Drosophila melanogaster

7 known processes

Prosbeta1 (Dmel_CG8392)

Proteasome beta1 subunit

(Aliases: l(2)05070,CG8392,8392,Dmel\CG8392)

Prosbeta1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
proteolysis GO:0006508 192 0.966
Yeast
modification dependent macromolecule catabolic process GO:0043632 79 0.933
Yeast
cellular catabolic process GO:0044248 372 0.881
Yeast
cellular response to dna damage stimulus GO:0006974 223 0.786
mitotic spindle elongation GO:0000022 81 0.774
modification dependent protein catabolic process GO:0019941 78 0.655
Yeast
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 37 0.536
ubiquitin dependent protein catabolic process GO:0006511 78 0.534
Yeast
proteasomal protein catabolic process GO:0010498 59 0.478
Yeast
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 54 0.454
Yeast
catabolic process GO:0009056 409 0.426
Yeast
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.416
Yeast
cellular protein catabolic process GO:0044257 83 0.348
Yeast
determination of adult lifespan GO:0008340 137 0.290
cellular macromolecule catabolic process GO:0044265 136 0.269
Yeast
protein catabolic process GO:0030163 101 0.256
Yeast
macromolecule catabolic process GO:0009057 161 0.248
Yeast
spindle assembly involved in mitosis GO:0090307 50 0.239
organic substance catabolic process GO:1901575 308 0.227
Yeast
multicellular organismal aging GO:0010259 140 0.218
cell proliferation GO:0008283 299 0.208
mitotic nuclear division GO:0007067 213 0.152
spindle assembly GO:0051225 80 0.105
nuclear division GO:0000280 332 0.103
embryo development ending in birth or egg hatching GO:0009792 152 0.091
Worm
mitotic spindle organization GO:0007052 220 0.091
protein complex biogenesis GO:0070271 201 0.088
single organism membrane fusion GO:0044801 42 0.079
microtubule cytoskeleton organization involved in mitosis GO:1902850 52 0.074
dna templated transcription elongation GO:0006354 18 0.073
spindle organization GO:0007051 253 0.071
proteasome assembly GO:0043248 2 0.069
spindle elongation GO:0051231 83 0.063
microtubule organizing center organization GO:0031023 168 0.063
positive regulation of proteasomal protein catabolic process GO:1901800 20 0.063
er associated ubiquitin dependent protein catabolic process GO:0030433 3 0.060
protein complex assembly GO:0006461 200 0.060
positive regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032436 19 0.057
carboxylic acid metabolic process GO:0019752 92 0.054
transcription from rna polymerase ii promoter GO:0006366 368 0.050
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.050
protein dna complex subunit organization GO:0071824 86 0.048
response to external biotic stimulus GO:0043207 293 0.048
aging GO:0007568 143 0.046
response to organic substance GO:0010033 284 0.045
organonitrogen compound metabolic process GO:1901564 318 0.043
organelle fission GO:0048285 340 0.042
mitotic g2 m transition checkpoint GO:0044818 70 0.041
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 24 0.040
regulation of cellular protein metabolic process GO:0032268 243 0.040
enzyme linked receptor protein signaling pathway GO:0007167 179 0.039
positive regulation of nucleic acid templated transcription GO:1903508 266 0.039
positive regulation of proteolysis GO:0045862 52 0.039
negative regulation of epithelial cell proliferation GO:0050680 4 0.039
organelle membrane fusion GO:0090174 16 0.039
regulation of proteolysis GO:0030162 87 0.038
larval development GO:0002164 104 0.038
Worm
appendage morphogenesis GO:0035107 397 0.037
immune system process GO:0002376 347 0.036
response to organic cyclic compound GO:0014070 89 0.035
molting cycle GO:0042303 56 0.031
response to endogenous stimulus GO:0009719 119 0.031
apoptotic process GO:0006915 159 0.030
Worm
eye development GO:0001654 323 0.030
organelle assembly GO:0070925 198 0.030
organophosphate metabolic process GO:0019637 195 0.028
homeostatic process GO:0042592 199 0.028
oxoacid metabolic process GO:0043436 103 0.027
small molecule metabolic process GO:0044281 305 0.027
dna damage checkpoint GO:0000077 78 0.026
camera type eye development GO:0043010 4 0.026
regulation of dna templated transcription elongation GO:0032784 17 0.026
cellular response to chemical stimulus GO:0070887 199 0.026
epithelial cell differentiation GO:0030855 322 0.025
endocytosis GO:0006897 310 0.025
regulation of cellular catabolic process GO:0031329 157 0.024
imaginal disc derived appendage development GO:0048737 399 0.024
mitotic g2 dna damage checkpoint GO:0007095 69 0.024
regulation of mitotic cell cycle GO:0007346 190 0.024
organic acid metabolic process GO:0006082 103 0.024
programmed cell death GO:0012501 257 0.023
Worm
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.023
single organism catabolic process GO:0044712 228 0.023
response to organonitrogen compound GO:0010243 75 0.023
positive regulation of catalytic activity GO:0043085 118 0.022
negative regulation of gene expression GO:0010629 387 0.022
cell death GO:0008219 279 0.022
Worm
response to bacterium GO:0009617 198 0.022
vesicle mediated transport GO:0016192 381 0.022
phagocytosis GO:0006909 215 0.022
macromolecular complex assembly GO:0065003 256 0.021
ion transport GO:0006811 145 0.021
purine nucleoside triphosphate catabolic process GO:0009146 108 0.020
appendage development GO:0048736 401 0.020
dna integrity checkpoint GO:0031570 81 0.020
ribonucleotide metabolic process GO:0009259 145 0.020
lateral inhibition GO:0046331 206 0.019
signal transduction by phosphorylation GO:0023014 107 0.019
cellular protein complex assembly GO:0043623 71 0.019
oxidoreduction coenzyme metabolic process GO:0006733 2 0.018
organic substance transport GO:0071702 257 0.018
regulation of cell cycle process GO:0010564 181 0.018
response to oxidative stress GO:0006979 86 0.018
response to biotic stimulus GO:0009607 294 0.018
positive regulation of transcription dna templated GO:0045893 266 0.018
heterocycle catabolic process GO:0046700 166 0.018
post embryonic appendage morphogenesis GO:0035120 385 0.018
response to nitrogen compound GO:1901698 90 0.017
regulation of localization GO:0032879 275 0.017
positive regulation of cellular protein metabolic process GO:0032270 118 0.017
defense response GO:0006952 300 0.017
positive regulation of cellular biosynthetic process GO:0031328 316 0.017
membrane organization GO:0061024 112 0.016
regulation of molecular function GO:0065009 217 0.016
positive regulation of molecular function GO:0044093 136 0.016
protein modification process GO:0036211 438 0.016
protein localization GO:0008104 284 0.016
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 44 0.016
pyridine nucleotide metabolic process GO:0019362 2 0.016
forebrain development GO:0030900 2 0.016
organophosphate catabolic process GO:0046434 112 0.015
positive regulation of peptidase activity GO:0010952 29 0.015
positive regulation of cellular catabolic process GO:0031331 95 0.015
peptide metabolic process GO:0006518 80 0.014
regulation of anatomical structure size GO:0090066 163 0.014
regulation of cellular ketone metabolic process GO:0010565 3 0.014
positive regulation of response to stimulus GO:0048584 323 0.014
developmental pigmentation GO:0048066 68 0.014
cellular protein modification process GO:0006464 438 0.014
posttranscriptional regulation of gene expression GO:0010608 145 0.014
ribonucleotide catabolic process GO:0009261 109 0.014
cellular nitrogen compound catabolic process GO:0044270 165 0.013
purine ribonucleotide metabolic process GO:0009150 145 0.013
nucleoside phosphate metabolic process GO:0006753 162 0.013
aromatic compound catabolic process GO:0019439 166 0.013
defense response to other organism GO:0098542 225 0.013
taxis GO:0042330 304 0.013
imaginal disc derived appendage morphogenesis GO:0035114 395 0.013
protein modification by small protein conjugation or removal GO:0070647 106 0.013
dna repair GO:0006281 54 0.013
striated muscle myosin thick filament assembly GO:0071688 3 0.013
carbohydrate derivative catabolic process GO:1901136 118 0.013
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.013
organic cyclic compound catabolic process GO:1901361 168 0.012
immune response GO:0006955 246 0.012
positive regulation of cellular component biogenesis GO:0044089 80 0.012
response to other organism GO:0051707 293 0.012
regulation of multicellular organismal development GO:2000026 414 0.012
intracellular signal transduction GO:0035556 300 0.012
purine nucleotide metabolic process GO:0006163 146 0.012
mitotic dna damage checkpoint GO:0044773 74 0.012
regulation of cellular component size GO:0032535 98 0.012
purine ribonucleotide catabolic process GO:0009154 109 0.012
dsrna fragmentation GO:0031050 15 0.012
regulation of sequestering of calcium ion GO:0051282 3 0.011
regulation of nuclear division GO:0051783 58 0.011
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 38 0.011
organonitrogen compound catabolic process GO:1901565 128 0.011
regulation of transport GO:0051049 181 0.011
purine nucleoside catabolic process GO:0006152 112 0.011
monocarboxylic acid catabolic process GO:0072329 10 0.011
cellular response to organic substance GO:0071310 132 0.011
body morphogenesis GO:0010171 2 0.011
cellular homeostasis GO:0019725 80 0.011
g2 dna damage checkpoint GO:0031572 69 0.011
cell cell signaling involved in cell fate commitment GO:0045168 210 0.011
autophagy GO:0006914 108 0.011
regulation of membrane potential GO:0042391 35 0.011
establishment or maintenance of polarity of follicular epithelium GO:0016334 26 0.011
regulation of phosphate metabolic process GO:0019220 210 0.011
nucleobase containing small molecule metabolic process GO:0055086 174 0.011
death GO:0016265 284 0.011
Worm
salivary gland cell autophagic cell death GO:0035071 83 0.011
wing disc morphogenesis GO:0007472 344 0.010
positive regulation of cellular protein catabolic process GO:1903364 24 0.010
regulation of protein modification by small protein conjugation or removal GO:1903320 25 0.010
negative regulation of sequestering of calcium ion GO:0051283 2 0.010
regulation of protein catabolic process GO:0042176 55 0.010

Prosbeta1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.070
motor neuron disease DOID:231 0 0.061
central nervous system disease DOID:331 0 0.061
neurodegenerative disease DOID:1289 0 0.061
nervous system disease DOID:863 0 0.061