Drosophila melanogaster

0 known processes

tobi (Dmel_CG11909)

target of brain insulin

(Aliases: CT33098,Dmel\CG11909,CG11909)

tobi biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
organonitrogen compound metabolic process GO:1901564 318 0.099
positive regulation of response to stimulus GO:0048584 323 0.082
single organism behavior GO:0044708 391 0.081
carboxylic acid metabolic process GO:0019752 92 0.074
imaginal disc derived appendage development GO:0048737 399 0.073
vesicle mediated transport GO:0016192 381 0.065
positive regulation of signal transduction GO:0009967 223 0.063
response to abiotic stimulus GO:0009628 341 0.063
organic acid metabolic process GO:0006082 103 0.060
phagocytosis GO:0006909 215 0.060
organic substance catabolic process GO:1901575 308 0.057
ethanolamine containing compound metabolic process GO:0042439 4 0.057
response to organic substance GO:0010033 284 0.055
cholesterol transport GO:0030301 2 0.054
sterol homeostasis GO:0055092 4 0.053
small molecule metabolic process GO:0044281 305 0.052
cellular amino acid metabolic process GO:0006520 61 0.052
cholesterol homeostasis GO:0042632 3 0.051
positive regulation of cell communication GO:0010647 250 0.050
organelle fission GO:0048285 340 0.049
kidney development GO:0001822 3 0.049
imaginal disc derived appendage morphogenesis GO:0035114 395 0.048
cellular catabolic process GO:0044248 372 0.048
phospholipid homeostasis GO:0055091 1 0.046
regionalization GO:0003002 416 0.045
biological adhesion GO:0022610 138 0.044
cellular protein modification process GO:0006464 438 0.044
organic substance transport GO:0071702 257 0.043
catabolic process GO:0009056 409 0.043
oxoacid metabolic process GO:0043436 103 0.040
negative regulation of gene expression GO:0010629 387 0.039
positive regulation of lipid storage GO:0010884 4 0.039
endocytosis GO:0006897 310 0.039
imaginal disc derived wing morphogenesis GO:0007476 337 0.038
sulfur compound metabolic process GO:0006790 59 0.038
positive regulation of signaling GO:0023056 243 0.038
carbohydrate derivative metabolic process GO:1901135 217 0.038
anion homeostasis GO:0055081 3 0.037
negative regulation of cellular metabolic process GO:0031324 382 0.036
locomotory behavior GO:0007626 176 0.035
regulation of behavior GO:0050795 75 0.035
organonitrogen compound catabolic process GO:1901565 128 0.034
intracellular signal transduction GO:0035556 300 0.034
single organism catabolic process GO:0044712 228 0.034
hormone catabolic process GO:0042447 3 0.033
regulation of localization GO:0032879 275 0.033
response to oxygen containing compound GO:1901700 200 0.033
cellular modified amino acid metabolic process GO:0006575 45 0.033
post embryonic appendage morphogenesis GO:0035120 385 0.033
wing disc morphogenesis GO:0007472 344 0.033
peptide metabolic process GO:0006518 80 0.032
response to other organism GO:0051707 293 0.032
regulation of intracellular signal transduction GO:1902531 236 0.031
appendage morphogenesis GO:0035107 397 0.031
nuclear division GO:0000280 332 0.031
meiotic nuclear division GO:0007126 151 0.031
positive regulation of intracellular signal transduction GO:1902533 116 0.030
acylglycerol biosynthetic process GO:0046463 2 0.029
neutral lipid catabolic process GO:0046461 3 0.029
regulation of anatomical structure morphogenesis GO:0022603 242 0.029
g protein coupled receptor signaling pathway GO:0007186 136 0.029
gland development GO:0048732 191 0.028
phosphatidylethanolamine metabolic process GO:0046337 1 0.028
appendage development GO:0048736 401 0.028
regulation of transport GO:0051049 181 0.028
carbohydrate derivative biosynthetic process GO:1901137 85 0.028
response to hypoxia GO:0001666 53 0.028
acylglycerol catabolic process GO:0046464 3 0.027
protein modification process GO:0036211 438 0.027
neutral lipid biosynthetic process GO:0046460 2 0.027
secretion GO:0046903 109 0.027
homeostatic process GO:0042592 199 0.027
body morphogenesis GO:0010171 2 0.027
response to copper ion GO:0046688 4 0.026
phosphatidic acid metabolic process GO:0046473 1 0.026
epithelial cell development GO:0002064 274 0.026
response to bacterium GO:0009617 198 0.026
cell cell signaling involved in cell fate commitment GO:0045168 210 0.025
oligosaccharide transport GO:0015772 2 0.025
ion transport GO:0006811 145 0.025
glycoprotein biosynthetic process GO:0009101 41 0.025
negative regulation of response to stimulus GO:0048585 258 0.025
lateral inhibition GO:0046331 206 0.024
response to external biotic stimulus GO:0043207 293 0.024
behavioral response to ethanol GO:0048149 49 0.024
renal system development GO:0072001 72 0.024
regulation of response to stress GO:0080134 200 0.023
male meiosis GO:0007140 52 0.023
lipid metabolic process GO:0006629 121 0.023
developmental maturation GO:0021700 172 0.023
organonitrogen compound biosynthetic process GO:1901566 117 0.023
dorsal ventral pattern formation GO:0009953 133 0.023
positive regulation of sequestering of triglyceride GO:0010890 1 0.022
response to temperature stimulus GO:0009266 106 0.022
cellular amine metabolic process GO:0044106 12 0.022
learning GO:0007612 75 0.022
phosphorylation GO:0016310 294 0.022
camera type eye development GO:0043010 4 0.022
cell death GO:0008219 279 0.022
response to decreased oxygen levels GO:0036293 58 0.022
cellular amide metabolic process GO:0043603 80 0.022
meiotic cell cycle process GO:1903046 132 0.022
triglyceride biosynthetic process GO:0019432 2 0.022
organophosphate metabolic process GO:0019637 195 0.022
cognition GO:0050890 141 0.021
chemosensory behavior GO:0007635 106 0.021
negative regulation of cellular biosynthetic process GO:0031327 277 0.021
regulation of cell shape GO:0008360 113 0.021
neurological system process GO:0050877 358 0.021
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.021
synaptic transmission GO:0007268 288 0.021
cellular response to chemical stimulus GO:0070887 199 0.021
actin filament based process GO:0030029 220 0.021
monocarboxylic acid transport GO:0015718 3 0.021
adult behavior GO:0030534 137 0.021
cell adhesion GO:0007155 136 0.021
cell proliferation GO:0008283 299 0.020
regulation of lipid transport GO:0032368 3 0.020
actin cytoskeleton organization GO:0030036 206 0.020
cellular lipid metabolic process GO:0044255 83 0.020
positive regulation of multicellular organismal process GO:0051240 143 0.020
cellular response to organic substance GO:0071310 132 0.020
regulation of cell death GO:0010941 173 0.019
regulation of sterol transport GO:0032371 1 0.019
l glutamate import GO:0051938 1 0.019
response to extracellular stimulus GO:0009991 116 0.019
embryonic pattern specification GO:0009880 174 0.019
establishment of localization in cell GO:0051649 402 0.019
ras protein signal transduction GO:0007265 88 0.019
transcription from rna polymerase ii promoter GO:0006366 368 0.019
positive regulation of phosphorus metabolic process GO:0010562 139 0.019
jak stat cascade GO:0007259 49 0.019
urogenital system development GO:0001655 72 0.019
protein complex biogenesis GO:0070271 201 0.019
epithelial cell differentiation GO:0030855 322 0.019
salivary gland morphogenesis GO:0007435 145 0.018
positive regulation of macromolecule metabolic process GO:0010604 405 0.018
negative regulation of nucleic acid templated transcription GO:1903507 240 0.018
rna processing GO:0006396 147 0.018
mrna processing GO:0006397 104 0.018
anatomical structure homeostasis GO:0060249 97 0.018
amine metabolic process GO:0009308 12 0.018
death GO:0016265 284 0.018
response to lipopolysaccharide GO:0032496 4 0.018
olfactory behavior GO:0042048 97 0.018
regulation of cell morphogenesis GO:0022604 163 0.017
axis specification GO:0009798 167 0.017
small gtpase mediated signal transduction GO:0007264 88 0.017
regulation of phosphorus metabolic process GO:0051174 210 0.017
negative regulation of cell differentiation GO:0045596 143 0.017
regulation of cellular protein metabolic process GO:0032268 243 0.017
regulation of phosphate metabolic process GO:0019220 210 0.017
regulation of sequestering of triglyceride GO:0010889 3 0.017
regulation of protein metabolic process GO:0051246 256 0.017
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.017
cellularization GO:0007349 90 0.017
negative regulation of developmental process GO:0051093 201 0.017
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.017
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.017
regulation of multicellular organismal development GO:2000026 414 0.017
response to oxygen levels GO:0070482 59 0.017
drinking behavior GO:0042756 2 0.017
nitrogen compound transport GO:0071705 85 0.016
negative regulation of signal transduction GO:0009968 206 0.016
mitotic nuclear division GO:0007067 213 0.016
response to biotic stimulus GO:0009607 294 0.016
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.016
anion transport GO:0006820 41 0.016
circadian sleep wake cycle sleep GO:0050802 23 0.016
glycosyl compound metabolic process GO:1901657 127 0.016
carbohydrate derivative catabolic process GO:1901136 118 0.016
organic hydroxy compound metabolic process GO:1901615 83 0.016
response to alcohol GO:0097305 95 0.016
heart process GO:0003015 37 0.016
positive regulation of biosynthetic process GO:0009891 316 0.016
carbohydrate metabolic process GO:0005975 82 0.016
l amino acid import GO:0043092 2 0.016
regulation of heart rate GO:0002027 11 0.016
single organism biosynthetic process GO:0044711 206 0.016
mating GO:0007618 120 0.016
telencephalon development GO:0021537 2 0.015
forebrain development GO:0030900 2 0.015
proteolysis GO:0006508 192 0.015
tissue death GO:0016271 102 0.015
mating behavior GO:0007617 106 0.015
negative regulation of biosynthetic process GO:0009890 277 0.015
positive regulation of phosphate metabolic process GO:0045937 139 0.015
oocyte differentiation GO:0009994 145 0.015
intracellular transport GO:0046907 228 0.015
aggressive behavior GO:0002118 63 0.015
cellular response to dna damage stimulus GO:0006974 223 0.015
negative regulation of protein metabolic process GO:0051248 85 0.015
regulation of cholesterol transport GO:0032374 1 0.015
lipid localization GO:0010876 54 0.015
cell division GO:0051301 248 0.015
digestive tract development GO:0048565 149 0.015
regulation of cellular amine metabolic process GO:0033238 3 0.015
purine nucleotide metabolic process GO:0006163 146 0.015
multicellular organismal aging GO:0010259 140 0.015
organophosphate catabolic process GO:0046434 112 0.015
positive regulation of transport GO:0051050 92 0.015
spermatogenesis GO:0007283 200 0.015
regulation of mitotic cell cycle GO:0007346 190 0.015
positive regulation of gene expression GO:0010628 290 0.015
regulation of circadian rhythm GO:0042752 49 0.015
detection of stimulus involved in sensory perception GO:0050906 92 0.014
transmembrane transport GO:0055085 139 0.014
macromolecule catabolic process GO:0009057 161 0.014
chromosome segregation GO:0007059 157 0.014
multi organism behavior GO:0051705 175 0.014
chromatin silencing GO:0006342 76 0.014
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.014
glycoprotein metabolic process GO:0009100 41 0.014
lipid homeostasis GO:0055088 33 0.014
regulation of gene expression epigenetic GO:0040029 128 0.014
regulation of molecular function GO:0065009 217 0.014
triglyceride catabolic process GO:0019433 3 0.014
mitochondrion organization GO:0007005 65 0.014
humoral immune response GO:0006959 117 0.014
protein complex assembly GO:0006461 200 0.014
adult locomotory behavior GO:0008344 76 0.014
cation transport GO:0006812 110 0.014
positive regulation of cellular biosynthetic process GO:0031328 316 0.014
regulation of cell cycle GO:0051726 291 0.014
trehalose transport GO:0015771 1 0.014
salivary gland cell autophagic cell death GO:0035071 83 0.014
cell maturation GO:0048469 144 0.014
regulation of cellular ketone metabolic process GO:0010565 3 0.014
single organism carbohydrate metabolic process GO:0044723 72 0.014
blastoderm segmentation GO:0007350 159 0.014
oocyte construction GO:0007308 112 0.014
negative regulation of cellular protein metabolic process GO:0032269 85 0.014
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.013
negative regulation of signaling GO:0023057 219 0.013
establishment of protein localization GO:0045184 163 0.013
positive regulation of cell motility GO:2000147 3 0.013
regulation of multi organism process GO:0043900 131 0.013
male gamete generation GO:0048232 201 0.013
regulation of catabolic process GO:0009894 170 0.013
tube development GO:0035295 244 0.013
oocyte axis specification GO:0007309 108 0.013
regulation of catalytic activity GO:0050790 185 0.013
segmentation GO:0035282 207 0.013
cell cycle phase transition GO:0044770 140 0.013
macromolecular complex assembly GO:0065003 256 0.013
rna localization GO:0006403 115 0.013
columnar cuboidal epithelial cell development GO:0002066 249 0.013
negative regulation of cell communication GO:0010648 223 0.013
meiosis i GO:0007127 59 0.013
lipopolysaccharide mediated signaling pathway GO:0031663 1 0.013
rhythmic process GO:0048511 106 0.013
actin filament organization GO:0007015 126 0.013
protein phosphorylation GO:0006468 169 0.012
nucleoside metabolic process GO:0009116 127 0.012
neuropeptide signaling pathway GO:0007218 45 0.012
single organism cellular localization GO:1902580 180 0.012
immune system process GO:0002376 347 0.012
meiotic cell cycle GO:0051321 171 0.012
steroid catabolic process GO:0006706 1 0.012
organic cyclic compound catabolic process GO:1901361 168 0.012
nucleotide metabolic process GO:0009117 161 0.012
ribonucleotide metabolic process GO:0009259 145 0.012
regulation of synaptic transmission GO:0050804 69 0.012
innate immune response GO:0045087 144 0.012
regulation of mitotic cell cycle phase transition GO:1901990 130 0.012
immune response regulating signaling pathway GO:0002764 2 0.012
protein transport GO:0015031 155 0.012
gland morphogenesis GO:0022612 145 0.012
rhythmic behavior GO:0007622 76 0.012
photoreceptor cell differentiation GO:0046530 170 0.012
histolysis GO:0007559 102 0.012
inorganic ion transmembrane transport GO:0098660 73 0.012
developmental programmed cell death GO:0010623 138 0.012
cellular response to molecule of bacterial origin GO:0071219 3 0.012
nucleobase containing small molecule metabolic process GO:0055086 174 0.012
negative regulation of rna metabolic process GO:0051253 251 0.012
gene silencing GO:0016458 138 0.012
positive regulation of cellular component organization GO:0051130 156 0.012
tissue morphogenesis GO:0048729 297 0.012
mrna metabolic process GO:0016071 124 0.012
organelle assembly GO:0070925 198 0.012
imaginal disc pattern formation GO:0007447 91 0.012
larval behavior GO:0030537 42 0.012
response to ethanol GO:0045471 59 0.012
mitotic spindle organization GO:0007052 220 0.012
regulation of small gtpase mediated signal transduction GO:0051056 93 0.012
developmental growth GO:0048589 280 0.012
response to organophosphorus GO:0046683 2 0.012
eye morphogenesis GO:0048592 260 0.012
cellular nitrogen compound catabolic process GO:0044270 165 0.012
autophagic cell death GO:0048102 83 0.012
sensory organ morphogenesis GO:0090596 260 0.012
positive regulation of cell migration GO:0030335 2 0.012
cellular macromolecule catabolic process GO:0044265 136 0.012
regulation of mapk cascade GO:0043408 92 0.012
response to organonitrogen compound GO:0010243 75 0.012
single organism intracellular transport GO:1902582 207 0.011
alditol phosphate metabolic process GO:0052646 2 0.011
apoptotic process GO:0006915 159 0.011
sperm individualization GO:0007291 48 0.011
spinal cord development GO:0021510 1 0.011
ribonucleoside triphosphate metabolic process GO:0009199 119 0.011
morphogenesis of an epithelium GO:0002009 276 0.011
negative regulation of translation GO:0017148 28 0.011
regulation of cellular amino acid metabolic process GO:0006521 0 0.011
amino sugar catabolic process GO:0046348 3 0.011
cell migration GO:0016477 238 0.011
chromosome organization GO:0051276 360 0.011
cell motility GO:0048870 251 0.011
enzyme linked receptor protein signaling pathway GO:0007167 179 0.011
cellular ketone metabolic process GO:0042180 24 0.011
metal ion transport GO:0030001 74 0.011
nucleoside phosphate metabolic process GO:0006753 162 0.011
multi multicellular organism process GO:0044706 123 0.011
heart contraction GO:0060047 26 0.011
ribonucleoside metabolic process GO:0009119 127 0.011
protein processing GO:0016485 68 0.011
cellular response to lipopolysaccharide GO:0071222 3 0.011
regulation of programmed cell death GO:0043067 152 0.011
inter male aggressive behavior GO:0002121 60 0.011
regulation of cell substrate adhesion GO:0010810 2 0.011
signal transduction by phosphorylation GO:0023014 107 0.011
camera type eye morphogenesis GO:0048593 2 0.011
anterior posterior axis specification embryo GO:0008595 103 0.011
tube morphogenesis GO:0035239 191 0.011
cellular response to biotic stimulus GO:0071216 4 0.011
chemical homeostasis GO:0048878 92 0.011
regulation of synapse structure and activity GO:0050803 128 0.011
regulation of system process GO:0044057 36 0.011
exocrine system development GO:0035272 162 0.011
response to starvation GO:0042594 97 0.011
positive regulation of cellular amine metabolic process GO:0033240 0 0.011
salivary gland histolysis GO:0035070 88 0.011
response to heat GO:0009408 63 0.011
lipid biosynthetic process GO:0008610 46 0.011
positive regulation of phosphorylation GO:0042327 87 0.011
heart development GO:0007507 82 0.011
acylglycerol metabolic process GO:0006639 12 0.011
growth GO:0040007 359 0.011
purine containing compound metabolic process GO:0072521 155 0.011
programmed cell death GO:0012501 257 0.011
alpha amino acid metabolic process GO:1901605 20 0.010
multicellular organismal reproductive behavior GO:0033057 110 0.010
reproductive behavior GO:0019098 122 0.010
compound eye morphogenesis GO:0001745 249 0.010
dorsal ventral axis specification GO:0009950 66 0.010
localization of cell GO:0051674 257 0.010
mapk cascade GO:0000165 107 0.010
negative regulation of mitotic cell cycle GO:0045930 109 0.010
wing disc pattern formation GO:0035222 66 0.010
sodium dependent phosphate transport GO:0044341 2 0.010
tripartite regional subdivision GO:0007351 103 0.010
hormone metabolic process GO:0042445 33 0.010
cytoplasmic transport GO:0016482 130 0.010
larval locomotory behavior GO:0008345 27 0.010
extrinsic apoptotic signaling pathway GO:0097191 1 0.010
limb development GO:0060173 1 0.010
positive regulation of rna biosynthetic process GO:1902680 266 0.010
connective tissue development GO:0061448 3 0.010
oocyte microtubule cytoskeleton organization GO:0016325 35 0.010
multicellular organismal homeostasis GO:0048871 41 0.010
sister chromatid segregation GO:0000819 92 0.010
response to calcium ion GO:0051592 1 0.010
regulation of protein modification process GO:0031399 112 0.010
hindbrain development GO:0030902 2 0.010
regulation of cellular catabolic process GO:0031329 157 0.010
endomembrane system organization GO:0010256 119 0.010
cellular response to hormone stimulus GO:0032870 44 0.010
regulation of organelle organization GO:0033043 196 0.010
phosphatidylcholine metabolic process GO:0046470 3 0.010
negative regulation of multicellular organismal process GO:0051241 142 0.010

tobi disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.112
disease of metabolism DOID:0014667 0 0.045
familial hyperlipidemia DOID:1168 0 0.045
lipid metabolism disorder DOID:3146 0 0.045
familial combined hyperlipidemia DOID:13809 0 0.045
inherited metabolic disorder DOID:655 0 0.045
familial lipoprotein lipase deficiency DOID:14118 0 0.045
diabetes mellitus DOID:9351 0 0.044
type 2 diabetes mellitus DOID:9352 0 0.044
carbohydrate metabolism disease DOID:0050013 0 0.044
glucose metabolism disease DOID:4194 0 0.044
acquired metabolic disease DOID:0060158 0 0.044
hair disease DOID:421 0 0.040
integumentary system disease DOID:16 0 0.040
hypotrichosis DOID:4535 0 0.040
nervous system disease DOID:863 0 0.032
familial hypertriglyceridemia DOID:0050527 0 0.031
cardiovascular system disease DOID:1287 0 0.015
musculoskeletal system disease DOID:17 0 0.015
urinary system disease DOID:18 0 0.014
central nervous system disease DOID:331 0 0.013
neurodegenerative disease DOID:1289 0 0.013
disease of cellular proliferation DOID:14566 0 0.013
sensory system disease DOID:0050155 0 0.012
eye and adnexa disease DOID:1492 0 0.011
eye disease DOID:5614 0 0.011
cancer DOID:162 0 0.011
organ system cancer DOID:0050686 0 0.011