Drosophila melanogaster

0 known processes

Bace (Dmel_CG13095)

beta-site APP-cleaving enzyme

(Aliases: CG13095,anon-WO0140519.142,dBACE,Dmel\CG13095)

Bace biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
negative regulation of response to stimulus GO:0048585 258 0.090
kidney development GO:0001822 3 0.086
immune system process GO:0002376 347 0.081
Human Rat
regulation of localization GO:0032879 275 0.080
response to bacterium GO:0009617 198 0.079
Fly
regulation of response to stress GO:0080134 200 0.071
response to biotic stimulus GO:0009607 294 0.066
Fly
defense response to gram negative bacterium GO:0050829 94 0.063
Fly
death GO:0016265 284 0.062
Fly
sterol homeostasis GO:0055092 4 0.059
regulation of immune system process GO:0002682 176 0.059
response to organic substance GO:0010033 284 0.059
Yeast
response to temperature stimulus GO:0009266 106 0.054
lateral inhibition GO:0046331 206 0.053
phospholipid homeostasis GO:0055091 1 0.051
gland development GO:0048732 191 0.049
Fly
response to external biotic stimulus GO:0043207 293 0.048
Fly
imaginal disc derived appendage morphogenesis GO:0035114 395 0.048
Fly
homeostatic process GO:0042592 199 0.047
regulation of transport GO:0051049 181 0.047
gland morphogenesis GO:0022612 145 0.046
Fly
macromolecular complex assembly GO:0065003 256 0.045
positive regulation of biosynthetic process GO:0009891 316 0.045
epithelial cell differentiation GO:0030855 322 0.044
Fly
regulation of defense response GO:0031347 102 0.043
camera type eye development GO:0043010 4 0.041
appendage development GO:0048736 401 0.041
Fly
cellular component assembly involved in morphogenesis GO:0010927 151 0.038
Fly
wing disc morphogenesis GO:0007472 344 0.038
Fly
cell death GO:0008219 279 0.037
Fly
endomembrane system organization GO:0010256 119 0.037
kidney epithelium development GO:0072073 3 0.037
exocrine system development GO:0035272 162 0.034
Fly
cellular response to organic substance GO:0071310 132 0.033
Yeast
vesicle mediated transport GO:0016192 381 0.033
regulation of cellular amine metabolic process GO:0033238 3 0.032
organic acid metabolic process GO:0006082 103 0.032
protein complex biogenesis GO:0070271 201 0.032
cell cell signaling involved in cell fate commitment GO:0045168 210 0.032
defense response to other organism GO:0098542 225 0.032
Fly
anatomical structure homeostasis GO:0060249 97 0.031
imaginal disc derived appendage development GO:0048737 399 0.031
Fly
programmed cell death GO:0012501 257 0.031
Fly
positive regulation of response to stimulus GO:0048584 323 0.031
protein modification process GO:0036211 438 0.031
developmental programmed cell death GO:0010623 138 0.030
Fly
autophagy GO:0006914 108 0.030
response to oxygen containing compound GO:1901700 200 0.030
intracellular protein transport GO:0006886 104 0.030
salivary gland morphogenesis GO:0007435 145 0.030
Fly
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.029
proteolysis GO:0006508 192 0.029
Human Yeast Rat
appendage morphogenesis GO:0035107 397 0.029
Fly
regulation of anatomical structure morphogenesis GO:0022603 242 0.029
very long chain fatty acid metabolic process GO:0000038 4 0.029
cell recognition GO:0008037 102 0.029
regulation of cellular localization GO:0060341 136 0.029
regulation of cellular component biogenesis GO:0044087 201 0.028
cholesterol homeostasis GO:0042632 3 0.027
positive regulation of cellular biosynthetic process GO:0031328 316 0.027
cellular protein modification process GO:0006464 438 0.027
regulation of multicellular organismal development GO:2000026 414 0.027
membrane organization GO:0061024 112 0.027
phagocytosis GO:0006909 215 0.027
negative regulation of multicellular organismal process GO:0051241 142 0.026
single organism cellular localization GO:1902580 180 0.026
endocytosis GO:0006897 310 0.026
synaptic growth at neuromuscular junction GO:0051124 119 0.026
histolysis GO:0007559 102 0.026
Fly
negative regulation of cell communication GO:0010648 223 0.026
sensory organ morphogenesis GO:0090596 260 0.026
protein complex assembly GO:0006461 200 0.025
protein ubiquitination GO:0016567 70 0.025
eye development GO:0001654 323 0.025
regulation of immune response GO:0050776 118 0.025
body morphogenesis GO:0010171 2 0.025
protein modification by small protein conjugation GO:0032446 79 0.025
chemical homeostasis GO:0048878 92 0.024
response to mechanical stimulus GO:0009612 28 0.024
single organism behavior GO:0044708 391 0.024
connective tissue development GO:0061448 3 0.024
telencephalon development GO:0021537 2 0.023
response to organic cyclic compound GO:0014070 89 0.023
developmental maturation GO:0021700 172 0.023
post embryonic appendage morphogenesis GO:0035120 385 0.023
Fly
macromolecule catabolic process GO:0009057 161 0.023
growth GO:0040007 359 0.023
cellular macromolecule localization GO:0070727 220 0.023
salivary gland development GO:0007431 162 0.022
Fly
regulation of autophagy GO:0010506 62 0.022
catabolic process GO:0009056 409 0.022
Yeast
cellular amine metabolic process GO:0044106 12 0.022
establishment of localization in cell GO:0051649 402 0.022
positive regulation of macromolecule metabolic process GO:0010604 405 0.022
carboxylic acid metabolic process GO:0019752 92 0.022
camera type eye morphogenesis GO:0048593 2 0.021
multicellular organismal homeostasis GO:0048871 41 0.021
actin filament organization GO:0007015 126 0.021
compound eye morphogenesis GO:0001745 249 0.021
cell proliferation GO:0008283 299 0.021
anion transport GO:0006820 41 0.021
single organism membrane organization GO:0044802 93 0.021
hindbrain development GO:0030902 2 0.021
protein modification by small protein conjugation or removal GO:0070647 106 0.021
single organism biosynthetic process GO:0044711 206 0.021
regulation of protein metabolic process GO:0051246 256 0.021
regulation of intracellular signal transduction GO:1902531 236 0.021
cellular protein complex assembly GO:0043623 71 0.021
ethanolamine containing compound metabolic process GO:0042439 4 0.021
positive regulation of rna biosynthetic process GO:1902680 266 0.021
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.021
Fly
long chain fatty acid metabolic process GO:0001676 3 0.020
positive regulation of signal transduction GO:0009967 223 0.020
positive regulation of protein transport GO:0051222 37 0.020
positive regulation of multicellular organismal process GO:0051240 143 0.020
response to other organism GO:0051707 293 0.020
Fly
immune response GO:0006955 246 0.020
tissue homeostasis GO:0001894 36 0.020
negative regulation of signal transduction GO:0009968 206 0.020
positive regulation of signaling GO:0023056 243 0.020
developmental induction GO:0031128 3 0.020
mitotic spindle organization GO:0007052 220 0.020
regulation of developmental growth GO:0048638 174 0.020
cell cycle phase transition GO:0044770 140 0.019
embryonic pattern specification GO:0009880 174 0.019
synapse organization GO:0050808 196 0.019
negative regulation of signaling GO:0023057 219 0.019
cellular protein localization GO:0034613 160 0.019
acylglycerol biosynthetic process GO:0046463 2 0.019
activation of innate immune response GO:0002218 4 0.019
cellular catabolic process GO:0044248 372 0.019
Yeast
response to copper ion GO:0046688 4 0.019
oxoacid metabolic process GO:0043436 103 0.019
protein transport GO:0015031 155 0.019
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.019
developmental growth GO:0048589 280 0.019
organic substance catabolic process GO:1901575 308 0.019
Yeast
chromatin organization GO:0006325 207 0.019
response to endogenous stimulus GO:0009719 119 0.019
positive regulation of transcription dna templated GO:0045893 266 0.018
axis specification GO:0009798 167 0.018
eye morphogenesis GO:0048592 260 0.018
chromosome organization GO:0051276 360 0.018
apoptotic process GO:0006915 159 0.018
Fly
regionalization GO:0003002 416 0.018
organic substance transport GO:0071702 257 0.018
regulation of synapse structure and activity GO:0050803 128 0.018
positive regulation of cell communication GO:0010647 250 0.018
developmental cell growth GO:0048588 52 0.018
cellular macromolecule catabolic process GO:0044265 136 0.018
columnar cuboidal epithelial cell development GO:0002066 249 0.017
Fly
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.017
response to nitrogen compound GO:1901698 90 0.017
synaptic transmission GO:0007268 288 0.017
outflow tract morphogenesis GO:0003151 4 0.017
negative regulation of developmental process GO:0051093 201 0.017
compound eye development GO:0048749 307 0.017
learning GO:0007612 75 0.017
forebrain development GO:0030900 2 0.017
chorion containing eggshell formation GO:0007304 105 0.017
Fly
cellular amino acid metabolic process GO:0006520 61 0.017
single organism intracellular transport GO:1902582 207 0.017
adult behavior GO:0030534 137 0.017
positive regulation of transport GO:0051050 92 0.017
regulation of protein transport GO:0051223 57 0.016
negative regulation of defense response GO:0031348 35 0.016
regulation of cellular response to stress GO:0080135 89 0.016
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.016
cell migration GO:0016477 238 0.016
regulation of cellular response to oxidative stress GO:1900407 4 0.016
regulation of cellular amino acid metabolic process GO:0006521 0 0.016
innate immune response GO:0045087 144 0.016
rhythmic process GO:0048511 106 0.016
renal system development GO:0072001 72 0.016
eggshell formation GO:0030703 105 0.016
Fly
epithelial cell development GO:0002064 274 0.016
Fly
intracellular transport GO:0046907 228 0.016
regulation of lipid storage GO:0010883 22 0.016
intracellular signal transduction GO:0035556 300 0.016
defense response GO:0006952 300 0.016
Fly
regulation of cellular protein metabolic process GO:0032268 243 0.016
positive regulation of intracellular protein transport GO:0090316 30 0.016
negative regulation of cell differentiation GO:0045596 143 0.016
nephron epithelium development GO:0072009 3 0.016
positive regulation of intracellular transport GO:0032388 42 0.016
anion homeostasis GO:0055081 3 0.016
positive regulation of axonogenesis GO:0050772 2 0.015
cell motility GO:0048870 251 0.015
cellular response to dna damage stimulus GO:0006974 223 0.015
regulation of cellular catabolic process GO:0031329 157 0.015
cell maturation GO:0048469 144 0.015
positive regulation of nucleic acid templated transcription GO:1903508 266 0.015
regulation of cell cycle GO:0051726 291 0.015
regulation of molecular function GO:0065009 217 0.015
response to cold GO:0009409 13 0.015
autophagic cell death GO:0048102 83 0.015
Fly
phosphorylation GO:0016310 294 0.015
ovarian follicle cell development GO:0030707 248 0.015
Fly
mitotic cell cycle phase transition GO:0044772 138 0.015
negative regulation of developmental growth GO:0048640 64 0.015
regulation of innate immune response GO:0045088 71 0.015
circadian rhythm GO:0007623 105 0.015
positive regulation of developmental process GO:0051094 143 0.015
regulation of intracellular transport GO:0032386 64 0.015
establishment of protein localization GO:0045184 163 0.015
protein catabolic process GO:0030163 101 0.015
response to organonitrogen compound GO:0010243 75 0.014
notch signaling pathway GO:0007219 120 0.014
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.014
amine metabolic process GO:0009308 12 0.014
cellular protein catabolic process GO:0044257 83 0.014
cellular response to chemical stimulus GO:0070887 199 0.014
Yeast
regulation of catabolic process GO:0009894 170 0.014
cellular macromolecular complex assembly GO:0034622 153 0.014
regulation of cell cycle process GO:0010564 181 0.014
kidney morphogenesis GO:0060993 3 0.014
enzyme linked receptor protein signaling pathway GO:0007167 179 0.014
localization of cell GO:0051674 257 0.014
negative regulation of cellular component organization GO:0051129 108 0.014
negative regulation of gene expression GO:0010629 387 0.014
taxis GO:0042330 304 0.014
fatty acid biosynthetic process GO:0006633 6 0.014
negative regulation of nervous system development GO:0051961 92 0.014
phosphatidylethanolamine metabolic process GO:0046337 1 0.014
developmental pigmentation GO:0048066 68 0.014
nephron tubule development GO:0072080 3 0.013
positive regulation of cell development GO:0010720 61 0.013
positive regulation of cell migration GO:0030335 2 0.013
regulation of gene expression epigenetic GO:0040029 128 0.013
negative regulation of immune response GO:0050777 39 0.013
regulation of vesicle mediated transport GO:0060627 59 0.013
cell projection assembly GO:0030031 94 0.013
regulation of cell differentiation GO:0045595 302 0.013
blastoderm segmentation GO:0007350 159 0.013
small molecule metabolic process GO:0044281 305 0.013
tissue death GO:0016271 102 0.013
Fly
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 65 0.013
regulation of notch signaling pathway GO:0008593 100 0.013
cellular response to starvation GO:0009267 61 0.013
positive regulation of protein metabolic process GO:0051247 128 0.013
tripartite regional subdivision GO:0007351 103 0.013
segmentation GO:0035282 207 0.013
regulation of cell death GO:0010941 173 0.013
triglyceride biosynthetic process GO:0019432 2 0.013
protein localization GO:0008104 284 0.013
signal transduction by phosphorylation GO:0023014 107 0.013
modification dependent protein catabolic process GO:0019941 78 0.013
salivary gland cell autophagic cell death GO:0035071 83 0.013
Fly
regulation of epithelial cell proliferation GO:0050678 4 0.013
cellular lipid metabolic process GO:0044255 83 0.013
regulation of protein localization GO:0032880 76 0.013
oocyte maturation GO:0001556 3 0.013
negative regulation of immune system process GO:0002683 50 0.013
positive regulation of intracellular signal transduction GO:1902533 116 0.013
urogenital system development GO:0001655 72 0.012
negative regulation of cellular response to oxidative stress GO:1900408 1 0.012
salivary gland histolysis GO:0035070 88 0.012
Fly
chromatin modification GO:0016568 147 0.012
neuromuscular junction development GO:0007528 149 0.012
extrinsic apoptotic signaling pathway GO:0097191 1 0.012
tissue morphogenesis GO:0048729 297 0.012
Fly
reproductive behavior GO:0019098 122 0.012
response to lipopolysaccharide GO:0032496 4 0.012
pyridine containing compound metabolic process GO:0072524 3 0.012
lipid metabolic process GO:0006629 121 0.012
protein polymerization GO:0051258 42 0.012
ion transmembrane transport GO:0034220 122 0.012
locomotory behavior GO:0007626 176 0.012
compound eye photoreceptor cell differentiation GO:0001751 140 0.012
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.012
positive regulation of reactive oxygen species metabolic process GO:2000379 0 0.012
limb development GO:0060173 1 0.012
regulation of epithelial cell differentiation GO:0030856 4 0.012
regulation of cell morphogenesis GO:0022604 163 0.012
positive regulation of i kappab kinase nf kappab signaling GO:0043123 1 0.012
nephron development GO:0072006 3 0.012
regulation of organelle organization GO:0033043 196 0.012
axon development GO:0061564 297 0.012
embryonic axis specification GO:0000578 107 0.012
regulation of heart morphogenesis GO:2000826 3 0.012
posttranscriptional regulation of gene expression GO:0010608 145 0.012
regulation of cytoplasmic transport GO:1903649 47 0.012
courtship behavior GO:0007619 68 0.012
regulation of cell substrate adhesion GO:0010810 2 0.012
epidermal cell differentiation GO:0009913 51 0.012
Fly
protein localization to plasma membrane GO:0072659 13 0.012
regulation of catalytic activity GO:0050790 185 0.012
negative regulation of cell development GO:0010721 62 0.012
ribonucleoside triphosphate metabolic process GO:0009199 119 0.011
lipid storage GO:0019915 38 0.011
positive regulation of cellular amine metabolic process GO:0033240 0 0.011
organophosphate catabolic process GO:0046434 112 0.011
ion transport GO:0006811 145 0.011
organelle fission GO:0048285 340 0.011
regulation of organ formation GO:0003156 3 0.011
monocarboxylic acid transport GO:0015718 3 0.011
eye photoreceptor cell development GO:0042462 81 0.011
spinal cord development GO:0021510 1 0.011
limb morphogenesis GO:0035108 1 0.011
regulation of response to oxidative stress GO:1902882 4 0.011
cuticle development GO:0042335 86 0.011
retina development in camera type eye GO:0060041 4 0.011
anterior posterior pattern specification GO:0009952 136 0.011
gene silencing GO:0016458 138 0.011
nucleus localization GO:0051647 34 0.011
somatic muscle development GO:0007525 66 0.011
immune effector process GO:0002252 98 0.011
rna processing GO:0006396 147 0.011
cranial nerve development GO:0021545 1 0.011
multicellular organismal reproductive behavior GO:0033057 110 0.011
cytoplasmic transport GO:0016482 130 0.011
mushroom body development GO:0016319 70 0.011
pigmentation GO:0043473 75 0.011
nephron epithelium morphogenesis GO:0072088 3 0.011
regulation of synapse assembly GO:0051963 94 0.011
imaginal disc derived wing morphogenesis GO:0007476 337 0.011
Fly
chemosensory behavior GO:0007635 106 0.011
small molecule biosynthetic process GO:0044283 37 0.011
endodermal cell fate commitment GO:0001711 3 0.011
cellular response to mechanical stimulus GO:0071260 2 0.011
l amino acid import GO:0043092 2 0.010
brain development GO:0007420 120 0.010
negative regulation of rna metabolic process GO:0051253 251 0.010
maintenance of location GO:0051235 73 0.010
regulation of cellular ketone metabolic process GO:0010565 3 0.010
axis elongation GO:0003401 3 0.010
response to abiotic stimulus GO:0009628 341 0.010
regulation of proteolysis GO:0030162 87 0.010
ubiquitin dependent protein catabolic process GO:0006511 78 0.010
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.010
social behavior GO:0035176 4 0.010
regulation of mitotic cell cycle phase transition GO:1901990 130 0.010
dorsal appendage formation GO:0046843 47 0.010
morphogenesis of an epithelium GO:0002009 276 0.010
Fly
cellular response to extracellular stimulus GO:0031668 64 0.010
regulation of response to dna damage stimulus GO:2001020 23 0.010
regulation of protein modification process GO:0031399 112 0.010
cognition GO:0050890 141 0.010
response to alcohol GO:0097305 95 0.010
regulation of protein modification by small protein conjugation or removal GO:1903320 25 0.010
mitotic g2 dna damage checkpoint GO:0007095 69 0.010
developmental growth involved in morphogenesis GO:0060560 65 0.010
eggshell chorion assembly GO:0007306 66 0.010
Fly

Bace disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
hypophosphatasia DOID:14213 0 0.178
disease of metabolism DOID:0014667 0 0.070
acquired metabolic disease DOID:0060158 0 0.065
disease of anatomical entity DOID:7 0 0.059
amyloidosis DOID:9120 0 0.027
familial visceral amyloidosis DOID:0050636 0 0.027
familial hyperlipidemia DOID:1168 0 0.021
lipid metabolism disorder DOID:3146 0 0.021
familial combined hyperlipidemia DOID:13809 0 0.021
inherited metabolic disorder DOID:655 0 0.021
sensory system disease DOID:0050155 0 0.018
nervous system disease DOID:863 0 0.018
carbohydrate metabolism disease DOID:0050013 0 0.015
glucose metabolism disease DOID:4194 0 0.015
diabetes mellitus DOID:9351 0 0.014
disease of cellular proliferation DOID:14566 0 0.013
type 2 diabetes mellitus DOID:9352 0 0.013
cancer DOID:162 0 0.011
cardiovascular system disease DOID:1287 0 0.011
eye and adnexa disease DOID:1492 0 0.010
eye disease DOID:5614 0 0.010