Drosophila melanogaster

13 known processes

Pros45 (Dmel_CG1489)

CG1489 gene product from transcript CG1489-RA

(Aliases: Rpt6,p42C,PRS8_DROME,Ug,Dm_Rpt6a,dRpt6,Dug,Dmel\CG1489,pros45,sug-1,1489,DUG,sug1,CG1489)

Pros45 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
proteasome assembly GO:0043248 2 0.659
Yeast
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.657
Yeast
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.600
Yeast
protein complex biogenesis GO:0070271 201 0.583
Yeast
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 37 0.491
proteolysis GO:0006508 192 0.481
cellular protein complex assembly GO:0043623 71 0.452
Yeast
modification dependent macromolecule catabolic process GO:0043632 79 0.447
Human Yeast Worm
positive regulation of cellular biosynthetic process GO:0031328 316 0.376
Yeast
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.360
Yeast
modification dependent protein catabolic process GO:0019941 78 0.346
Human Yeast Worm
transcription from rna polymerase ii promoter GO:0006366 368 0.339
Yeast
protein complex assembly GO:0006461 200 0.332
Yeast
transcription initiation from rna polymerase ii promoter GO:0006367 25 0.327
Yeast
macromolecular complex assembly GO:0065003 256 0.325
Yeast
mitotic spindle elongation GO:0000022 81 0.304
proteasomal protein catabolic process GO:0010498 59 0.298
Human Yeast Worm
positive regulation of transcription dna templated GO:0045893 266 0.266
Yeast
dna templated transcription initiation GO:0006352 25 0.255
Yeast
spindle assembly GO:0051225 80 0.254
regulation of cellular component biogenesis GO:0044087 201 0.254
Yeast Rat
positive regulation of rna metabolic process GO:0051254 271 0.248
Yeast
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 54 0.239
Human Yeast Worm
embryo development ending in birth or egg hatching GO:0009792 152 0.232
Worm
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.230
Yeast
positive regulation of rna biosynthetic process GO:1902680 266 0.227
Yeast
cellular macromolecular complex assembly GO:0034622 153 0.220
Yeast
catabolic process GO:0009056 409 0.212
Human Yeast Rat Worm
positive regulation of nucleic acid templated transcription GO:1903508 266 0.197
Yeast
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.196
Yeast
cellular response to dna damage stimulus GO:0006974 223 0.195
rna polymerase ii transcriptional preinitiation complex assembly GO:0051123 20 0.190
Yeast
cellular macromolecule catabolic process GO:0044265 136 0.157
Human Yeast Worm
spindle elongation GO:0051231 83 0.153
cellular catabolic process GO:0044248 372 0.144
Human Yeast Rat Worm
negative regulation of cell communication GO:0010648 223 0.140
nuclear division GO:0000280 332 0.140
Worm
positive regulation of proteolysis GO:0045862 52 0.133
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 44 0.130
mitotic spindle organization GO:0007052 220 0.125
negative regulation of cellular biosynthetic process GO:0031327 277 0.124
Mouse
spindle organization GO:0007051 253 0.122
cellular protein catabolic process GO:0044257 83 0.118
Human Yeast Worm
centrosome organization GO:0051297 163 0.116
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.115
Human Yeast Worm
body morphogenesis GO:0010171 2 0.109
positive regulation of proteasomal protein catabolic process GO:1901800 20 0.101
lateral inhibition GO:0046331 206 0.100
organic substance catabolic process GO:1901575 308 0.100
Human Yeast Rat Worm
protein catabolic process GO:0030163 101 0.099
Human Yeast Worm
ubiquitin dependent protein catabolic process GO:0006511 78 0.094
Human Yeast Worm
regulation of macroautophagy GO:0016241 15 0.090
regulation of behavior GO:0050795 75 0.087
dna templated transcriptional preinitiation complex assembly GO:0070897 20 0.082
Yeast
organelle fission GO:0048285 340 0.080
Worm
regulation of proteasomal protein catabolic process GO:0061136 39 0.080
positive regulation of peptidase activity GO:0010952 29 0.078
multicellular organismal aging GO:0010259 140 0.076
Worm
protein localization GO:0008104 284 0.075
positive regulation of biosynthetic process GO:0009891 316 0.075
Yeast
positive regulation of cellular component organization GO:0051130 156 0.074
Yeast Rat
negative regulation of biosynthetic process GO:0009890 277 0.072
Mouse
ion transmembrane transport GO:0034220 122 0.070
death GO:0016265 284 0.067
negative regulation of gene expression GO:0010629 387 0.065
Mouse
positive regulation of cellular component biogenesis GO:0044089 80 0.065
Yeast Rat
microtubule cytoskeleton organization involved in mitosis GO:1902850 52 0.059
determination of adult lifespan GO:0008340 137 0.057
Worm
gland development GO:0048732 191 0.057
macromolecule catabolic process GO:0009057 161 0.055
Human Yeast Worm
cell death GO:0008219 279 0.052
positive regulation of gene expression GO:0010628 290 0.052
Yeast
regulation of rna polymerase ii transcriptional preinitiation complex assembly GO:0045898 1 0.052
Yeast
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 24 0.052
organonitrogen compound metabolic process GO:1901564 318 0.051
Rat
regulation of mitotic cell cycle GO:0007346 190 0.051
Worm
regulation of organelle organization GO:0033043 196 0.051
Worm
learning GO:0007612 75 0.050
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.047
Mouse
microtubule organizing center organization GO:0031023 168 0.047
mitotic nuclear division GO:0007067 213 0.046
Worm
negative regulation of cellular metabolic process GO:0031324 382 0.046
Mouse
cellular protein modification process GO:0006464 438 0.046
regulation of cellular protein metabolic process GO:0032268 243 0.045
regulation of endopeptidase activity GO:0052548 36 0.044
regulation of cellular ketone metabolic process GO:0010565 3 0.043
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.043
Mouse
organelle assembly GO:0070925 198 0.042
protein modification process GO:0036211 438 0.041
aging GO:0007568 143 0.040
Worm
neurological system process GO:0050877 358 0.038
negative regulation of signal transduction GO:0009968 206 0.038
apoptotic process GO:0006915 159 0.038
response to nutrient levels GO:0031667 114 0.038
forebrain development GO:0030900 2 0.038
positive regulation of endopeptidase activity GO:0010950 26 0.038
metal ion transport GO:0030001 74 0.037
regulation of proteolysis GO:0030162 87 0.037
regulation of protein complex assembly GO:0043254 42 0.037
Yeast
phagocytosis GO:0006909 215 0.036
positive regulation of cell communication GO:0010647 250 0.035
negative regulation of cellular protein metabolic process GO:0032269 85 0.035
regulation of cell development GO:0060284 215 0.034
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.034
Mouse
regulation of peptidase activity GO:0052547 39 0.034
spindle assembly involved in mitosis GO:0090307 50 0.033
negative regulation of transcription dna templated GO:0045892 237 0.033
Mouse
cellular response to chemical stimulus GO:0070887 199 0.032
purine containing compound metabolic process GO:0072521 155 0.032
Rat
positive regulation of macromolecule metabolic process GO:0010604 405 0.032
Yeast
taxis GO:0042330 304 0.032
aromatic compound catabolic process GO:0019439 166 0.032
Yeast Rat
positive regulation of protein complex assembly GO:0031334 22 0.031
Yeast
sensory perception GO:0007600 196 0.031
single organism behavior GO:0044708 391 0.030
regulation of cellular protein catabolic process GO:1903362 44 0.030
nucleoside catabolic process GO:0009164 112 0.030
Rat
positive regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032436 19 0.030
cellular homeostasis GO:0019725 80 0.030
regulation of response to stress GO:0080134 200 0.030
purine ribonucleotide metabolic process GO:0009150 145 0.029
Rat
rna processing GO:0006396 147 0.029
chemotaxis GO:0006935 249 0.029
purine ribonucleoside metabolic process GO:0046128 127 0.028
Rat
negative regulation of protein metabolic process GO:0051248 85 0.028
regulation of protein catabolic process GO:0042176 55 0.028
cellular macromolecule localization GO:0070727 220 0.028
regulation of cellular catabolic process GO:0031329 157 0.028
purine nucleoside catabolic process GO:0006152 112 0.028
Rat
response to organic substance GO:0010033 284 0.028
nucleoside monophosphate metabolic process GO:0009123 52 0.028
Rat
larval development GO:0002164 104 0.027
Worm
intracellular signal transduction GO:0035556 300 0.027
limb development GO:0060173 1 0.027
carbohydrate derivative metabolic process GO:1901135 217 0.027
Rat
nucleobase containing compound catabolic process GO:0034655 165 0.026
Yeast Rat
multicellular organismal reproductive behavior GO:0033057 110 0.026
regulation of cell cycle process GO:0010564 181 0.026
Worm
cation transport GO:0006812 110 0.025
meiotic cell cycle GO:0051321 171 0.025
chromosome segregation GO:0007059 157 0.025
Worm
negative regulation of response to stimulus GO:0048585 258 0.025
regulation of response to external stimulus GO:0032101 115 0.025
regulation of catalytic activity GO:0050790 185 0.025
ion transport GO:0006811 145 0.024
dna metabolic process GO:0006259 227 0.024
Yeast
regulation of cell projection organization GO:0031344 92 0.024
cell cell signaling involved in cell fate commitment GO:0045168 210 0.024
positive regulation of cellular protein metabolic process GO:0032270 118 0.023
regulation of gene expression epigenetic GO:0040029 128 0.023
negative regulation of signaling GO:0023057 219 0.023
positive regulation of cellular catabolic process GO:0031331 95 0.023
cellular component assembly involved in morphogenesis GO:0010927 151 0.023
cognition GO:0050890 141 0.022
exocrine system development GO:0035272 162 0.022
establishment of protein localization GO:0045184 163 0.022
regulation of cell cycle GO:0051726 291 0.021
Worm
heterocycle catabolic process GO:0046700 166 0.021
Yeast Rat
positive regulation of response to stimulus GO:0048584 323 0.021
positive regulation of intracellular signal transduction GO:1902533 116 0.021
regulation of multicellular organismal development GO:2000026 414 0.021
response to oxidative stress GO:0006979 86 0.021
associative learning GO:0008306 65 0.021
nucleoside phosphate catabolic process GO:1901292 110 0.021
Rat
microtubule polymerization or depolymerization GO:0031109 39 0.020
establishment of localization in cell GO:0051649 402 0.020
mrna processing GO:0006397 104 0.020
er associated ubiquitin dependent protein catabolic process GO:0030433 3 0.019
regulation of molecular function GO:0065009 217 0.019
Yeast
positive regulation of catabolic process GO:0009896 105 0.019
protein transport GO:0015031 155 0.019
regulation of catabolic process GO:0009894 170 0.019
protein deubiquitination GO:0016579 17 0.018
organic substance transport GO:0071702 257 0.018
positive regulation of signaling GO:0023056 243 0.018
cellular chemical homeostasis GO:0055082 40 0.018
response to light stimulus GO:0009416 124 0.018
ribonucleoside triphosphate metabolic process GO:0009199 119 0.018
Rat
positive regulation of molecular function GO:0044093 136 0.018
Yeast
vesicle mediated transport GO:0016192 381 0.018
regulation of intracellular signal transduction GO:1902531 236 0.018
gene silencing GO:0016458 138 0.017
nucleoside phosphate metabolic process GO:0006753 162 0.017
Rat
regulation of cell differentiation GO:0045595 302 0.017
negative regulation of cell development GO:0010721 62 0.017
divalent inorganic cation transport GO:0072511 30 0.017
endomembrane system organization GO:0010256 119 0.017
regulation of mitosis GO:0007088 56 0.016
Worm
regulation of cellular response to stress GO:0080135 89 0.016
regulation of dna templated transcription elongation GO:0032784 17 0.016
Yeast
protein phosphorylation GO:0006468 169 0.016
response to radiation GO:0009314 155 0.016
transcription elongation from rna polymerase ii promoter GO:0006368 18 0.016
Yeast
mrna cis splicing via spliceosome GO:0045292 1 0.016
negative regulation of cellular catabolic process GO:0031330 34 0.016
reproductive structure development GO:0048608 74 0.016
Worm
negative regulation of proteasomal protein catabolic process GO:1901799 16 0.016
cellular cation homeostasis GO:0030003 38 0.016
camera type eye development GO:0043010 4 0.015
regulation of protein modification process GO:0031399 112 0.015
mitotic cell cycle phase transition GO:0044772 138 0.015
Worm
ribonucleotide catabolic process GO:0009261 109 0.015
Rat
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 38 0.015
nucleoside triphosphate catabolic process GO:0009143 108 0.015
Rat
regulation of cell division GO:0051302 72 0.015
Worm
regulation of cellular amine metabolic process GO:0033238 3 0.015
peptide biosynthetic process GO:0043043 42 0.015
nucleus localization GO:0051647 34 0.015
posttranscriptional gene silencing by rna GO:0035194 45 0.015
regulation of protein transport GO:0051223 57 0.015
transmembrane transport GO:0055085 139 0.015
purine nucleoside monophosphate catabolic process GO:0009128 38 0.015
Rat
programmed cell death GO:0012501 257 0.014
response to other organism GO:0051707 293 0.014
regulation of multi organism process GO:0043900 131 0.014
homeostatic process GO:0042592 199 0.014
single organism catabolic process GO:0044712 228 0.014
Rat Worm
carbohydrate derivative catabolic process GO:1901136 118 0.014
Rat
nucleobase containing small molecule metabolic process GO:0055086 174 0.014
Rat
single organism cellular localization GO:1902580 180 0.014
positive regulation of signal transduction GO:0009967 223 0.014
negative regulation of cell cycle GO:0045786 116 0.014
cell proliferation GO:0008283 299 0.013
regulation of gene silencing GO:0060968 63 0.013
positive regulation of protein catabolic process GO:0045732 34 0.013
protein localization to organelle GO:0033365 82 0.013
learning or memory GO:0007611 141 0.013
rna interference GO:0016246 27 0.013
negative regulation of cellular component organization GO:0051129 108 0.013
regulation of phosphate metabolic process GO:0019220 210 0.012
regulation of hydrolase activity GO:0051336 97 0.012
regulation of synapse assembly GO:0051963 94 0.012
protein dna complex subunit organization GO:0071824 86 0.012
Yeast
ribose phosphate metabolic process GO:0019693 145 0.012
Rat
response to biotic stimulus GO:0009607 294 0.012
organonitrogen compound catabolic process GO:1901565 128 0.012
Rat
protein ubiquitination GO:0016567 70 0.012
endocytosis GO:0006897 310 0.012
regulation of locomotion GO:0040012 42 0.012
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 73 0.012
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.012
Rat
nucleotide catabolic process GO:0009166 109 0.012
Rat
organophosphate catabolic process GO:0046434 112 0.012
Rat
response to oxygen containing compound GO:1901700 200 0.012
purine nucleoside triphosphate metabolic process GO:0009144 119 0.012
Rat
amine metabolic process GO:0009308 12 0.012
ribonucleoside monophosphate catabolic process GO:0009158 39 0.012
Rat
salivary gland morphogenesis GO:0007435 145 0.011
molting cycle GO:0042303 56 0.011
regulation of microtubule based process GO:0032886 49 0.011
telencephalon development GO:0021537 2 0.011
response to organonitrogen compound GO:0010243 75 0.011
amide biosynthetic process GO:0043604 42 0.011
nucleoside metabolic process GO:0009116 127 0.011
Rat
cytoplasmic transport GO:0016482 130 0.011
development of primary sexual characteristics GO:0045137 50 0.011
Worm
meiotic nuclear division GO:0007126 151 0.011
cellular amine metabolic process GO:0044106 12 0.011
regulation of epithelial cell proliferation GO:0050678 4 0.010
response to endogenous stimulus GO:0009719 119 0.010
protein polymerization GO:0051258 42 0.010
positive regulation of phosphate metabolic process GO:0045937 139 0.010
regulation of innate immune response GO:0045088 71 0.010
organonitrogen compound biosynthetic process GO:1901566 117 0.010
regulation of immune system process GO:0002682 176 0.010

Pros45 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.029
nervous system disease DOID:863 0 0.015