Drosophila melanogaster

97 known processes

dre4 (Dmel_CG1828)

CG1828 gene product from transcript CG1828-RB

(Aliases: DRE4/dSPT16,CG1828,Spt16,dSPT16,spt16,dSpt16,dspt16,l(3)dre4,Dmel\CG1828,l(3)62Bg)

dre4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cell cycle checkpoint GO:0000075 95 0.697
mitotic dna damage checkpoint GO:0044773 74 0.681
positive regulation of rna metabolic process GO:0051254 271 0.536
dna damage checkpoint GO:0000077 78 0.520
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.505
negative regulation of cell cycle GO:0045786 116 0.494
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.492
embryo development ending in birth or egg hatching GO:0009792 152 0.483
Worm
cellular response to dna damage stimulus GO:0006974 223 0.460
male gamete generation GO:0048232 201 0.389
cell cycle phase transition GO:0044770 140 0.389
g2 dna damage checkpoint GO:0031572 69 0.374
mitotic cell cycle checkpoint GO:0007093 88 0.310
dna metabolic process GO:0006259 227 0.296
negative regulation of cell cycle phase transition GO:1901988 103 0.296
negative regulation of mitotic cell cycle GO:0045930 109 0.293
negative regulation of gene expression GO:0010629 387 0.281
cellular protein modification process GO:0006464 438 0.266
mitotic cell cycle phase transition GO:0044772 138 0.257
negative regulation of biosynthetic process GO:0009890 277 0.244
protein modification by small protein conjugation or removal GO:0070647 106 0.213
positive regulation of gene expression GO:0010628 290 0.204
regulation of cell cycle phase transition GO:1901987 130 0.197
spermatogenesis GO:0007283 200 0.196
regionalization GO:0003002 416 0.196
larval development GO:0002164 104 0.194
sister chromatid segregation GO:0000819 92 0.193
protein complex assembly GO:0006461 200 0.186
negative regulation of transcription dna templated GO:0045892 237 0.171
protein transport GO:0015031 155 0.165
positive regulation of cellular biosynthetic process GO:0031328 316 0.163
dna repair GO:0006281 54 0.162
determination of adult lifespan GO:0008340 137 0.162
establishment or maintenance of cell polarity GO:0007163 167 0.161
regulation of mitotic cell cycle phase transition GO:1901990 130 0.158
spermatid differentiation GO:0048515 114 0.158
proteolysis GO:0006508 192 0.157
mitotic g2 m transition checkpoint GO:0044818 70 0.152
macromolecular complex assembly GO:0065003 256 0.151
protein ubiquitination GO:0016567 70 0.149
vesicle mediated transport GO:0016192 381 0.146
organelle assembly GO:0070925 198 0.145
cellular protein localization GO:0034613 160 0.141
growth GO:0040007 359 0.140
dna integrity checkpoint GO:0031570 81 0.139
regulation of cell cycle process GO:0010564 181 0.131
regulation of dna templated transcription elongation GO:0032784 17 0.130
aging GO:0007568 143 0.129
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.129
negative regulation of cell cycle process GO:0010948 109 0.122
gene silencing GO:0016458 138 0.119
mitotic dna integrity checkpoint GO:0044774 75 0.117
cell migration GO:0016477 238 0.116
immune system process GO:0002376 347 0.113
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.113
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.113
apoptotic process GO:0006915 159 0.111
developmental maturation GO:0021700 172 0.110
embryonic development via the syncytial blastoderm GO:0001700 148 0.107
protein maturation GO:0051604 71 0.105
regulation of cellular localization GO:0060341 136 0.104
negative regulation of cellular metabolic process GO:0031324 382 0.101
protein localization GO:0008104 284 0.101
single organism cellular localization GO:1902580 180 0.099
nucleobase containing small molecule metabolic process GO:0055086 174 0.096
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.095
spermatid development GO:0007286 98 0.094
regulation of neurogenesis GO:0050767 158 0.094
regulation of molecular function GO:0065009 217 0.092
regulation of gene expression epigenetic GO:0040029 128 0.091
purine nucleoside metabolic process GO:0042278 127 0.091
purine containing compound catabolic process GO:0072523 112 0.088
protein complex biogenesis GO:0070271 201 0.088
cell maturation GO:0048469 144 0.087
reproductive system development GO:0061458 74 0.087
body morphogenesis GO:0010171 2 0.085
mrna splice site selection GO:0006376 1 0.080
protein modification by small protein conjugation GO:0032446 79 0.079
embryonic morphogenesis GO:0048598 206 0.078
mitotic g2 dna damage checkpoint GO:0007095 69 0.077
positive regulation of rna biosynthetic process GO:1902680 266 0.077
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.077
protein processing GO:0016485 68 0.076
multicellular organismal aging GO:0010259 140 0.076
regulation of developmental growth GO:0048638 174 0.074
multicellular organism growth GO:0035264 46 0.073
positive regulation of signal transduction GO:0009967 223 0.071
dna templated transcription elongation GO:0006354 18 0.070
protein catabolic process GO:0030163 101 0.070
chromatin organization GO:0006325 207 0.069
ribose phosphate metabolic process GO:0019693 145 0.069
negative regulation of cellular biosynthetic process GO:0031327 277 0.069
cellular macromolecule catabolic process GO:0044265 136 0.068
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.067
protein modification process GO:0036211 438 0.066
glycosyl compound catabolic process GO:1901658 112 0.064
embryonic pattern specification GO:0009880 174 0.064
cell proliferation GO:0008283 299 0.062
developmental programmed cell death GO:0010623 138 0.062
cellular macromolecular complex assembly GO:0034622 153 0.060
negative regulation of developmental process GO:0051093 201 0.060
purine nucleoside triphosphate catabolic process GO:0009146 108 0.060
protein import GO:0017038 55 0.058
regulation of proteolysis GO:0030162 87 0.058
positive regulation of proteolysis GO:0045862 52 0.057
establishment of localization in cell GO:0051649 402 0.057
phosphorylation GO:0016310 294 0.056
meiotic cell cycle GO:0051321 171 0.055
regulation of cellular protein metabolic process GO:0032268 243 0.055
positive regulation of macromolecule metabolic process GO:0010604 405 0.055
regulation of mitotic cell cycle GO:0007346 190 0.055
single organism intracellular transport GO:1902582 207 0.054
chromosome organization GO:0051276 360 0.054
organonitrogen compound metabolic process GO:1901564 318 0.054
programmed cell death GO:0012501 257 0.053
negative regulation of nucleic acid templated transcription GO:1903507 240 0.053
posttranscriptional gene silencing by rna GO:0035194 45 0.051
sex differentiation GO:0007548 81 0.051
cytoskeleton dependent cytokinesis GO:0061640 81 0.051
genitalia development GO:0048806 26 0.051
imaginal disc derived wing morphogenesis GO:0007476 337 0.051
ubiquitin dependent protein catabolic process GO:0006511 78 0.050
mitotic sister chromatid segregation GO:0000070 87 0.050
developmental growth GO:0048589 280 0.050
nucleoside metabolic process GO:0009116 127 0.049
purine containing compound metabolic process GO:0072521 155 0.049
regulation of meiosis GO:0040020 3 0.048
spindle organization GO:0007051 253 0.048
notch signaling pathway GO:0007219 120 0.048
zymogen activation GO:0031638 20 0.048
purine ribonucleoside metabolic process GO:0046128 127 0.047
modification dependent macromolecule catabolic process GO:0043632 79 0.047
death GO:0016265 284 0.047
axon development GO:0061564 297 0.046
activation of cysteine type endopeptidase activity GO:0097202 17 0.045
cell motility GO:0048870 251 0.045
mrna processing GO:0006397 104 0.045
heterocycle catabolic process GO:0046700 166 0.045
cellular catabolic process GO:0044248 372 0.045
macromolecule catabolic process GO:0009057 161 0.045
cellular protein complex assembly GO:0043623 71 0.043
positive regulation of catabolic process GO:0009896 105 0.041
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 16 0.041
catabolic process GO:0009056 409 0.041
positive regulation of peptidase activity GO:0010952 29 0.040
histone mrna metabolic process GO:0008334 8 0.040
positive regulation of immune response GO:0050778 63 0.040
reproductive structure development GO:0048608 74 0.040
regulation of small gtpase mediated signal transduction GO:0051056 93 0.039
positive regulation of biosynthetic process GO:0009891 316 0.039
regulation of cellular component biogenesis GO:0044087 201 0.039
intracellular transport GO:0046907 228 0.039
positive regulation of signaling GO:0023056 243 0.039
stem cell differentiation GO:0048863 117 0.038
protein dna complex subunit organization GO:0071824 86 0.038
positive regulation of immune system process GO:0002684 68 0.038
positive regulation of molecular function GO:0044093 136 0.038
dendrite development GO:0016358 204 0.038
compound eye photoreceptor cell differentiation GO:0001751 140 0.038
spindle assembly involved in mitosis GO:0090307 50 0.037
multicellular organismal reproductive behavior GO:0033057 110 0.037
nucleoside phosphate metabolic process GO:0006753 162 0.036
transcription from rna polymerase ii promoter GO:0006366 368 0.036
negative regulation of rna biosynthetic process GO:1902679 240 0.035
protein modification by small protein removal GO:0070646 28 0.035
cellular macromolecule localization GO:0070727 220 0.035
purine nucleotide metabolic process GO:0006163 146 0.035
endocytosis GO:0006897 310 0.035
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.035
multi organism behavior GO:0051705 175 0.035
purine nucleoside catabolic process GO:0006152 112 0.034
regulation of multi organism process GO:0043900 131 0.034
regulation of cell cycle GO:0051726 291 0.034
regulation of cell differentiation GO:0045595 302 0.034
regulation of multicellular organism growth GO:0040014 40 0.033
rna splicing via transesterification reactions GO:0000375 73 0.033
intracellular signal transduction GO:0035556 300 0.033
hemopoiesis GO:0030097 46 0.033
cell division GO:0051301 248 0.032
multi multicellular organism process GO:0044706 123 0.032
modification dependent protein catabolic process GO:0019941 78 0.032
ribonucleoside catabolic process GO:0042454 112 0.032
humoral immune response GO:0006959 117 0.032
establishment of organelle localization GO:0051656 122 0.032
positive regulation of catalytic activity GO:0043085 118 0.031
positive regulation of developmental growth GO:0048639 62 0.031
molting cycle GO:0042303 56 0.030
Worm
cellular protein catabolic process GO:0044257 83 0.030
gonad development GO:0008406 50 0.030
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 54 0.030
rna processing GO:0006396 147 0.030
synapse organization GO:0050808 196 0.029
cellular response to lipopolysaccharide GO:0071222 3 0.029
organic substance catabolic process GO:1901575 308 0.029
nucleoside triphosphate metabolic process GO:0009141 120 0.029
mrna splicing via spliceosome GO:0000398 73 0.029
chromosome segregation GO:0007059 157 0.029
small gtpase mediated signal transduction GO:0007264 88 0.028
mrna metabolic process GO:0016071 124 0.028
establishment of protein localization GO:0045184 163 0.028
positive regulation of nucleic acid templated transcription GO:1903508 266 0.028
positive regulation of cell communication GO:0010647 250 0.028
carbohydrate derivative metabolic process GO:1901135 217 0.027
organelle fission GO:0048285 340 0.027
cytoplasmic transport GO:0016482 130 0.027
cellular nitrogen compound catabolic process GO:0044270 165 0.026
epithelial cell development GO:0002064 274 0.026
purine ribonucleotide metabolic process GO:0009150 145 0.026
chromatin modification GO:0016568 147 0.026
posttranscriptional regulation of gene expression GO:0010608 145 0.026
cellular protein complex disassembly GO:0043624 35 0.026
appendage morphogenesis GO:0035107 397 0.026
morphogenesis of an epithelium GO:0002009 276 0.026
protein dna complex assembly GO:0065004 63 0.025
protein targeting to nucleus GO:0044744 51 0.025
protein deubiquitination GO:0016579 17 0.025
covalent chromatin modification GO:0016569 106 0.025
proteasomal protein catabolic process GO:0010498 59 0.025
regulation of immune system process GO:0002682 176 0.025
regulation of notch signaling pathway GO:0008593 100 0.025
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.025
protein targeting GO:0006605 64 0.025
organonitrogen compound catabolic process GO:1901565 128 0.024
regulation of phosphorylation GO:0042325 147 0.024
ribonucleoside triphosphate metabolic process GO:0009199 119 0.024
intracellular protein transport GO:0006886 104 0.024
necrotic cell death GO:0070265 1 0.024
regulation of catalytic activity GO:0050790 185 0.024
regulation of intracellular signal transduction GO:1902531 236 0.024
mrna catabolic process GO:0006402 33 0.024
positive regulation of protein metabolic process GO:0051247 128 0.023
regulation of protein transport GO:0051223 57 0.023
axis specification GO:0009798 167 0.023
regulation of phosphorus metabolic process GO:0051174 210 0.023
response to oxidative stress GO:0006979 86 0.023
small molecule metabolic process GO:0044281 305 0.022
positive regulation of endopeptidase activity GO:0010950 26 0.022
carbohydrate derivative catabolic process GO:1901136 118 0.022
spliceosomal complex assembly GO:0000245 1 0.022
ribonucleotide catabolic process GO:0009261 109 0.022
axonogenesis GO:0007409 290 0.022
nucleoside catabolic process GO:0009164 112 0.022
germarium derived egg chamber formation GO:0007293 101 0.022
eye photoreceptor cell differentiation GO:0001754 145 0.022
ras protein signal transduction GO:0007265 88 0.021
multi organism reproductive behavior GO:0044705 121 0.021
development of primary sexual characteristics GO:0045137 50 0.021
negative regulation of neuroblast proliferation GO:0007406 27 0.021
regulation of protein complex disassembly GO:0043244 29 0.021
positive regulation of response to stimulus GO:0048584 323 0.021
neuroblast proliferation GO:0007405 74 0.021
nucleobase containing compound catabolic process GO:0034655 165 0.021
postreplication repair GO:0006301 2 0.020
regulation of multicellular organismal development GO:2000026 414 0.020
stem cell development GO:0048864 79 0.020
phagocytosis GO:0006909 215 0.020
ribonucleoside metabolic process GO:0009119 127 0.020
regulation of programmed cell death GO:0043067 152 0.020
organophosphate metabolic process GO:0019637 195 0.020
mitotic nuclear division GO:0007067 213 0.019
gene silencing by rna GO:0031047 57 0.019
rna splicing GO:0008380 83 0.019
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.019
tissue morphogenesis GO:0048729 297 0.019
aromatic compound catabolic process GO:0019439 166 0.018
establishment of protein localization to organelle GO:0072594 62 0.018
negative regulation of rna metabolic process GO:0051253 251 0.018
regulation of protein modification process GO:0031399 112 0.018
posttranscriptional gene silencing GO:0016441 46 0.018
regulation of immune response GO:0050776 118 0.018
negative regulation of proteasomal protein catabolic process GO:1901799 16 0.018
regulation of cellular ketone metabolic process GO:0010565 3 0.018
glycosyl compound metabolic process GO:1901657 127 0.018
regulation of protein metabolic process GO:0051246 256 0.018
regulation of cell death GO:0010941 173 0.018
regulation of catabolic process GO:0009894 170 0.018
regulation of response to stress GO:0080134 200 0.018
positive regulation of hydrolase activity GO:0051345 78 0.017
regulation of phosphate metabolic process GO:0019220 210 0.017
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 23 0.017
camera type eye development GO:0043010 4 0.017
double strand break repair GO:0006302 26 0.017
regulation of protein localization GO:0032880 76 0.017
localization of cell GO:0051674 257 0.017
ovarian follicle cell development GO:0030707 248 0.016
receptor mediated endocytosis GO:0006898 21 0.016
defense response to other organism GO:0098542 225 0.016
cellular component disassembly GO:0022411 46 0.016
nuclear division GO:0000280 332 0.016
rna interference GO:0016246 27 0.016
organic substance transport GO:0071702 257 0.016
positive regulation of cellular component organization GO:0051130 156 0.016
stem cell maintenance GO:0019827 67 0.015
ribonucleoside monophosphate metabolic process GO:0009161 51 0.015
negative regulation of intrinsic apoptotic signaling pathway GO:2001243 1 0.015
positive regulation of transcription dna templated GO:0045893 266 0.015
protein localization to organelle GO:0033365 82 0.015
regulation of protein catabolic process GO:0042176 55 0.015
defense response to bacterium GO:0042742 178 0.015
cellular amine metabolic process GO:0044106 12 0.015
regulation of mrna metabolic process GO:1903311 72 0.015
purine nucleoside triphosphate metabolic process GO:0009144 119 0.015
blastoderm segmentation GO:0007350 159 0.015
peptidyl amino acid modification GO:0018193 105 0.015
hematopoietic or lymphoid organ development GO:0048534 57 0.015
alternative mrna splicing via spliceosome GO:0000380 60 0.015
purine ribonucleoside catabolic process GO:0046130 112 0.014
rna 3 end processing GO:0031123 45 0.014
microtubule organizing center organization GO:0031023 168 0.014
anterior posterior axis specification GO:0009948 109 0.014
regulation of response to external stimulus GO:0032101 115 0.014
cellular response to molecule of bacterial origin GO:0071219 3 0.014
mitotic cytokinesis GO:0000281 50 0.014
molting cycle chitin based cuticle GO:0007591 56 0.014
nuclear rna surveillance GO:0071027 3 0.014
negative regulation of protein complex disassembly GO:0043242 23 0.014
neuron projection guidance GO:0097485 241 0.013
negative regulation of cellular catabolic process GO:0031330 34 0.013
positive regulation of intracellular signal transduction GO:1902533 116 0.013
regulation of cellular amino acid metabolic process GO:0006521 0 0.013
response to biotic stimulus GO:0009607 294 0.013
lipid localization GO:0010876 54 0.013
regulation of protein localization to nucleus GO:1900180 29 0.013
appendage development GO:0048736 401 0.013
response to oxygen containing compound GO:1901700 200 0.013
ncrna metabolic process GO:0034660 43 0.013
regulation of g2 m transition of mitotic cell cycle GO:0010389 15 0.013
negative regulation of sister chromatid segregation GO:0033046 13 0.013
enzyme linked receptor protein signaling pathway GO:0007167 179 0.013
cytokinesis GO:0000910 90 0.013
maternal determination of anterior posterior axis embryo GO:0008358 74 0.013
regulation of hydrolase activity GO:0051336 97 0.013
actin filament based process GO:0030029 220 0.013
positive regulation of protein transport GO:0051222 37 0.012
imaginal disc derived appendage morphogenesis GO:0035114 395 0.012
nuclear import GO:0051170 51 0.012
negative regulation of response to stimulus GO:0048585 258 0.012
columnar cuboidal epithelial cell development GO:0002066 249 0.012
regulation of meiotic cell cycle GO:0051445 9 0.012
regulation of localization GO:0032879 275 0.012
tripartite regional subdivision GO:0007351 103 0.012
protein localization to nucleus GO:0034504 55 0.012
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.012
negative regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032435 16 0.012
mitotic spindle organization GO:0007052 220 0.012
positive regulation of growth GO:0045927 75 0.012
response to abiotic stimulus GO:0009628 341 0.011
response to external biotic stimulus GO:0043207 293 0.011
cell death GO:0008219 279 0.011
histone h3 k4 methylation GO:0051568 16 0.011
neuron maturation GO:0042551 31 0.011
cellular response to biotic stimulus GO:0071216 4 0.011
photoreceptor cell differentiation GO:0046530 170 0.011
nucleosome assembly GO:0006334 35 0.011
negative regulation of neural precursor cell proliferation GO:2000178 27 0.011
positive regulation of protein import into nucleus GO:0042307 21 0.011
ribonucleoprotein complex subunit organization GO:0071826 28 0.011
oviposition GO:0018991 19 0.011
eye development GO:0001654 323 0.011
transcription initiation from rna polymerase ii promoter GO:0006367 25 0.011
dna packaging GO:0006323 91 0.011
single organism catabolic process GO:0044712 228 0.011
regulation of defense response GO:0031347 102 0.010
negative regulation of chromosome segregation GO:0051985 14 0.010
histone mrna 3 end processing GO:0006398 8 0.010
purine nucleotide catabolic process GO:0006195 109 0.010
negative regulation of cell differentiation GO:0045596 143 0.010
segmentation GO:0035282 207 0.010
dna conformation change GO:0071103 105 0.010
oocyte anterior posterior axis specification GO:0007314 72 0.010
innate immune response GO:0045087 144 0.010
positive regulation of phosphorus metabolic process GO:0010562 139 0.010
regulation of intracellular transport GO:0032386 64 0.010
positive regulation of protein localization to nucleus GO:1900182 21 0.010
negative regulation of catabolic process GO:0009895 36 0.010
purine ribonucleotide catabolic process GO:0009154 109 0.010

dre4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.034
nervous system disease DOID:863 0 0.034
cancer DOID:162 0 0.010
disease of cellular proliferation DOID:14566 0 0.010