112 0.013
regulation of hydrolase activity GO:0051336 97 0.013
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.013
positive regulation of multicellular organismal process GO:0051240 143 0.013
regulation of cellular localization GO:0060341 136 0.013
chromosome organization GO:0051276 360 0.013
regulation of epithelial cell proliferation GO:0050678 4 0.013
regulation of cell cycle GO:0051726 291 0.013
response to nutrient levels GO:0031667 114 0.013
imaginal disc growth GO:0007446 37 0.013
purine ribonucleoside metabolic process GO:0046128 127 0.013
regulation of rna splicing GO:0043484 69 0.013
purine ribonucleotide catabolic process GO:0009154 109 0.013
axis specification GO:0009798 167 0.013
regulation of autophagy GO:0010506 62 0.013
salivary gland cell autophagic cell death GO:0035071 83 0.013
purine nucleoside metabolic process GO:0042278 127 0.013
regulation of anatomical structure morphogenesis GO:0022603 242 0.013
mushroom body development GO:0016319 70 0.013
negative regulation of epithelial cell proliferation GO:0050680 4 0.013
appendage morphogenesis GO:0035107 397 0.013
regulation of catalytic activity GO:0050790 185 0.013
mitotic g2 dna damage checkpoint GO:0007095 69 0.013
regulation of organ growth GO:0046620 42 0.013
autophagic cell death GO:0048102 83 0.013
wing disc morphogenesis GO:0007472 344 0.012
actin filament organization GO:0007015 126 0.012
regulation of cellular ketone metabolic process GO:0010565 3 0.012
organ growth GO:0035265 56 0.012
cellular cation homeostasis GO:0030003 38 0.012
golgi vesicle transport GO:0048193 27 0.012
purine nucleoside triphosphate metabolic process GO:0009144 119 0.012
purine containing compound catabolic process GO:0072523 112 0.012
telencephalon development GO:0021537 2 0.012
regulation of ras protein signal transduction GO:0046578 93 0.012
retina development in camera type eye GO:0060041 4 0.012
gland development GO:0048732 191 0.012
water homeostasis GO:0030104 3 0.012
cellular response to dna damage stimulus GO:0006974 223 0.012
anterior posterior axis specification embryo GO:0008595 103 0.012
positive regulation of transport GO:0051050 92 0.012
regulation of synapse organization GO:0050807 110 0.012
stress activated protein kinase signaling cascade GO:0031098 55 0.012
nucleoside triphosphate catabolic process GO:0009143 108 0.012
post embryonic appendage morphogenesis GO:0035120 385 0.012
innate immune response GO:0045087 144 0.012
response to glucose GO:0009749 2 0.012
reproductive behavior GO:0019098 122 0.012
nucleoside triphosphate metabolic process GO:0009141 120 0.012
organonitrogen compound biosynthetic process GO:1901566 117 0.012
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.012
regulation of lipid transport GO:0032368 3 0.012
jnk cascade GO:0007254 50 0.012
embryonic pattern specification GO:0009880 174 0.012
cell cell junction organization GO:0045216 55 0.012
oocyte axis specification GO:0007309 108 0.012
response to lipopolysaccharide GO:0032496 4 0.012
cellular chemical homeostasis GO:0055082 40 0.011
regulation of purine nucleotide metabolic process GO:1900542 62 0.011
nucleobase containing compound transport GO:0015931 56 0.011
cytoplasm organization GO:0007028 64 0.011
adult locomotory behavior GO:0008344 76 0.011
purine ribonucleoside catabolic process GO:0046130 112 0.011
morphogenesis of embryonic epithelium GO:0016331 94 0.011
epithelial cell differentiation GO:0030855 322 0.011
anterior posterior axis specification GO:0009948 109 0.011
spindle assembly GO:0051225 80 0.011
cell aging GO:0007569 2 0.011
determination of adult lifespan GO:0008340 137 0.011
nucleotide metabolic process GO:0009117 161 0.011
guanosine containing compound metabolic process GO:1901068 74 0.011
regulation of cell substrate adhesion GO:0010810 2 0.011
imaginal disc pattern formation GO:0007447 91 0.011
transcription from rna polymerase ii promoter GO:0006366 368 0.011
establishment of planar polarity GO:0001736 87 0.011
compound eye photoreceptor cell differentiation GO:0001751 140 0.011
wing disc pattern formation GO:0035222 66 0.011
cell cell signaling involved in cell fate commitment GO:0045168 210 0.011
tripartite regional subdivision GO:0007351 103 0.011
germ line stem cell maintenance GO:0030718 50 0.011
protein dna complex subunit organization GO:0071824 86 0.011
positive regulation of developmental growth GO:0048639 62 0.011
synaptic transmission GO:0007268 288 0.011
epithelial cell migration GO:0010631 148 0.011
stem cell differentiation GO:0048863 117 0.010
actin cytoskeleton organization GO:0030036 206 0.010
actin filament based process GO:0030029 220 0.010
vesicle organization GO:0016050 44 0.010
eye photoreceptor cell development GO:0042462 81 0.010
response to starvation GO:0042594 97 0.010
positive regulation of synaptic growth at neuromuscular junction GO:0045887 26 0.010
mitotic dna damage checkpoint GO:0044773 74 0.010
regulation of mitotic cell cycle phase transition GO:1901990 130 0.010
regulation of mrna processing GO:0050684 71 0.010
regulation of purine nucleotide catabolic process GO:0033121 48 0.010
rna localization GO:0006403 115 0.010
positive regulation of catalytic activity GO:0043085 118 0.010
regulation of organelle organization GO:0033043 196 0.010
adherens junction organization GO:0034332 27 0.010
atp metabolic process GO:0046034 49 0.010
compound eye photoreceptor development GO:0042051 78 0.010
embryonic axis specification GO:0000578 107 0.010

Ire1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.018
nervous system disease DOID:863 0 0.018
cancer DOID:162 0 0.014
disease of cellular proliferation DOID:14566 0 0.014
disease of metabolism DOID:0014667 0 0.013
vascular disease DOID:178 0 0.012
cardiovascular system disease DOID:1287 0 0.012
organ system cancer DOID:0050686 0 0.011
inherited metabolic disorder DOID:655 0 0.010