Drosophila melanogaster

41 known processes

Clic (Dmel_CG10997)

Chloride intracellular channel

(Aliases: DmCLIC,l(1)G0053,CG10997,DCLIC,Dmel\CG10997,l(1)G0472)

Clic biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
gravitaxis GO:0042332 26 0.330
wing disc morphogenesis GO:0007472 344 0.280
imaginal disc derived appendage morphogenesis GO:0035114 395 0.232
adult behavior GO:0030534 137 0.210
intracellular transport GO:0046907 228 0.187
post embryonic appendage morphogenesis GO:0035120 385 0.186
imaginal disc derived appendage development GO:0048737 399 0.145
cellular macromolecule localization GO:0070727 220 0.139
appendage development GO:0048736 401 0.121
taxis GO:0042330 304 0.117
cellular protein modification process GO:0006464 438 0.101
establishment of localization in cell GO:0051649 402 0.098
vesicle mediated transport GO:0016192 381 0.091
intracellular signal transduction GO:0035556 300 0.090
locomotory behavior GO:0007626 176 0.089
imaginal disc derived wing morphogenesis GO:0007476 337 0.085
response to abiotic stimulus GO:0009628 341 0.084
endocytosis GO:0006897 310 0.075
cellular protein localization GO:0034613 160 0.074
single organism intracellular transport GO:1902582 207 0.072
appendage morphogenesis GO:0035107 397 0.071
protein localization GO:0008104 284 0.071
Mouse
synapse organization GO:0050808 196 0.070
regulation of anatomical structure morphogenesis GO:0022603 242 0.069
dorsal closure GO:0007391 79 0.068
cuticle pigmentation GO:0048067 22 0.067
organelle assembly GO:0070925 198 0.066
tissue morphogenesis GO:0048729 297 0.066
Mouse
single organism catabolic process GO:0044712 228 0.065
actin filament based process GO:0030029 220 0.065
morphogenesis of embryonic epithelium GO:0016331 94 0.061
single organism cellular localization GO:1902580 180 0.061
synaptic transmission GO:0007268 288 0.060
cytoplasmic transport GO:0016482 130 0.059
cell projection assembly GO:0030031 94 0.058
positive regulation of phosphate metabolic process GO:0045937 139 0.058
macromolecular complex assembly GO:0065003 256 0.057
protein transport GO:0015031 155 0.056
regulation of phosphate metabolic process GO:0019220 210 0.055
regulation of phosphorus metabolic process GO:0051174 210 0.054
open tracheal system development GO:0007424 204 0.053
establishment of protein localization GO:0045184 163 0.053
respiratory system development GO:0060541 213 0.051
regulation of cell shape GO:0008360 113 0.049
cellular catabolic process GO:0044248 372 0.048
negative regulation of response to stimulus GO:0048585 258 0.047
pigmentation GO:0043473 75 0.047
organophosphate catabolic process GO:0046434 112 0.046
developmental pigmentation GO:0048066 68 0.045
adult chitin containing cuticle pigmentation GO:0048085 16 0.045
positive regulation of phosphorus metabolic process GO:0010562 139 0.044
microtubule based movement GO:0007018 51 0.044
positive regulation of response to stimulus GO:0048584 323 0.044
protein modification process GO:0036211 438 0.044
regulation of anatomical structure size GO:0090066 163 0.044
response to gravity GO:0009629 26 0.043
regulation of localization GO:0032879 275 0.042
defense response to other organism GO:0098542 225 0.042
regulation of cell morphogenesis GO:0022604 163 0.041
ribonucleoside triphosphate catabolic process GO:0009203 108 0.041
photoreceptor cell differentiation GO:0046530 170 0.040
positive regulation of cell size GO:0045793 21 0.040
adult locomotory behavior GO:0008344 76 0.040
positive regulation of signaling GO:0023056 243 0.039
ras protein signal transduction GO:0007265 88 0.038
positive regulation of cell communication GO:0010647 250 0.038
proteolysis GO:0006508 192 0.037
small gtpase mediated signal transduction GO:0007264 88 0.037
homeostatic process GO:0042592 199 0.037
Mouse
organic substance transport GO:0071702 257 0.037
cilium morphogenesis GO:0060271 39 0.037
protein complex biogenesis GO:0070271 201 0.036
immune system process GO:0002376 347 0.036
embryonic morphogenesis GO:0048598 206 0.035
Mouse
transcription from rna polymerase ii promoter GO:0006366 368 0.035
regulation of mapk cascade GO:0043408 92 0.035
response to bacterium GO:0009617 198 0.034
eye development GO:0001654 323 0.033
Mouse
organelle localization GO:0051640 148 0.033
regulation of cellular protein metabolic process GO:0032268 243 0.033
organophosphate metabolic process GO:0019637 195 0.032
nucleoside phosphate catabolic process GO:1901292 110 0.032
catabolic process GO:0009056 409 0.032
negative regulation of cell communication GO:0010648 223 0.032
regulation of catalytic activity GO:0050790 185 0.032
regulation of phosphorylation GO:0042325 147 0.032
regulation of notch signaling pathway GO:0008593 100 0.032
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.031
head development GO:0060322 135 0.031
positive regulation of phosphorylation GO:0042327 87 0.031
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.031
phagocytosis GO:0006909 215 0.031
axonogenesis GO:0007409 290 0.031
stress activated protein kinase signaling cascade GO:0031098 55 0.030
cytoskeleton dependent intracellular transport GO:0030705 44 0.030
defense response GO:0006952 300 0.029
regulation of molecular function GO:0065009 217 0.029
notch signaling pathway GO:0007219 120 0.029
chemical homeostasis GO:0048878 92 0.028
Mouse
regulation of mitotic cell cycle GO:0007346 190 0.028
heterocycle catabolic process GO:0046700 166 0.028
ribose phosphate metabolic process GO:0019693 145 0.028
epithelial cell development GO:0002064 274 0.028
Mouse
phosphorylation GO:0016310 294 0.028
regulation of growth GO:0040008 233 0.028
membrane organization GO:0061024 112 0.028
regulation of cell cycle GO:0051726 291 0.027
positive regulation of signal transduction GO:0009967 223 0.027
rho protein signal transduction GO:0007266 14 0.027
organonitrogen compound metabolic process GO:1901564 318 0.027
regulation of intracellular signal transduction GO:1902531 236 0.027
regulation of response to stress GO:0080134 200 0.027
regulation of adult chitin containing cuticle pigmentation GO:0048082 13 0.027
lateral inhibition GO:0046331 206 0.027
microtubule based transport GO:0010970 42 0.027
nucleobase containing small molecule metabolic process GO:0055086 174 0.026
cytoskeleton dependent cytokinesis GO:0061640 81 0.026
embryo development ending in birth or egg hatching GO:0009792 152 0.026
intracellular protein transport GO:0006886 104 0.026
glycosyl compound catabolic process GO:1901658 112 0.026
cation transport GO:0006812 110 0.026
purine ribonucleotide metabolic process GO:0009150 145 0.026
regulation of synapse organization GO:0050807 110 0.025
organic cyclic compound catabolic process GO:1901361 168 0.025
positive regulation of biosynthetic process GO:0009891 316 0.025
single organism behavior GO:0044708 391 0.025
positive regulation of molecular function GO:0044093 136 0.025
nucleoside phosphate metabolic process GO:0006753 162 0.025
axon guidance GO:0007411 233 0.024
biological adhesion GO:0022610 138 0.024
response to light stimulus GO:0009416 124 0.024
carbohydrate derivative metabolic process GO:1901135 217 0.024
nucleotide metabolic process GO:0009117 161 0.024
signal transduction in response to dna damage GO:0042770 3 0.023
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.023
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.023
regulation of cell development GO:0060284 215 0.023
regulation of cellular component biogenesis GO:0044087 201 0.023
regulation of protein modification process GO:0031399 112 0.022
nucleoside catabolic process GO:0009164 112 0.022
cell adhesion GO:0007155 136 0.022
cellular macromolecular complex assembly GO:0034622 153 0.022
muscle structure development GO:0061061 224 0.022
tube development GO:0035295 244 0.022
Mouse
regulation of cellular amine metabolic process GO:0033238 3 0.021
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.021
regulation of developmental growth GO:0048638 174 0.021
growth GO:0040007 359 0.021
Mouse
regionalization GO:0003002 416 0.021
single organism membrane organization GO:0044802 93 0.021
skeletal muscle fiber development GO:0048741 3 0.021
organic substance catabolic process GO:1901575 308 0.021
secretion GO:0046903 109 0.020
positive regulation of macromolecule metabolic process GO:0010604 405 0.020
nuclear transport GO:0051169 72 0.020
nucleobase containing compound catabolic process GO:0034655 165 0.020
establishment of organelle localization GO:0051656 122 0.020
neurological system process GO:0050877 358 0.020
Mouse
purine containing compound metabolic process GO:0072521 155 0.020
intracellular mrna localization involved in pattern specification process GO:0060810 56 0.020
positive regulation of transport GO:0051050 92 0.020
developmental growth GO:0048589 280 0.020
positive regulation of catalytic activity GO:0043085 118 0.020
nucleotide catabolic process GO:0009166 109 0.020
sensory perception of mechanical stimulus GO:0050954 72 0.020
Mouse
developmental maturation GO:0021700 172 0.019
programmed cell death GO:0012501 257 0.019
purine nucleoside triphosphate catabolic process GO:0009146 108 0.019
regulation of cell size GO:0008361 63 0.019
maternal determination of anterior posterior axis embryo GO:0008358 74 0.019
embryonic development via the syncytial blastoderm GO:0001700 148 0.019
embryonic pattern specification GO:0009880 174 0.019
regulation of protein metabolic process GO:0051246 256 0.019
immune response GO:0006955 246 0.019
membrane fusion GO:0061025 42 0.019
positive regulation of protein metabolic process GO:0051247 128 0.019
aromatic compound catabolic process GO:0019439 166 0.019
golgi localization GO:0051645 2 0.019
actin filament organization GO:0007015 126 0.018
morphogenesis of an epithelium GO:0002009 276 0.018
Mouse
regulation of transport GO:0051049 181 0.018
chemotaxis GO:0006935 249 0.018
regulation of cuticle pigmentation GO:0048079 16 0.018
positive regulation of mapk cascade GO:0043410 63 0.018
eggshell formation GO:0030703 105 0.018
cellular homeostasis GO:0019725 80 0.018
Mouse
dna damage checkpoint GO:0000077 78 0.018
response to nutrient levels GO:0031667 114 0.018
Mouse
regulation of organelle organization GO:0033043 196 0.018
cellular component assembly involved in morphogenesis GO:0010927 151 0.018
small molecule metabolic process GO:0044281 305 0.017
regulation of cellular localization GO:0060341 136 0.017
nucleocytoplasmic transport GO:0006913 72 0.017
gland morphogenesis GO:0022612 145 0.017
metal ion transport GO:0030001 74 0.017
cell junction assembly GO:0034329 42 0.017
regulation of tube architecture open tracheal system GO:0035152 68 0.017
regulation of synapse structure and activity GO:0050803 128 0.017
chitin based cuticle sclerotization GO:0007593 19 0.017
cell growth GO:0016049 108 0.017
positive regulation of protein transport GO:0051222 37 0.017
regulation of jnk cascade GO:0046328 40 0.017
negative regulation of signal transduction GO:0009968 206 0.017
nucleoside monophosphate catabolic process GO:0009125 39 0.017
protein localization to organelle GO:0033365 82 0.017
response to hexose GO:0009746 3 0.017
ion transmembrane transport GO:0034220 122 0.016
cell maturation GO:0048469 144 0.016
regulation of cellular component size GO:0032535 98 0.016
initiation of dorsal closure GO:0007392 12 0.016
vesicle organization GO:0016050 44 0.016
rna processing GO:0006396 147 0.016
oocyte differentiation GO:0009994 145 0.016
regulation of immune system process GO:0002682 176 0.016
macromolecule catabolic process GO:0009057 161 0.016
detection of stimulus GO:0051606 156 0.016
cellular carbohydrate metabolic process GO:0044262 22 0.016
regulation of hydrolase activity GO:0051336 97 0.016
positive regulation of cellular amine metabolic process GO:0033240 0 0.016
regulation of intracellular transport GO:0032386 64 0.016
camera type eye development GO:0043010 4 0.016
Mouse
eye morphogenesis GO:0048592 260 0.016
cilium organization GO:0044782 41 0.015
compound eye development GO:0048749 307 0.015
response to organic substance GO:0010033 284 0.015
negative regulation of cellular metabolic process GO:0031324 382 0.015
carbohydrate derivative catabolic process GO:1901136 118 0.015
ribonucleotide metabolic process GO:0009259 145 0.015
sensory perception GO:0007600 196 0.015
Mouse
nucleoside triphosphate catabolic process GO:0009143 108 0.015
ph reduction GO:0045851 7 0.015
Mouse
establishment of protein localization to organelle GO:0072594 62 0.015
hippo signaling GO:0035329 20 0.015
regulation of cellular catabolic process GO:0031329 157 0.015
regulation of cellular amino acid metabolic process GO:0006521 0 0.015
cell cell signaling involved in cell fate commitment GO:0045168 210 0.015
eye photoreceptor cell differentiation GO:0001754 145 0.015
ion transport GO:0006811 145 0.015
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.015
response to heat GO:0009408 63 0.015
positive regulation of gene expression GO:0010628 290 0.014
mapk cascade GO:0000165 107 0.014
purine containing compound catabolic process GO:0072523 112 0.014
peptidyl amino acid modification GO:0018193 105 0.014
protein catabolic process GO:0030163 101 0.014
positive regulation of hydrolase activity GO:0051345 78 0.014
response to other organism GO:0051707 293 0.014
purine nucleotide metabolic process GO:0006163 146 0.014
defense response to gram negative bacterium GO:0050829 94 0.014
maintenance of location GO:0051235 73 0.014
segmentation GO:0035282 207 0.014
positive regulation of intracellular signal transduction GO:1902533 116 0.014
regulation of stress activated protein kinase signaling cascade GO:0070302 42 0.014
muscle attachment GO:0016203 36 0.014
jnk cascade GO:0007254 50 0.014
innate immune response GO:0045087 144 0.014
negative regulation of programmed cell death GO:0043069 72 0.014
positive regulation of protein modification process GO:0031401 58 0.014
immune response activating signal transduction GO:0002757 2 0.014
negative regulation of developmental process GO:0051093 201 0.014
positive regulation of developmental growth GO:0048639 62 0.014
actin cytoskeleton organization GO:0030036 206 0.014
dephosphorylation GO:0016311 51 0.014
stress activated mapk cascade GO:0051403 52 0.014
imaginal disc fusion GO:0046528 19 0.013
regulation of cellular response to stress GO:0080135 89 0.013
negative regulation of cell differentiation GO:0045596 143 0.013
central nervous system development GO:0007417 201 0.013
gastrulation with mouth forming first GO:0001703 36 0.013
single organism biosynthetic process GO:0044711 206 0.013
regulation of intracellular protein transport GO:0033157 46 0.013
anterior posterior axis specification embryo GO:0008595 103 0.013
endomembrane system organization GO:0010256 119 0.013
spermatid development GO:0007286 98 0.013
positive regulation of cellular biosynthetic process GO:0031328 316 0.013
regulation of nucleocytoplasmic transport GO:0046822 35 0.013
regulation of cell cycle process GO:0010564 181 0.013
localization of cell GO:0051674 257 0.013
purine ribonucleoside metabolic process GO:0046128 127 0.013
purine nucleoside catabolic process GO:0006152 112 0.013
erk1 and erk2 cascade GO:0070371 39 0.013
pole plasm assembly GO:0007315 61 0.013
regulation of ras protein signal transduction GO:0046578 93 0.013
protein dna complex subunit organization GO:0071824 86 0.013
establishment of nucleus localization GO:0040023 26 0.013
regulation of protein localization GO:0032880 76 0.013
oocyte construction GO:0007308 112 0.013
regulation of transferase activity GO:0051338 58 0.013
cell division GO:0051301 248 0.013
ovarian follicle cell development GO:0030707 248 0.013
phagosome acidification GO:0090383 1 0.013
multi organism reproductive behavior GO:0044705 121 0.013
positive regulation of cellular protein metabolic process GO:0032270 118 0.013
regulation of chitin based cuticle tanning GO:0007564 14 0.013
kidney development GO:0001822 3 0.012
positive regulation of nucleic acid templated transcription GO:1903508 266 0.012
positive regulation of growth GO:0045927 75 0.012
molting cycle GO:0042303 56 0.012
chromatin silencing GO:0006342 76 0.012
regulation of tube size open tracheal system GO:0035151 43 0.012
negative regulation of phosphorus metabolic process GO:0010563 45 0.012
anterior posterior pattern specification GO:0009952 136 0.012
response to radiation GO:0009314 155 0.012
protein import GO:0017038 55 0.012
anatomical structure homeostasis GO:0060249 97 0.012
cellular response to dna damage stimulus GO:0006974 223 0.012
negative regulation of intracellular signal transduction GO:1902532 57 0.012
response to biotic stimulus GO:0009607 294 0.012
response to glucose GO:0009749 2 0.012
cell death GO:0008219 279 0.012
single organism carbohydrate metabolic process GO:0044723 72 0.012
regulation of protein transport GO:0051223 57 0.012
collateral sprouting GO:0048668 3 0.012
gene silencing GO:0016458 138 0.012
ribonucleotide catabolic process GO:0009261 109 0.012
positive regulation of cellular component organization GO:0051130 156 0.012
multicellular organismal reproductive behavior GO:0033057 110 0.012
multi multicellular organism process GO:0044706 123 0.012
smoothened signaling pathway GO:0007224 49 0.012
apoptotic process GO:0006915 159 0.012
cytokinesis GO:0000910 90 0.012
protein phosphorylation GO:0006468 169 0.012
positive regulation of ras protein signal transduction GO:0046579 43 0.012
detection of light stimulus GO:0009583 58 0.012
ion homeostasis GO:0050801 55 0.012
Mouse
positive regulation of cell migration GO:0030335 2 0.012
response to external biotic stimulus GO:0043207 293 0.012
dna integrity checkpoint GO:0031570 81 0.012
purine ribonucleotide catabolic process GO:0009154 109 0.012
protein complex assembly GO:0006461 200 0.012
intracellular mrna localization involved in anterior posterior axis specification GO:0060811 53 0.012
regulation of establishment of protein localization GO:0070201 61 0.012
nuclear migration GO:0007097 20 0.011
ribonucleoside catabolic process GO:0042454 112 0.011
digestive system development GO:0055123 149 0.011
posttranscriptional regulation of gene expression GO:0010608 145 0.011
cell cell junction assembly GO:0007043 38 0.011
hemocyte migration GO:0035099 19 0.011
compound eye photoreceptor development GO:0042051 78 0.011
maintenance of protein location GO:0045185 28 0.011
renal filtration GO:0097205 7 0.011
circulatory system process GO:0003013 37 0.011
ribonucleoside monophosphate catabolic process GO:0009158 39 0.011
response to lipopolysaccharide GO:0032496 4 0.011
nephron development GO:0072006 3 0.011
positive regulation of cell projection organization GO:0031346 29 0.011
cilium assembly GO:0042384 38 0.011
cortical actin cytoskeleton organization GO:0030866 24 0.011
regulation of cellular ph GO:0030641 7 0.011
Mouse
organelle fission GO:0048285 340 0.011
negative regulation of growth GO:0045926 84 0.011
positive regulation of intracellular transport GO:0032388 42 0.011
outflow tract morphogenesis GO:0003151 4 0.011
positive regulation of cellular catabolic process GO:0031331 95 0.011
protein targeting GO:0006605 64 0.011
negative regulation of phosphate metabolic process GO:0045936 45 0.011
signal transduction by phosphorylation GO:0023014 107 0.011
eye pigmentation GO:0048069 43 0.011
larval development GO:0002164 104 0.011
compound eye morphogenesis GO:0001745 249 0.011
neuromuscular junction development GO:0007528 149 0.011
histone h4 k16 acetylation GO:0043984 4 0.010
transmembrane transport GO:0055085 139 0.010
pyridine containing compound metabolic process GO:0072524 3 0.010
regulation of lipid storage GO:0010883 22 0.010
immune response regulating signaling pathway GO:0002764 2 0.010
cellular amine metabolic process GO:0044106 12 0.010
protein import into nucleus GO:0006606 51 0.010
regulation of cytoplasmic transport GO:1903649 47 0.010
regulation of neuron differentiation GO:0045664 103 0.010
cell aging GO:0007569 2 0.010
organelle fusion GO:0048284 46 0.010
rrna processing GO:0006364 3 0.010
nuclear division GO:0000280 332 0.010
positive regulation of erk1 and erk2 cascade GO:0070374 36 0.010
amine metabolic process GO:0009308 12 0.010
sensory perception of pain GO:0019233 4 0.010
cellular monovalent inorganic cation homeostasis GO:0030004 7 0.010
Mouse
membrane depolarization GO:0051899 4 0.010

Clic disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.033
nervous system disease DOID:863 0 0.022
sensory system disease DOID:0050155 0 0.014
eye and adnexa disease DOID:1492 0 0.014
eye disease DOID:5614 0 0.014