Drosophila melanogaster

132 known processes

Bub1 (Dmel_CG14030)

Bub1 homologue

(Aliases: BUB1,BubRI,CG14030,BubR1,BUB1-like,Dmel\CG14030,CG14030/Bub1,bub1)

Bub1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of gene expression epigenetic GO:0040029 128 0.193
protein modification process GO:0036211 438 0.158
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.144
transcription from rna polymerase ii promoter GO:0006366 368 0.118
negative regulation of signaling GO:0023057 219 0.113
negative regulation of cellular metabolic process GO:0031324 382 0.107
macromolecular complex assembly GO:0065003 256 0.096
negative regulation of rna metabolic process GO:0051253 251 0.080
protein complex assembly GO:0006461 200 0.078
regulation of intracellular signal transduction GO:1902531 236 0.074
Mouse
regulation of programmed cell death GO:0043067 152 0.071
Mouse
apoptotic process GO:0006915 159 0.069
Mouse Worm
growth GO:0040007 359 0.063
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.062
single organism behavior GO:0044708 391 0.059
negative regulation of signal transduction GO:0009968 206 0.057
neurological system process GO:0050877 358 0.053
chromatin modification GO:0016568 147 0.051
regulation of cellular ketone metabolic process GO:0010565 3 0.050
protein catabolic process GO:0030163 101 0.047
positive regulation of cellular component organization GO:0051130 156 0.047
regulation of localization GO:0032879 275 0.044
regulation of ras protein signal transduction GO:0046578 93 0.044
positive regulation of multicellular organismal process GO:0051240 143 0.042
regulation of cellular localization GO:0060341 136 0.042
oxoacid metabolic process GO:0043436 103 0.042
chromatin silencing GO:0006342 76 0.041
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.040
positive regulation of developmental process GO:0051094 143 0.040
regulation of cell differentiation GO:0045595 302 0.039
positive regulation of cell death GO:0010942 69 0.039
Mouse
regulation of protein localization GO:0032880 76 0.039
cell death GO:0008219 279 0.039
Mouse Worm
morphogenesis of an epithelium GO:0002009 276 0.039
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.038
negative regulation of nucleic acid templated transcription GO:1903507 240 0.038
cellular protein modification process GO:0006464 438 0.037
regulation of cellular amino acid metabolic process GO:0006521 0 0.037
regulation of protein transport GO:0051223 57 0.037
positive regulation of biosynthetic process GO:0009891 316 0.037
regulation of cellular amine metabolic process GO:0033238 3 0.037
ras protein signal transduction GO:0007265 88 0.036
regulation of neuron differentiation GO:0045664 103 0.036
regulation of multicellular organismal development GO:2000026 414 0.035
gene silencing GO:0016458 138 0.034
homeostatic process GO:0042592 199 0.034
positive regulation of proteolysis GO:0045862 52 0.033
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.033
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.033
regulation of cell death GO:0010941 173 0.033
Mouse
larval development GO:0002164 104 0.032
Worm
positive regulation of cell communication GO:0010647 250 0.032
Mouse
positive regulation of cellular amine metabolic process GO:0033240 0 0.032
localization of cell GO:0051674 257 0.031
sensory organ morphogenesis GO:0090596 260 0.030
programmed cell death GO:0012501 257 0.030
Mouse Worm
single organism catabolic process GO:0044712 228 0.029
zymogen activation GO:0031638 20 0.028
lipid metabolic process GO:0006629 121 0.028
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.028
single organism biosynthetic process GO:0044711 206 0.028
response to abiotic stimulus GO:0009628 341 0.027
regulation of establishment of protein localization GO:0070201 61 0.027
intracellular signal transduction GO:0035556 300 0.027
Mouse
carboxylic acid metabolic process GO:0019752 92 0.026
cellular amine metabolic process GO:0044106 12 0.026
negative regulation of cellular protein metabolic process GO:0032269 85 0.026
protein complex biogenesis GO:0070271 201 0.026
organonitrogen compound metabolic process GO:1901564 318 0.025
positive regulation of signaling GO:0023056 243 0.025
Mouse
organic substance catabolic process GO:1901575 308 0.025
histone modification GO:0016570 106 0.024
tissue morphogenesis GO:0048729 297 0.024
embryo development ending in birth or egg hatching GO:0009792 152 0.024
Worm
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.024
regulation of phosphate metabolic process GO:0019220 210 0.024
organonitrogen compound biosynthetic process GO:1901566 117 0.024
regulation of molecular function GO:0065009 217 0.023
cellular amino acid metabolic process GO:0006520 61 0.023
positive regulation of programmed cell death GO:0043068 62 0.023
Mouse
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.023
negative regulation of gene expression epigenetic GO:0045814 77 0.023
peptidyl lysine modification GO:0018205 57 0.023
signal transduction by phosphorylation GO:0023014 107 0.023
regulation of proteolysis GO:0030162 87 0.022
amine metabolic process GO:0009308 12 0.022
cognition GO:0050890 141 0.022
dna metabolic process GO:0006259 227 0.022
body morphogenesis GO:0010171 2 0.021
regulation of cellular component biogenesis GO:0044087 201 0.021
regulation of mapk cascade GO:0043408 92 0.021
negative regulation of developmental process GO:0051093 201 0.021
actin filament based process GO:0030029 220 0.021
mapk cascade GO:0000165 107 0.020
regulation of protein complex assembly GO:0043254 42 0.020
cellular ketone metabolic process GO:0042180 24 0.020
small molecule metabolic process GO:0044281 305 0.020
regulation of protein metabolic process GO:0051246 256 0.020
chromatin organization GO:0006325 207 0.020
negative regulation of cellular biosynthetic process GO:0031327 277 0.020
small gtpase mediated signal transduction GO:0007264 88 0.020
peptidyl amino acid modification GO:0018193 105 0.020
macromolecule catabolic process GO:0009057 161 0.019
organic acid metabolic process GO:0006082 103 0.019
maintenance of protein location in cell GO:0032507 26 0.019
appendage development GO:0048736 401 0.019
regionalization GO:0003002 416 0.019
protein phosphorylation GO:0006468 169 0.019
regulation of transport GO:0051049 181 0.019
compound eye photoreceptor cell differentiation GO:0001751 140 0.019
segmentation GO:0035282 207 0.019
humoral immune response GO:0006959 117 0.018
response to biotic stimulus GO:0009607 294 0.018
positive regulation of phosphorus metabolic process GO:0010562 139 0.018
chromatin remodeling GO:0006338 72 0.018
defense response to other organism GO:0098542 225 0.018
mitotic nuclear division GO:0007067 213 0.018
negative regulation of cell communication GO:0010648 223 0.018
negative regulation of response to stimulus GO:0048585 258 0.018
posttranscriptional gene silencing GO:0016441 46 0.018
ubiquitin dependent protein catabolic process GO:0006511 78 0.018
regulation of multi organism process GO:0043900 131 0.017
axon development GO:0061564 297 0.017
negative regulation of multicellular organismal process GO:0051241 142 0.017
regulation of cell development GO:0060284 215 0.017
learning or memory GO:0007611 141 0.017
enzyme linked receptor protein signaling pathway GO:0007167 179 0.017
response to other organism GO:0051707 293 0.017
protein modification by small protein conjugation or removal GO:0070647 106 0.017
catabolic process GO:0009056 409 0.017
embryonic pattern specification GO:0009880 174 0.017
positive regulation of nucleic acid templated transcription GO:1903508 266 0.017
positive regulation of response to stimulus GO:0048584 323 0.016
Mouse
regulation of gene silencing GO:0060968 63 0.016
cellular macromolecule catabolic process GO:0044265 136 0.016
eye photoreceptor cell differentiation GO:0001754 145 0.016
positive regulation of gene expression GO:0010628 290 0.016
camera type eye development GO:0043010 4 0.016
anterior posterior pattern specification GO:0009952 136 0.016
nuclear division GO:0000280 332 0.016
regulation of nervous system development GO:0051960 248 0.016
mitotic g2 m transition checkpoint GO:0044818 70 0.016
response to endogenous stimulus GO:0009719 119 0.015
cellular macromolecule localization GO:0070727 220 0.015
immune system process GO:0002376 347 0.015
blastoderm segmentation GO:0007350 159 0.015
response to external biotic stimulus GO:0043207 293 0.015
protein maturation GO:0051604 71 0.015
defense response GO:0006952 300 0.015
hematopoietic or lymphoid organ development GO:0048534 57 0.015
regulation of phosphorus metabolic process GO:0051174 210 0.015
phagocytosis GO:0006909 215 0.015
maintenance of location in cell GO:0051651 28 0.015
axis specification GO:0009798 167 0.015
locomotor rhythm GO:0045475 56 0.015
central nervous system development GO:0007417 201 0.015
regulation of organelle organization GO:0033043 196 0.015
endocytosis GO:0006897 310 0.015
immune response GO:0006955 246 0.015
protein localization GO:0008104 284 0.015
positive regulation of organelle organization GO:0010638 65 0.015
positive regulation of cell migration GO:0030335 2 0.015
chemical homeostasis GO:0048878 92 0.014
establishment of localization in cell GO:0051649 402 0.014
muscle system process GO:0003012 21 0.014
nucleus organization GO:0006997 45 0.014
camera type eye morphogenesis GO:0048593 2 0.014
negative regulation of erk1 and erk2 cascade GO:0070373 3 0.014
protein acylation GO:0043543 42 0.014
regulation of growth GO:0040008 233 0.014
organic cyclic compound catabolic process GO:1901361 168 0.014
microtubule organizing center organization GO:0031023 168 0.014
death GO:0016265 284 0.014
Mouse Worm
response to oxygen containing compound GO:1901700 200 0.014
negative regulation of biosynthetic process GO:0009890 277 0.014
positive regulation of apoptotic signaling pathway GO:2001235 4 0.013
Mouse
response to organic substance GO:0010033 284 0.013
protein ubiquitination GO:0016567 70 0.013
negative regulation of protein metabolic process GO:0051248 85 0.013
amide biosynthetic process GO:0043604 42 0.013
negative regulation of ras protein signal transduction GO:0046580 13 0.013
protein transport GO:0015031 155 0.013
respiratory system development GO:0060541 213 0.013
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 16 0.013
positive regulation of rna metabolic process GO:0051254 271 0.013
posttranscriptional gene silencing by rna GO:0035194 45 0.013
negative regulation of cell differentiation GO:0045596 143 0.013
rna processing GO:0006396 147 0.013
regulation of small gtpase mediated signal transduction GO:0051056 93 0.013
activation of cysteine type endopeptidase activity GO:0097202 17 0.013
chromosome organization GO:0051276 360 0.013
regulation of cell substrate adhesion GO:0010810 2 0.012
phosphorylation GO:0016310 294 0.012
covalent chromatin modification GO:0016569 106 0.012
photoreceptor cell differentiation GO:0046530 170 0.012
erk1 and erk2 cascade GO:0070371 39 0.012
cell proliferation GO:0008283 299 0.012
Rat
regulation of epithelial cell proliferation GO:0050678 4 0.012
negative regulation of rna biosynthetic process GO:1902679 240 0.012
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 54 0.012
modification dependent macromolecule catabolic process GO:0043632 79 0.012
positive regulation of phosphate metabolic process GO:0045937 139 0.012
dorsal ventral axis specification GO:0009950 66 0.012
mrna metabolic process GO:0016071 124 0.012
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.012
proteasomal protein catabolic process GO:0010498 59 0.012
proteolysis GO:0006508 192 0.012
positive regulation of cellular biosynthetic process GO:0031328 316 0.012
cell motility GO:0048870 251 0.012
positive regulation of rna biosynthetic process GO:1902680 266 0.012
actin cytoskeleton organization GO:0030036 206 0.012
regulation of mitotic cell cycle GO:0007346 190 0.012
locomotory behavior GO:0007626 176 0.012
positive regulation of cell differentiation GO:0045597 64 0.012
heart development GO:0007507 82 0.011
kidney development GO:0001822 3 0.011
cell migration GO:0016477 238 0.011
cellular macromolecular complex assembly GO:0034622 153 0.011
protein alkylation GO:0008213 43 0.011
nucleoside triphosphate metabolic process GO:0009141 120 0.011
dorsal ventral pattern formation GO:0009953 133 0.011
intracellular transport GO:0046907 228 0.011
organelle assembly GO:0070925 198 0.011
regulation of cell proliferation GO:0042127 163 0.011
regulation of phosphorylation GO:0042325 147 0.011
response to alcohol GO:0097305 95 0.011
organonitrogen compound catabolic process GO:1901565 128 0.011
retina development in camera type eye GO:0060041 4 0.011
purine ribonucleotide catabolic process GO:0009154 109 0.011
defense response to bacterium GO:0042742 178 0.011
positive regulation of protein metabolic process GO:0051247 128 0.011
cell aging GO:0007569 2 0.011
regulation of protein catabolic process GO:0042176 55 0.011
regulation of immune system process GO:0002682 176 0.011
peptide biosynthetic process GO:0043043 42 0.011
developmental maturation GO:0021700 172 0.011
positive regulation of transcription dna templated GO:0045893 266 0.011
positive regulation of protein complex assembly GO:0031334 22 0.010
regulation of cytoskeleton organization GO:0051493 89 0.010
organophosphate metabolic process GO:0019637 195 0.010
immune effector process GO:0002252 98 0.010
nucleoside triphosphate catabolic process GO:0009143 108 0.010
hematopoietic progenitor cell differentiation GO:0002244 1 0.010
heterocycle catabolic process GO:0046700 166 0.010
nucleotide metabolic process GO:0009117 161 0.010
negative regulation of cell death GO:0060548 81 0.010
open tracheal system development GO:0007424 204 0.010
positive regulation of mapk cascade GO:0043410 63 0.010
purine nucleotide metabolic process GO:0006163 146 0.010

Bub1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.016
sensory system disease DOID:0050155 0 0.016
eye and adnexa disease DOID:1492 0 0.016
nervous system disease DOID:863 0 0.016
cancer DOID:162 0 0.013
disease of cellular proliferation DOID:14566 0 0.013
organ system cancer DOID:0050686 0 0.013
eye disease DOID:5614 0 0.012