Drosophila melanogaster

67 known processes

Spf45 (Dmel_CG17540)

CG17540 gene product from transcript CG17540-RB

(Aliases: Dmel\CG17540,RBM17,dSPF45,SPF45,CG17540,spf45,spf-45)

Spf45 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
establishment of localization in cell GO:0051649 402 0.269
catabolic process GO:0009056 409 0.261
cellular response to abiotic stimulus GO:0071214 58 0.248
phosphorylation GO:0016310 294 0.224
ribose phosphate metabolic process GO:0019693 145 0.205
intracellular signal transduction GO:0035556 300 0.187
regulation of cell cycle GO:0051726 291 0.183
negative regulation of cell cycle phase transition GO:1901988 103 0.183
cell cycle phase transition GO:0044770 140 0.180
mitotic dna integrity checkpoint GO:0044774 75 0.173
regulation of protein metabolic process GO:0051246 256 0.165
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.158
negative regulation of cellular metabolic process GO:0031324 382 0.145
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.140
positive regulation of biosynthetic process GO:0009891 316 0.139
positive regulation of cellular biosynthetic process GO:0031328 316 0.137
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.132
protein modification process GO:0036211 438 0.127
dna metabolic process GO:0006259 227 0.126
organic substance transport GO:0071702 257 0.125
regulation of programmed cell death GO:0043067 152 0.125
mitotic g2 dna damage checkpoint GO:0007095 69 0.124
chromosome organization GO:0051276 360 0.120
ribonucleotide metabolic process GO:0009259 145 0.116
purine containing compound metabolic process GO:0072521 155 0.110
cell proliferation GO:0008283 299 0.110
negative regulation of cell cycle process GO:0010948 109 0.108
response to alkaloid GO:0043279 26 0.106
negative regulation of mitotic cell cycle GO:0045930 109 0.105
organic substance catabolic process GO:1901575 308 0.105
amine metabolic process GO:0009308 12 0.104
apoptotic process GO:0006915 159 0.103
mitotic dna damage checkpoint GO:0044773 74 0.102
regulation of cellular amine metabolic process GO:0033238 3 0.099
positive regulation of nucleotide metabolic process GO:0045981 55 0.095
nucleotide metabolic process GO:0009117 161 0.095
cell death GO:0008219 279 0.093
cellular response to dna damage stimulus GO:0006974 223 0.092
regulation of cell death GO:0010941 173 0.092
negative regulation of cell communication GO:0010648 223 0.092
cellular protein modification process GO:0006464 438 0.091
cyclic nucleotide biosynthetic process GO:0009190 25 0.089
regulation of cellular amino acid metabolic process GO:0006521 0 0.088
regulation of cell proliferation GO:0042127 163 0.088
mitotic cell cycle checkpoint GO:0007093 88 0.087
regulation of phosphate metabolic process GO:0019220 210 0.086
purine nucleotide metabolic process GO:0006163 146 0.084
glycosyl compound metabolic process GO:1901657 127 0.083
cellular catabolic process GO:0044248 372 0.081
regulation of cellular component biogenesis GO:0044087 201 0.081
response to organic substance GO:0010033 284 0.080
cell cycle checkpoint GO:0000075 95 0.080
cellular response to oxygen containing compound GO:1901701 79 0.080
carbohydrate derivative metabolic process GO:1901135 217 0.079
positive regulation of phosphorus metabolic process GO:0010562 139 0.079
regulation of cellular ketone metabolic process GO:0010565 3 0.078
positive regulation of cell communication GO:0010647 250 0.077
death GO:0016265 284 0.076
response to heat GO:0009408 63 0.076
positive regulation of signaling GO:0023056 243 0.074
transcription from rna polymerase ii promoter GO:0006366 368 0.074
response to organic cyclic compound GO:0014070 89 0.072
regulation of cell cycle process GO:0010564 181 0.072
cell division GO:0051301 248 0.072
eye development GO:0001654 323 0.072
dna damage checkpoint GO:0000077 78 0.071
purine ribonucleotide metabolic process GO:0009150 145 0.071
negative regulation of signaling GO:0023057 219 0.070
response to biotic stimulus GO:0009607 294 0.070
protein phosphorylation GO:0006468 169 0.069
mitotic g2 m transition checkpoint GO:0044818 70 0.068
calcium ion homeostasis GO:0055074 23 0.067
organophosphate metabolic process GO:0019637 195 0.067
regulation of apoptotic process GO:0042981 130 0.066
negative regulation of cell cycle GO:0045786 116 0.066
organonitrogen compound metabolic process GO:1901564 318 0.065
synaptic transmission GO:0007268 288 0.064
mitotic cell cycle phase transition GO:0044772 138 0.064
positive regulation of multicellular organismal process GO:0051240 143 0.064
regulation of phosphorus metabolic process GO:0051174 210 0.064
neurological system process GO:0050877 358 0.063
positive regulation of molecular function GO:0044093 136 0.063
small molecule metabolic process GO:0044281 305 0.062
single organism behavior GO:0044708 391 0.061
negative regulation of apoptotic process GO:0043066 63 0.061
response to external biotic stimulus GO:0043207 293 0.061
regulation of cell cycle phase transition GO:1901987 130 0.060
dna repair GO:0006281 54 0.059
nitrogen compound transport GO:0071705 85 0.058
camera type eye development GO:0043010 4 0.058
response to abiotic stimulus GO:0009628 341 0.057
secretion GO:0046903 109 0.057
regulation of molecular function GO:0065009 217 0.056
cellular response to organic substance GO:0071310 132 0.055
neuron death GO:0070997 27 0.055
response to light stimulus GO:0009416 124 0.054
response to other organism GO:0051707 293 0.054
negative regulation of phosphorylation GO:0042326 35 0.054
programmed cell death GO:0012501 257 0.053
response to bacterium GO:0009617 198 0.053
peptidyl amino acid modification GO:0018193 105 0.053
secretion by cell GO:0032940 101 0.051
regulation of organelle organization GO:0033043 196 0.051
homeostatic process GO:0042592 199 0.051
regulation of cellular protein metabolic process GO:0032268 243 0.051
g protein coupled receptor signaling pathway GO:0007186 136 0.050
cellular macromolecule localization GO:0070727 220 0.050
ion transport GO:0006811 145 0.050
regulation of catalytic activity GO:0050790 185 0.049
regulation of mitotic cell cycle GO:0007346 190 0.049
response to hexose GO:0009746 3 0.048
regulation of phosphorylation GO:0042325 147 0.048
single organism catabolic process GO:0044712 228 0.047
positive regulation of cell death GO:0010942 69 0.047
positive regulation of signal transduction GO:0009967 223 0.047
cellular ketone metabolic process GO:0042180 24 0.046
negative regulation of transcription dna templated GO:0045892 237 0.045
cellular amine metabolic process GO:0044106 12 0.045
defense response to other organism GO:0098542 225 0.044
negative regulation of nucleic acid templated transcription GO:1903507 240 0.043
mitotic nuclear division GO:0007067 213 0.043
regulation of purine nucleotide metabolic process GO:1900542 62 0.043
positive regulation of response to stimulus GO:0048584 323 0.043
g2 dna damage checkpoint GO:0031572 69 0.043
intracellular transport GO:0046907 228 0.043
chromosome segregation GO:0007059 157 0.042
cellular ion homeostasis GO:0006873 39 0.042
cell motility GO:0048870 251 0.042
response to monosaccharide GO:0034284 4 0.041
cellular cation homeostasis GO:0030003 38 0.041
response to oxidative stress GO:0006979 86 0.041
negative regulation of multicellular organismal process GO:0051241 142 0.041
cellular response to chemical stimulus GO:0070887 199 0.040
positive regulation of rna metabolic process GO:0051254 271 0.040
positive regulation of catalytic activity GO:0043085 118 0.039
regulation of intracellular signal transduction GO:1902531 236 0.039
response to temperature stimulus GO:0009266 106 0.038
regulation of mitotic cell cycle phase transition GO:1901990 130 0.038
positive regulation of macromolecule metabolic process GO:0010604 405 0.038
negative regulation of cell death GO:0060548 81 0.038
cation homeostasis GO:0055080 51 0.038
single organism biosynthetic process GO:0044711 206 0.037
adult behavior GO:0030534 137 0.037
tissue migration GO:0090130 155 0.037
cellular response to extracellular stimulus GO:0031668 64 0.037
macromolecular complex assembly GO:0065003 256 0.037
negative regulation of phosphate metabolic process GO:0045936 45 0.036
nuclear division GO:0000280 332 0.036
glycosyl compound catabolic process GO:1901658 112 0.036
regionalization GO:0003002 416 0.036
protein localization GO:0008104 284 0.035
cellular amino acid metabolic process GO:0006520 61 0.035
nucleobase containing small molecule metabolic process GO:0055086 174 0.035
sensory perception GO:0007600 196 0.035
positive regulation of protein metabolic process GO:0051247 128 0.034
cellular response to external stimulus GO:0071496 66 0.034
cytoplasmic transport GO:0016482 130 0.034
response to oxygen containing compound GO:1901700 200 0.033
cellular macromolecule catabolic process GO:0044265 136 0.033
defense response GO:0006952 300 0.032
positive regulation of purine nucleotide metabolic process GO:1900544 55 0.032
cellular response to organic cyclic compound GO:0071407 32 0.031
negative regulation of signal transduction GO:0009968 206 0.031
single organism intracellular transport GO:1902582 207 0.031
positive regulation of cyclase activity GO:0031281 9 0.031
divalent inorganic cation homeostasis GO:0072507 29 0.031
regulation of protein modification process GO:0031399 112 0.031
response to ketone GO:1901654 34 0.030
organonitrogen compound catabolic process GO:1901565 128 0.030
regulation of tube size GO:0035150 46 0.030
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.030
metal ion homeostasis GO:0055065 44 0.029
negative regulation of biosynthetic process GO:0009890 277 0.029
vesicle mediated transport GO:0016192 381 0.029
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.029
negative regulation of gene expression GO:0010629 387 0.029
negative regulation of phosphorus metabolic process GO:0010563 45 0.029
sister chromatid segregation GO:0000819 92 0.029
response to alcohol GO:0097305 95 0.029
positive regulation of cyclic nucleotide biosynthetic process GO:0030804 9 0.028
cellular protein localization GO:0034613 160 0.028
cellular nitrogen compound catabolic process GO:0044270 165 0.028
regulation of system process GO:0044057 36 0.028
positive regulation of gene expression GO:0010628 290 0.028
retina development in camera type eye GO:0060041 4 0.028
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.027
purine containing compound catabolic process GO:0072523 112 0.027
organic cyclic compound catabolic process GO:1901361 168 0.027
response to endogenous stimulus GO:0009719 119 0.026
blood circulation GO:0008015 26 0.026
ion homeostasis GO:0050801 55 0.026
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.026
cellular metal ion homeostasis GO:0006875 31 0.026
negative regulation of programmed cell death GO:0043069 72 0.026
cellular homeostasis GO:0019725 80 0.026
ribose phosphate biosynthetic process GO:0046390 28 0.026
purine nucleoside triphosphate catabolic process GO:0009146 108 0.026
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger GO:0007187 17 0.025
regulation of transport GO:0051049 181 0.025
positive regulation of intracellular signal transduction GO:1902533 116 0.025
regulation of protein phosphorylation GO:0001932 64 0.025
response to mechanical stimulus GO:0009612 28 0.025
body morphogenesis GO:0010171 2 0.025
purine nucleoside metabolic process GO:0042278 127 0.025
response to transforming growth factor beta GO:0071559 18 0.025
response to organophosphorus GO:0046683 2 0.025
regulation of transmembrane transport GO:0034762 27 0.025
response to axon injury GO:0048678 12 0.025
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.024
organelle fission GO:0048285 340 0.024
cellular response to nutrient levels GO:0031669 62 0.024
nucleoside triphosphate catabolic process GO:0009143 108 0.024
mapk cascade GO:0000165 107 0.024
cellular response to biotic stimulus GO:0071216 4 0.023
negative regulation of response to stimulus GO:0048585 258 0.023
purine ribonucleotide catabolic process GO:0009154 109 0.023
organophosphate biosynthetic process GO:0090407 46 0.023
positive regulation of rna biosynthetic process GO:1902680 266 0.023
heterocycle catabolic process GO:0046700 166 0.023
regulation of neuron death GO:1901214 26 0.023
positive regulation of transcription dna templated GO:0045893 266 0.023
organic acid metabolic process GO:0006082 103 0.022
ribonucleoside catabolic process GO:0042454 112 0.022
actin filament based process GO:0030029 220 0.022
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.022
response to growth factor GO:0070848 31 0.022
heart process GO:0003015 37 0.022
regulation of nucleotide metabolic process GO:0006140 62 0.022
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.022
positive regulation of nucleic acid templated transcription GO:1903508 266 0.022
sensory perception of pain GO:0019233 4 0.022
organelle assembly GO:0070925 198 0.022
defense response to gram negative bacterium GO:0050829 94 0.022
cation transport GO:0006812 110 0.022
wound healing GO:0042060 75 0.021
cell migration GO:0016477 238 0.021
response to organonitrogen compound GO:0010243 75 0.021
purine ribonucleoside catabolic process GO:0046130 112 0.021
appendage development GO:0048736 401 0.021
meiotic cell cycle GO:0051321 171 0.021
negative regulation of cell proliferation GO:0008285 69 0.020
protein complex assembly GO:0006461 200 0.020
metal ion transport GO:0030001 74 0.020
chromatin modification GO:0016568 147 0.020
regulation of anatomical structure size GO:0090066 163 0.020
regulation of blood circulation GO:1903522 21 0.020
cellular response to nitrogen compound GO:1901699 51 0.020
small gtpase mediated signal transduction GO:0007264 88 0.020
defense response to bacterium GO:0042742 178 0.020
regulation of cellular localization GO:0060341 136 0.020
macromolecule catabolic process GO:0009057 161 0.019
transmembrane transport GO:0055085 139 0.019
dna double strand break processing GO:0000729 3 0.019
regulation of catabolic process GO:0009894 170 0.019
nucleotide catabolic process GO:0009166 109 0.019
dna integrity checkpoint GO:0031570 81 0.019
cellular response to endogenous stimulus GO:0071495 80 0.019
carbohydrate derivative biosynthetic process GO:1901137 85 0.019
purine nucleotide catabolic process GO:0006195 109 0.019
purine nucleoside triphosphate metabolic process GO:0009144 119 0.019
aromatic compound catabolic process GO:0019439 166 0.019
nucleoside triphosphate metabolic process GO:0009141 120 0.019
regulation of ras protein signal transduction GO:0046578 93 0.019
cellular response to heat GO:0034605 24 0.019
response to wounding GO:0009611 94 0.019
protein ubiquitination GO:0016567 70 0.019
regulation of multicellular organismal development GO:2000026 414 0.019
cytosolic calcium ion homeostasis GO:0051480 11 0.018
growth GO:0040007 359 0.018
cellular divalent inorganic cation homeostasis GO:0072503 23 0.018
ribonucleoside triphosphate metabolic process GO:0009199 119 0.018
response to ethanol GO:0045471 59 0.018
chromatin organization GO:0006325 207 0.018
protein catabolic process GO:0030163 101 0.018
nucleoside catabolic process GO:0009164 112 0.018
compound eye development GO:0048749 307 0.018
positive regulation of transport GO:0051050 92 0.017
positive regulation of developmental process GO:0051094 143 0.017
purine nucleoside catabolic process GO:0006152 112 0.017
protein modification by small protein conjugation GO:0032446 79 0.017
cellular response to growth factor stimulus GO:0071363 30 0.017
nucleoside phosphate biosynthetic process GO:1901293 34 0.017
ras protein signal transduction GO:0007265 88 0.017
embryo development ending in birth or egg hatching GO:0009792 152 0.017
regulation of cellular response to stress GO:0080135 89 0.017
negative regulation of rna biosynthetic process GO:1902679 240 0.017
cellular macromolecular complex assembly GO:0034622 153 0.017
negative regulation of protein modification process GO:0031400 29 0.017
signal release GO:0023061 49 0.017
protein transport GO:0015031 155 0.016
imaginal disc derived leg segmentation GO:0036011 26 0.016
ubiquitin dependent protein catabolic process GO:0006511 78 0.016
endocytosis GO:0006897 310 0.016
negative regulation of rna metabolic process GO:0051253 251 0.016
regulation of proteolysis GO:0030162 87 0.016
cellular response to metal ion GO:0071248 6 0.016
carboxylic acid catabolic process GO:0046395 16 0.016
cellular response to organonitrogen compound GO:0071417 36 0.016
ribonucleotide catabolic process GO:0009261 109 0.016
positive regulation of programmed cell death GO:0043068 62 0.016
axis specification GO:0009798 167 0.015
rna splicing via transesterification reactions GO:0000375 73 0.015
purine ribonucleoside metabolic process GO:0046128 127 0.015
nucleobase containing compound catabolic process GO:0034655 165 0.015
positive regulation of phosphate metabolic process GO:0045937 139 0.015
oxoacid metabolic process GO:0043436 103 0.015
protein complex biogenesis GO:0070271 201 0.015
regulation of developmental growth GO:0048638 174 0.015
regulation of response to stress GO:0080134 200 0.015
ameboidal type cell migration GO:0001667 151 0.015
nucleoside phosphate catabolic process GO:1901292 110 0.015
proteolysis GO:0006508 192 0.015
gtp catabolic process GO:0006184 72 0.015
localization of cell GO:0051674 257 0.015
actin cytoskeleton organization GO:0030036 206 0.015
establishment of protein localization GO:0045184 163 0.015
nucleoside metabolic process GO:0009116 127 0.014
regulation of cellular catabolic process GO:0031329 157 0.014
negative regulation of cellular biosynthetic process GO:0031327 277 0.014
negative regulation of developmental process GO:0051093 201 0.014
positive regulation of cellular component organization GO:0051130 156 0.014
ribonucleoside triphosphate catabolic process GO:0009203 108 0.014
positive regulation of cell proliferation GO:0008284 47 0.014
organophosphate catabolic process GO:0046434 112 0.014
cyclic nucleotide metabolic process GO:0009187 28 0.014
regulation of nucleotide biosynthetic process GO:0030808 14 0.014
regulation of cellular protein catabolic process GO:1903362 44 0.014
appendage segmentation GO:0035285 26 0.013
ribonucleoside metabolic process GO:0009119 127 0.013
regulation of cytoskeleton organization GO:0051493 89 0.013
response to lipopolysaccharide GO:0032496 4 0.013
modification dependent protein catabolic process GO:0019941 78 0.013
rna processing GO:0006396 147 0.013
appendage morphogenesis GO:0035107 397 0.013
regulation of mapk cascade GO:0043408 92 0.013
positive regulation of mapk cascade GO:0043410 63 0.013
single organism cellular localization GO:1902580 180 0.013
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.013
chromosome separation GO:0051304 42 0.013
negative regulation of cellular component organization GO:0051129 108 0.013
cellular response to transforming growth factor beta stimulus GO:0071560 18 0.012
signal transduction by phosphorylation GO:0023014 107 0.012
stress activated protein kinase signaling cascade GO:0031098 55 0.012
epithelial cell migration GO:0010631 148 0.012
regulation of small gtpase mediated signal transduction GO:0051056 93 0.012
regulation of transferase activity GO:0051338 58 0.012
mrna processing GO:0006397 104 0.012
immune system process GO:0002376 347 0.012
cell cycle arrest GO:0007050 4 0.012
nucleotide excision repair GO:0006289 8 0.012
intracellular protein transport GO:0006886 104 0.012
developmental growth GO:0048589 280 0.012
regulation of synaptic transmission GO:0050804 69 0.012
aging GO:0007568 143 0.012
cellular protein complex disassembly GO:0043624 35 0.012
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 73 0.012
response to hypoxia GO:0001666 53 0.012
double strand break repair GO:0006302 26 0.012
response to decreased oxygen levels GO:0036293 58 0.012
telencephalon development GO:0021537 2 0.012
circulatory system process GO:0003013 37 0.012
establishment of rna localization GO:0051236 47 0.011
regulation of purine nucleotide biosynthetic process GO:1900371 14 0.011
positive regulation of apoptotic process GO:0043065 47 0.011
organonitrogen compound biosynthetic process GO:1901566 117 0.011
guanosine containing compound metabolic process GO:1901068 74 0.011
regulation of protein kinase activity GO:0045859 51 0.011
rna splicing GO:0008380 83 0.011
mitotic sister chromatid segregation GO:0000070 87 0.011
positive regulation of cyclic nucleotide metabolic process GO:0030801 9 0.011
cellular calcium ion homeostasis GO:0006874 21 0.011
positive regulation of cellular catabolic process GO:0031331 95 0.011
cell cell signaling involved in cell fate commitment GO:0045168 210 0.011
response to drug GO:0042493 17 0.011
gtp metabolic process GO:0046039 72 0.011
posttranscriptional regulation of gene expression GO:0010608 145 0.010
anterior posterior axis specification GO:0009948 109 0.010
positive regulation of phosphorylation GO:0042327 87 0.010
forebrain development GO:0030900 2 0.010
anterior posterior pattern specification GO:0009952 136 0.010
salivary gland histolysis GO:0035070 88 0.010
regulation of protein catabolic process GO:0042176 55 0.010
morphogenesis of a polarized epithelium GO:0001738 93 0.010
regulation of growth GO:0040008 233 0.010
regulation of alternative mrna splicing via spliceosome GO:0000381 60 0.010
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 54 0.010
response to uv GO:0009411 24 0.010
organ growth GO:0035265 56 0.010

Spf45 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.047
cardiovascular system disease DOID:1287 0 0.031
artery disease DOID:0050828 0 0.015
vascular disease DOID:178 0 0.015
central nervous system disease DOID:331 0 0.014
nervous system disease DOID:863 0 0.014