Drosophila melanogaster

12 known processes

Toll-4 (Dmel_CG18241)

CG18241 gene product from transcript CG18241-RA

(Aliases: dToll4,CT29238,Tl-4,dTLR4,TL4,Dmel\CG18241,toll,CG18241)

Toll-4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
neurological system process GO:0050877 358 0.059
epithelial cell differentiation GO:0030855 322 0.049
detection of stimulus GO:0051606 156 0.045
positive regulation of rna biosynthetic process GO:1902680 266 0.040
response to external biotic stimulus GO:0043207 293 0.038
Fly
detection of stimulus involved in sensory perception GO:0050906 92 0.038
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.038
response to other organism GO:0051707 293 0.037
Fly
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.037
Fly
epithelial cell development GO:0002064 274 0.037
positive regulation of nucleic acid templated transcription GO:1903508 266 0.037
transcription from rna polymerase ii promoter GO:0006366 368 0.037
positive regulation of rna metabolic process GO:0051254 271 0.036
small molecule metabolic process GO:0044281 305 0.036
appendage development GO:0048736 401 0.035
imaginal disc derived appendage development GO:0048737 399 0.034
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.034
sensory perception of smell GO:0007608 80 0.034
wing disc morphogenesis GO:0007472 344 0.034
imaginal disc derived appendage morphogenesis GO:0035114 395 0.034
positive regulation of biosynthetic process GO:0009891 316 0.034
Fly
organic substance transport GO:0071702 257 0.033
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.033
establishment of localization in cell GO:0051649 402 0.033
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.032
positive regulation of macromolecule metabolic process GO:0010604 405 0.032
post embryonic appendage morphogenesis GO:0035120 385 0.032
positive regulation of cellular biosynthetic process GO:0031328 316 0.031
Fly
single organism behavior GO:0044708 391 0.031
appendage morphogenesis GO:0035107 397 0.031
negative regulation of rna metabolic process GO:0051253 251 0.031
imaginal disc derived wing morphogenesis GO:0007476 337 0.031
cellular protein modification process GO:0006464 438 0.031
positive regulation of transcription dna templated GO:0045893 266 0.031
organonitrogen compound metabolic process GO:1901564 318 0.031
Fly
sensory perception of chemical stimulus GO:0007606 116 0.031
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.030
detection of chemical stimulus involved in sensory perception of smell GO:0050911 50 0.029
sensory perception GO:0007600 196 0.029
compound eye development GO:0048749 307 0.029
positive regulation of gene expression GO:0010628 290 0.028
negative regulation of cellular metabolic process GO:0031324 382 0.028
regulation of cell cycle GO:0051726 291 0.028
detection of chemical stimulus GO:0009593 93 0.027
response to biotic stimulus GO:0009607 294 0.027
Fly
forebrain development GO:0030900 2 0.027
response to oxygen containing compound GO:1901700 200 0.027
organelle fission GO:0048285 340 0.027
single organism biosynthetic process GO:0044711 206 0.026
regulation of localization GO:0032879 275 0.026
catabolic process GO:0009056 409 0.026
protein modification process GO:0036211 438 0.026
negative regulation of rna biosynthetic process GO:1902679 240 0.026
response to abiotic stimulus GO:0009628 341 0.025
organic substance catabolic process GO:1901575 308 0.025
negative regulation of gene expression GO:0010629 387 0.025
nuclear division GO:0000280 332 0.025
detection of chemical stimulus involved in sensory perception GO:0050907 75 0.025
cellular amine metabolic process GO:0044106 12 0.024
cell death GO:0008219 279 0.024
columnar cuboidal epithelial cell development GO:0002066 249 0.024
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.024
negative regulation of biosynthetic process GO:0009890 277 0.024
regulation of cell cycle process GO:0010564 181 0.023
death GO:0016265 284 0.023
body morphogenesis GO:0010171 2 0.023
g protein coupled receptor signaling pathway GO:0007186 136 0.023
positive regulation of response to stimulus GO:0048584 323 0.023
Fly
ovarian follicle cell development GO:0030707 248 0.023
endocytosis GO:0006897 310 0.022
cell motility GO:0048870 251 0.022
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.022
positive regulation of cell communication GO:0010647 250 0.022
morphogenesis of an epithelium GO:0002009 276 0.022
gland development GO:0048732 191 0.022
negative regulation of nucleic acid templated transcription GO:1903507 240 0.022
cellular catabolic process GO:0044248 372 0.022
negative regulation of response to stimulus GO:0048585 258 0.022
dendrite development GO:0016358 204 0.021
regulation of multicellular organismal development GO:2000026 414 0.021
response to lipopolysaccharide GO:0032496 4 0.021
eye morphogenesis GO:0048592 260 0.021
eye development GO:0001654 323 0.021
intracellular signal transduction GO:0035556 300 0.021
growth GO:0040007 359 0.021
developmental growth GO:0048589 280 0.021
localization of cell GO:0051674 257 0.021
positive regulation of signaling GO:0023056 243 0.021
defense response GO:0006952 300 0.020
Fly
regulation of cellular amine metabolic process GO:0033238 3 0.020
cell division GO:0051301 248 0.020
negative regulation of signal transduction GO:0009968 206 0.020
negative regulation of cell communication GO:0010648 223 0.020
response to bacterium GO:0009617 198 0.020
regulation of protein metabolic process GO:0051246 256 0.020
response to organic substance GO:0010033 284 0.020
embryonic morphogenesis GO:0048598 206 0.020
amine metabolic process GO:0009308 12 0.020
chromosome organization GO:0051276 360 0.020
programmed cell death GO:0012501 257 0.020
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.020
cellular amino acid metabolic process GO:0006520 61 0.019
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.019
regulation of mitotic cell cycle GO:0007346 190 0.019
camera type eye development GO:0043010 4 0.019
organic acid metabolic process GO:0006082 103 0.019
organic hydroxy compound metabolic process GO:1901615 83 0.019
carboxylic acid metabolic process GO:0019752 92 0.019
ameboidal type cell migration GO:0001667 151 0.019
regionalization GO:0003002 416 0.019
regulation of molecular function GO:0065009 217 0.019
negative regulation of cellular biosynthetic process GO:0031327 277 0.019
oxoacid metabolic process GO:0043436 103 0.019
cell proliferation GO:0008283 299 0.019
organophosphate metabolic process GO:0019637 195 0.019
carbohydrate derivative metabolic process GO:1901135 217 0.018
tissue morphogenesis GO:0048729 297 0.018
kidney development GO:0001822 3 0.018
olfactory behavior GO:0042048 97 0.018
regulation of organelle organization GO:0033043 196 0.018
vesicle mediated transport GO:0016192 381 0.018
mitotic nuclear division GO:0007067 213 0.018
spindle organization GO:0007051 253 0.018
dendrite morphogenesis GO:0048813 199 0.018
negative regulation of transcription dna templated GO:0045892 237 0.018
response to radiation GO:0009314 155 0.018
protein localization GO:0008104 284 0.018
homeostatic process GO:0042592 199 0.018
developmental programmed cell death GO:0010623 138 0.018
negative regulation of developmental process GO:0051093 201 0.018
response to light stimulus GO:0009416 124 0.017
regulation of catalytic activity GO:0050790 185 0.017
eggshell formation GO:0030703 105 0.017
macromolecular complex assembly GO:0065003 256 0.017
phosphorylation GO:0016310 294 0.017
intracellular transport GO:0046907 228 0.017
negative regulation of signaling GO:0023057 219 0.017
sensory organ morphogenesis GO:0090596 260 0.017
salivary gland development GO:0007431 162 0.017
embryonic development via the syncytial blastoderm GO:0001700 148 0.017
positive regulation of signal transduction GO:0009967 223 0.017
regulation of transport GO:0051049 181 0.017
single organism intracellular transport GO:1902582 207 0.017
telencephalon development GO:0021537 2 0.016
respiratory system development GO:0060541 213 0.016
positive regulation of transport GO:0051050 92 0.016
phagocytosis GO:0006909 215 0.016
exocrine system development GO:0035272 162 0.016
regulation of intracellular signal transduction GO:1902531 236 0.016
regulation of anatomical structure size GO:0090066 163 0.016
immune system process GO:0002376 347 0.016
Fly
chemosensory behavior GO:0007635 106 0.016
ion transmembrane transport GO:0034220 122 0.016
cell cell signaling involved in cell fate commitment GO:0045168 210 0.016
cellular response to chemical stimulus GO:0070887 199 0.016
salivary gland morphogenesis GO:0007435 145 0.016
cellular macromolecule localization GO:0070727 220 0.016
compound eye morphogenesis GO:0001745 249 0.016
positive regulation of cell migration GO:0030335 2 0.016
actin filament organization GO:0007015 126 0.016
defense response to bacterium GO:0042742 178 0.016
mating GO:0007618 120 0.016
cellular component assembly involved in morphogenesis GO:0010927 151 0.016
eye photoreceptor cell differentiation GO:0001754 145 0.016
taxis GO:0042330 304 0.015
monocarboxylic acid transport GO:0015718 3 0.015
protein complex assembly GO:0006461 200 0.015
regulation of cellular ketone metabolic process GO:0010565 3 0.015
regulation of cellular protein metabolic process GO:0032268 243 0.015
regulation of cellular component biogenesis GO:0044087 201 0.015
multi multicellular organism process GO:0044706 123 0.015
cell migration GO:0016477 238 0.015
chemotaxis GO:0006935 249 0.015
axon development GO:0061564 297 0.015
nucleobase containing small molecule metabolic process GO:0055086 174 0.015
cellular ketone metabolic process GO:0042180 24 0.015
hindbrain development GO:0030902 2 0.015
embryo development ending in birth or egg hatching GO:0009792 152 0.015
positive regulation of intracellular signal transduction GO:1902533 116 0.014
lipid metabolic process GO:0006629 121 0.014
regulation of cell differentiation GO:0045595 302 0.014
proteolysis GO:0006508 192 0.014
regulation of phosphorus metabolic process GO:0051174 210 0.014
cellular response to dna damage stimulus GO:0006974 223 0.014
signal transduction by phosphorylation GO:0023014 107 0.014
single organism catabolic process GO:0044712 228 0.014
transmembrane transport GO:0055085 139 0.014
defense response to other organism GO:0098542 225 0.014
nucleotide metabolic process GO:0009117 161 0.014
regulation of nervous system development GO:0051960 248 0.014
open tracheal system development GO:0007424 204 0.014
connective tissue development GO:0061448 3 0.014
locomotory behavior GO:0007626 176 0.014
protein heterooligomerization GO:0051291 4 0.014
central nervous system development GO:0007417 201 0.014
multi organism behavior GO:0051705 175 0.014
Fly
photoreceptor cell differentiation GO:0046530 170 0.014
regulation of cellular localization GO:0060341 136 0.014
actin filament based process GO:0030029 220 0.014
response to organophosphorus GO:0046683 2 0.014
gland morphogenesis GO:0022612 145 0.014
mitotic spindle organization GO:0007052 220 0.014
positive regulation of cell motility GO:2000147 3 0.014
cellular response to organic substance GO:0071310 132 0.014
regulation of growth GO:0040008 233 0.013
retina development in camera type eye GO:0060041 4 0.013
nucleoside phosphate metabolic process GO:0006753 162 0.013
axon guidance GO:0007411 233 0.013
gene silencing GO:0016458 138 0.013
purine containing compound metabolic process GO:0072521 155 0.013
positive regulation of multicellular organismal process GO:0051240 143 0.013
dna metabolic process GO:0006259 227 0.013
developmental maturation GO:0021700 172 0.013
ethanolamine containing compound metabolic process GO:0042439 4 0.013
immune response activating signal transduction GO:0002757 2 0.013
tube morphogenesis GO:0035239 191 0.013
establishment of protein localization GO:0045184 163 0.013
apoptotic process GO:0006915 159 0.013
biological adhesion GO:0022610 138 0.013
response to endogenous stimulus GO:0009719 119 0.013
synaptic transmission GO:0007268 288 0.013
pigmentation GO:0043473 75 0.013
protein transport GO:0015031 155 0.013
tissue death GO:0016271 102 0.013
segmentation GO:0035282 207 0.013
mapk cascade GO:0000165 107 0.013
neuron recognition GO:0008038 101 0.013
regulation of cell proliferation GO:0042127 163 0.013
cellular response to molecule of bacterial origin GO:0071219 3 0.013
negative regulation of nervous system development GO:0051961 92 0.013
regulation of phosphate metabolic process GO:0019220 210 0.013
protein complex biogenesis GO:0070271 201 0.012
autophagic cell death GO:0048102 83 0.012
wnt signaling pathway GO:0016055 98 0.012
salivary gland histolysis GO:0035070 88 0.012
anatomical structure homeostasis GO:0060249 97 0.012
response to alcohol GO:0097305 95 0.012
regulation of mapk cascade GO:0043408 92 0.012
spermatogenesis GO:0007283 200 0.012
chromatin organization GO:0006325 207 0.012
embryonic pattern specification GO:0009880 174 0.012
regulation of developmental growth GO:0048638 174 0.012
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.012
negative regulation of cellular component organization GO:0051129 108 0.012
compound eye photoreceptor cell differentiation GO:0001751 140 0.012
photoreceptor cell development GO:0042461 96 0.012
sterol homeostasis GO:0055092 4 0.012
positive regulation of cellular component organization GO:0051130 156 0.012
positive regulation of catalytic activity GO:0043085 118 0.012
regulation of programmed cell death GO:0043067 152 0.012
adult locomotory behavior GO:0008344 76 0.012
carbohydrate derivative biosynthetic process GO:1901137 85 0.012
tube development GO:0035295 244 0.012
negative regulation of multicellular organismal process GO:0051241 142 0.012
regulation of cell death GO:0010941 173 0.012
actin cytoskeleton organization GO:0030036 206 0.012
regulation of immune system process GO:0002682 176 0.012
Fly
ribonucleotide metabolic process GO:0009259 145 0.012
endomembrane system organization GO:0010256 119 0.012
positive regulation of molecular function GO:0044093 136 0.012
secretion GO:0046903 109 0.012
neuron projection guidance GO:0097485 241 0.012
chromosome segregation GO:0007059 157 0.012
cellular protein localization GO:0034613 160 0.012
axonogenesis GO:0007409 290 0.012
regulation of lipid transport GO:0032368 3 0.012
regulation of anatomical structure morphogenesis GO:0022603 242 0.012
cellular response to lipopolysaccharide GO:0071222 3 0.012
adult behavior GO:0030534 137 0.012
organonitrogen compound biosynthetic process GO:1901566 117 0.012
Fly
regulation of cellular amino acid metabolic process GO:0006521 0 0.011
salivary gland cell autophagic cell death GO:0035071 83 0.011
purine nucleotide metabolic process GO:0006163 146 0.011
chorion containing eggshell formation GO:0007304 105 0.011
immune response regulating signaling pathway GO:0002764 2 0.011
positive regulation of phosphorus metabolic process GO:0010562 139 0.011
positive regulation of protein metabolic process GO:0051247 128 0.011
mesenchymal cell differentiation GO:0048762 1 0.011
cognition GO:0050890 141 0.011
chromatin modification GO:0016568 147 0.011
positive regulation of cellular amine metabolic process GO:0033240 0 0.011
regulation of response to stress GO:0080134 200 0.011
lateral inhibition GO:0046331 206 0.011
regulation of cell morphogenesis GO:0022604 163 0.011
cellular response to carbohydrate stimulus GO:0071322 4 0.011
memory GO:0007613 94 0.011
organonitrogen compound catabolic process GO:1901565 128 0.011
enzyme linked receptor protein signaling pathway GO:0007167 179 0.011
cellular response to biotic stimulus GO:0071216 4 0.011
notch signaling pathway GO:0007219 120 0.011
regulation of hormone levels GO:0010817 40 0.011
regulation of mitosis GO:0007088 56 0.011
organelle assembly GO:0070925 198 0.011
cell fate determination GO:0001709 91 0.011
cellular homeostasis GO:0019725 80 0.011
leg disc development GO:0035218 92 0.011
secretion by cell GO:0032940 101 0.011
digestive tract development GO:0048565 149 0.011
cytoplasmic transport GO:0016482 130 0.011
rna processing GO:0006396 147 0.011
maintenance of location GO:0051235 73 0.011
neuropeptide signaling pathway GO:0007218 45 0.011
mesenchymal cell development GO:0014031 1 0.011
hematopoietic progenitor cell differentiation GO:0002244 1 0.011
macromolecule catabolic process GO:0009057 161 0.011
establishment or maintenance of cell polarity GO:0007163 167 0.011
regulation of mitotic cell cycle phase transition GO:1901990 130 0.011
negative regulation of cell cycle GO:0045786 116 0.011
cell recognition GO:0008037 102 0.011
blastoderm segmentation GO:0007350 159 0.011
synapse organization GO:0050808 196 0.011
regulation of gene expression epigenetic GO:0040029 128 0.011
negative regulation of mitotic cell cycle GO:0045930 109 0.011
regulation of cell development GO:0060284 215 0.011
brain development GO:0007420 120 0.011
regulation of cell shape GO:0008360 113 0.011
negative regulation of cell cycle process GO:0010948 109 0.011
organic cyclic compound catabolic process GO:1901361 168 0.011
regulation of notch signaling pathway GO:0008593 100 0.011
cell adhesion GO:0007155 136 0.011
negative regulation of cell differentiation GO:0045596 143 0.011
response to nitrogen compound GO:1901698 90 0.011
mitotic cell cycle phase transition GO:0044772 138 0.011
protein phosphorylation GO:0006468 169 0.010
positive regulation of phosphorylation GO:0042327 87 0.010
regulation of behavior GO:0050795 75 0.010
lipid localization GO:0010876 54 0.010
nephron development GO:0072006 3 0.010
regulation of epithelial cell differentiation GO:0030856 4 0.010
immune response GO:0006955 246 0.010
Fly
chemical homeostasis GO:0048878 92 0.010
epithelial cell migration GO:0010631 148 0.010
camera type eye morphogenesis GO:0048593 2 0.010
positive regulation of phosphate metabolic process GO:0045937 139 0.010
positive regulation of cellular component biogenesis GO:0044089 80 0.010
cholesterol transport GO:0030301 2 0.010
tissue migration GO:0090130 155 0.010
aromatic compound catabolic process GO:0019439 166 0.010
cholesterol homeostasis GO:0042632 3 0.010
regulation of gene silencing GO:0060968 63 0.010
hormone catabolic process GO:0042447 3 0.010
ribose phosphate metabolic process GO:0019693 145 0.010
digestive system development GO:0055123 149 0.010
regulation of hydrolase activity GO:0051336 97 0.010
negative regulation of cell cycle phase transition GO:1901988 103 0.010
regulation of phosphorylation GO:0042325 147 0.010
spinal cord development GO:0021510 1 0.010
heterocycle catabolic process GO:0046700 166 0.010

Toll-4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.052
nervous system disease DOID:863 0 0.018
disease of metabolism DOID:0014667 0 0.017
musculoskeletal system disease DOID:17 0 0.016
inherited metabolic disorder DOID:655 0 0.012
acquired metabolic disease DOID:0060158 0 0.012
connective tissue disease DOID:65 0 0.011
bone disease DOID:0080001 0 0.010