Drosophila melanogaster

98 known processes

pk (Dmel_CG11084)

prickle

(Aliases: Pk-Sple,Sple,sple,CG11084,Dmel\CG11084,pk-sple,CG12830,Pk)

pk biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
morphogenesis of a polarized epithelium GO:0001738 93 0.998
imaginal disc derived wing hair organization GO:0035317 45 0.996
establishment of planar polarity GO:0001736 87 0.991
establishment of tissue polarity GO:0007164 87 0.974
morphogenesis of an epithelium GO:0002009 276 0.972
establishment of ommatidial planar polarity GO:0042067 49 0.957
hair cell differentiation GO:0035315 47 0.936
tissue morphogenesis GO:0048729 297 0.906
imaginal disc derived wing hair site selection GO:0035320 4 0.843
dendrite self avoidance GO:0070593 8 0.839
Fly
post embryonic appendage morphogenesis GO:0035120 385 0.834
compound eye morphogenesis GO:0001745 249 0.825
establishment of imaginal disc derived wing hair orientation GO:0001737 24 0.796
appendage morphogenesis GO:0035107 397 0.758
imaginal disc derived appendage morphogenesis GO:0035114 395 0.755
establishment of epithelial cell apical basal polarity GO:0045198 10 0.753
epithelial cell differentiation GO:0030855 322 0.729
establishment of body hair or bristle planar orientation GO:0048104 6 0.700
establishment of proximal distal cell polarity GO:0022606 4 0.682
non sensory hair organization GO:0035316 47 0.681
establishment or maintenance of cell polarity GO:0007163 167 0.647
eye morphogenesis GO:0048592 260 0.620
equator specification GO:0045317 4 0.616
wing disc morphogenesis GO:0007472 344 0.615
imaginal disc derived appendage development GO:0048737 399 0.604
eye development GO:0001654 323 0.602
establishment of apical basal cell polarity GO:0035089 12 0.545
appendage development GO:0048736 401 0.497
establishment of monopolar cell polarity GO:0061162 15 0.463
muscle cell differentiation GO:0042692 103 0.446
Human
cilium assembly GO:0042384 38 0.445
muscle cell fate commitment GO:0042693 14 0.441
compound eye development GO:0048749 307 0.417
regulation of organ morphogenesis GO:2000027 78 0.413
imaginal disc derived wing morphogenesis GO:0007476 337 0.411
regulation of establishment of planar polarity GO:0090175 22 0.391
establishment or maintenance of monopolar cell polarity GO:0061339 15 0.378
cell division GO:0051301 248 0.339
sensory organ morphogenesis GO:0090596 260 0.314
establishment of body hair planar orientation GO:0048105 1 0.290
growth GO:0040007 359 0.281
eye antennal disc development GO:0035214 60 0.276
polarized epithelial cell differentiation GO:0030859 10 0.260
regulation of multicellular organismal development GO:2000026 414 0.258
Human
positive regulation of macromolecule metabolic process GO:0010604 405 0.250
Human
regulation of tube architecture open tracheal system GO:0035152 68 0.244
digestive tract development GO:0048565 149 0.228
Zebrafish
wnt signaling pathway planar cell polarity pathway GO:0060071 6 0.208
regulation of anatomical structure size GO:0090066 163 0.198
cellular protein modification process GO:0006464 438 0.191
Human
protein modification process GO:0036211 438 0.188
Human
tube morphogenesis GO:0035239 191 0.188
Human Zebrafish
regulation of tube length open tracheal system GO:0035159 24 0.186
tube development GO:0035295 244 0.183
Human Zebrafish
wnt signaling pathway GO:0016055 98 0.177
Human Zebrafish
embryonic morphogenesis GO:0048598 206 0.175
Human Zebrafish
regulation of anatomical structure morphogenesis GO:0022603 242 0.173
establishment or maintenance of apical basal cell polarity GO:0035088 34 0.172
Mouse
blastoderm segmentation GO:0007350 159 0.171
homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 18 0.171
antennal development GO:0007469 25 0.155
regulation of protein metabolic process GO:0051246 256 0.148
Human
regulation of molecular function GO:0065009 217 0.148
establishment or maintenance of epithelial cell apical basal polarity GO:0045197 24 0.142
Mouse
cell proliferation GO:0008283 299 0.137
digestive system development GO:0055123 149 0.135
Zebrafish
regulation of tube size open tracheal system GO:0035151 43 0.134
chaeta development GO:0022416 97 0.134
chaeta morphogenesis GO:0008407 42 0.129
columnar cuboidal epithelial cell development GO:0002066 249 0.129
regionalization GO:0003002 416 0.128
striated muscle cell differentiation GO:0051146 90 0.117
Human
mushroom body development GO:0016319 70 0.116
secretion by cell GO:0032940 101 0.113
determination of imaginal disc primordium GO:0007445 11 0.111
cell cell adhesion GO:0098609 26 0.107
developmental growth involved in morphogenesis GO:0060560 65 0.104
regulation of growth GO:0040008 233 0.103
chemotaxis GO:0006935 249 0.103
regulation of cell proliferation GO:0042127 163 0.103
actin cytoskeleton organization GO:0030036 206 0.101
ommatidial rotation GO:0016318 20 0.100
negative regulation of cellular biosynthetic process GO:0031327 277 0.096
Human
neurological system process GO:0050877 358 0.095
compound eye photoreceptor fate commitment GO:0001752 36 0.095
epidermis development GO:0008544 65 0.093
cell motility GO:0048870 251 0.092
Zebrafish
regulation of organelle organization GO:0033043 196 0.089
regulation of cell differentiation GO:0045595 302 0.088
Human
cell cell adhesion via plasma membrane adhesion molecules GO:0098742 26 0.085
regulation of wnt signaling pathway GO:0030111 68 0.085
Human
compound eye photoreceptor cell differentiation GO:0001751 140 0.084
respiratory system development GO:0060541 213 0.083
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.082
Human
central nervous system development GO:0007417 201 0.082
Zebrafish
neural retina development GO:0003407 4 0.080
Zebrafish
regulation of localization GO:0032879 275 0.079
axis elongation GO:0003401 3 0.078
nephron development GO:0072006 3 0.077
establishment or maintenance of bipolar cell polarity GO:0061245 34 0.077
Mouse
cilium morphogenesis GO:0060271 39 0.075
developmental growth GO:0048589 280 0.075
establishment of cell polarity GO:0030010 40 0.074
Zebrafish
leg disc development GO:0035218 92 0.073
positive regulation of protein metabolic process GO:0051247 128 0.072
Human
embryonic axis specification GO:0000578 107 0.071
ameboidal type cell migration GO:0001667 151 0.070
Zebrafish
epithelial cell development GO:0002064 274 0.070
regulation of cell cycle GO:0051726 291 0.069
establishment of epithelial cell polarity GO:0090162 13 0.068
eye photoreceptor cell differentiation GO:0001754 145 0.067
cell death GO:0008219 279 0.066
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.065
negative regulation of cellular metabolic process GO:0031324 382 0.064
Human
open tracheal system development GO:0007424 204 0.063
imaginal disc derived leg segmentation GO:0036011 26 0.063
wing and notum subfield formation GO:0035309 13 0.063
negative regulation of biosynthetic process GO:0009890 277 0.062
Human
anterior posterior pattern specification GO:0009952 136 0.062
biological adhesion GO:0022610 138 0.060
positive regulation of cellular protein metabolic process GO:0032270 118 0.060
Human
positive regulation of transcription dna templated GO:0045893 266 0.060
notch signaling pathway GO:0007219 120 0.059
positive regulation of gene expression GO:0010628 290 0.059
secretion GO:0046903 109 0.059
regulation of tube size GO:0035150 46 0.058
organic substance transport GO:0071702 257 0.058
Human Rat
malpighian tubule development GO:0072002 64 0.057
kidney morphogenesis GO:0060993 3 0.056
actin filament based process GO:0030029 220 0.056
cilium organization GO:0044782 41 0.055
circulatory system development GO:0072359 82 0.055
Human Zebrafish
embryonic pattern specification GO:0009880 174 0.055
formation of anatomical boundary GO:0048859 37 0.052
tissue migration GO:0090130 155 0.050
determination of genital disc primordium GO:0035225 10 0.050
epidermal cell differentiation GO:0009913 51 0.049
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.048
Human
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.048
positive regulation of response to stimulus GO:0048584 323 0.047
photoreceptor cell fate commitment GO:0046552 41 0.047
regulation of intracellular signal transduction GO:1902531 236 0.047
cell adhesion GO:0007155 136 0.045
dendrite development GO:0016358 204 0.044
body morphogenesis GO:0010171 2 0.043
limb morphogenesis GO:0035108 1 0.042
cell fate commitment involved in pattern specification GO:0060581 31 0.042
regulation of cell cell adhesion GO:0022407 21 0.042
eggshell formation GO:0030703 105 0.041
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.041
regulation of developmental growth GO:0048638 174 0.041
regulation of actin cytoskeleton organization GO:0032956 42 0.040
axon extension GO:0048675 32 0.040
regulation of embryonic development GO:0045995 68 0.040
positive regulation of multicellular organismal process GO:0051240 143 0.040
protein phosphorylation GO:0006468 169 0.039
antennal morphogenesis GO:0048800 14 0.039
mitotic cytokinesis GO:0000281 50 0.038
female sex differentiation GO:0046660 20 0.038
camera type eye photoreceptor cell differentiation GO:0060219 2 0.038
regulation of smoothened signaling pathway GO:0008589 28 0.038
positive regulation of biosynthetic process GO:0009891 316 0.038
phosphorylation GO:0016310 294 0.038
regulation of execution phase of apoptosis GO:1900117 5 0.038
development of primary female sexual characteristics GO:0046545 12 0.037
negative regulation of gene expression GO:0010629 387 0.037
Human
negative regulation of nucleic acid templated transcription GO:1903507 240 0.037
Human
transcription from rna polymerase ii promoter GO:0006366 368 0.037
dendrite morphogenesis GO:0048813 199 0.037
cell cell adhesion mediated by cadherin GO:0044331 6 0.037
single organism cell adhesion GO:0098602 47 0.036
convergent extension GO:0060026 2 0.036
Zebrafish
positive regulation of nucleic acid templated transcription GO:1903508 266 0.036
regulation of neuron projection development GO:0010975 69 0.035
leg disc proximal distal pattern formation GO:0007479 9 0.035
appendage segmentation GO:0035285 26 0.035
cellular component assembly involved in morphogenesis GO:0010927 151 0.034
regulation of dendrite morphogenesis GO:0048814 28 0.034
imaginal disc growth GO:0007446 37 0.034
regulation of protein modification process GO:0031399 112 0.034
Human
photoreceptor cell differentiation GO:0046530 170 0.033
imaginal disc derived leg joint morphogenesis GO:0016348 15 0.033
spinal cord patterning GO:0021511 1 0.032
axis specification GO:0009798 167 0.032
regulation of mitotic cell cycle GO:0007346 190 0.032
proteolysis GO:0006508 192 0.032
Human
regulation of cell division GO:0051302 72 0.032
cuticle development GO:0042335 86 0.032
negative regulation of developmental process GO:0051093 201 0.032
Human
negative regulation of signal transduction GO:0009968 206 0.032
genital disc sexually dimorphic development GO:0035263 4 0.032
regulation of proteolysis GO:0030162 87 0.031
Human
neuron projection extension GO:1990138 32 0.031
non canonical wnt signaling pathway GO:0035567 8 0.030
kidney development GO:0001822 3 0.030
eye photoreceptor cell fate commitment GO:0042706 37 0.029
negative regulation of response to stimulus GO:0048585 258 0.029
imaginal disc derived leg morphogenesis GO:0007480 80 0.028
negative regulation of rna biosynthetic process GO:1902679 240 0.028
Human
anterior posterior axis specification GO:0009948 109 0.028
synapse organization GO:0050808 196 0.028
establishment of spindle orientation GO:0051294 18 0.028
Zebrafish
regulation of cellular component size GO:0032535 98 0.027
stem cell proliferation GO:0072089 88 0.027
positive regulation of cell projection organization GO:0031346 29 0.027
morphogenesis of embryonic epithelium GO:0016331 94 0.027
Human
neuron migration GO:0001764 5 0.027
Zebrafish
imaginal disc derived wing margin morphogenesis GO:0008587 41 0.027
epithelial tube morphogenesis GO:0060562 88 0.027
Human Zebrafish
urogenital system development GO:0001655 72 0.027
negative regulation of transcription dna templated GO:0045892 237 0.027
Human
salivary gland development GO:0007431 162 0.027
cell migration GO:0016477 238 0.027
Zebrafish
digestive tract morphogenesis GO:0048546 127 0.026
Zebrafish
negative regulation of notch signaling pathway GO:0045746 41 0.026
negative regulation of wnt signaling pathway GO:0030178 28 0.025
Human
negative regulation of cell communication GO:0010648 223 0.025
regulation of imaginal disc derived wing size GO:0044719 20 0.025
larval development GO:0002164 104 0.025
organ formation GO:0048645 39 0.025
single organismal cell cell adhesion GO:0016337 45 0.025
positive regulation of developmental process GO:0051094 143 0.025
regulation of catalytic activity GO:0050790 185 0.024
regulation of phosphorus metabolic process GO:0051174 210 0.024
limb development GO:0060173 1 0.024
regulation of programmed cell death GO:0043067 152 0.024
regulation of cell cycle process GO:0010564 181 0.024
gonad development GO:0008406 50 0.024
imaginal disc derived wing vein specification GO:0007474 48 0.023
wound healing GO:0042060 75 0.023
leg disc morphogenesis GO:0007478 80 0.023
rho protein signal transduction GO:0007266 14 0.023
localization of cell GO:0051674 257 0.022
Zebrafish
neuron recognition GO:0008038 101 0.022
Fly
negative regulation of cell death GO:0060548 81 0.022
regulation of peptidase activity GO:0052547 39 0.022
regulation of imaginal disc growth GO:0045570 26 0.022
axonogenesis GO:0007409 290 0.022
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.021
positive regulation of cell communication GO:0010647 250 0.021
regulation of cellular component biogenesis GO:0044087 201 0.021
locomotory behavior GO:0007626 176 0.021
epithelial cell migration GO:0010631 148 0.021
positive regulation of molecular function GO:0044093 136 0.021
negative regulation of signaling GO:0023057 219 0.021
dorsal ventral pattern formation GO:0009953 133 0.021
eye antennal disc morphogenesis GO:0007455 34 0.020
regulation of cell morphogenesis GO:0022604 163 0.020
r3 r4 cell fate commitment GO:0007464 10 0.019
cell cell junction organization GO:0045216 55 0.019
regulation of transport GO:0051049 181 0.019
regulation of cell death GO:0010941 173 0.019
positive regulation of rna biosynthetic process GO:1902680 266 0.019
sensory neuron axon guidance GO:0097374 2 0.019
renal system development GO:0072001 72 0.018
neuron fate commitment GO:0048663 50 0.018
regulation of nervous system development GO:0051960 248 0.018
intracellular signal transduction GO:0035556 300 0.018
learning or memory GO:0007611 141 0.018
activation of cysteine type endopeptidase activity GO:0097202 17 0.018
posttranscriptional regulation of gene expression GO:0010608 145 0.018
female gonad development GO:0008585 12 0.018
retina development in camera type eye GO:0060041 4 0.018
Zebrafish
skin development GO:0043588 65 0.017
apical protein localization GO:0045176 5 0.017
embryonic hindgut morphogenesis GO:0048619 48 0.017
regulation of cytoskeleton organization GO:0051493 89 0.017
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.017
Human
muscle attachment GO:0016203 36 0.017
carbohydrate derivative biosynthetic process GO:1901137 85 0.017
regulation of cell development GO:0060284 215 0.017
Human
skeletal muscle fiber development GO:0048741 3 0.017
Human
regulation of axonogenesis GO:0050770 32 0.017
retina morphogenesis in camera type eye GO:0060042 2 0.016
programmed cell death GO:0012501 257 0.016
negative chemotaxis GO:0050919 15 0.016
tube formation GO:0035148 21 0.016
Human
regulation of epithelial cell differentiation GO:0030856 4 0.016
negative regulation of programmed cell death GO:0043069 72 0.016
cell fate determination GO:0001709 91 0.016
regulation of apoptotic process GO:0042981 130 0.016
reproductive structure development GO:0048608 74 0.016
establishment of localization in cell GO:0051649 402 0.015
Human Zebrafish Rat
positive regulation of peptidase activity GO:0010952 29 0.015
regulation of epithelial cell proliferation GO:0050678 4 0.015
regulation of actin filament based process GO:0032970 42 0.015
taxis GO:0042330 304 0.015
negative regulation of rna metabolic process GO:0051253 251 0.015
Human
nephron epithelium morphogenesis GO:0072088 3 0.015
regulation of neurogenesis GO:0050767 158 0.015
somatic muscle development GO:0007525 66 0.015
protein localization GO:0008104 284 0.015
Human Rat
macromolecular complex assembly GO:0065003 256 0.015
cell fate specification GO:0001708 71 0.015
spinal cord development GO:0021510 1 0.015
regulation of cellular protein metabolic process GO:0032268 243 0.015
Human
catabolic process GO:0009056 409 0.014
Human
amine metabolic process GO:0009308 12 0.014
regulation of stress activated protein kinase signaling cascade GO:0070302 42 0.014
nonmotile primary cilium assembly GO:0035058 8 0.014
positive regulation of cell differentiation GO:0045597 64 0.014
female genitalia development GO:0030540 6 0.014
regulation of protein localization GO:0032880 76 0.014
regulation of cell shape GO:0008360 113 0.014
compound eye photoreceptor development GO:0042051 78 0.014
cellular catabolic process GO:0044248 372 0.014
Human
phagocytosis GO:0006909 215 0.014
regulation of phosphate metabolic process GO:0019220 210 0.014
adult chitin based cuticle development GO:0008365 2 0.013
cuticle pigmentation GO:0048067 22 0.013
intracellular mrna localization GO:0008298 66 0.013
vesicle organization GO:0016050 44 0.013
negative regulation of cell cycle phase transition GO:1901988 103 0.013
nitrogen compound transport GO:0071705 85 0.013
negative regulation of imaginal disc growth GO:0045571 8 0.013
regulation of hydrolase activity GO:0051336 97 0.013
cell projection assembly GO:0030031 94 0.013
hemocyte differentiation GO:0042386 38 0.013
malpighian tubule morphogenesis GO:0007443 44 0.013
sex differentiation GO:0007548 81 0.013
retinal cone cell differentiation GO:0042670 2 0.013
establishment of mitotic spindle orientation GO:0000132 13 0.013
Zebrafish
stem cell differentiation GO:0048863 117 0.012
Human
response to abiotic stimulus GO:0009628 341 0.012
ovarian follicle cell development GO:0030707 248 0.012
positive regulation of proteolysis GO:0045862 52 0.012
Human
cellular homeostasis GO:0019725 80 0.012
homeostatic process GO:0042592 199 0.012
positive regulation of catalytic activity GO:0043085 118 0.012
embryonic development via the syncytial blastoderm GO:0001700 148 0.012
epithelial cell proliferation involved in malpighian tubule morphogenesis GO:0061331 11 0.012
nephrocyte diaphragm assembly GO:0036059 3 0.012
positive regulation of signaling GO:0023056 243 0.012
organic substance catabolic process GO:1901575 308 0.011
Human
protein maturation GO:0051604 71 0.011
cell recognition GO:0008037 102 0.011
Fly
positive regulation of cysteine type endopeptidase activity GO:2001056 24 0.011
negative regulation of nervous system development GO:0051961 92 0.011
regulation of erbb signaling pathway GO:1901184 42 0.011
head development GO:0060322 135 0.011
Zebrafish
regulation of axon extension GO:0030516 8 0.011
cell cell signaling involved in cell fate commitment GO:0045168 210 0.011
male gamete generation GO:0048232 201 0.011
negative regulation of organelle organization GO:0010639 56 0.011
imaginal disc derived wing vein morphogenesis GO:0008586 44 0.011
cell growth GO:0016049 108 0.011
nephron morphogenesis GO:0072028 3 0.011
cell fate specification involved in pattern specification GO:0060573 8 0.011
regulation of protein phosphorylation GO:0001932 64 0.011
cuticle pattern formation GO:0035017 27 0.011
rna localization GO:0006403 115 0.011
wnt signaling pathway calcium modulating pathway GO:0007223 2 0.011
striated muscle cell development GO:0055002 50 0.010
Human
regulation of actin filament length GO:0030832 27 0.010
cardiovascular system development GO:0072358 82 0.010
Human Zebrafish
muscle cell fate specification GO:0042694 7 0.010
wing disc pattern formation GO:0035222 66 0.010
actin polymerization or depolymerization GO:0008154 31 0.010
anterior posterior axis specification embryo GO:0008595 103 0.010

pk disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.039
Human