Drosophila melanogaster

4 known processes

Spn77Bc (Dmel_CG6289)

Serpin 77Bc

(Aliases: CG6289,Dmel\CG6289)

Spn77Bc biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
insemination GO:0007320 22 0.268
sperm competition GO:0046692 21 0.176
sperm storage GO:0046693 10 0.125
small molecule metabolic process GO:0044281 305 0.106
cholesterol homeostasis GO:0042632 3 0.094
sterol homeostasis GO:0055092 4 0.078
organic acid metabolic process GO:0006082 103 0.076
oxoacid metabolic process GO:0043436 103 0.073
peptidyl proline hydroxylation GO:0019511 1 0.056
defense response GO:0006952 300 0.054
carboxylic acid metabolic process GO:0019752 92 0.053
organonitrogen compound metabolic process GO:1901564 318 0.050
organic hydroxy compound metabolic process GO:1901615 83 0.048
negative regulation of response to stimulus GO:0048585 258 0.046
protein hydroxylation GO:0018126 1 0.046
female mating behavior GO:0060180 30 0.046
defense response to other organism GO:0098542 225 0.046
negative regulation of cell communication GO:0010648 223 0.045
vesicle mediated transport GO:0016192 381 0.045
developmental growth GO:0048589 280 0.045
multicellular organismal reproductive behavior GO:0033057 110 0.043
regulation of female receptivity GO:0045924 24 0.042
homeostatic process GO:0042592 199 0.040
growth GO:0040007 359 0.040
protein modification process GO:0036211 438 0.039
single organism biosynthetic process GO:0044711 206 0.039
regulation of female receptivity post mating GO:0046008 17 0.039
regulation of immune system process GO:0002682 176 0.038
endocytosis GO:0006897 310 0.037
chemical homeostasis GO:0048878 92 0.037
response to other organism GO:0051707 293 0.036
catabolic process GO:0009056 409 0.035
positive regulation of response to stimulus GO:0048584 323 0.035
regionalization GO:0003002 416 0.035
cellular protein modification process GO:0006464 438 0.034
negative regulation of signaling GO:0023057 219 0.034
negative regulation of female receptivity GO:0007621 14 0.033
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.033
response to biotic stimulus GO:0009607 294 0.032
positive regulation of cellular biosynthetic process GO:0031328 316 0.032
response to external biotic stimulus GO:0043207 293 0.032
negative regulation of signal transduction GO:0009968 206 0.032
mating GO:0007618 120 0.032
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.032
regulation of multicellular organismal development GO:2000026 414 0.031
regulation of response to stress GO:0080134 200 0.031
response to bacterium GO:0009617 198 0.031
defense response to bacterium GO:0042742 178 0.031
body morphogenesis GO:0010171 2 0.030
gland development GO:0048732 191 0.030
rna processing GO:0006396 147 0.030
immune response GO:0006955 246 0.029
cellular catabolic process GO:0044248 372 0.029
negative regulation of cellular metabolic process GO:0031324 382 0.029
anion homeostasis GO:0055081 3 0.029
response to abiotic stimulus GO:0009628 341 0.029
regulation of multi organism process GO:0043900 131 0.028
peptidyl proline modification GO:0018208 3 0.028
lipid metabolic process GO:0006629 121 0.028
salivary gland development GO:0007431 162 0.028
organic substance catabolic process GO:1901575 308 0.028
immune system process GO:0002376 347 0.027
cellular modified amino acid metabolic process GO:0006575 45 0.027
oxidation reduction process GO:0055114 123 0.026
regulation of molecular function GO:0065009 217 0.025
acylglycerol catabolic process GO:0046464 3 0.025
regulation of response to external stimulus GO:0032101 115 0.025
regulation of defense response GO:0031347 102 0.025
cell death GO:0008219 279 0.025
peptidyl amino acid modification GO:0018193 105 0.025
positive regulation of cell communication GO:0010647 250 0.024
single organism behavior GO:0044708 391 0.024
regulation of immune response GO:0050776 118 0.024
cellular amino acid metabolic process GO:0006520 61 0.024
peptide metabolic process GO:0006518 80 0.024
response to organic substance GO:0010033 284 0.024
triglyceride catabolic process GO:0019433 3 0.024
single organism catabolic process GO:0044712 228 0.024
mating behavior GO:0007617 106 0.024
regulation of protein metabolic process GO:0051246 256 0.024
phosphorylation GO:0016310 294 0.023
gland morphogenesis GO:0022612 145 0.023
phagocytosis GO:0006909 215 0.023
humoral immune response GO:0006959 117 0.023
antimicrobial humoral response GO:0019730 99 0.023
steroid catabolic process GO:0006706 1 0.023
negative regulation of gene expression GO:0010629 387 0.022
amine metabolic process GO:0009308 12 0.022
positive regulation of biosynthetic process GO:0009891 316 0.022
negative regulation of female receptivity post mating GO:0045434 12 0.022
cellular lipid metabolic process GO:0044255 83 0.022
wing disc morphogenesis GO:0007472 344 0.022
appendage development GO:0048736 401 0.022
neutral lipid catabolic process GO:0046461 3 0.022
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.022
organic substance transport GO:0071702 257 0.022
lipid homeostasis GO:0055088 33 0.022
reproductive behavior GO:0019098 122 0.021
intracellular signal transduction GO:0035556 300 0.021
positive regulation of signaling GO:0023056 243 0.021
embryonic pattern specification GO:0009880 174 0.021
exocrine system development GO:0035272 162 0.021
pheromone biosynthetic process GO:0042811 3 0.021
multi multicellular organism process GO:0044706 123 0.021
compound eye development GO:0048749 307 0.021
transcription from rna polymerase ii promoter GO:0006366 368 0.021
triglyceride biosynthetic process GO:0019432 2 0.021
neutral lipid biosynthetic process GO:0046460 2 0.021
phospholipid homeostasis GO:0055091 1 0.021
pigment metabolic process GO:0042440 84 0.021
regulation of cell development GO:0060284 215 0.021
establishment of localization in cell GO:0051649 402 0.021
response to lipopolysaccharide GO:0032496 4 0.021
regulation of cellular protein metabolic process GO:0032268 243 0.021
regulation of catalytic activity GO:0050790 185 0.020
neurological system process GO:0050877 358 0.020
positive regulation of signal transduction GO:0009967 223 0.020
appendage morphogenesis GO:0035107 397 0.020
lateral inhibition GO:0046331 206 0.020
regulation of humoral immune response GO:0002920 51 0.020
imaginal disc derived wing morphogenesis GO:0007476 337 0.020
blastoderm segmentation GO:0007350 159 0.020
proteolysis GO:0006508 192 0.020
compound eye morphogenesis GO:0001745 249 0.020
camera type eye development GO:0043010 4 0.020
cellular amine metabolic process GO:0044106 12 0.020
regulation of cell cycle GO:0051726 291 0.020
cellular ketone metabolic process GO:0042180 24 0.019
programmed cell death GO:0012501 257 0.019
regulation of sterol transport GO:0032371 1 0.019
ethanolamine containing compound metabolic process GO:0042439 4 0.019
death GO:0016265 284 0.019
eye development GO:0001654 323 0.019
regulation of developmental growth GO:0048638 174 0.019
open tracheal system development GO:0007424 204 0.019
l glutamate import GO:0051938 1 0.019
defense response to gram negative bacterium GO:0050829 94 0.019
positive regulation of rna metabolic process GO:0051254 271 0.018
kidney development GO:0001822 3 0.018
forebrain development GO:0030900 2 0.018
respiratory system development GO:0060541 213 0.018
eye morphogenesis GO:0048592 260 0.018
carbohydrate derivative metabolic process GO:1901135 217 0.018
salivary gland morphogenesis GO:0007435 145 0.018
post embryonic appendage morphogenesis GO:0035120 385 0.018
columnar cuboidal epithelial cell development GO:0002066 249 0.018
xenobiotic catabolic process GO:0042178 1 0.018
organophosphate metabolic process GO:0019637 195 0.018
negative regulation of developmental process GO:0051093 201 0.018
imaginal disc derived appendage development GO:0048737 399 0.018
immune effector process GO:0002252 98 0.017
ion transport GO:0006811 145 0.017
macromolecular complex assembly GO:0065003 256 0.017
epithelial cell development GO:0002064 274 0.017
positive regulation of lipid storage GO:0010884 4 0.017
imaginal disc derived appendage morphogenesis GO:0035114 395 0.017
cholesterol transport GO:0030301 2 0.017
steroid metabolic process GO:0008202 20 0.017
organonitrogen compound biosynthetic process GO:1901566 117 0.017
cell division GO:0051301 248 0.017
positive regulation of macromolecule metabolic process GO:0010604 405 0.017
epithelial cell differentiation GO:0030855 322 0.017
negative regulation of cellular biosynthetic process GO:0031327 277 0.017
hormone metabolic process GO:0042445 33 0.017
segmentation GO:0035282 207 0.017
sensory organ morphogenesis GO:0090596 260 0.017
hormone catabolic process GO:0042447 3 0.017
positive regulation of transcription dna templated GO:0045893 266 0.017
ras protein signal transduction GO:0007265 88 0.017
macromolecule catabolic process GO:0009057 161 0.017
cell proliferation GO:0008283 299 0.017
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.017
response to radiation GO:0009314 155 0.016
regulation of cell differentiation GO:0045595 302 0.016
androgen metabolic process GO:0008209 1 0.016
chromosome organization GO:0051276 360 0.016
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.016
aromatic compound catabolic process GO:0019439 166 0.016
response to extracellular stimulus GO:0009991 116 0.016
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.016
innate immune response GO:0045087 144 0.016
regulation of lipid transport GO:0032368 3 0.016
multi organism behavior GO:0051705 175 0.016
regulation of cellular ketone metabolic process GO:0010565 3 0.016
axis specification GO:0009798 167 0.016
regulation of growth GO:0040008 233 0.016
regulation of production of molecular mediator of immune response GO:0002700 44 0.016
regulation of cellular amide metabolic process GO:0034248 39 0.016
regulation of apoptotic process GO:0042981 130 0.016
protein maturation GO:0051604 71 0.016
developmental maturation GO:0021700 172 0.016
response to fungus GO:0009620 50 0.016
taxis GO:0042330 304 0.016
cell cell signaling involved in cell fate commitment GO:0045168 210 0.016
regulation of cellular amine metabolic process GO:0033238 3 0.016
defense response to gram positive bacterium GO:0050830 41 0.016
regulation of phosphorus metabolic process GO:0051174 210 0.016
regulation of localization GO:0032879 275 0.016
cellular amide metabolic process GO:0043603 80 0.015
positive regulation of multicellular organismal process GO:0051240 143 0.015
monocarboxylic acid metabolic process GO:0032787 29 0.015
regulation of response to biotic stimulus GO:0002831 63 0.015
negative regulation of growth GO:0045926 84 0.015
defense response to fungus GO:0050832 48 0.015
regulation of antimicrobial humoral response GO:0002759 50 0.015
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.015
negative regulation of multicellular organismal process GO:0051241 142 0.015
response to hexose GO:0009746 3 0.015
acylglycerol biosynthetic process GO:0046463 2 0.015
negative regulation of nucleic acid templated transcription GO:1903507 240 0.015
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.015
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.015
response to temperature stimulus GO:0009266 106 0.015
organelle fission GO:0048285 340 0.015
regulation of catabolic process GO:0009894 170 0.015
protein complex biogenesis GO:0070271 201 0.015
heterocycle catabolic process GO:0046700 166 0.015
male gamete generation GO:0048232 201 0.015
connective tissue development GO:0061448 3 0.015
negative regulation of biosynthetic process GO:0009890 277 0.015
regulation of cellular response to stress GO:0080135 89 0.015
nuclear division GO:0000280 332 0.015
response to endogenous stimulus GO:0009719 119 0.015
ncrna metabolic process GO:0034660 43 0.015
positive regulation of nucleic acid templated transcription GO:1903508 266 0.015
small gtpase mediated signal transduction GO:0007264 88 0.015
estrogen metabolic process GO:0008210 1 0.015
organic cyclic compound catabolic process GO:1901361 168 0.015
regulation of programmed cell death GO:0043067 152 0.014
intracellular transport GO:0046907 228 0.014
very long chain fatty acid metabolic process GO:0000038 4 0.014
positive regulation of gene expression GO:0010628 290 0.014
alcohol metabolic process GO:0006066 25 0.014
telencephalon development GO:0021537 2 0.014
chromatin remodeling GO:0006338 72 0.014
response to nutrient levels GO:0031667 114 0.014
dna metabolic process GO:0006259 227 0.014
acylglycerol homeostasis GO:0055090 19 0.014
morphogenesis of an epithelium GO:0002009 276 0.014
response to organophosphorus GO:0046683 2 0.014
cellular response to ethanol GO:0071361 4 0.014
regulation of cell death GO:0010941 173 0.014
spermatogenesis GO:0007283 200 0.014
regulation of sequestering of triglyceride GO:0010889 3 0.014
maintenance of location GO:0051235 73 0.014
zymogen activation GO:0031638 20 0.014
protein complex assembly GO:0006461 200 0.014
adult behavior GO:0030534 137 0.014
single organism intracellular transport GO:1902582 207 0.014
nucleobase containing small molecule metabolic process GO:0055086 174 0.014
response to monosaccharide GO:0034284 4 0.014
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.014
antimicrobial peptide production GO:0002775 46 0.014
regulation of intracellular signal transduction GO:1902531 236 0.014
negative regulation of protein metabolic process GO:0051248 85 0.014
regulation of phosphate metabolic process GO:0019220 210 0.014
anterior posterior pattern specification GO:0009952 136 0.014
glycerolipid catabolic process GO:0046503 3 0.014
sensory perception of smell GO:0007608 80 0.014
regulation of mitotic cell cycle phase transition GO:1901990 130 0.014
sensory perception GO:0007600 196 0.013
small molecule biosynthetic process GO:0044283 37 0.013
multicellular organismal aging GO:0010259 140 0.013
chromatin organization GO:0006325 207 0.013
regulation of proteolysis GO:0030162 87 0.013
regulation of anatomical structure morphogenesis GO:0022603 242 0.013
chromatin modification GO:0016568 147 0.013
membrane organization GO:0061024 112 0.013
regulation of hormone levels GO:0010817 40 0.013
nucleoside phosphate metabolic process GO:0006753 162 0.013
long chain fatty acid metabolic process GO:0001676 3 0.013
cellular response to organic substance GO:0071310 132 0.013
head development GO:0060322 135 0.013
cellular macromolecule catabolic process GO:0044265 136 0.013
dorsal ventral pattern formation GO:0009953 133 0.013
response to oxygen containing compound GO:1901700 200 0.013
cellular nitrogen compound catabolic process GO:0044270 165 0.013
response to copper ion GO:0046688 4 0.013
regulation of organelle organization GO:0033043 196 0.013
regulation of transport GO:0051049 181 0.013
embryo development ending in birth or egg hatching GO:0009792 152 0.013
mitotic cell cycle phase transition GO:0044772 138 0.013
cell cycle phase transition GO:0044770 140 0.013
muscle organ development GO:0007517 127 0.013
regulation of cell cycle phase transition GO:1901987 130 0.013
regulation of synapse structure and activity GO:0050803 128 0.013
regulation of notch signaling pathway GO:0008593 100 0.013
organelle assembly GO:0070925 198 0.013
sensory perception of chemical stimulus GO:0007606 116 0.013
regulation of tube architecture open tracheal system GO:0035152 68 0.013
protein localization GO:0008104 284 0.013
somatic muscle development GO:0007525 66 0.013
cation transport GO:0006812 110 0.013
positive regulation of rna biosynthetic process GO:1902680 266 0.013
single organism membrane organization GO:0044802 93 0.013
negative regulation of cellular protein metabolic process GO:0032269 85 0.013
production of molecular mediator of immune response GO:0002440 46 0.013
regulation of hydrolase activity GO:0051336 97 0.013
g protein coupled receptor signaling pathway GO:0007186 136 0.012
regulation of cellular catabolic process GO:0031329 157 0.012
dendrite development GO:0016358 204 0.012
hindbrain development GO:0030902 2 0.012
response to glucose GO:0009749 2 0.012
cell migration GO:0016477 238 0.012
apoptotic process GO:0006915 159 0.012
enzyme linked receptor protein signaling pathway GO:0007167 179 0.012
nucleotide metabolic process GO:0009117 161 0.012
regulation of nervous system development GO:0051960 248 0.012
regulation of cellular localization GO:0060341 136 0.012
ribonucleotide metabolic process GO:0009259 145 0.012
lipid biosynthetic process GO:0008610 46 0.012
negative regulation of rna biosynthetic process GO:1902679 240 0.012
positive regulation of cell motility GO:2000147 3 0.012
negative regulation of cell differentiation GO:0045596 143 0.012
locomotory behavior GO:0007626 176 0.012
notch signaling pathway GO:0007219 120 0.012
cellular response to dna damage stimulus GO:0006974 223 0.012
negative regulation of rna metabolic process GO:0051253 251 0.012
protein processing GO:0016485 68 0.012
anterior posterior axis specification GO:0009948 109 0.012
tripartite regional subdivision GO:0007351 103 0.012
positive regulation of developmental process GO:0051094 143 0.012
mitotic nuclear division GO:0007067 213 0.012
muscle structure development GO:0061061 224 0.012
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.012
regulation of mitotic cell cycle GO:0007346 190 0.012
regulation of cellular amino acid metabolic process GO:0006521 0 0.012
purine containing compound metabolic process GO:0072521 155 0.012
tissue morphogenesis GO:0048729 297 0.012
phosphatidylethanolamine metabolic process GO:0046337 1 0.012
regulation of cell cycle process GO:0010564 181 0.012
secondary metabolite biosynthetic process GO:0044550 24 0.012
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.012
metal ion transport GO:0030001 74 0.012
response to oxygen levels GO:0070482 59 0.011
localization of cell GO:0051674 257 0.011
limb development GO:0060173 1 0.011
courtship behavior GO:0007619 68 0.011
imaginal disc pattern formation GO:0007447 91 0.011
anterior posterior axis specification embryo GO:0008595 103 0.011
cellular homeostasis GO:0019725 80 0.011
response to ethanol GO:0045471 59 0.011
ion homeostasis GO:0050801 55 0.011
striated muscle cell differentiation GO:0051146 90 0.011
cellular response to chemical stimulus GO:0070887 199 0.011
single organism cellular localization GO:1902580 180 0.011
hematopoietic progenitor cell differentiation GO:0002244 1 0.011
dendrite morphogenesis GO:0048813 199 0.011
positive regulation of intracellular signal transduction GO:1902533 116 0.011
regulation of organ growth GO:0046620 42 0.011
positive regulation of cellular amine metabolic process GO:0033240 0 0.011
retina development in camera type eye GO:0060041 4 0.011
nitrogen compound transport GO:0071705 85 0.011
secondary metabolic process GO:0019748 75 0.011
male courtship behavior GO:0008049 63 0.011
ribose phosphate metabolic process GO:0019693 145 0.011
organophosphate catabolic process GO:0046434 112 0.011
biological adhesion GO:0022610 138 0.011
benzene containing compound metabolic process GO:0042537 3 0.011
copulation GO:0007620 26 0.011
response to starvation GO:0042594 97 0.011
regulation of gene expression epigenetic GO:0040029 128 0.011
regulation of mapk cascade GO:0043408 92 0.011
axon guidance GO:0007411 233 0.011
positive regulation of molecular function GO:0044093 136 0.011
muscle cell differentiation GO:0042692 103 0.011
synapse organization GO:0050808 196 0.011
embryonic axis specification GO:0000578 107 0.011
tube morphogenesis GO:0035239 191 0.011
gene silencing GO:0016458 138 0.011
protein phosphorylation GO:0006468 169 0.011
cellular macromolecule localization GO:0070727 220 0.011
alditol phosphate metabolic process GO:0052646 2 0.011
eye photoreceptor cell differentiation GO:0001754 145 0.011
central nervous system development GO:0007417 201 0.011
phosphatidic acid metabolic process GO:0046473 1 0.011
response to metal ion GO:0010038 23 0.011
positive regulation of catabolic process GO:0009896 105 0.011
signal transduction by phosphorylation GO:0023014 107 0.011
positive regulation of transport GO:0051050 92 0.011
cell motility GO:0048870 251 0.011
purine nucleoside metabolic process GO:0042278 127 0.011
response to calcium ion GO:0051592 1 0.011
purine nucleotide metabolic process GO:0006163 146 0.011
response to light stimulus GO:0009416 124 0.011
regulation of cholesterol transport GO:0032374 1 0.010
regulation of ras protein signal transduction GO:0046578 93 0.010
nucleobase containing compound catabolic process GO:0034655 165 0.010
cellular response to lipopolysaccharide GO:0071222 3 0.010
mesenchymal cell development GO:0014031 1 0.010
immune response activating signal transduction GO:0002757 2 0.010
compound eye photoreceptor cell differentiation GO:0001751 140 0.010
regulation of phosphorylation GO:0042325 147 0.010
transition metal ion transport GO:0000041 16 0.010
cation homeostasis GO:0055080 51 0.010
microtubule organizing center organization GO:0031023 168 0.010
synaptic transmission GO:0007268 288 0.010
developmental programmed cell death GO:0010623 138 0.010
rna localization GO:0006403 115 0.010
photoreceptor cell development GO:0042461 96 0.010
protein catabolic process GO:0030163 101 0.010
response to nitrogen compound GO:1901698 90 0.010
salivary gland cell autophagic cell death GO:0035071 83 0.010
response to alcohol GO:0097305 95 0.010
regulation of cellular component biogenesis GO:0044087 201 0.010
endomembrane system organization GO:0010256 119 0.010
cytoplasmic transport GO:0016482 130 0.010
protein transport GO:0015031 155 0.010
establishment or maintenance of cell polarity GO:0007163 167 0.010
cellular response to molecule of bacterial origin GO:0071219 3 0.010
lipid localization GO:0010876 54 0.010
cellular response to biotic stimulus GO:0071216 4 0.010
negative regulation of cellular component organization GO:0051129 108 0.010
spindle organization GO:0007051 253 0.010
positive regulation of apoptotic signaling pathway GO:2001235 4 0.010
positive regulation of phosphorus metabolic process GO:0010562 139 0.010
regulation of antimicrobial peptide production GO:0002784 44 0.010
neuromuscular synaptic transmission GO:0007274 67 0.010
ameboidal type cell migration GO:0001667 151 0.010
camera type eye morphogenesis GO:0048593 2 0.010
protein heterooligomerization GO:0051291 4 0.010
negative regulation of cell death GO:0060548 81 0.010

Spn77Bc disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.038
diabetes mellitus DOID:9351 0 0.023
type 2 diabetes mellitus DOID:9352 0 0.023
disease of metabolism DOID:0014667 0 0.023
carbohydrate metabolism disease DOID:0050013 0 0.023
glucose metabolism disease DOID:4194 0 0.023
acquired metabolic disease DOID:0060158 0 0.023
inherited metabolic disorder DOID:655 0 0.021
nervous system disease DOID:863 0 0.018
hair disease DOID:421 0 0.014
integumentary system disease DOID:16 0 0.014
familial hypertriglyceridemia DOID:0050527 0 0.012
lipid metabolism disorder DOID:3146 0 0.012
sensory system disease DOID:0050155 0 0.011
eye and adnexa disease DOID:1492 0 0.011
familial hyperlipidemia DOID:1168 0 0.011
familial lipoprotein lipase deficiency DOID:14118 0 0.010
cancer DOID:162 0 0.010
disease of cellular proliferation DOID:14566 0 0.010