Drosophila melanogaster

95 known processes

Shc (Dmel_CG3715)

SHC-adaptor protein

(Aliases: Dmel\CG3715,D-Shc,dshc,dShc,shc,DSHC,CG3715)

Shc biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
ameboidal type cell migration GO:0001667 151 1.000
epithelial cell migration GO:0010631 148 1.000
ovarian follicle cell migration GO:0007297 121 0.999
tissue migration GO:0090130 155 0.999
cell migration GO:0016477 238 0.995
ovarian follicle cell development GO:0030707 248 0.993
epithelium migration GO:0090132 148 0.992
cell motility GO:0048870 251 0.992
border follicle cell migration GO:0007298 113 0.989
tissue morphogenesis GO:0048729 297 0.986
localization of cell GO:0051674 257 0.978
melanotic encapsulation of foreign target GO:0035011 30 0.970
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.929
epithelial cell development GO:0002064 274 0.912
columnar cuboidal epithelial cell development GO:0002066 249 0.909
immune effector process GO:0002252 98 0.892
asymmetric stem cell division GO:0098722 49 0.869
immune system process GO:0002376 347 0.832
embryonic morphogenesis GO:0048598 206 0.829
wing disc morphogenesis GO:0007472 344 0.790
neuroblast division GO:0055057 35 0.781
establishment of planar polarity GO:0001736 87 0.765
erbb signaling pathway GO:0038127 58 0.746
encapsulation of foreign target GO:0035010 38 0.746
membrane organization GO:0061024 112 0.746
post embryonic appendage morphogenesis GO:0035120 385 0.720
male gamete generation GO:0048232 201 0.718
small gtpase mediated signal transduction GO:0007264 88 0.712
regulation of intracellular signal transduction GO:1902531 236 0.711
Human Mouse Rat
ras protein signal transduction GO:0007265 88 0.692
regulation of ras protein signal transduction GO:0046578 93 0.679
imaginal disc derived wing morphogenesis GO:0007476 337 0.670
morphogenesis of embryonic epithelium GO:0016331 94 0.666
cellular response to organic substance GO:0071310 132 0.666
Rat
immune response GO:0006955 246 0.646
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.590
signal transduction by phosphorylation GO:0023014 107 0.569
Human Mouse Rat
establishment or maintenance of cell polarity GO:0007163 167 0.544
cellular nitrogen compound catabolic process GO:0044270 165 0.519
vesicle mediated transport GO:0016192 381 0.506
imaginal disc derived appendage morphogenesis GO:0035114 395 0.506
embryonic pattern specification GO:0009880 174 0.490
regulation of multicellular organismal development GO:2000026 414 0.482
purine nucleoside metabolic process GO:0042278 127 0.481
morphogenesis of an epithelium GO:0002009 276 0.476
organonitrogen compound metabolic process GO:1901564 318 0.460
learning or memory GO:0007611 141 0.460
Mouse
melanization defense response GO:0035006 45 0.459
positive regulation of phosphate metabolic process GO:0045937 139 0.455
Human Mouse Rat Worm
regionalization GO:0003002 416 0.452
nucleotide catabolic process GO:0009166 109 0.450
epithelial cell differentiation GO:0030855 322 0.435
actin cytoskeleton organization GO:0030036 206 0.429
Mouse Rat
negative regulation of rna metabolic process GO:0051253 251 0.424
positive regulation of cell communication GO:0010647 250 0.421
Human Mouse Rat
protein modification process GO:0036211 438 0.400
Human Mouse Rat
regulation of developmental growth GO:0048638 174 0.396
appendage development GO:0048736 401 0.394
positive regulation of fibroblast growth factor receptor signaling pathway GO:0045743 5 0.391
imaginal disc derived appendage development GO:0048737 399 0.383
developmental growth GO:0048589 280 0.382
erk1 and erk2 cascade GO:0070371 39 0.377
nucleotide metabolic process GO:0009117 161 0.371
establishment of organelle localization GO:0051656 122 0.350
purine nucleoside triphosphate metabolic process GO:0009144 119 0.340
regulation of phosphate metabolic process GO:0019220 210 0.340
Human Mouse Rat Worm
regulation of cellular component biogenesis GO:0044087 201 0.334
cellular catabolic process GO:0044248 372 0.333
open tracheal system development GO:0007424 204 0.333
catabolic process GO:0009056 409 0.314
purine nucleotide metabolic process GO:0006163 146 0.310
macromolecular complex assembly GO:0065003 256 0.309
response to abiotic stimulus GO:0009628 341 0.304
Rat
epidermal growth factor receptor signaling pathway GO:0007173 58 0.304
dorsal ventral axis specification ovarian follicular epithelium GO:0008069 13 0.304
appendage morphogenesis GO:0035107 397 0.294
regulation of small gtpase mediated signal transduction GO:0051056 93 0.290
regulation of phosphorylation GO:0042325 147 0.288
Human Mouse Rat Worm
purine nucleoside triphosphate catabolic process GO:0009146 108 0.286
negative regulation of rna biosynthetic process GO:1902679 240 0.282
response to organic substance GO:0010033 284 0.275
Rat
purine nucleoside catabolic process GO:0006152 112 0.274
intracellular signal transduction GO:0035556 300 0.274
ribonucleoside triphosphate catabolic process GO:0009203 108 0.272
compound eye photoreceptor fate commitment GO:0001752 36 0.271
phosphorylation GO:0016310 294 0.271
Human Mouse Rat Worm
regulation of cellular protein metabolic process GO:0032268 243 0.268
Human Mouse Rat
glycosyl compound metabolic process GO:1901657 127 0.266
response to fibroblast growth factor GO:0071774 10 0.265
nucleobase containing small molecule metabolic process GO:0055086 174 0.253
single organism membrane organization GO:0044802 93 0.251
asymmetric neuroblast division GO:0055059 33 0.249
negative regulation of transcription dna templated GO:0045892 237 0.249
establishment of localization in cell GO:0051649 402 0.249
neural precursor cell proliferation GO:0061351 75 0.248
negative regulation of biosynthetic process GO:0009890 277 0.246
organic substance catabolic process GO:1901575 308 0.244
mapk cascade GO:0000165 107 0.243
Human Mouse Rat
positive regulation of macromolecule metabolic process GO:0010604 405 0.241
Human Mouse Rat
small molecule metabolic process GO:0044281 305 0.240
heterocycle catabolic process GO:0046700 166 0.240
negative regulation of signal transduction GO:0009968 206 0.227
organic cyclic compound catabolic process GO:1901361 168 0.223
guanosine containing compound catabolic process GO:1901069 74 0.213
cognition GO:0050890 141 0.210
Mouse
cellular response to chemical stimulus GO:0070887 199 0.205
Rat
neuronal stem cell division GO:0036445 35 0.201
fibroblast growth factor receptor signaling pathway GO:0008543 10 0.200
secondary metabolic process GO:0019748 75 0.199
positive regulation of phosphorus metabolic process GO:0010562 139 0.193
Human Mouse Rat Worm
positive regulation of cellular component biogenesis GO:0044089 80 0.192
organonitrogen compound catabolic process GO:1901565 128 0.191
cell death GO:0008219 279 0.188
Mouse
enzyme linked receptor protein signaling pathway GO:0007167 179 0.187
neurological system process GO:0050877 358 0.183
Mouse
epithelial cell migration open tracheal system GO:0007427 32 0.183
carbohydrate derivative metabolic process GO:1901135 217 0.182
nucleobase containing compound catabolic process GO:0034655 165 0.181
regulation of phosphorus metabolic process GO:0051174 210 0.181
Human Mouse Rat Worm
spermatogenesis GO:0007283 200 0.178
establishment or maintenance of apical basal cell polarity GO:0035088 34 0.176
positive regulation of gene expression GO:0010628 290 0.175
eye photoreceptor cell fate commitment GO:0042706 37 0.173
positive regulation of intracellular signal transduction GO:1902533 116 0.171
Human Mouse Rat
growth GO:0040007 359 0.170
nucleoside phosphate catabolic process GO:1901292 110 0.167
negative regulation of nucleic acid templated transcription GO:1903507 240 0.167
tube morphogenesis GO:0035239 191 0.166
somatic stem cell division GO:0048103 37 0.165
regulation of nervous system development GO:0051960 248 0.165
axis specification GO:0009798 167 0.163
response to growth factor GO:0070848 31 0.162
negative regulation of response to stimulus GO:0048585 258 0.156
macromolecule catabolic process GO:0009057 161 0.156
regulation of mapk cascade GO:0043408 92 0.155
Human Mouse Rat
reciprocal meiotic recombination GO:0007131 19 0.154
oocyte dorsal ventral axis specification GO:0007310 34 0.152
aromatic compound catabolic process GO:0019439 166 0.151
positive regulation of response to stimulus GO:0048584 323 0.150
Human Mouse Rat
purine ribonucleotide catabolic process GO:0009154 109 0.150
neuron projection guidance GO:0097485 241 0.147
central nervous system development GO:0007417 201 0.147
ribonucleoside metabolic process GO:0009119 127 0.143
regulation of erk1 and erk2 cascade GO:0070372 39 0.143
endocytosis GO:0006897 310 0.142
rna localization GO:0006403 115 0.141
purine ribonucleoside metabolic process GO:0046128 127 0.140
dendrite development GO:0016358 204 0.139
oocyte microtubule cytoskeleton organization GO:0016325 35 0.137
sex differentiation GO:0007548 81 0.135
cellular protein modification process GO:0006464 438 0.133
Human Mouse Rat
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.132
regulation of catabolic process GO:0009894 170 0.131
regulation of protein metabolic process GO:0051246 256 0.130
Human Mouse Rat
nucleoside triphosphate catabolic process GO:0009143 108 0.130
negative regulation of gene expression GO:0010629 387 0.129
nucleoside catabolic process GO:0009164 112 0.128
stem cell division GO:0017145 69 0.127
purine ribonucleoside catabolic process GO:0046130 112 0.125
regulation of stress activated protein kinase signaling cascade GO:0070302 42 0.125
rho protein signal transduction GO:0007266 14 0.125
positive regulation of catabolic process GO:0009896 105 0.124
nucleoside triphosphate metabolic process GO:0009141 120 0.124
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.122
purine nucleotide catabolic process GO:0006195 109 0.122
guanosine containing compound metabolic process GO:1901068 74 0.121
ribonucleotide catabolic process GO:0009261 109 0.121
purine containing compound catabolic process GO:0072523 112 0.120
response to endogenous stimulus GO:0009719 119 0.120
Rat
morphogenesis of a polarized epithelium GO:0001738 93 0.119
learning GO:0007612 75 0.119
cellular response to fibroblast growth factor stimulus GO:0044344 10 0.118
positive regulation of nucleoside metabolic process GO:0045979 47 0.118
nucleoside metabolic process GO:0009116 127 0.117
segmentation GO:0035282 207 0.117
regulation of response to stress GO:0080134 200 0.115
purine ribonucleotide metabolic process GO:0009150 145 0.114
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.113
eye development GO:0001654 323 0.112
regulation of actin filament based process GO:0032970 42 0.112
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.108
Rat
positive regulation of signaling GO:0023056 243 0.106
Human Mouse Rat
axon guidance GO:0007411 233 0.105
regulation of cell morphogenesis GO:0022604 163 0.105
protein localization GO:0008104 284 0.105
neuromuscular junction development GO:0007528 149 0.104
negative regulation of cellular protein metabolic process GO:0032269 85 0.104
ribonucleotide metabolic process GO:0009259 145 0.103
establishment of tissue polarity GO:0007164 87 0.103
eye photoreceptor cell differentiation GO:0001754 145 0.102
photoreceptor cell development GO:0042461 96 0.100
regulation of organ morphogenesis GO:2000027 78 0.100
reproductive structure development GO:0048608 74 0.100
single organism catabolic process GO:0044712 228 0.100
single organism cellular localization GO:1902580 180 0.100
oocyte axis specification GO:0007309 108 0.098
positive regulation of signal transduction GO:0009967 223 0.097
Human Mouse Rat
establishment of vesicle localization GO:0051650 51 0.096
purine containing compound metabolic process GO:0072521 155 0.094
inositol lipid mediated signaling GO:0048017 4 0.094
chemotaxis GO:0006935 249 0.094
forebrain development GO:0030900 2 0.094
negative regulation of cellular component organization GO:0051129 108 0.093
cellular macromolecule catabolic process GO:0044265 136 0.093
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.091
stem cell proliferation GO:0072089 88 0.089
axonogenesis GO:0007409 290 0.087
negative regulation of signaling GO:0023057 219 0.087
intracellular transport GO:0046907 228 0.086
synaptic transmission GO:0007268 288 0.085
Mouse
integrin mediated signaling pathway GO:0007229 3 0.085
regulation of growth GO:0040008 233 0.084
double strand break repair GO:0006302 26 0.084
blastoderm segmentation GO:0007350 159 0.083
ribonucleoside catabolic process GO:0042454 112 0.082
photoreceptor cell differentiation GO:0046530 170 0.082
axon development GO:0061564 297 0.082
regulation of transport GO:0051049 181 0.082
regulation of erbb signaling pathway GO:1901184 42 0.079
regulation of cellular response to stress GO:0080135 89 0.079
phenol containing compound metabolic process GO:0018958 57 0.079
negative regulation of peptidyl tyrosine phosphorylation GO:0050732 6 0.078
oocyte microtubule cytoskeleton polarization GO:0008103 22 0.078
neuroblast proliferation GO:0007405 74 0.077
developmental growth involved in morphogenesis GO:0060560 65 0.077
cellular response to endogenous stimulus GO:0071495 80 0.076
Rat
stem cell differentiation GO:0048863 117 0.075
Mouse
regulation of actin filament polymerization GO:0030833 25 0.075
organophosphate catabolic process GO:0046434 112 0.075
meiotic nuclear division GO:0007126 151 0.074
rna processing GO:0006396 147 0.074
gtp catabolic process GO:0006184 72 0.074
response to radiation GO:0009314 155 0.073
synaptic growth at neuromuscular junction GO:0051124 119 0.073
regulation of actin cytoskeleton organization GO:0032956 42 0.073
reciprocal dna recombination GO:0035825 19 0.072
cell proliferation GO:0008283 299 0.072
Mouse Rat
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 44 0.071
nucleoside phosphate metabolic process GO:0006753 162 0.071
protein complex biogenesis GO:0070271 201 0.070
chromosome separation GO:0051304 42 0.070
anatomical structure homeostasis GO:0060249 97 0.070
single organism behavior GO:0044708 391 0.069
Mouse
negative regulation of small gtpase mediated signal transduction GO:0051058 13 0.069
cell junction organization GO:0034330 57 0.065
regulation of actin filament length GO:0030832 27 0.064
carbohydrate derivative catabolic process GO:1901136 118 0.064
regulation of actin polymerization or depolymerization GO:0008064 27 0.064
determination of adult lifespan GO:0008340 137 0.064
multicellular organismal aging GO:0010259 140 0.063
cell division GO:0051301 248 0.063
positive regulation of nucleotide metabolic process GO:0045981 55 0.062
programmed cell death GO:0012501 257 0.062
Mouse
meiosis i GO:0007127 59 0.061
regulation of cell differentiation GO:0045595 302 0.061
respiratory system development GO:0060541 213 0.061
actin filament polymerization GO:0030041 27 0.061
wnt signaling pathway GO:0016055 98 0.061
regulation of stress activated mapk cascade GO:0032872 41 0.061
endomembrane system organization GO:0010256 119 0.060
cellular macromolecule localization GO:0070727 220 0.060
regulation of cellular component size GO:0032535 98 0.059
transcription from rna polymerase ii promoter GO:0006366 368 0.059
regulation of synaptic growth at neuromuscular junction GO:0008582 89 0.058
vesicle organization GO:0016050 44 0.058
regulation of anatomical structure morphogenesis GO:0022603 242 0.058
protein complex assembly GO:0006461 200 0.058
death GO:0016265 284 0.058
Mouse
regulation of cell proliferation GO:0042127 163 0.058
Mouse Rat
compound eye photoreceptor cell differentiation GO:0001751 140 0.057
anterior posterior axis specification GO:0009948 109 0.057
development of primary sexual characteristics GO:0045137 50 0.056
positive regulation of erk1 and erk2 cascade GO:0070374 36 0.054
torc1 signaling GO:0038202 12 0.054
positive regulation of mapk cascade GO:0043410 63 0.054
Human Mouse Rat
regulation of cellular amino acid metabolic process GO:0006521 0 0.053
protein phosphorylation GO:0006468 169 0.053
Human Mouse Rat
spermatid development GO:0007286 98 0.052
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.052
taxis GO:0042330 304 0.051
tube development GO:0035295 244 0.051
cell projection assembly GO:0030031 94 0.050
glycosyl compound catabolic process GO:1901658 112 0.050
positive regulation of actin filament polymerization GO:0030838 11 0.050
ribose phosphate metabolic process GO:0019693 145 0.050
positive regulation of molecular function GO:0044093 136 0.050
Human Mouse Rat Worm
ribonucleoside triphosphate metabolic process GO:0009199 119 0.050
regulation of epithelial cell proliferation GO:0050678 4 0.049
regulation of rho protein signal transduction GO:0035023 20 0.049
cytoplasmic transport GO:0016482 130 0.049
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.049
positive regulation of cell proliferation GO:0008284 47 0.048
Mouse Rat
embryonic development via the syncytial blastoderm GO:0001700 148 0.048
negative regulation of cellular biosynthetic process GO:0031327 277 0.048
spindle organization GO:0007051 253 0.047
mesoderm development GO:0007498 78 0.047
camera type eye morphogenesis GO:0048593 2 0.047
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.047
vesicle localization GO:0051648 55 0.046
anterior posterior pattern specification GO:0009952 136 0.046
cellular response to dna damage stimulus GO:0006974 223 0.045
positive regulation of cellular protein metabolic process GO:0032270 118 0.044
Human Mouse Rat
regulation of jnk cascade GO:0046328 40 0.044
organic hydroxy compound metabolic process GO:1901615 83 0.044
dendrite morphogenesis GO:0048813 199 0.044
meiotic cell cycle process GO:1903046 132 0.044
r7 cell differentiation GO:0045466 43 0.044
associative learning GO:0008306 65 0.043
regulation of organelle organization GO:0033043 196 0.043
positive regulation of hydrolase activity GO:0051345 78 0.043
peptidyl tyrosine modification GO:0018212 24 0.043
hemocyte migration GO:0035099 19 0.042
positive regulation of protein phosphorylation GO:0001934 34 0.042
Human Mouse Rat
vesicle fusion GO:0006906 19 0.042
innate immune response GO:0045087 144 0.042
anterior posterior axis specification embryo GO:0008595 103 0.042
stress activated protein kinase signaling cascade GO:0031098 55 0.041
reproductive system development GO:0061458 74 0.041
regulation of cell development GO:0060284 215 0.041
proteasomal protein catabolic process GO:0010498 59 0.041
digestive tract morphogenesis GO:0048546 127 0.041
rna catabolic process GO:0006401 37 0.040
dorsal ventral axis specification GO:0009950 66 0.040
imaginal disc derived wing vein specification GO:0007474 48 0.040
amine metabolic process GO:0009308 12 0.040
meiotic cell cycle GO:0051321 171 0.040
regulation of wound healing GO:0061041 13 0.039
regulation of cellular amine metabolic process GO:0033238 3 0.039
circulatory system process GO:0003013 37 0.039
Rat
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.039
Rat
negative regulation of protein metabolic process GO:0051248 85 0.039
regulation of cellular catabolic process GO:0031329 157 0.039
positive regulation of secretion by cell GO:1903532 20 0.039
positive regulation of rna biosynthetic process GO:1902680 266 0.039
positive regulation of gtp catabolic process GO:0033126 43 0.038
endosomal transport GO:0016197 44 0.038
gravitaxis GO:0042332 26 0.038
phagocytosis GO:0006909 215 0.038
positive regulation of cellular component organization GO:0051130 156 0.037
asymmetric protein localization GO:0008105 33 0.037
immune system development GO:0002520 57 0.037
proteolysis GO:0006508 192 0.036
muscle structure development GO:0061061 224 0.036
epithelial tube morphogenesis GO:0060562 88 0.036
positive regulation of ras protein signal transduction GO:0046579 43 0.036
protein maturation GO:0051604 71 0.035
photoreceptor cell fate commitment GO:0046552 41 0.035
eye photoreceptor cell development GO:0042462 81 0.035
cellularization GO:0007349 90 0.035
establishment or maintenance of polarity of follicular epithelium GO:0016334 26 0.035
negative regulation of epithelial cell proliferation GO:0050680 4 0.035
regulation of hydrolase activity GO:0051336 97 0.035
positive regulation of ras gtpase activity GO:0032320 36 0.034
spermatid differentiation GO:0048515 114 0.034
cell cell junction organization GO:0045216 55 0.034
mitotic spindle organization GO:0007052 220 0.034
regulation of molecular function GO:0065009 217 0.034
Human Mouse Rat Worm
regulation of protein modification process GO:0031399 112 0.034
Human Mouse Rat
intracellular protein transport GO:0006886 104 0.033
reproductive behavior GO:0019098 122 0.033
axis elongation GO:0003401 3 0.033
regulation of protein phosphorylation GO:0001932 64 0.033
Human Mouse Rat
negative regulation of mapk cascade GO:0043409 23 0.032
positive regulation of biosynthetic process GO:0009891 316 0.032
Rat
gonad development GO:0008406 50 0.032
eye morphogenesis GO:0048592 260 0.032
chemical homeostasis GO:0048878 92 0.032
regulation of anatomical structure size GO:0090066 163 0.032
Rat
stress activated mapk cascade GO:0051403 52 0.032
synaptic vesicle localization GO:0097479 53 0.032
negative regulation of cellular metabolic process GO:0031324 382 0.031
regulation of cell projection organization GO:0031344 92 0.031
regulation of map kinase activity GO:0043405 17 0.031
Human Mouse Rat
positive regulation of purine nucleotide metabolic process GO:1900544 55 0.031
regulation of behavior GO:0050795 75 0.031
regulation of vesicle mediated transport GO:0060627 59 0.030
gtp metabolic process GO:0046039 72 0.030
regulation of nucleoside metabolic process GO:0009118 50 0.030
positive regulation of transcription dna templated GO:0045893 266 0.030
organelle localization GO:0051640 148 0.030
regulation of protein polymerization GO:0032271 28 0.030
hematopoietic progenitor cell differentiation GO:0002244 1 0.030
organophosphate metabolic process GO:0019637 195 0.030
regulation of localization GO:0032879 275 0.030
actin filament organization GO:0007015 126 0.030
regulation of nucleotide catabolic process GO:0030811 48 0.030
regulation of cell shape GO:0008360 113 0.030
regulation of immune system process GO:0002682 176 0.029
negative regulation of programmed cell death GO:0043069 72 0.029
regulation of catalytic activity GO:0050790 185 0.029
Human Mouse Rat Worm
melanin metabolic process GO:0006582 47 0.028
hematopoietic or lymphoid organ development GO:0048534 57 0.028
cytoskeleton dependent cytokinesis GO:0061640 81 0.028
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.028
phosphatidylinositol mediated signaling GO:0048015 4 0.027
regulation of protein complex assembly GO:0043254 42 0.027
response to oxygen containing compound GO:1901700 200 0.026
Rat
regulation of cell death GO:0010941 173 0.026
negative regulation of synapse assembly GO:0051964 39 0.026
aging GO:0007568 143 0.026
Rat
larval development GO:0002164 104 0.026
chromosome segregation GO:0007059 157 0.026
regulation of epidermal growth factor receptor signaling pathway GO:0042058 42 0.026
positive regulation of neurogenesis GO:0050769 41 0.026
cellular ketone metabolic process GO:0042180 24 0.026
embryonic axis specification GO:0000578 107 0.026
establishment or maintenance of cytoskeleton polarity GO:0030952 44 0.026
single organism intracellular transport GO:1902582 207 0.025
dna metabolic process GO:0006259 227 0.025
Rat
organonitrogen compound biosynthetic process GO:1901566 117 0.025
homeostatic process GO:0042592 199 0.025
positive regulation of purine nucleotide catabolic process GO:0033123 46 0.025
negative regulation of phosphorus metabolic process GO:0010563 45 0.025
head development GO:0060322 135 0.024
morphogenesis of follicular epithelium GO:0016333 36 0.024
regulation of cell morphogenesis involved in differentiation GO:0010769 61 0.024
mitotic cytokinesis GO:0000281 50 0.024
establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 41 0.023
regulation of cellular ketone metabolic process GO:0010565 3 0.023
jnk cascade GO:0007254 50 0.023
response to uv GO:0009411 24 0.023
synapse assembly GO:0007416 143 0.023
negative regulation of erk1 and erk2 cascade GO:0070373 3 0.023
regulation of secretion by cell GO:1903530 39 0.023
eggshell formation GO:0030703 105 0.023
regulation of immune response GO:0050776 118 0.022
positive regulation of organelle organization GO:0010638 65 0.022
regulation of gtp catabolic process GO:0033124 44 0.022
regulation of nucleotide metabolic process GO:0006140 62 0.022
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 4 0.022
regulation of peptidyl tyrosine phosphorylation GO:0050730 10 0.022
positive regulation of protein serine threonine kinase activity GO:0071902 15 0.022
Human Mouse Rat
regulation of gtpase activity GO:0043087 44 0.021
nucleocytoplasmic transport GO:0006913 72 0.021
digestive tract development GO:0048565 149 0.021
positive regulation of cellular catabolic process GO:0031331 95 0.021
cellular macromolecular complex assembly GO:0034622 153 0.021
regulation of axonogenesis GO:0050770 32 0.021
regulation of transferase activity GO:0051338 58 0.021
Human Mouse Rat Worm
establishment or maintenance of neuroblast polarity GO:0045196 8 0.021
meiotic chromosome segregation GO:0045132 59 0.020
adherens junction assembly GO:0034333 11 0.020
germarium derived egg chamber formation GO:0007293 101 0.020
embryo development ending in birth or egg hatching GO:0009792 152 0.020
cellular amine metabolic process GO:0044106 12 0.020
positive regulation of gtpase activity GO:0043547 43 0.020
positive regulation of catalytic activity GO:0043085 118 0.020
Human Mouse Rat Worm
tripartite regional subdivision GO:0007351 103 0.020
negative regulation of receptor activity GO:2000272 3 0.020
regulation of protein serine threonine kinase activity GO:0071900 25 0.019
Human Mouse Rat
regulation of sister chromatid segregation GO:0033045 28 0.019
protein processing GO:0016485 68 0.019
regulation of gene expression epigenetic GO:0040029 128 0.019
cell adhesion GO:0007155 136 0.019
Mouse
cellular protein complex assembly GO:0043623 71 0.019
response to organic cyclic compound GO:0014070 89 0.019
Rat
positive regulation of nucleic acid templated transcription GO:1903508 266 0.019
cellular component disassembly GO:0022411 46 0.019
positive regulation of rna metabolic process GO:0051254 271 0.019
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 54 0.019
positive regulation of protein complex assembly GO:0031334 22 0.018
peptidyl tyrosine phosphorylation GO:0018108 24 0.018
organelle transport along microtubule GO:0072384 7 0.018
cellular protein catabolic process GO:0044257 83 0.018
ubiquitin dependent protein catabolic process GO:0006511 78 0.018
response to x ray GO:0010165 8 0.018
pole plasm oskar mrna localization GO:0045451 46 0.018
blood circulation GO:0008015 26 0.018
Rat
regulation of synapse assembly GO:0051963 94 0.018
digestive system development GO:0055123 149 0.018
oocyte construction GO:0007308 112 0.018
regulation of response to external stimulus GO:0032101 115 0.017
negative regulation of ras protein signal transduction GO:0046580 13 0.017
female meiotic division GO:0007143 70 0.017
response to wounding GO:0009611 94 0.017
mitotic sister chromatid separation GO:0051306 30 0.017
filopodium assembly GO:0046847 33 0.017
regulation of system process GO:0044057 36 0.017
Rat
compound eye development GO:0048749 307 0.017
positive regulation of rho gtpase activity GO:0032321 19 0.017
regulation of lamellipodium assembly GO:0010591 15 0.017
regulation of programmed cell death GO:0043067 152 0.016
response to lipid GO:0033993 38 0.016
Rat
negative regulation of phosphate metabolic process GO:0045936 45 0.016
negative regulation of phosphorylation GO:0042326 35 0.016
protein catabolic process GO:0030163 101 0.016
microtubule organizing center organization GO:0031023 168 0.016
actin polymerization or depolymerization GO:0008154 31 0.016
cellular response to growth factor stimulus GO:0071363 30 0.016
cell junction assembly GO:0034329 42 0.016
regulation of cell cycle GO:0051726 291 0.016
jak stat cascade GO:0007259 49 0.016

Shc disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.073
disease of cellular proliferation DOID:14566 0 0.052
cancer DOID:162 0 0.049
nervous system disease DOID:863 0 0.028
organ system cancer DOID:0050686 0 0.020