Drosophila melanogaster

39 known processes

bnk (Dmel_CG1480)

bottleneck

(Aliases: Bnk,Dmel\CG1480,CG1480)

bnk biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
detection of stimulus involved in sensory perception GO:0050906 92 0.304
detection of chemical stimulus involved in sensory perception GO:0050907 75 0.214
detection of stimulus GO:0051606 156 0.198
detection of chemical stimulus GO:0009593 93 0.195
detection of chemical stimulus involved in sensory perception of smell GO:0050911 50 0.175
sensory perception GO:0007600 196 0.139
neurological system process GO:0050877 358 0.134
sensory perception of chemical stimulus GO:0007606 116 0.117
lateral inhibition GO:0046331 206 0.092
protein hydroxylation GO:0018126 1 0.068
peptidyl proline hydroxylation GO:0019511 1 0.064
sensory perception of smell GO:0007608 80 0.064
gland development GO:0048732 191 0.057
cell cell signaling involved in cell fate commitment GO:0045168 210 0.056
salivary gland development GO:0007431 162 0.054
cellular protein modification process GO:0006464 438 0.052
salivary gland morphogenesis GO:0007435 145 0.050
protein modification process GO:0036211 438 0.050
protein heterooligomerization GO:0051291 4 0.049
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.043
macromolecular complex assembly GO:0065003 256 0.042
body morphogenesis GO:0010171 2 0.041
gland morphogenesis GO:0022612 145 0.041
exocrine system development GO:0035272 162 0.037
peptidyl proline modification GO:0018208 3 0.036
single organism behavior GO:0044708 391 0.035
response to abiotic stimulus GO:0009628 341 0.035
positive regulation of biosynthetic process GO:0009891 316 0.034
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.033
single organism cellular localization GO:1902580 180 0.032
establishment of localization in cell GO:0051649 402 0.032
response to lipopolysaccharide GO:0032496 4 0.031
positive regulation of macromolecule metabolic process GO:0010604 405 0.030
tissue morphogenesis GO:0048729 297 0.030
organonitrogen compound metabolic process GO:1901564 318 0.029
protein complex assembly GO:0006461 200 0.028
negative regulation of response to stimulus GO:0048585 258 0.028
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.028
positive regulation of transcription dna templated GO:0045893 266 0.028
regionalization GO:0003002 416 0.027
positive regulation of rna metabolic process GO:0051254 271 0.027
epithelial cell differentiation GO:0030855 322 0.027
protein complex biogenesis GO:0070271 201 0.027
response to external biotic stimulus GO:0043207 293 0.026
organic substance transport GO:0071702 257 0.026
small molecule metabolic process GO:0044281 305 0.026
positive regulation of cellular biosynthetic process GO:0031328 316 0.026
transcription from rna polymerase ii promoter GO:0006366 368 0.026
negative regulation of cellular metabolic process GO:0031324 382 0.026
positive regulation of rna biosynthetic process GO:1902680 266 0.026
regulation of cell differentiation GO:0045595 302 0.025
peptidyl amino acid modification GO:0018193 105 0.025
negative regulation of gene expression GO:0010629 387 0.025
locomotory behavior GO:0007626 176 0.024
growth GO:0040007 359 0.024
forebrain development GO:0030900 2 0.024
intracellular transport GO:0046907 228 0.024
imaginal disc derived wing morphogenesis GO:0007476 337 0.024
cytoskeleton dependent intracellular transport GO:0030705 44 0.024
developmental growth GO:0048589 280 0.024
response to biotic stimulus GO:0009607 294 0.024
carboxylic acid metabolic process GO:0019752 92 0.024
regulation of localization GO:0032879 275 0.024
muscle structure development GO:0061061 224 0.024
positive regulation of gene expression GO:0010628 290 0.024
regulation of phosphate metabolic process GO:0019220 210 0.023
death GO:0016265 284 0.023
compound eye development GO:0048749 307 0.023
regulation of developmental growth GO:0048638 174 0.023
vesicle mediated transport GO:0016192 381 0.023
organelle localization GO:0051640 148 0.023
regulation of cell development GO:0060284 215 0.023
positive regulation of nucleic acid templated transcription GO:1903508 266 0.023
tube development GO:0035295 244 0.022
tube morphogenesis GO:0035239 191 0.022
wing disc morphogenesis GO:0007472 344 0.022
eye development GO:0001654 323 0.022
embryonic development via the syncytial blastoderm GO:0001700 148 0.022
immune response GO:0006955 246 0.022
response to other organism GO:0051707 293 0.022
immune system process GO:0002376 347 0.022
positive regulation of response to stimulus GO:0048584 323 0.021
oxoacid metabolic process GO:0043436 103 0.021
post embryonic appendage morphogenesis GO:0035120 385 0.021
mating behavior GO:0007617 106 0.021
regulation of growth GO:0040008 233 0.021
phosphorylation GO:0016310 294 0.021
morphogenesis of an epithelium GO:0002009 276 0.021
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.021
single organism biosynthetic process GO:0044711 206 0.021
sensory organ morphogenesis GO:0090596 260 0.021
defense response GO:0006952 300 0.021
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.020
appendage morphogenesis GO:0035107 397 0.020
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.020
negative regulation of multicellular organismal process GO:0051241 142 0.020
programmed cell death GO:0012501 257 0.020
single organism intracellular transport GO:1902582 207 0.020
organic substance catabolic process GO:1901575 308 0.020
cellular response to dna damage stimulus GO:0006974 223 0.020
embryonic morphogenesis GO:0048598 206 0.020
cell death GO:0008219 279 0.020
respiratory system development GO:0060541 213 0.020
camera type eye development GO:0043010 4 0.020
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.020
imaginal disc derived appendage morphogenesis GO:0035114 395 0.020
localization of cell GO:0051674 257 0.020
cell division GO:0051301 248 0.019
negative regulation of nucleic acid templated transcription GO:1903507 240 0.019
homeostatic process GO:0042592 199 0.019
organic acid metabolic process GO:0006082 103 0.019
eye morphogenesis GO:0048592 260 0.019
appendage development GO:0048736 401 0.019
regulation of multicellular organismal development GO:2000026 414 0.019
negative regulation of developmental process GO:0051093 201 0.019
catabolic process GO:0009056 409 0.019
response to oxygen containing compound GO:1901700 200 0.019
carbohydrate derivative metabolic process GO:1901135 217 0.019
innate immune response GO:0045087 144 0.018
negative regulation of cellular biosynthetic process GO:0031327 277 0.018
regulation of cell cycle GO:0051726 291 0.018
humoral immune response GO:0006959 117 0.018
developmental programmed cell death GO:0010623 138 0.018
regulation of phosphorus metabolic process GO:0051174 210 0.018
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.018
anatomical structure homeostasis GO:0060249 97 0.018
microtubule based transport GO:0010970 42 0.018
microtubule based movement GO:0007018 51 0.018
positive regulation of signal transduction GO:0009967 223 0.018
reproductive behavior GO:0019098 122 0.018
response to nutrient levels GO:0031667 114 0.018
single organism catabolic process GO:0044712 228 0.018
regulation of cellular ketone metabolic process GO:0010565 3 0.018
tissue death GO:0016271 102 0.018
cellular response to chemical stimulus GO:0070887 199 0.017
actin cytoskeleton organization GO:0030036 206 0.017
columnar cuboidal epithelial cell development GO:0002066 249 0.017
response to organic substance GO:0010033 284 0.017
hindbrain development GO:0030902 2 0.017
negative regulation of biosynthetic process GO:0009890 277 0.017
multi organism behavior GO:0051705 175 0.017
positive regulation of cell communication GO:0010647 250 0.017
synaptic transmission GO:0007268 288 0.017
regulation of cell cycle process GO:0010564 181 0.017
amine metabolic process GO:0009308 12 0.017
negative regulation of signaling GO:0023057 219 0.017
steroid catabolic process GO:0006706 1 0.017
regulation of response to stress GO:0080134 200 0.017
phagocytosis GO:0006909 215 0.016
cellular catabolic process GO:0044248 372 0.016
imaginal disc derived appendage development GO:0048737 399 0.016
mating GO:0007618 120 0.016
positive regulation of cellular component organization GO:0051130 156 0.016
response to organic cyclic compound GO:0014070 89 0.016
protein localization GO:0008104 284 0.016
developmental maturation GO:0021700 172 0.016
cell proliferation GO:0008283 299 0.016
epithelial cell development GO:0002064 274 0.016
negative regulation of rna biosynthetic process GO:1902679 240 0.016
response to temperature stimulus GO:0009266 106 0.016
somatic muscle development GO:0007525 66 0.016
multi organism reproductive behavior GO:0044705 121 0.016
response to nitrogen compound GO:1901698 90 0.016
taxis GO:0042330 304 0.016
nucleobase containing small molecule metabolic process GO:0055086 174 0.016
response to radiation GO:0009314 155 0.016
courtship behavior GO:0007619 68 0.016
regulation of immune response GO:0050776 118 0.016
chromosome organization GO:0051276 360 0.016
compound eye morphogenesis GO:0001745 249 0.016
positive regulation of signaling GO:0023056 243 0.016
cellular amino acid metabolic process GO:0006520 61 0.016
regulation of nervous system development GO:0051960 248 0.016
negative regulation of growth GO:0045926 84 0.016
telencephalon development GO:0021537 2 0.016
ribonucleotide metabolic process GO:0009259 145 0.015
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.015
regulation of protein metabolic process GO:0051246 256 0.015
dorsal ventral pattern formation GO:0009953 133 0.015
organophosphate metabolic process GO:0019637 195 0.015
detection of external stimulus GO:0009581 66 0.015
muscle organ development GO:0007517 127 0.015
negative regulation of cell communication GO:0010648 223 0.015
regulation of cellular amine metabolic process GO:0033238 3 0.015
regulation of molecular function GO:0065009 217 0.015
organonitrogen compound biosynthetic process GO:1901566 117 0.015
regulation of immune system process GO:0002682 176 0.015
intracellular signal transduction GO:0035556 300 0.015
regulation of gene expression epigenetic GO:0040029 128 0.015
dendrite development GO:0016358 204 0.015
gene silencing GO:0016458 138 0.015
regulation of cellular protein metabolic process GO:0032268 243 0.015
response to bacterium GO:0009617 198 0.015
multicellular organismal reproductive behavior GO:0033057 110 0.015
embryo development ending in birth or egg hatching GO:0009792 152 0.015
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.015
dendrite morphogenesis GO:0048813 199 0.015
regulation of cellular amino acid metabolic process GO:0006521 0 0.015
nuclear division GO:0000280 332 0.015
response to monosaccharide GO:0034284 4 0.015
response to wounding GO:0009611 94 0.015
negative regulation of rna metabolic process GO:0051253 251 0.015
antimicrobial humoral response GO:0019730 99 0.015
sensory perception of pain GO:0019233 4 0.015
spindle organization GO:0007051 253 0.015
segmentation GO:0035282 207 0.015
regulation of transport GO:0051049 181 0.015
histolysis GO:0007559 102 0.015
endocytosis GO:0006897 310 0.015
actin filament based process GO:0030029 220 0.015
nucleotide metabolic process GO:0009117 161 0.015
nephron development GO:0072006 3 0.015
regulation of phosphorylation GO:0042325 147 0.014
mitotic nuclear division GO:0007067 213 0.014
response to light stimulus GO:0009416 124 0.014
regulation of anatomical structure size GO:0090066 163 0.014
negative regulation of transcription dna templated GO:0045892 237 0.014
regulation of organelle organization GO:0033043 196 0.014
ion transmembrane transport GO:0034220 122 0.014
axis specification GO:0009798 167 0.014
negative regulation of signal transduction GO:0009968 206 0.014
response to hexose GO:0009746 3 0.014
cell motility GO:0048870 251 0.014
organelle fission GO:0048285 340 0.014
regulation of cell death GO:0010941 173 0.014
cell migration GO:0016477 238 0.014
cation transport GO:0006812 110 0.014
digestive system development GO:0055123 149 0.014
multi multicellular organism process GO:0044706 123 0.014
blastoderm segmentation GO:0007350 159 0.014
ovarian follicle cell development GO:0030707 248 0.014
regulation of multi organism process GO:0043900 131 0.014
digestive tract development GO:0048565 149 0.014
anterior posterior pattern specification GO:0009952 136 0.014
open tracheal system development GO:0007424 204 0.014
organelle assembly GO:0070925 198 0.014
regulation of catalytic activity GO:0050790 185 0.014
regulation of cellular component biogenesis GO:0044087 201 0.014
cellular component assembly involved in morphogenesis GO:0010927 151 0.014
posttranscriptional regulation of gene expression GO:0010608 145 0.014
chorion containing eggshell formation GO:0007304 105 0.013
salivary gland histolysis GO:0035070 88 0.013
male gamete generation GO:0048232 201 0.013
eggshell formation GO:0030703 105 0.013
regulation of cell morphogenesis GO:0022604 163 0.013
response to endogenous stimulus GO:0009719 119 0.013
regulation of mitotic cell cycle GO:0007346 190 0.013
response to organophosphorus GO:0046683 2 0.013
regulation of synapse structure and activity GO:0050803 128 0.013
cellular macromolecule localization GO:0070727 220 0.013
nucleoside phosphate metabolic process GO:0006753 162 0.013
negative regulation of cell differentiation GO:0045596 143 0.013
positive regulation of molecular function GO:0044093 136 0.013
response to extracellular stimulus GO:0009991 116 0.013
wound healing GO:0042060 75 0.013
hindgut morphogenesis GO:0007442 58 0.013
regulation of anatomical structure morphogenesis GO:0022603 242 0.013
cellular amine metabolic process GO:0044106 12 0.013
transmembrane transport GO:0055085 139 0.013
autophagic cell death GO:0048102 83 0.013
retina development in camera type eye GO:0060041 4 0.013
chemosensory behavior GO:0007635 106 0.013
macromolecule catabolic process GO:0009057 161 0.013
feeding behavior GO:0007631 50 0.013
male courtship behavior GO:0008049 63 0.013
cellular response to oxygen containing compound GO:1901701 79 0.013
central nervous system development GO:0007417 201 0.013
chemotaxis GO:0006935 249 0.013
enzyme linked receptor protein signaling pathway GO:0007167 179 0.013
kidney development GO:0001822 3 0.013
regulation of notch signaling pathway GO:0008593 100 0.013
regulation of response to external stimulus GO:0032101 115 0.013
epiboly GO:0090504 2 0.012
digestive tract morphogenesis GO:0048546 127 0.012
positive regulation of phosphorus metabolic process GO:0010562 139 0.012
regulation of intracellular signal transduction GO:1902531 236 0.012
behavioral response to pain GO:0048266 3 0.012
endomembrane system organization GO:0010256 119 0.012
negative regulation of cell cycle process GO:0010948 109 0.012
camera type eye morphogenesis GO:0048593 2 0.012
organ growth GO:0035265 56 0.012
positive regulation of multicellular organismal process GO:0051240 143 0.012
connective tissue development GO:0061448 3 0.012
negative regulation of developmental growth GO:0048640 64 0.012
photoreceptor cell differentiation GO:0046530 170 0.012
detection of abiotic stimulus GO:0009582 66 0.012
neuron projection guidance GO:0097485 241 0.012
salivary gland cell autophagic cell death GO:0035071 83 0.012
ion transport GO:0006811 145 0.012
cell maturation GO:0048469 144 0.012
eye photoreceptor cell differentiation GO:0001754 145 0.012
multicellular organismal aging GO:0010259 140 0.012
cellular protein localization GO:0034613 160 0.012
cellular ketone metabolic process GO:0042180 24 0.012
purine ribonucleotide metabolic process GO:0009150 145 0.012
defense response to gram negative bacterium GO:0050829 94 0.012
cell growth GO:0016049 108 0.012
regulation of organ growth GO:0046620 42 0.012
proteolysis GO:0006508 192 0.012
regulation of catabolic process GO:0009894 170 0.012
notch signaling pathway GO:0007219 120 0.012
chaeta development GO:0022416 97 0.012
chromatin silencing GO:0006342 76 0.012
anterior posterior axis specification embryo GO:0008595 103 0.012
positive regulation of phosphate metabolic process GO:0045937 139 0.012
positive regulation of intracellular signal transduction GO:1902533 116 0.012
axonogenesis GO:0007409 290 0.012
embryonic axis specification GO:0000578 107 0.012
actin filament organization GO:0007015 126 0.012
purine containing compound metabolic process GO:0072521 155 0.011
rna localization GO:0006403 115 0.011
establishment of protein localization GO:0045184 163 0.011
defense response to bacterium GO:0042742 178 0.011
inorganic ion transmembrane transport GO:0098660 73 0.011
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.011
chromatin modification GO:0016568 147 0.011
cellular response to molecule of bacterial origin GO:0071219 3 0.011
vitamin metabolic process GO:0006766 2 0.011
epiboly involved in wound healing GO:0090505 2 0.011
response to pain GO:0048265 3 0.011
secretion by cell GO:0032940 101 0.011
oocyte differentiation GO:0009994 145 0.011
regulation of behavior GO:0050795 75 0.011
ribose phosphate metabolic process GO:0019693 145 0.011
spermatogenesis GO:0007283 200 0.011
negative regulation of gene expression epigenetic GO:0045814 77 0.011
water homeostasis GO:0030104 3 0.011
purine nucleotide metabolic process GO:0006163 146 0.011
aromatic compound catabolic process GO:0019439 166 0.011
chemical homeostasis GO:0048878 92 0.011
dna metabolic process GO:0006259 227 0.011
mitotic spindle organization GO:0007052 220 0.011
regulation of gene silencing GO:0060968 63 0.011
establishment or maintenance of cell polarity GO:0007163 167 0.011
dna integrity checkpoint GO:0031570 81 0.011
regulation of epithelial cell differentiation GO:0030856 4 0.011
organic cyclic compound catabolic process GO:1901361 168 0.011
cellular response to organic substance GO:0071310 132 0.011
spinal cord development GO:0021510 1 0.011
response to alcohol GO:0097305 95 0.011
regulation of neuron differentiation GO:0045664 103 0.011
benzene containing compound metabolic process GO:0042537 3 0.011
mitotic cell cycle checkpoint GO:0007093 88 0.011
stem cell differentiation GO:0048863 117 0.011
regulation of cellular component size GO:0032535 98 0.010
determination of adult lifespan GO:0008340 137 0.010
chromatin organization GO:0006325 207 0.010
pigment metabolic process GO:0042440 84 0.010
regulation of response to biotic stimulus GO:0002831 63 0.010
imaginal disc pattern formation GO:0007447 91 0.010
cell cycle phase transition GO:0044770 140 0.010
cellular homeostasis GO:0019725 80 0.010
sensory perception of mechanical stimulus GO:0050954 72 0.010
embryonic pattern specification GO:0009880 174 0.010
regulation of defense response GO:0031347 102 0.010
chromosome segregation GO:0007059 157 0.010
mesenchymal cell differentiation GO:0048762 1 0.010
dorsal ventral axis specification GO:0009950 66 0.010
regulation of mitotic cell cycle phase transition GO:1901990 130 0.010
cellular macromolecular complex assembly GO:0034622 153 0.010
hematopoietic progenitor cell differentiation GO:0002244 1 0.010
cellular response to biotic stimulus GO:0071216 4 0.010
cell adhesion GO:0007155 136 0.010
rhythmic behavior GO:0007622 76 0.010
response to heat GO:0009408 63 0.010
rna processing GO:0006396 147 0.010
cellular response to lipopolysaccharide GO:0071222 3 0.010
head development GO:0060322 135 0.010
positive regulation of catalytic activity GO:0043085 118 0.010
heterocycle catabolic process GO:0046700 166 0.010
mesenchymal cell development GO:0014031 1 0.010
small gtpase mediated signal transduction GO:0007264 88 0.010
positive regulation of cell motility GO:2000147 3 0.010
monocarboxylic acid transport GO:0015718 3 0.010

bnk disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.056
disease of metabolism DOID:0014667 0 0.027
inherited metabolic disorder DOID:655 0 0.017
urinary system disease DOID:18 0 0.016
nervous system disease DOID:863 0 0.014
renal tubular transport disease DOID:447 0 0.014
kidney disease DOID:557 0 0.014
respiratory system disease DOID:1579 0 0.014
acquired metabolic disease DOID:0060158 0 0.013
musculoskeletal system disease DOID:17 0 0.011
liddle syndrome DOID:0050477 0 0.010
cardiovascular system disease DOID:1287 0 0.010