Drosophila melanogaster

13 known processes

sick (Dmel_CG42589)

sickie

(Aliases: CG42589,Dmel_CG34343,CG13959,Dmel_CG13964,CG10662,Dmel_CG33316,CG33316,CG13964,CG34343,CG13960,CG13961,Dmel_CG10662,Dmel\CG42589)

sick biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
positive regulation of transcription dna templated GO:0045893 266 0.081
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.072
positive regulation of rna metabolic process GO:0051254 271 0.058
positive regulation of nucleic acid templated transcription GO:1903508 266 0.057
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.055
neurological system process GO:0050877 358 0.053
intracellular signal transduction GO:0035556 300 0.051
positive regulation of rna biosynthetic process GO:1902680 266 0.051
cation transmembrane transport GO:0098655 88 0.047
salt aversion GO:0035199 3 0.047
synaptic transmission GO:0007268 288 0.046
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.046
positive regulation of cellular biosynthetic process GO:0031328 316 0.046
regionalization GO:0003002 416 0.044
ion transport GO:0006811 145 0.044
transcription from rna polymerase ii promoter GO:0006366 368 0.043
tissue morphogenesis GO:0048729 297 0.043
ion transmembrane transport GO:0034220 122 0.041
transmembrane transport GO:0055085 139 0.041
adult behavior GO:0030534 137 0.040
positive regulation of biosynthetic process GO:0009891 316 0.039
regulation of multicellular organismal development GO:2000026 414 0.039
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.038
protein modification process GO:0036211 438 0.038
synapse assembly GO:0007416 143 0.038
positive regulation of cell communication GO:0010647 250 0.037
inter male aggressive behavior GO:0002121 60 0.037
organelle assembly GO:0070925 198 0.036
positive regulation of gene expression GO:0010628 290 0.036
regulation of intracellular signal transduction GO:1902531 236 0.036
positive regulation of signaling GO:0023056 243 0.036
cellular macromolecule localization GO:0070727 220 0.036
cellular protein modification process GO:0006464 438 0.034
positive regulation of signal transduction GO:0009967 223 0.033
positive regulation of macromolecule metabolic process GO:0010604 405 0.033
positive regulation of transport GO:0051050 92 0.033
morphogenesis of an epithelium GO:0002009 276 0.032
locomotory behavior GO:0007626 176 0.031
sensory perception of salty taste GO:0050914 3 0.031
embryonic pattern specification GO:0009880 174 0.030
regulation of localization GO:0032879 275 0.030
actin cytoskeleton organization GO:0030036 206 0.029
regulation of molecular function GO:0065009 217 0.028
adenylate cyclase modulating g protein coupled receptor signaling pathway GO:0007188 17 0.028
positive regulation of molecular function GO:0044093 136 0.028
regulation of cellular protein metabolic process GO:0032268 243 0.028
developmental growth GO:0048589 280 0.028
endocytosis GO:0006897 310 0.028
segmentation GO:0035282 207 0.027
regulation of nervous system development GO:0051960 248 0.027
phosphorylation GO:0016310 294 0.027
protein localization GO:0008104 284 0.027
compound eye development GO:0048749 307 0.026
negative regulation of cellular metabolic process GO:0031324 382 0.026
positive regulation of response to stimulus GO:0048584 323 0.026
neuromuscular junction development GO:0007528 149 0.026
positive regulation of protein metabolic process GO:0051247 128 0.025
vesicle mediated transport GO:0016192 381 0.025
secretion GO:0046903 109 0.025
forebrain development GO:0030900 2 0.025
negative regulation of nucleic acid templated transcription GO:1903507 240 0.025
anterior posterior pattern specification GO:0009952 136 0.025
regulation of cell differentiation GO:0045595 302 0.025
cell proliferation GO:0008283 299 0.025
blastoderm segmentation GO:0007350 159 0.025
synaptic growth at neuromuscular junction GO:0051124 119 0.025
cation transport GO:0006812 110 0.025
synapse organization GO:0050808 196 0.025
embryonic morphogenesis GO:0048598 206 0.024
tube development GO:0035295 244 0.024
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.024
connective tissue development GO:0061448 3 0.024
spermatogenesis GO:0007283 200 0.024
protein complex biogenesis GO:0070271 201 0.024
camera type eye development GO:0043010 4 0.024
positive regulation of phosphorus metabolic process GO:0010562 139 0.023
homeostatic process GO:0042592 199 0.023
positive regulation of cellular component organization GO:0051130 156 0.023
positive regulation of phosphate metabolic process GO:0045937 139 0.023
kidney development GO:0001822 3 0.023
regulation of transport GO:0051049 181 0.023
small gtpase mediated signal transduction GO:0007264 88 0.023
growth GO:0040007 359 0.023
regulation of protein metabolic process GO:0051246 256 0.023
retina development in camera type eye GO:0060041 4 0.022
regulation of organelle organization GO:0033043 196 0.022
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.022
response to abiotic stimulus GO:0009628 341 0.022
actin filament based process GO:0030029 220 0.022
cell cell signaling involved in cell fate commitment GO:0045168 210 0.022
organonitrogen compound metabolic process GO:1901564 318 0.022
regulation of phosphorus metabolic process GO:0051174 210 0.022
regulation of catalytic activity GO:0050790 185 0.021
central nervous system development GO:0007417 201 0.021
tube morphogenesis GO:0035239 191 0.021
protein heterooligomerization GO:0051291 4 0.021
protein complex assembly GO:0006461 200 0.021
regulation of cellular amine metabolic process GO:0033238 3 0.021
cell migration GO:0016477 238 0.020
cognition GO:0050890 141 0.020
developmental maturation GO:0021700 172 0.020
oocyte construction GO:0007308 112 0.020
telencephalon development GO:0021537 2 0.020
negative regulation of rna metabolic process GO:0051253 251 0.020
regulation of synaptic transmission GO:0050804 69 0.020
detection of stimulus GO:0051606 156 0.020
regulation of phosphate metabolic process GO:0019220 210 0.020
positive regulation of cellular component biogenesis GO:0044089 80 0.020
head development GO:0060322 135 0.020
spindle organization GO:0007051 253 0.020
gland development GO:0048732 191 0.020
phagocytosis GO:0006909 215 0.019
behavioral response to pain GO:0048266 3 0.019
cell death GO:0008219 279 0.019
macromolecular complex assembly GO:0065003 256 0.019
regulation of cellular component biogenesis GO:0044087 201 0.019
body morphogenesis GO:0010171 2 0.019
metal ion transport GO:0030001 74 0.019
small molecule metabolic process GO:0044281 305 0.019
localization of cell GO:0051674 257 0.019
eye development GO:0001654 323 0.019
negative regulation of gene expression GO:0010629 387 0.018
gene silencing GO:0016458 138 0.018
mrna metabolic process GO:0016071 124 0.018
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.018
cellular homeostasis GO:0019725 80 0.018
neuron recognition GO:0008038 101 0.018
single organism cellular localization GO:1902580 180 0.018
sensory perception of chemical stimulus GO:0007606 116 0.018
regulation of mrna metabolic process GO:1903311 72 0.018
catabolic process GO:0009056 409 0.018
lateral inhibition GO:0046331 206 0.018
sensory organ morphogenesis GO:0090596 260 0.017
regulation of cell cycle GO:0051726 291 0.017
olfactory learning GO:0008355 56 0.017
cell adhesion GO:0007155 136 0.017
positive regulation of cellular protein metabolic process GO:0032270 118 0.017
positive regulation of developmental process GO:0051094 143 0.017
rna processing GO:0006396 147 0.017
positive regulation of catalytic activity GO:0043085 118 0.017
stem cell proliferation GO:0072089 88 0.017
ras protein signal transduction GO:0007265 88 0.017
organophosphate metabolic process GO:0019637 195 0.017
negative regulation of signal transduction GO:0009968 206 0.017
malpighian tubule development GO:0072002 64 0.017
regulation of cellular ketone metabolic process GO:0010565 3 0.017
sensory perception GO:0007600 196 0.017
organic substance transport GO:0071702 257 0.017
regulation of cellular localization GO:0060341 136 0.017
neural precursor cell proliferation GO:0061351 75 0.017
cation homeostasis GO:0055080 51 0.016
negative regulation of signaling GO:0023057 219 0.016
mrna processing GO:0006397 104 0.016
regulation of synapse structure and activity GO:0050803 128 0.016
mitotic spindle organization GO:0007052 220 0.016
nucleobase containing compound catabolic process GO:0034655 165 0.016
carbohydrate derivative metabolic process GO:1901135 217 0.016
dendrite development GO:0016358 204 0.016
negative regulation of developmental process GO:0051093 201 0.016
protein phosphorylation GO:0006468 169 0.016
metal ion homeostasis GO:0055065 44 0.016
regulation of neural precursor cell proliferation GO:2000177 35 0.016
establishment or maintenance of cell polarity GO:0007163 167 0.016
response to oxygen containing compound GO:1901700 200 0.016
actin filament organization GO:0007015 126 0.016
immune effector process GO:0002252 98 0.016
regulation of gene expression epigenetic GO:0040029 128 0.016
cell fate specification GO:0001708 71 0.016
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.016
death GO:0016265 284 0.015
positive regulation of phosphorylation GO:0042327 87 0.015
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.015
learning or memory GO:0007611 141 0.015
monocarboxylic acid transport GO:0015718 3 0.015
organic substance catabolic process GO:1901575 308 0.015
cellular catabolic process GO:0044248 372 0.015
regulation of cytoskeleton organization GO:0051493 89 0.015
mesenchymal cell development GO:0014031 1 0.015
positive regulation of intracellular signal transduction GO:1902533 116 0.015
endomembrane system organization GO:0010256 119 0.015
heterocycle catabolic process GO:0046700 166 0.015
rna splicing via transesterification reactions GO:0000375 73 0.015
negative regulation of nervous system development GO:0051961 92 0.015
eye morphogenesis GO:0048592 260 0.015
cilium organization GO:0044782 41 0.015
gland morphogenesis GO:0022612 145 0.015
learning GO:0007612 75 0.015
negative regulation of multicellular organismal process GO:0051241 142 0.015
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.014
regulation of catabolic process GO:0009894 170 0.014
negative regulation of cell differentiation GO:0045596 143 0.014
establishment of localization in cell GO:0051649 402 0.014
organelle localization GO:0051640 148 0.014
regulation of neurogenesis GO:0050767 158 0.014
associative learning GO:0008306 65 0.014
regulation of cell proliferation GO:0042127 163 0.014
carboxylic acid metabolic process GO:0019752 92 0.014
axonogenesis GO:0007409 290 0.014
exocrine system development GO:0035272 162 0.014
response to alcohol GO:0097305 95 0.014
respiratory system development GO:0060541 213 0.014
regulation of multi organism process GO:0043900 131 0.014
cellular component assembly involved in morphogenesis GO:0010927 151 0.014
proteolysis GO:0006508 192 0.014
embryonic development via the syncytial blastoderm GO:0001700 148 0.014
cell maturation GO:0048469 144 0.014
nucleoside triphosphate catabolic process GO:0009143 108 0.014
muscle organ development GO:0007517 127 0.014
compound eye morphogenesis GO:0001745 249 0.013
establishment of protein localization GO:0045184 163 0.013
cellular response to dna damage stimulus GO:0006974 223 0.013
detection of stimulus involved in sensory perception GO:0050906 92 0.013
nephron epithelium development GO:0072009 3 0.013
response to organic substance GO:0010033 284 0.013
imaginal disc derived wing morphogenesis GO:0007476 337 0.013
embryo development ending in birth or egg hatching GO:0009792 152 0.013
behavioral response to ethanol GO:0048149 49 0.013
positive regulation of protein modification process GO:0031401 58 0.013
imaginal disc pattern formation GO:0007447 91 0.013
regulation of cell development GO:0060284 215 0.013
cellular protein localization GO:0034613 160 0.013
negative regulation of response to stimulus GO:0048585 258 0.013
regulation of protein modification process GO:0031399 112 0.013
axis specification GO:0009798 167 0.013
compound eye photoreceptor cell differentiation GO:0001751 140 0.013
regulation of transmembrane transport GO:0034762 27 0.013
positive regulation of cell migration GO:0030335 2 0.013
spinal cord development GO:0021510 1 0.013
cell projection assembly GO:0030031 94 0.013
ribonucleotide metabolic process GO:0009259 145 0.013
imaginal disc derived appendage development GO:0048737 399 0.013
regulation of mapk cascade GO:0043408 92 0.013
multi organism behavior GO:0051705 175 0.013
cellular nitrogen compound catabolic process GO:0044270 165 0.013
organonitrogen compound biosynthetic process GO:1901566 117 0.013
regulation of stem cell proliferation GO:0072091 40 0.013
anterior posterior axis specification GO:0009948 109 0.013
regulation of ion transmembrane transport GO:0034765 27 0.013
regulation of rna splicing GO:0043484 69 0.013
mapk cascade GO:0000165 107 0.013
negative regulation of biosynthetic process GO:0009890 277 0.012
purine nucleoside triphosphate catabolic process GO:0009146 108 0.012
single organism behavior GO:0044708 391 0.012
brain development GO:0007420 120 0.012
digestive tract development GO:0048565 149 0.012
acid secretion GO:0046717 1 0.012
response to decreased oxygen levels GO:0036293 58 0.012
regulation of apoptotic process GO:0042981 130 0.012
camera type eye morphogenesis GO:0048593 2 0.012
single organismal cell cell adhesion GO:0016337 45 0.012
nucleotide metabolic process GO:0009117 161 0.012
aggressive behavior GO:0002118 63 0.012
positive regulation of catabolic process GO:0009896 105 0.012
taxis GO:0042330 304 0.012
single organism intracellular transport GO:1902582 207 0.012
spermatid development GO:0007286 98 0.012
positive regulation of mapk cascade GO:0043410 63 0.012
positive regulation of ion transmembrane transporter activity GO:0032414 4 0.012
aromatic compound catabolic process GO:0019439 166 0.012
negative regulation of cellular biosynthetic process GO:0031327 277 0.012
regulation of phosphorylation GO:0042325 147 0.012
specification of segmental identity head GO:0007380 11 0.012
epithelial tube morphogenesis GO:0060562 88 0.012
regulation of cellular component size GO:0032535 98 0.012
neuromuscular synaptic transmission GO:0007274 67 0.012
inorganic ion transmembrane transport GO:0098660 73 0.012
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 73 0.012
cellular macromolecular complex assembly GO:0034622 153 0.012
axon development GO:0061564 297 0.012
wing disc morphogenesis GO:0007472 344 0.012
mrna splicing via spliceosome GO:0000398 73 0.012
stem cell differentiation GO:0048863 117 0.012
apoptotic process GO:0006915 159 0.012
regulation of mrna processing GO:0050684 71 0.012
immune response GO:0006955 246 0.012
purine nucleotide metabolic process GO:0006163 146 0.012
long term memory GO:0007616 62 0.012
dna metabolic process GO:0006259 227 0.012
axon guidance GO:0007411 233 0.012
segment specification GO:0007379 33 0.012
negative regulation of transcription dna templated GO:0045892 237 0.012
protein transport GO:0015031 155 0.012
post embryonic appendage morphogenesis GO:0035120 385 0.012
regulation of excitatory postsynaptic membrane potential GO:0060079 3 0.012
negative regulation of mitotic cell cycle GO:0045930 109 0.012
muscle structure development GO:0061061 224 0.011
regulation of small gtpase mediated signal transduction GO:0051056 93 0.011
signal transduction by phosphorylation GO:0023014 107 0.011
positive regulation of cell motility GO:2000147 3 0.011
regulation of neuron differentiation GO:0045664 103 0.011
positive regulation of synaptic transmission glutamatergic GO:0051968 3 0.011
positive regulation of hydrolase activity GO:0051345 78 0.011
glycosyl compound metabolic process GO:1901657 127 0.011
convergent extension GO:0060026 2 0.011
hindbrain development GO:0030902 2 0.011
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger GO:0007187 17 0.011
chitin based cuticle development GO:0040003 49 0.011
response to wounding GO:0009611 94 0.011
membrane organization GO:0061024 112 0.011
rna localization GO:0006403 115 0.011
negative regulation of cell communication GO:0010648 223 0.011
regulation of cell death GO:0010941 173 0.011
eye photoreceptor cell differentiation GO:0001754 145 0.011
nucleotide catabolic process GO:0009166 109 0.011
regulation of transferase activity GO:0051338 58 0.011
chromosome organization GO:0051276 360 0.011
purine nucleoside catabolic process GO:0006152 112 0.011
oocyte axis specification GO:0007309 108 0.011
neuroblast proliferation GO:0007405 74 0.011
larval development GO:0002164 104 0.011
intraspecies interaction between organisms GO:0051703 4 0.011
protein modification by small protein conjugation or removal GO:0070647 106 0.011
regulation of neuroblast proliferation GO:1902692 34 0.011
regulation of hydrolase activity GO:0051336 97 0.011
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.011
intracellular transport GO:0046907 228 0.011
negative regulation of gene expression epigenetic GO:0045814 77 0.011
store operated calcium entry GO:0002115 3 0.011
rna splicing GO:0008380 83 0.011
appendage morphogenesis GO:0035107 397 0.011
open tracheal system development GO:0007424 204 0.011
ion homeostasis GO:0050801 55 0.011
regulation of cell cycle process GO:0010564 181 0.011
oocyte differentiation GO:0009994 145 0.011
single organism biosynthetic process GO:0044711 206 0.011
oxoacid metabolic process GO:0043436 103 0.011
ribonucleoside metabolic process GO:0009119 127 0.011
digestive tract morphogenesis GO:0048546 127 0.011
regulation of response to external stimulus GO:0032101 115 0.011
organic cyclic compound catabolic process GO:1901361 168 0.011
mitotic nuclear division GO:0007067 213 0.011
nucleoside triphosphate metabolic process GO:0009141 120 0.010
intracellular mrna localization involved in anterior posterior axis specification GO:0060811 53 0.010
positive regulation of cellular catabolic process GO:0031331 95 0.010
purine nucleotide catabolic process GO:0006195 109 0.010
negative regulation of cell cycle GO:0045786 116 0.010
regulation of gene silencing GO:0060968 63 0.010
ribonucleotide catabolic process GO:0009261 109 0.010
regulation of cellular amino acid metabolic process GO:0006521 0 0.010
chromatin organization GO:0006325 207 0.010
appendage development GO:0048736 401 0.010
cell recognition GO:0008037 102 0.010
regulation of kinase activity GO:0043549 53 0.010
cellular cation homeostasis GO:0030003 38 0.010
photoreceptor cell fate commitment GO:0046552 41 0.010
chromatin silencing GO:0006342 76 0.010
nucleobase containing small molecule metabolic process GO:0055086 174 0.010
negative regulation of rna biosynthetic process GO:1902679 240 0.010
regulation of programmed cell death GO:0043067 152 0.010
embryonic axis specification GO:0000578 107 0.010
purine containing compound metabolic process GO:0072521 155 0.010
regulation of cellular catabolic process GO:0031329 157 0.010
wound healing GO:0042060 75 0.010
negative regulation of cellular component organization GO:0051129 108 0.010
maternal determination of anterior posterior axis embryo GO:0008358 74 0.010

sick disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.029
renal tubular transport disease DOID:447 0 0.017
kidney disease DOID:557 0 0.017
urinary system disease DOID:18 0 0.017
nervous system disease DOID:863 0 0.013
disease of cellular proliferation DOID:14566 0 0.013
liddle syndrome DOID:0050477 0 0.011
disease of metabolism DOID:0014667 0 0.010
inherited metabolic disorder DOID:655 0 0.010